{"id":"https://openalex.org/W7154683003","doi":"https://doi.org/10.1158/1538-7445.am2026-sy23-02","title":"Abstract SY23-02: Tumor-derived mitochondrial transfer dictates immune cell fate and therapeutic vulnerability","display_name":"Abstract SY23-02: Tumor-derived mitochondrial transfer dictates immune cell fate and therapeutic vulnerability","publication_year":2026,"publication_date":"2026-04-17","ids":{"openalex":"https://openalex.org/W7154683003","doi":"https://doi.org/10.1158/1538-7445.am2026-sy23-02"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2026-sy23-02","doi":"https://doi.org/10.1158/1538-7445.am2026-sy23-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-sy23-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071703898","display_name":"Yosuke Togashi","orcid":"https://orcid.org/0000-0001-9910-0164","observed_orcids":["https://orcid.org/0000-0001-9910-0164"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yosuke Togashi","raw_affiliation_strings":["Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071703898"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"8_Supplement","first_page":"SY23","last_page":"02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-transfer","display_name":"mitochondrial transfer","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.7649999856948853},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.906000018119812},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tunneling-nanotubes","display_name":"tunneling nanotubes","score":1.0},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5460000038146973},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.37700000405311584},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7670000195503235},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7457000017166138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6710000038146973},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49810001254081726},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48489999771118164},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.45080000162124634},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4345000088214874},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4147000014781952},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C111491248","wikidata":"https://www.wikidata.org/wiki/Q18033821","display_name":"DNAJA3","level":5,"score":0.349700003862381},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.3483000099658966},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3366999924182892},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.3068999946117401},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27379998564720154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27140000462532043},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2026-sy23-02","doi":"https://doi.org/10.1158/1538-7445.am2026-sy23-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-sy23-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Immune":[1],"checkpoint":[2],"inhibitors":[3],"(ICIs)":[4],"function":[5],"by":[6,67,79],"reactivating":[7],"exhausted":[8],"T":[9,24,86],"cells":[10],"in":[11,32,37,49,69,107,114],"tumor-infiltrating":[12],"lymphocytes":[13],"(TILs).":[14],"Given":[15],"that":[16,61],"mitochondrial":[17,29,55,92,129,151,165,185],"dysfunction":[18,93],"is":[19],"a":[20,168],"known":[21],"driver":[22],"of":[23,40,104,137,170,197],"cell":[25,87,172,189],"exhaustion,":[26],"we":[27],"sequenced":[28],"DNA":[30],"(mtDNA)":[31],"TILs":[33],"and":[34,82,97,144,155,191,212],"identified":[35],"mutations":[36,43,106],"approximately":[38],"40%":[39],"cases.":[41],"Many":[42],"were":[44,65,120],"also":[45,121],"identical":[46],"to":[47,123,158,177],"those":[48],"paired":[50],"tumor":[51,63,99,108],"cells,":[52,125],"suggesting":[53],"inter-cellular":[54],"transfer.":[56],"In":[57,89],"vitro":[58],"assays":[59],"confirmed":[60],"labeled":[62],"mitochondria":[64,119,139],"internalized":[66],"TILs,":[68],"some":[70],"cases":[71],"reaching":[72],"mutant":[73,76,138,150],"homoplasmy.":[74],"The":[75],"transfer,":[77],"mediated":[78],"extracellular":[80],"vesicles":[81],"tunneling":[83],"nanotubes,":[84],"impaired":[85,98],"functions.":[88],"vivo,":[90],"such":[91],"compromised":[94],"anti-PD-1":[95],"efficacy":[96],"rejection.":[100],"Clinically,":[101],"the":[102,135,198],"presence":[103],"mtDNA":[105],"tissues":[109],"correlated":[110],"with":[111],"shorter":[112],"survival":[113],"ICI-treated":[115],"patients.":[116],"Furthermore,":[117],"tumor-derived":[118,164],"transferred":[122],"myeloid":[124],"including":[126],"macrophages.":[127],"While":[128],"transfer":[130,136,152,166,186],"generally":[131],"promoted":[132],"macrophage":[133,147],"maturation,":[134],"induced":[140],"hypoxia/VEGFA-enriched,":[141],"glycolysis-biased":[142],"programs":[143],"expanded":[145],"pro-angiogenic":[146],"subsets.":[148],"Functionally,":[149],"increased":[153],"neovascularization":[154],"sensitized":[156],"tumors":[157],"anti-angiogenic":[159],"therapy.":[160],"These":[161],"findings":[162],"reveal":[163],"as":[167],"determinant":[169],"immune":[171,188],"fate,":[173],"linking":[174],"organelle":[175],"genetics":[176],"therapeutic":[178,192],"vulnerabilities.":[179],"Citation":[180],"Format:":[181],"Yosuke":[182],"Togashi.":[183],"Tumor-derived":[184],"dictates":[187],"fate":[190],"vulnerability":[193],"[abstract].":[194],"In:":[195],"Proceedings":[196],"American":[199],"Association":[200],"for":[201],"Cancer":[202,224],"Research":[203],"Annual":[204],"Meeting":[205],"2026;":[206],"Part":[207],"2":[208],"(Late-Breaking,":[209],"Clinical":[210],"Trial,":[211],"Invited":[213],"Abstracts);":[214],"2026":[215],"Apr":[216],"17-22;":[217],"San":[218],"Diego,":[219],"CA.":[220],"Philadelphia":[221],"(PA):":[222],"AACR;":[223],"Res":[225],"2026;86(8_Suppl):Abstract":[226],"nr":[227],"SY23-02.":[228]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-04-18T00:00:00"}