{"id":"https://openalex.org/W7152127153","doi":"https://doi.org/10.1016/j.tibs.2026.03.001","title":"Powerful polymerases synthesize labeled RNA better, faster, stronger","display_name":"Powerful polymerases synthesize labeled RNA better, faster, stronger","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7152127153","doi":"https://doi.org/10.1016/j.tibs.2026.03.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/41956842"},"language":"en","primary_location":{"id":"doi:10.1016/j.tibs.2026.03.001","doi":"https://doi.org/10.1016/j.tibs.2026.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2026.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133170488","display_name":"Aria A. Khalique","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141778976","display_name":"Pitzer College","ror":"https://ror.org/0197n2v40","country_code":"US","type":"education","lineage":["https://openalex.org/I141778976"]},{"id":"https://openalex.org/I16970960","display_name":"Scripps College","ror":"https://ror.org/00p55jd14","country_code":"US","type":"education","lineage":["https://openalex.org/I16970960"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aria A. Khalique","raw_affiliation_strings":["Department of Natural Sciences of Pitzer, Scripps Colleges, Claremont, CA 91711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Natural Sciences of Pitzer, Scripps Colleges, Claremont, CA 91711, USA","institution_ids":["https://openalex.org/I141778976","https://openalex.org/I16970960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047874372","display_name":"Aaron M. Leconte","orcid":"https://orcid.org/0000-0002-5789-9147","observed_orcids":["https://orcid.org/0000-0002-5789-9147"]},"institutions":[{"id":"https://openalex.org/I141778976","display_name":"Pitzer College","ror":"https://ror.org/0197n2v40","country_code":"US","type":"education","lineage":["https://openalex.org/I141778976"]},{"id":"https://openalex.org/I16970960","display_name":"Scripps College","ror":"https://ror.org/00p55jd14","country_code":"US","type":"education","lineage":["https://openalex.org/I16970960"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron M. Leconte","raw_affiliation_strings":["Department of Natural Sciences of Pitzer, Scripps Colleges, Claremont, CA 91711, USA. Electronic address: aleconte@natsci.claremont.edu"],"raw_orcid":"https://orcid.org/0000-0002-5789-9147","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences of Pitzer, Scripps Colleges, Claremont, CA 91711, USA. Electronic address: aleconte@natsci.claremont.edu","institution_ids":["https://openalex.org/I141778976","https://openalex.org/I16970960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047874372"],"corresponding_institution_ids":["https://openalex.org/I141778976","https://openalex.org/I16970960"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17796492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"7","first_page":"652","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-synthesis","display_name":"RNA synthesis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/site-specific-labeling","display_name":"site-specific labeling","score":0.6610000133514404},{"id":"https://openalex.org/keywords/rna-labeling","display_name":"RNA labeling","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6309999823570251},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5425000190734863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5188000202178955},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5044000148773193},{"id":"https://openalex.org/C153574943","wikidata":"https://www.wikidata.org/wiki/Q408939","display_name":"Nucleotidyltransferase","level":4,"score":0.38199999928474426},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.334199994802475},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3190000057220459},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C70916841","wikidata":"https://www.wikidata.org/wiki/Q3501658","display_name":"RNA polymerase III","level":5,"score":0.3073999881744385},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30219998955726624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2996000051498413},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2824000120162964},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.275299996137619},{"id":"https://openalex.org/C2991743866","wikidata":"https://www.wikidata.org/wiki/Q417379","display_name":"Rna processing","level":4,"score":0.2628999948501587},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.2612999975681305}],"mesh":[{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tibs.2026.03.001","doi":"https://doi.org/10.1016/j.tibs.2026.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2026.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},{"id":"pmid:41956842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41956842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biochemical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2452998500","display_name":null,"funder_award_id":"CS-SEED-2004-006","funder_id":"https://openalex.org/F4320311304","funder_display_name":"Research Corporation for Scientific Advancement"}],"funders":[{"id":"https://openalex.org/F4320311304","display_name":"Research Corporation for Scientific Advancement","ror":"https://ror.org/00jp8d455"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1225833829","https://openalex.org/W2068659296","https://openalex.org/W2154545304","https://openalex.org/W2340611904","https://openalex.org/W2583249474","https://openalex.org/W4380154199","https://openalex.org/W4380763093","https://openalex.org/W4406334378","https://openalex.org/W7119087929"],"related_works":["https://openalex.org/W4397007824","https://openalex.org/W4406334378","https://openalex.org/W7202352727","https://openalex.org/W7119087929","https://openalex.org/W4367176288","https://openalex.org/W2167159452","https://openalex.org/W1979609439","https://openalex.org/W633951851","https://openalex.org/W2923984392","https://openalex.org/W7098103978"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-04-09T00:00:00"}