{"id":"https://openalex.org/W7154472004","doi":"https://doi.org/10.1016/j.jddst.2026.108331","title":"Recent advances in dry eye disease: Pathophysiology, diagnostics, and innovative drug delivery approaches","display_name":"Recent advances in dry eye disease: Pathophysiology, diagnostics, and innovative drug delivery approaches","publication_year":2026,"publication_date":"2026-04-15","ids":{"openalex":"https://openalex.org/W7154472004","doi":"https://doi.org/10.1016/j.jddst.2026.108331"},"language":"en","primary_location":{"id":"doi:10.1016/j.jddst.2026.108331","doi":"https://doi.org/10.1016/j.jddst.2026.108331","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2026.108331","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006621618","display_name":"Pinal Chaudhari","orcid":"https://orcid.org/0000-0002-1480-2237","observed_orcids":["https://orcid.org/0000-0002-1480-2237"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Pinal Chaudhari","raw_affiliation_strings":["Amity Institute of Pharmacy, Amity University Punjab, Mohali, 140306, India"],"raw_orcid":"https://orcid.org/0000-0002-1480-2237","affiliations":[{"raw_affiliation_string":"Amity Institute of Pharmacy, Amity University Punjab, Mohali, 140306, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125121662","display_name":"Abhijith. K. Shaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhijith Shaji","raw_affiliation_strings":["Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057585482","display_name":"Shaila Angela Lewis","orcid":"https://orcid.org/0000-0002-2884-0015","observed_orcids":["https://orcid.org/0000-0002-2884-0015"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shaila Lewis","raw_affiliation_strings":["Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112588951","display_name":"Sonima Prasad","orcid":"https://orcid.org/0000-0002-2202-3639","observed_orcids":["https://orcid.org/0000-0002-2202-3639"]},"institutions":[{"id":"https://openalex.org/I4210139590","display_name":"Institute of Chartered Financial Analysts of India University, Jaipur","ror":"https://ror.org/03vr3gq96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210139590"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sonima Prasad","raw_affiliation_strings":["ICFAI School of Pharmaceutical Sciences, The ICFAI University, Jaipur, Rajasthan, 302021, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICFAI School of Pharmaceutical Sciences, The ICFAI University, Jaipur, Rajasthan, 302021, India","institution_ids":["https://openalex.org/I4210139590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133639181","display_name":"Priyanka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Sharma","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India","institution_ids":["https://openalex.org/I74319210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021147829","display_name":"Avneet Kour","orcid":"https://orcid.org/0000-0002-6870-3517","observed_orcids":["https://orcid.org/0000-0002-6870-3517"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Avneet Kour","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India","institution_ids":["https://openalex.org/I74319210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006621618"],"corresponding_institution_ids":["https://openalex.org/I191972202"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"121","issue":null,"first_page":"108331","last_page":"108331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":1.0},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ocular-bioavailability","display_name":"ocular bioavailability","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/novel-therapeutic-agents","display_name":"novel therapeutic agents","score":0.6309999823570251},{"id":"https://openalex.org/keywords/digital-screen-use","display_name":"digital screen use","score":0.75},{"id":"https://openalex.org/keywords/eye-drops","display_name":"eye drops","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6963000297546387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5020999908447266},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4650000035762787},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.3540000021457672},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.2644999921321869},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.23880000412464142},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.23749999701976776}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jddst.2026.108331","doi":"https://doi.org/10.1016/j.jddst.2026.108331","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2026.108331","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":250,"referenced_works":["https://openalex.org/W247771020","https://openalex.org/W888421902","https://openalex.org/W1435962211","https://openalex.org/W1523354060","https://openalex.org/W1530639720","https://openalex.org/W1601530247","https://openalex.org/W1957004931","https://openalex.org/W1965219244","https://openalex.org/W1966022925","https://openalex.org/W1966999230","https://openalex.org/W1971840952","https://openalex.org/W1972501597","https://openalex.org/W1974782875","https://openalex.org/W1979323310","https://openalex.org/W1980833693","https://openalex.org/W1983067328","https://openalex.org/W1984309285","https://openalex.org/W1984709649","https://openalex.org/W1989291233","https://openalex.org/W1995636668","https://openalex.org/W1998005154","https://openalex.org/W1998747151","https://openalex.org/W2000659908","https://openalex.org/W2002102189","https://openalex.org/W2004352917","https://openalex.org/W2004684388","https://openalex.org/W2008014733","https://openalex.org/W2008448108","https://openalex.org/W2008730765","https://openalex.org/W2010052599","https://openalex.org/W2013281526","https://openalex.org/W2014144868","https://openalex.org/W2017984480","https://openalex.org/W2019467202","https://openalex.org/W2019761152","https://openalex.org/W2021491704","https://openalex.org/W2023378519","https://openalex.org/W2024484902","https://openalex.org/W2024921065","https://openalex.org/W2027735186","https://openalex.org/W2027853781","https://openalex.org/W2027975733","https://openalex.org/W2032060118","https://openalex.org/W2036379334","https://openalex.org/W2042794878","https://openalex.org/W2045978101","https://openalex.org/W2048741183","https://openalex.org/W2049817960","https://openalex.org/W2050870367","https://openalex.org/W2055879989","https://openalex.org/W2056565496","https://openalex.org/W2056709743","https://openalex.org/W2058556985","https://openalex.org/W2058816841","https://openalex.org/W2064236528","https://openalex.org/W2065254628","https://openalex.org/W2065975423","https://openalex.org/W2066618391","https://openalex.org/W2068584868","https://openalex.org/W2069871523","https://openalex.org/W2070026700","https://openalex.org/W2070122680","https://openalex.org/W2070963101","https://openalex.org/W2071604294","https://openalex.org/W2071658063","https://openalex.org/W2073791489","https://openalex.org/W2088675292","https://openalex.org/W2089479073","https://openalex.org/W2089894237","https://openalex.org/W2090760171","https://openalex.org/W2093220756","https://openalex.org/W2096180690","https://openalex.org/W2112797831","https://openalex.org/W2128532429","https://openalex.org/W2129401613","https://openalex.org/W2141246891","https://openalex.org/W2150801281","https://openalex.org/W2162277824","https://openalex.org/W2163251275","https://openalex.org/W2167206966","https://openalex.org/W2167209244","https://openalex.org/W2176407061","https://openalex.org/W2184413367","https://openalex.org/W2184917771","https://openalex.org/W2223303194","https://openalex.org/W2241627328","https://openalex.org/W2242496409","https://openalex.org/W2293232340","https://openalex.org/W2296153481","https://openalex.org/W2298184967","https://openalex.org/W2316746946","https://openalex.org/W2322887915","https://openalex.org/W2329950081","https://openalex.org/W2333205243","https://openalex.org/W2430913327","https://openalex.org/W2481777962","https://openalex.org/W2492082046","https://openalex.org/W2521601013","https://openalex.org/W2531417318","https://openalex.org/W2541357500","https://openalex.org/W2557702725","https://openalex.org/W2574040535","https://openalex.org/W2584113495","https://openalex.org/W2596391620","https://openalex.org/W2604355945","https://openalex.org/W2605563843","https://openalex.org/W2616932792","https://openalex.org/W2621361010","https://openalex.org/W2735954633","https://openalex.org/W2737439597","https://openalex.org/W2737642784","https://openalex.org/W2737725878","https://openalex.org/W2737787547","https://openalex.org/W2739359388","https://openalex.org/W2739410682","https://openalex.org/W2747197238","https://openalex.org/W2759060967","https://openalex.org/W2762917366","https://openalex.org/W2779535358","https://openalex.org/W2784031181","https://openalex.org/W2789843372","https://openalex.org/W2802344932","https://openalex.org/W2896653471","https://openalex.org/W2900424219","https://openalex.org/W2902007513","https://openalex.org/W2903493717","https://openalex.org/W2905101120","https://openalex.org/W2914403907","https://openalex.org/W2918005780","https://openalex.org/W2919261402","https://openalex.org/W2945721120","https://openalex.org/W2947214495","https://openalex.org/W2965678854","https://openalex.org/W2969171940","https://openalex.org/W2972203500","https://openalex.org/W2982982994","https://openalex.org/W2985064232","https://openalex.org/W2985285467","https://openalex.org/W2990549024","https://openalex.org/W3006344946","https://openalex.org/W3010559933","https://openalex.org/W3012365685","https://openalex.org/W3021739351","https://openalex.org/W3036547471","https://openalex.org/W3036870694","https://openalex.org/W3047027365","https://openalex.org/W3082834524","https://openalex.org/W3088875869","https://openalex.org/W3101689783","https://openalex.org/W3107483346","https://openalex.org/W3118578035","https://openalex.org/W3128891592","https://openalex.org/W3133915727","https://openalex.org/W3134341495","https://openalex.org/W3134922238","https://openalex.org/W3155878425","https://openalex.org/W3163274996","https://openalex.org/W3172255251","https://openalex.org/W3196440973","https://openalex.org/W3198903385","https://openalex.org/W3200562110","https://openalex.org/W3200708931","https://openalex.org/W3207648359","https://openalex.org/W3207954711","https://openalex.org/W3210117516","https://openalex.org/W3212838083","https://openalex.org/W3217356099","https://openalex.org/W4200305309","https://openalex.org/W4200467235","https://openalex.org/W4206688902","https://openalex.org/W4207080391","https://openalex.org/W4213388826","https://openalex.org/W4214690685","https://openalex.org/W4220707929","https://openalex.org/W4224680750","https://openalex.org/W4225260819","https://openalex.org/W4229041002","https://openalex.org/W4229858891","https://openalex.org/W4253760541","https://openalex.org/W4280518442","https://openalex.org/W4283524876","https://openalex.org/W4283786572","https://openalex.org/W4286629432","https://openalex.org/W4293692903","https://openalex.org/W4293724774","https://openalex.org/W4296772255","https://openalex.org/W4297965258","https://openalex.org/W4301599914","https://openalex.org/W4303446532","https://openalex.org/W4303928092","https://openalex.org/W4307659318","https://openalex.org/W4308322103","https://openalex.org/W4311663425","https://openalex.org/W4313442383","https://openalex.org/W4315649339","https://openalex.org/W4316687599","https://openalex.org/W4318473868","https://openalex.org/W4319786112","https://openalex.org/W4320499627","https://openalex.org/W4321122484","https://openalex.org/W4362692277","https://openalex.org/W4362692290","https://openalex.org/W4378515493","https://openalex.org/W4379093921","https://openalex.org/W4380990559","https://openalex.org/W4381611392","https://openalex.org/W4385618161","https://openalex.org/W4386028989","https://openalex.org/W4390394959","https://openalex.org/W4391242066","https://openalex.org/W4391574080","https://openalex.org/W4391818379","https://openalex.org/W4392432781","https://openalex.org/W4392860052","https://openalex.org/W4393857803","https://openalex.org/W4395042710","https://openalex.org/W4396765628","https://openalex.org/W4398169030","https://openalex.org/W4398191354","https://openalex.org/W4399154160","https://openalex.org/W4399178654","https://openalex.org/W4400498118","https://openalex.org/W4401038108","https://openalex.org/W4401266738","https://openalex.org/W4401474234","https://openalex.org/W4402271896","https://openalex.org/W4402614818","https://openalex.org/W4403632202","https://openalex.org/W4403835754","https://openalex.org/W4403989453","https://openalex.org/W4405966027","https://openalex.org/W4406206641","https://openalex.org/W4406463817","https://openalex.org/W4406627570","https://openalex.org/W4407308404","https://openalex.org/W4408196784","https://openalex.org/W4409530083","https://openalex.org/W4410488858","https://openalex.org/W4410954137","https://openalex.org/W4411025867","https://openalex.org/W4411179693","https://openalex.org/W4411454152","https://openalex.org/W4411558259","https://openalex.org/W4412124918","https://openalex.org/W4412550312","https://openalex.org/W4416029450","https://openalex.org/W4416029510","https://openalex.org/W7117994691","https://openalex.org/W7119496044","https://openalex.org/W7121097948"],"related_works":["https://openalex.org/W4313398014","https://openalex.org/W4307659318","https://openalex.org/W7147510187","https://openalex.org/W4280518442","https://openalex.org/W4387424906","https://openalex.org/W4412849827","https://openalex.org/W7160907441","https://openalex.org/W4327952030","https://openalex.org/W4313472318","https://openalex.org/W2071604294"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-04-16T00:00:00"}