{"id":"https://openalex.org/W7154697339","doi":"https://doi.org/10.55606/termometer.v4i2.5974","title":"Strategi Optimasi Self Nanoemulsifying Drug Delivery System (SNEDDS) Menggunakan Simplex Lattice Design untuk Meningkatkan Karakteristik Fisikokimia: Artikel Tinjauan","display_name":"Strategi Optimasi Self Nanoemulsifying Drug Delivery System (SNEDDS) Menggunakan Simplex Lattice Design untuk Meningkatkan Karakteristik Fisikokimia: Artikel Tinjauan","publication_year":2026,"publication_date":"2026-04-17","ids":{"openalex":"https://openalex.org/W7154697339","doi":"https://doi.org/10.55606/termometer.v4i2.5974"},"language":"en","primary_location":{"id":"doi:10.55606/termometer.v4i2.5974","doi":"https://doi.org/10.55606/termometer.v4i2.5974","is_oa":true,"landing_page_url":"https://doi.org/10.55606/termometer.v4i2.5974","pdf_url":"https://ejurnal.politeknikpratama.ac.id/index.php/Termometer/article/download/5974/5292","source":{"id":"https://openalex.org/S4387286103","display_name":"Termometer Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran","issn_l":"2964-9668","issn":["2964-9668","2964-9676"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ejurnal.politeknikpratama.ac.id/index.php/Termometer/article/download/5974/5292","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133838784","display_name":"Triana Anggraini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12833781","display_name":"Lampung University","ror":"https://ror.org/05wtz9f44","country_code":"ID","type":"education","lineage":["https://openalex.org/I12833781"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Triana Anggraini","raw_affiliation_strings":["Universitas Lampung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Lampung","institution_ids":["https://openalex.org/I12833781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124911847","display_name":"Afriyani Afriyani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12833781","display_name":"Lampung University","ror":"https://ror.org/05wtz9f44","country_code":"ID","type":"education","lineage":["https://openalex.org/I12833781"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Afriyani Afriyani","raw_affiliation_strings":["Universitas Lampung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Lampung","institution_ids":["https://openalex.org/I12833781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073074540","display_name":"Atri Sri Ulandari","orcid":"https://orcid.org/0000-0001-9906-0414","observed_orcids":["https://orcid.org/0000-0001-9906-0414"]},"institutions":[{"id":"https://openalex.org/I12833781","display_name":"Lampung University","ror":"https://ror.org/05wtz9f44","country_code":"ID","type":"education","lineage":["https://openalex.org/I12833781"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Atri Sri Ulandari","raw_affiliation_strings":["Universitas Lampung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Lampung","institution_ids":["https://openalex.org/I12833781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074010272","display_name":"Zulpakor Oktoba","orcid":"https://orcid.org/0000-0001-5478-8751","observed_orcids":["https://orcid.org/0000-0001-5478-8751"]},"institutions":[{"id":"https://openalex.org/I12833781","display_name":"Lampung University","ror":"https://ror.org/05wtz9f44","country_code":"ID","type":"education","lineage":["https://openalex.org/I12833781"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Zulpakor Oktoba","raw_affiliation_strings":["Universitas Lampung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Lampung","institution_ids":["https://openalex.org/I12833781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12833781"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"2","first_page":"27","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-nanoemulsifying-drug-delivery-system","display_name":"self-nanoemulsifying drug delivery system","score":0.9850000143051147},{"id":"https://openalex.org/keywords/simplex-lattice-design","display_name":"simplex lattice design","score":0.925000011920929},{"id":"https://openalex.org/keywords/formulation-optimization","display_name":"formulation optimization","score":0.9729999899864197},{"id":"https://openalex.org/keywords/physicochemical-characterization","display_name":"physicochemical characterization","score":0.7170000076293945},{"id":"https://openalex.org/keywords/droplet-size","display_name":"droplet size","score":0.8240000009536743},{"id":"https://openalex.org/keywords/polydispersity-index","display_name":"polydispersity index","score":0.875},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.9990000128746033},{"id":"https://openalex.org/keywords/emulsification-time","display_name":"emulsification time","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lipid-based-drug-delivery-systems","display_name":"lipid-based drug delivery","score":0.765999972820282},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lipophilic-drugs","display_name":"lipophilic drugs","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6930000185966492},{"id":"https://openalex.org/C144521790","wikidata":"https://www.wikidata.org/wiki/Q134164","display_name":"Simplex algorithm","level":3,"score":0.5742999911308289},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5620999932289124},{"id":"https://openalex.org/C62438384","wikidata":"https://www.wikidata.org/wiki/Q331350","display_name":"Simplex","level":2,"score":0.5562999844551086},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.5515999794006348},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5306000113487244},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.48089998960494995},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.4438999891281128},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.3962000012397766},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3666999936103821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34290000796318054},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3370000123977661},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29120001196861267},{"id":"https://openalex.org/C31352089","wikidata":"https://www.wikidata.org/wiki/Q3750474","display_name":"Systems design","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C2781204021","wikidata":"https://www.wikidata.org/wiki/Q6497091","display_name":"Lattice (music)","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C186394612","wikidata":"https://www.wikidata.org/wiki/Q7098942","display_name":"Optimal design","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2678000032901764}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55606/termometer.v4i2.5974","doi":"https://doi.org/10.55606/termometer.v4i2.5974","is_oa":true,"landing_page_url":"https://doi.org/10.55606/termometer.v4i2.5974","pdf_url":"https://ejurnal.politeknikpratama.ac.id/index.php/Termometer/article/download/5974/5292","source":{"id":"https://openalex.org/S4387286103","display_name":"Termometer Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran","issn_l":"2964-9668","issn":["2964-9668","2964-9676"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55606/termometer.v4i2.5974","doi":"https://doi.org/10.55606/termometer.v4i2.5974","is_oa":true,"landing_page_url":"https://doi.org/10.55606/termometer.v4i2.5974","pdf_url":"https://ejurnal.politeknikpratama.ac.id/index.php/Termometer/article/download/5974/5292","source":{"id":"https://openalex.org/S4387286103","display_name":"Termometer Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran","issn_l":"2964-9668","issn":["2964-9668","2964-9676"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7154697339.pdf","grobid_xml":"https://content.openalex.org/works/W7154697339.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2808925180","https://openalex.org/W2981437837","https://openalex.org/W3082301689","https://openalex.org/W3202075988","https://openalex.org/W4210391213","https://openalex.org/W4281609143","https://openalex.org/W4285455219","https://openalex.org/W4298108638","https://openalex.org/W4309073406","https://openalex.org/W4383295310","https://openalex.org/W4392407444","https://openalex.org/W4401989884","https://openalex.org/W4404984473","https://openalex.org/W4412185435"],"related_works":["https://openalex.org/W3207157072","https://openalex.org/W3082301689","https://openalex.org/W7217860699","https://openalex.org/W4286603659","https://openalex.org/W2166547808","https://openalex.org/W7164140719","https://openalex.org/W2078063658","https://openalex.org/W7160912763","https://openalex.org/W7162434419","https://openalex.org/W3178363231"],"abstract_inverted_index":{"The":[0,109],"Self-Nanoemulsifying":[1],"Drug":[2],"Delivery":[3],"System":[4],"(SNEDDS)":[5],"is":[6,25],"a":[7,31,63,150],"drug":[8,191],"delivery":[9,192],"system":[10,175],"developed":[11],"to":[12,29,137,183,194],"enhance":[13,195],"the":[14,43,52,78,90,97,104,114,117,187,196],"solubility":[15],"and":[16,33,58,74,106,145,152,169,174,199],"bioavailability":[17,200],"of":[18,22,37,55,93,116,126,147,189,201],"lipophilic":[19],"compounds.":[20],"Optimization":[21],"SNEDDS":[23,161],"formulation":[24],"an":[26],"essential":[27],"step":[28],"obtain":[30],"stable":[32,151],"efficient":[34],"system,":[35],"one":[36],"which":[38],"can":[39,165],"be":[40,184],"achieved":[41],"using":[42,77],"Simplex":[44],"Lattice":[45],"Design":[46],"(SLD)":[47],"method":[48,119,179],"that":[49,113],"mathematically":[50],"determines":[51],"optimal":[53],"composition":[54],"oil,":[56],"surfactant,":[57],"co-surfactant.":[59],"This":[60],"study":[61],"employed":[62],"narrative":[64],"review":[65,110],"approach":[66],"by":[67],"collecting":[68],"literature":[69,98],"from":[70,135],"Google":[71],"Scholar,":[72],"ScienceDirect,":[73],"NCBI":[75],"databases":[76],"keywords":[79],"\u201cSNEDDS":[80],"AND":[81,85,87],"simplex":[82],"lattice":[83],"design":[84],"optimization":[86],"physicochemical\u201d":[88],"within":[89],"publication":[91],"range":[92],"2016-2025.":[94],"Based":[95],"on":[96],"screening,":[99],"five":[100],"relevan":[101],"articles":[102],"met":[103],"inclusion":[105],"exclusion":[107],"criteria.":[108],"results":[111],"showed":[112],"application":[115],"SLD":[118,155],"consistently":[120],"produced":[121],"formulations":[122,162],"with":[123],"droplet":[124],"sizes":[125],"16-200":[127],"nm,":[128],"PDI":[129],"<0.3,":[130],"zeta":[131],"potential":[132,182],"values":[133],"ranging":[134],"-31":[136],"-61":[138],"mV,":[139],"emulsification":[140],"time":[141,168],"between":[142],"8-47":[143],"seconds,":[144],"%transmittance":[146],"95-98%,":[148],"indicating":[149],"homogeneous":[153],"system.":[154],"has":[156,180],"proven":[157],"effective":[158],"in":[159,186],"optimizing":[160],"as":[163],"it":[164],"reduce":[166],"research":[167],"cost":[170],"while":[171],"improving":[172],"efficiency":[173],"stability.":[176],"Therefore,":[177],"this":[178],"great":[181],"applied":[185],"development":[188],"lipid-based":[190],"systems":[193],"physicochemical":[197],"characteristics":[198],"liphophilic":[202],"drugs.":[203]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-18T00:00:00"}