{"id":"https://openalex.org/W7154386830","doi":"https://doi.org/10.1038/s41433-026-04425-0","title":"Early real-world outcomes of aflibercept 8 mg in previously treated neovascular age-related macular degeneration","display_name":"Early real-world outcomes of aflibercept 8 mg in previously treated neovascular age-related macular degeneration","publication_year":2026,"publication_date":"2026-04-14","ids":{"openalex":"https://openalex.org/W7154386830","doi":"https://doi.org/10.1038/s41433-026-04425-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41981257","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13269804"},"language":"en","primary_location":{"id":"doi:10.1038/s41433-026-04425-0","doi":"https://doi.org/10.1038/s41433-026-04425-0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41433-026-04425-0","pdf_url":null,"source":{"id":"https://openalex.org/S167047176","display_name":"Eye","issn_l":"0078-5334","issn":["0078-5334","0950-222X","1476-5454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13269804/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040996953","display_name":"Imran Karim Janmohamed","orcid":"https://orcid.org/0000-0003-0755-7242","observed_orcids":["https://orcid.org/0000-0003-0755-7242"]},"institutions":[{"id":"https://openalex.org/I2801780664","display_name":"Maidstone Hospital","ror":"https://ror.org/047v2cv91","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I150517883","https://openalex.org/I2801780664"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Imran Karim Janmohamed","raw_affiliation_strings":["Maidstone General Hospital, Maidstone, UK"],"raw_orcid":"https://orcid.org/0000-0003-0755-7242","affiliations":[{"raw_affiliation_string":"Maidstone General Hospital, Maidstone, UK","institution_ids":["https://openalex.org/I2801780664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133610507","display_name":"Havena Harahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801780664","display_name":"Maidstone Hospital","ror":"https://ror.org/047v2cv91","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I150517883","https://openalex.org/I2801780664"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Havena Harahn","raw_affiliation_strings":["Maidstone General Hospital, Maidstone, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maidstone General Hospital, Maidstone, UK","institution_ids":["https://openalex.org/I2801780664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133607329","display_name":"Barnaby Carr","orcid":"https://orcid.org/0009-0006-3820-5812","observed_orcids":["https://orcid.org/0009-0006-3820-5812"]},"institutions":[{"id":"https://openalex.org/I2801780664","display_name":"Maidstone Hospital","ror":"https://ror.org/047v2cv91","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I150517883","https://openalex.org/I2801780664"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barnaby Carr","raw_affiliation_strings":["Maidstone General Hospital, Maidstone, UK"],"raw_orcid":"https://orcid.org/0009-0006-3820-5812","affiliations":[{"raw_affiliation_string":"Maidstone General Hospital, Maidstone, UK","institution_ids":["https://openalex.org/I2801780664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133621395","display_name":"Saleh Sahbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saleh Sahbi","raw_affiliation_strings":["GKT School of Medical Education, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GKT School of Medical Education, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133565099","display_name":"Hasan Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800290887","display_name":"Peterborough City Hospital","ror":"https://ror.org/02q69x434","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800290887","https://openalex.org/I4210158470"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hasan Ahmed","raw_affiliation_strings":["Peterborough City Hospital, Peterborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peterborough City Hospital, Peterborough, UK","institution_ids":["https://openalex.org/I2800290887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133581673","display_name":"Abdelrahman Farahat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801780664","display_name":"Maidstone Hospital","ror":"https://ror.org/047v2cv91","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I150517883","https://openalex.org/I2801780664"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Abdelrahman Farahat","raw_affiliation_strings":["Maidstone General Hospital, Maidstone, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maidstone General Hospital, Maidstone, UK","institution_ids":["https://openalex.org/I2801780664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047453258","display_name":"Shabeeba Hannan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801780664","display_name":"Maidstone Hospital","ror":"https://ror.org/047v2cv91","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I150517883","https://openalex.org/I2801780664"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shabeeba Hannan","raw_affiliation_strings":["Maidstone General Hospital, Maidstone, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maidstone General Hospital, Maidstone, UK","institution_ids":["https://openalex.org/I2801780664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008260799","display_name":"Luke Membrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801780664","display_name":"Maidstone Hospital","ror":"https://ror.org/047v2cv91","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I150517883","https://openalex.org/I2801780664"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Luke Membrey","raw_affiliation_strings":["Maidstone General Hospital, Maidstone, UK. lukemembrey@nhs.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maidstone General Hospital, Maidstone, UK. lukemembrey@nhs.net","institution_ids":["https://openalex.org/I2801780664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008260799"],"corresponding_institution_ids":["https://openalex.org/I2801780664"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":9.5239,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.95846843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"40","issue":"9","first_page":"1351","last_page":"1357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-interval-extension","display_name":"treatment interval extension","score":0.5170000195503235},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/best-corrected-visual-acuity","display_name":"best-corrected visual acuity","score":0.921999990940094},{"id":"https://openalex.org/keywords/central-macular-thickness","display_name":"central macular thickness","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pigment-epithelial-detachment","display_name":"pigment epithelial detachment","score":0.9649999737739563},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.703000009059906},{"id":"https://openalex.org/keywords/previously-treated-patients","display_name":"previously treated patients","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.9793999791145325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9309999942779541},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8337000012397766},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.7351999878883362},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7059000134468079},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6840999722480774},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5498999953269958},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.5199000239372253},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.39980000257492065},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3781000077724457},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.3732999861240387},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3614000082015991},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.26350000500679016}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41433-026-04425-0","doi":"https://doi.org/10.1038/s41433-026-04425-0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41433-026-04425-0","pdf_url":null,"source":{"id":"https://openalex.org/S167047176","display_name":"Eye","issn_l":"0078-5334","issn":["0078-5334","0950-222X","1476-5454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye","raw_type":"journal-article"},{"id":"pmid:41981257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41981257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13269804","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13269804/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye (Lond)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13269804","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13269804/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye (Lond)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2004117352","https://openalex.org/W2085712747","https://openalex.org/W2160226180","https://openalex.org/W2990343807","https://openalex.org/W4206959584","https://openalex.org/W4385514340","https://openalex.org/W4390729362","https://openalex.org/W4392545215","https://openalex.org/W4400333607","https://openalex.org/W4401142956","https://openalex.org/W4401715546","https://openalex.org/W4402087507","https://openalex.org/W4406824817","https://openalex.org/W4407249671","https://openalex.org/W4407500130","https://openalex.org/W4409154931","https://openalex.org/W4411002005","https://openalex.org/W4414081369"],"related_works":["https://openalex.org/W4411002005","https://openalex.org/W4414081369","https://openalex.org/W4415117954","https://openalex.org/W7127126447","https://openalex.org/W7162463822","https://openalex.org/W7161641183","https://openalex.org/W7220418225","https://openalex.org/W7164813315","https://openalex.org/W4412724744","https://openalex.org/W7133559002"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-15T00:00:00"}
