{"id":"https://openalex.org/W7154459751","doi":"https://doi.org/10.58564/aimcj3.1.2026.242","title":"Association of IL-6 and TNF-\u03b1 with IgA/IgG in Iraqi Patients with Multiple Sclerosis","display_name":"Association of IL-6 and TNF-\u03b1 with IgA/IgG in Iraqi Patients with Multiple Sclerosis","publication_year":2026,"publication_date":"2026-04-15","ids":{"openalex":"https://openalex.org/W7154459751","doi":"https://doi.org/10.58564/aimcj3.1.2026.242"},"language":"en","primary_location":{"id":"doi:10.58564/aimcj3.1.2026.242","doi":"https://doi.org/10.58564/aimcj3.1.2026.242","is_oa":true,"landing_page_url":"https://doi.org/10.58564/aimcj3.1.2026.242","pdf_url":"https://aimcj.aliraqia.edu.iq/index.php/pub/article/download/242/132","source":{"id":"https://openalex.org/S5407050341","display_name":"Al-Iraqia Medical College Journal","issn_l":"3104-4557","issn":["3104-4557","3104-4565"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Al-Iraqia Medical College Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aimcj.aliraqia.edu.iq/index.php/pub/article/download/242/132","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122080030","display_name":"Worood Younis Azawi","orcid":"https://orcid.org/0009-0008-3301-7286","observed_orcids":["https://orcid.org/0009-0008-3301-7286"]},"institutions":[{"id":"https://openalex.org/I4210115078","display_name":"Middle Technical University","ror":"https://ror.org/02fvkg758","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210115078"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Worood Younis Azawi","raw_affiliation_strings":["Balad Technical Institute, Middle Technical University, Salah Al-Din, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Balad Technical Institute, Middle Technical University, Salah Al-Din, Iraq","institution_ids":["https://openalex.org/I4210115078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5122080030"],"corresponding_institution_ids":["https://openalex.org/I4210115078"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"1","first_page":"14","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.996999979019165},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/immunoglobulin-a","display_name":"immunoglobulin A","score":0.9729999899864197},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9490000009536743},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7850000262260437},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/serum-cytokine-levels","display_name":"serum cytokine levels","score":0.8180000185966492},{"id":"https://openalex.org/keywords/iraqi-patients","display_name":"Iraqi patients","score":0.8140000104904175},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9269999861717224},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.7099999785423279},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7372999787330627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7202000021934509},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6312999725341797},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.623199999332428},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5576000213623047},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5189999938011169},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.44620001316070557},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4357999861240387},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4327000081539154},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.40400001406669617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4009999930858612},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.38089999556541443},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3521000146865845},{"id":"https://openalex.org/C2910239545","wikidata":"https://www.wikidata.org/wiki/Q3843811","display_name":"Immune Dysfunction","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3395000100135803},{"id":"https://openalex.org/C2992282259","wikidata":"https://www.wikidata.org/wiki/Q3149136","display_name":"Immune status","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2777000069618225}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.58564/aimcj3.1.2026.242","doi":"https://doi.org/10.58564/aimcj3.1.2026.242","is_oa":true,"landing_page_url":"https://doi.org/10.58564/aimcj3.1.2026.242","pdf_url":"https://aimcj.aliraqia.edu.iq/index.php/pub/article/download/242/132","source":{"id":"https://openalex.org/S5407050341","display_name":"Al-Iraqia Medical College Journal","issn_l":"3104-4557","issn":["3104-4557","3104-4565"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Al-Iraqia Medical College Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.58564/aimcj3.1.2026.242","doi":"https://doi.org/10.58564/aimcj3.1.2026.242","is_oa":true,"landing_page_url":"https://doi.org/10.58564/aimcj3.1.2026.242","pdf_url":"https://aimcj.aliraqia.edu.iq/index.php/pub/article/download/242/132","source":{"id":"https://openalex.org/S5407050341","display_name":"Al-Iraqia Medical College Journal","issn_l":"3104-4557","issn":["3104-4557","3104-4565"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Al-Iraqia Medical College Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7154459751.pdf","grobid_xml":"https://content.openalex.org/works/W7154459751.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2777074421","https://openalex.org/W3112344668","https://openalex.org/W4207047655","https://openalex.org/W4232069583","https://openalex.org/W4284988364","https://openalex.org/W4295222529","https://openalex.org/W4297338420","https://openalex.org/W4307778335","https://openalex.org/W4309738120","https://openalex.org/W4367299631","https://openalex.org/W4385406796","https://openalex.org/W4387607347","https://openalex.org/W4391896474","https://openalex.org/W4398765625","https://openalex.org/W4401793492","https://openalex.org/W4413865457"],"related_works":["https://openalex.org/W4405073740","https://openalex.org/W1978825269","https://openalex.org/W4412441065","https://openalex.org/W7218073522","https://openalex.org/W7216879827","https://openalex.org/W1982089028","https://openalex.org/W2088934796","https://openalex.org/W2404473177","https://openalex.org/W2125876756","https://openalex.org/W2355344166"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3],"a":[4,24],"chronic":[5],"inflammatory":[6],"demyelinating":[7],"disorder":[8],"of":[9,57,135,168,238],"the":[10,42,92,265],"central":[11],"nervous":[12],"system":[13],"with":[14,66,75,144,187],"immune-mediated":[15],"demyelination.":[16],"Proinflammatory":[17],"cytokines,":[18],"including":[19],"IL-6":[20,96,136,207],"and":[21,29,33,61,68,79,82,97,107,109,122,137,174,193,208,216,219,233,235,242,255,271],"TNF-\u03b1,":[22,59,240],"play":[23],"crucial":[25],"role":[26],"in":[27,63,91,142,155,184,246],"neuroinflammation,":[28],"immunoglobulin":[30],"dysfunction":[31],"(IgA":[32],"IgG)":[34],"reflects":[35],"humoral":[36],"immune":[37],"reactivity.":[38],"In":[39],"Iraqi":[40,64,247],"patients,":[41],"relationship":[43],"between":[44,206,217,231,253],"these":[45],"markers":[46],"remains":[47],"poorly":[48],"recognized.":[49],"The":[50,132,250],"study":[51],"aims":[52],"to":[53,69],"assess":[54],"serum":[55,133],"levels":[56,99,111,134],"IL-6,":[58,239],"IgA,":[60,241],"IgG":[62,110,169,209,243],"patients":[65,74,143,185],"MS":[67,78,145,248],"examine":[70],"their":[71],"interrelationships.":[72],"Sixty":[73],"clinically":[76],"diagnosed":[77],"60":[80],"age-":[81],"sex-matched":[83],"healthy":[84],"controls,":[85],"aged":[86],"18\u201360":[87],"years,":[88],"were":[89,100,112,118,139,180,204],"included":[90],"case-control":[93],"study.":[94],"Serum":[95],"TNF-\u03b1":[98,138,218,254],"measured":[101,113],"by":[102,114],"enzyme-linked":[103],"immunosorbent":[104],"assay":[105],"(ELISA),":[106],"IgA":[108,175,220,256],"nephelometry.":[115],"Statistical":[116],"analyses":[117],"performed":[119],"using":[120],"t-tests":[121],"Pearson's":[123],"correlation;":[124],"p":[125,198,213,224],"<":[126,199,214,225],"0.05":[127],"was":[128],"considered":[129],"statistically":[130],"significant.":[131],"significantly":[140,182],"higher":[141],"(15.87":[146],"\u00b1":[147,151,158,162,171,177,190,195],"4.62":[148],"pg/mL;":[149,160],"24.65":[150],"6.73":[152],"pg/mL)":[153],"than":[154],"controls":[156,188],"(7.94":[157],"2.18":[159],"12.18":[161],"3.54":[163],"pg/mL,":[164],"respectively;":[165],"p<0.001).":[166],"Levels":[167],"(14.52":[170],"2.96":[172],"g/L)":[173,179],"(3.01":[176],"0.78":[178],"also":[181],"elevated":[183],"compared":[186],"(11.84":[189],"2.41":[191],"g/L":[192],"2.35":[194],"0.65":[196],"g/L,":[197],"0.01).":[200],"Significant":[201],"positive":[202],"correlations":[203],"found":[205],"(r":[210,221],"=":[211,222],"0.418,":[212],"0.001)":[215],"0.496,":[223],"0.001).":[226],"A":[227],"strong":[228,251],"association":[229],"exists":[230],"cytokines":[232],"immunoglobulins,":[234],"concurrent":[236],"elevations":[237],"are":[244],"observed":[245],"patients.":[249],"correlation":[252],"may":[257],"reflect":[258],"distinct":[259],"genetic":[260],"or":[261],"environmental":[262],"factors,":[263],"underscoring":[264],"need":[266],"for":[267],"region-specific":[268],"biomarker":[269],"research":[270],"tailored":[272],"monitoring":[273],"plans.":[274]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-16T00:00:00"}