{"id":"https://openalex.org/W7154580452","doi":"https://doi.org/10.64898/2026.04.13.718278","title":"Small-molecule IGF1R inhibitors extend healthspan in a mouse model","display_name":"Small-molecule IGF1R inhibitors extend healthspan in a mouse model","publication_year":2026,"publication_date":"2026-04-15","ids":{"openalex":"https://openalex.org/W7154580452","doi":"https://doi.org/10.64898/2026.04.13.718278","pmid":"https://pubmed.ncbi.nlm.nih.gov/42039448"},"language":"en","primary_location":{"id":"doi:10.64898/2026.04.13.718278","doi":"https://doi.org/10.64898/2026.04.13.718278","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.13.718278","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.04.13.718278","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133747916","display_name":"Yulia Balandina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulia Balandina","raw_affiliation_strings":["ReGENE LLC, Belchertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ReGENE LLC, Belchertown, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133758432","display_name":"Tom Stadnikov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Stadnikov","raw_affiliation_strings":["ReGENE LLC, Belchertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ReGENE LLC, Belchertown, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027471457","display_name":"Gregory S. Basarab","orcid":"https://orcid.org/0000-0001-5684-6046","observed_orcids":["https://orcid.org/0000-0001-5684-6046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory Basarab","raw_affiliation_strings":["ReGENE LLC, Belchertown, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-5684-6046","affiliations":[{"raw_affiliation_string":"ReGENE LLC, Belchertown, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033369594","display_name":"Charles J. Eyermann","orcid":"https://orcid.org/0000-0001-8658-8084","observed_orcids":["https://orcid.org/0000-0001-8658-8084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles J. Eyermann","raw_affiliation_strings":["ReGENE LLC, Belchertown, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-8658-8084","affiliations":[{"raw_affiliation_string":"ReGENE LLC, Belchertown, MA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002597398","display_name":"Alexander Suvorov","orcid":"https://orcid.org/0000-0002-2757-5897","observed_orcids":["https://orcid.org/0000-0002-2757-5897"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Suvorov","raw_affiliation_strings":["ReGENE LLC, Belchertown, MA, USA","University of Massachusetts, Environmental Health Sciences, Amherst, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2757-5897","affiliations":[{"raw_affiliation_string":"ReGENE LLC, Belchertown, MA, USA","institution_ids":[]},{"raw_affiliation_string":"University of Massachusetts, Environmental Health Sciences, Amherst, MA, USA","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002597398"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf1r-inhibitors","display_name":"IGF1R inhibitors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.8529999852180481},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7900000214576721},{"id":"https://openalex.org/keywords/picropodophyllin","display_name":"picropodophyllin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.6129999756813049},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.8679999709129333},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gray-hair","display_name":"gray hair","score":0.8970000147819519},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.6660000085830688},{"id":"https://openalex.org/keywords/anti-aging-treatment","display_name":"anti-aging therapy","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.6980000138282776},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.6858999729156494},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.5819000005722046},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5115000009536743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46299999952316284},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46000000834465027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4528000056743622},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4140999913215637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4047999978065491},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C2779403534","wikidata":"https://www.wikidata.org/wiki/Q2944360","display_name":"Centenarian","level":3,"score":0.3801000118255615},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.3637999892234802},{"id":"https://openalex.org/C2777433710","wikidata":"https://www.wikidata.org/wiki/Q5609571","display_name":"Grip strength","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.3499000072479248},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.34549999237060547},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.04.13.718278","doi":"https://doi.org/10.64898/2026.04.13.718278","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.13.718278","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42039448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42039448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13104936","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13104936/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.04.13.718278","doi":"https://doi.org/10.64898/2026.04.13.718278","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.13.718278","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000884124","display_name":"Targeting Type 3 Diabetes (T3D) Mechanism of Alzheimer's Disease (AD) and AD-Related Dementias","funder_award_id":"5r43ag085738-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W128151115","https://openalex.org/W1511210758","https://openalex.org/W1513756754","https://openalex.org/W1519109490","https://openalex.org/W1577577364","https://openalex.org/W1585420775","https://openalex.org/W1812816875","https://openalex.org/W1916328219","https://openalex.org/W1966537913","https://openalex.org/W1969967075","https://openalex.org/W1985425785","https://openalex.org/W1987985846","https://openalex.org/W1989657978","https://openalex.org/W1995375315","https://openalex.org/W2016670297","https://openalex.org/W2031373028","https://openalex.org/W2040826404","https://openalex.org/W2041780807","https://openalex.org/W2050096609","https://openalex.org/W2055618066","https://openalex.org/W2057913302","https://openalex.org/W2062306706","https://openalex.org/W2077180087","https://openalex.org/W2079261494","https://openalex.org/W2091880370","https://openalex.org/W2096452837","https://openalex.org/W2115147895","https://openalex.org/W2128615772","https://openalex.org/W2143302321","https://openalex.org/W2156003677","https://openalex.org/W2410614972","https://openalex.org/W2424236546","https://openalex.org/W2607028609","https://openalex.org/W2610763259","https://openalex.org/W2799890768","https://openalex.org/W2807914406","https://openalex.org/W2808892246","https://openalex.org/W2901225686","https://openalex.org/W2914710045","https://openalex.org/W2914950669","https://openalex.org/W2992097690","https://openalex.org/W3032648743","https://openalex.org/W3046678438","https://openalex.org/W3121447888","https://openalex.org/W3165641760","https://openalex.org/W3189702222","https://openalex.org/W4214704144","https://openalex.org/W4282939243","https://openalex.org/W4283818364","https://openalex.org/W4285008054","https://openalex.org/W4308186175","https://openalex.org/W4319333745","https://openalex.org/W4379208082","https://openalex.org/W4386407074","https://openalex.org/W4401470424","https://openalex.org/W4402169297"],"related_works":[],"abstract_inverted_index":{"Antagonistic":[0],"pleiotropy":[1],"of":[2,27,78,187,191],"the":[3,153,157,161,188],"IGF-1":[4],"signaling":[5],"cascade":[6],"is":[7,30],"well":[8,86],"recognized,":[9],"as":[10,46,85,87,206],"it":[11],"promotes":[12],"growth":[13],"and":[14,19,54,80,82,106,118,125,196,215],"development":[15],"at":[16,75],"younger":[17],"ages":[18],"delays":[20],"aging":[21],"later":[22],"in":[23,33,104,109,116,129,132,140,152,160,167,221],"life.":[24],"The":[25],"goal":[26],"this":[28,222],"study":[29,223],"to":[31],"test":[32],"a":[34,170,207],"mouse":[35],"longevity":[36],"experiment":[37],"whether":[38],"orally":[39],"delivered":[40],"small-molecule":[41,201],"IGF1R":[42,64,202],"inhibitors":[43,203],"have":[44,224],"promise":[45,205],"an":[47],"anti-aging":[48,231],"therapy.":[49],"C57BL/6":[50],"mice":[51,57],"(25":[52],"male":[53],"25":[55],"female":[56,133],"per":[58],"treatment)":[59],"were":[60,89,136,150],"treated":[61],"with":[62,181],"selective":[63],"inhibitors,":[65],"picropodophyllin":[66],"(PPP)":[67],"or":[68],"5-[3-(phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[3-d]pyrimidin-4-amine":[69],"(NVP-ADW742),":[70],"via":[71],"powdered":[72],"diets":[73],"starting":[74],"13":[76],"months":[77],"age,":[79],"physiological":[81],"behavioral":[83],"parameters,":[84],"survival,":[88],"assessed.":[90],"Both":[91],"compounds":[92],"protected":[93,126],"both":[94,110,218],"sexes":[95],"from":[96],"short-term":[97],"memory":[98],"decline;":[99],"reduced":[100,123],"systolic":[101],"blood":[102],"pressure":[103],"males":[105],"pulse":[107],"rate":[108],"sexes;":[111],"rescued":[112],"declining":[113],"glucose":[114],"tolerance":[115],"males;":[117],"abolished":[119],"grey":[120],"hair":[121],"development,":[122],"frailty,":[124],"against":[127],"decline":[128],"grip":[130],"strength":[131],"mice.":[134],"There":[135],"no":[137],"sex":[138],"differences":[139,147],"survival":[141,158],"curves":[142],"within":[143],"groups.":[144],"No":[145],"significant":[146],"between":[148],"groups":[149],"observed":[151],"Kaplan-Meier":[154],"analysis.":[155],"However,":[156],"curve":[159],"NVP-ADW742":[162,192],"group":[163],"was":[164,179],"\"squarer\"":[165],"than":[166],"controls,":[168],"indicating":[169],"93-day":[171],"longer":[172],"healthspan":[173],"(p":[174],"=":[175],"0.02).":[176],"PPP":[177],"treatment":[178],"associated":[180],"toxicity":[182],"(GI":[183],"bleeding).":[184],"Additional":[185],"analysis":[186],"drug":[189],"likeness":[190],"demonstrated":[193],"potential":[194],"cardiotoxicity":[195],"brain":[197],"bioaccumulation.":[198],"To":[199],"conclude,":[200],"hold":[204],"therapy":[208],"that":[209,227],"may":[210,228],"improve":[211],"human":[212],"health":[213],"span":[214],"lifespan;":[216],"however,":[217],"molecules":[219],"tested":[220],"side":[225],"effects":[226],"outweigh":[229],"their":[230],"effects.":[232]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-04-17T00:00:00"}
