{"id":"https://openalex.org/W7152120879","doi":"https://doi.org/10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","title":"Fabrication de nano-aiguilles en silicium en vue d'une d\u00e9tection intracellulaire de biomarqueurs de maladies neurod\u00e9g\u00e9n\u00e9ratives","display_name":"Fabrication de nano-aiguilles en silicium en vue d'une d\u00e9tection intracellulaire de biomarqueurs de maladies neurod\u00e9g\u00e9n\u00e9ratives","publication_year":2023,"publication_date":"2023-12-19","ids":{"openalex":"https://openalex.org/W7152120879","doi":"https://doi.org/10.70675/67dec800z76b6z42f6z9498z3b005d5b0376"},"language":"fr","primary_location":{"id":"doi:10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","doi":"https://doi.org/10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","is_oa":false,"landing_page_url":"https://doi.org/10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 de Lille (2022-....)","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-05436885","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032140569","display_name":"Paul Moustiez","orcid":"https://orcid.org/0000-0003-1914-5579","observed_orcids":["https://orcid.org/0000-0003-1914-5579"]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Paul Moustiez","raw_affiliation_strings":["Universit\u00e9 de Lille (2022-....)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lille (2022-....)","institution_ids":["https://openalex.org/I2279609970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032140569"],"corresponding_institution_ids":["https://openalex.org/I2279609970"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11272","display_name":"Nanowire Synthesis and Applications","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7760000228881836},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nanosphere-lithography","display_name":"nanosphere lithography","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dry-etching","display_name":"dry etching","score":0.5720000267028809},{"id":"https://openalex.org/keywords/wet-etching","display_name":"wet etching","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sers","display_name":"SERS","score":0.746999979019165},{"id":"https://openalex.org/keywords/neuronal-viability","display_name":"neuronal viability","score":0.34299999475479126},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3946000039577484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31119999289512634},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.23909999430179596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22310000658035278},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.21439999341964722},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.16189999878406525},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13760000467300415},{"id":"https://openalex.org/C2781019423","wikidata":"https://www.wikidata.org/wiki/Q902100","display_name":"Diphenylacetylene","level":3,"score":0.133200004696846},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.12890000641345978},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.12530000507831573}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","doi":"https://doi.org/10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","is_oa":false,"landing_page_url":"https://doi.org/10.70675/67dec800z76b6z42f6z9498z3b005d5b0376","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 de Lille (2022-....)","raw_type":"dissertation"},{"id":"pmh:2023ULILN054","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2023ULILN054","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:HAL:tel-05436885v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-05436885","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Micro et nanotechnologies/Micro\u00e9lectronique. Universit\u00e9 de Lille, 2023. Fran\u00e7ais. ⟨NNT : 2023ULILN054⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:HAL:tel-05471950v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/tel-05471950","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physique [physics]. Universit\u00e9 de Lille, 2023. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:lilloa.univ-lille.fr:20.500.12210/132191","doi":null,"is_oa":true,"landing_page_url":"https://lilloa.univ-lille.fr/handle/20.500.12210/132191","pdf_url":null,"source":{"id":"https://openalex.org/S4306402203","display_name":"LillOA (Universit\u00e9 de Lille (University Of Lille))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210123514","host_organization_name":"Centre d'\u00c9tudes en Civilisations, Langues et Lettres \u00c9trang\u00e8res","host_organization_lineage":["https://openalex.org/I4210123514"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:HAL:tel-05436885v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-05436885","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Micro et nanotechnologies/Micro\u00e9lectronique. Universit\u00e9 de Lille, 2023. Fran\u00e7ais. ⟨NNT : 2023ULILN054⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":361,"referenced_works":["https://openalex.org/W20930938","https://openalex.org/W33750631","https://openalex.org/W57032373","https://openalex.org/W1568717374","https://openalex.org/W1602771322","https://openalex.org/W1622645825","https://openalex.org/W1677356194","https://openalex.org/W1885354525","https://openalex.org/W1922984690","https://openalex.org/W1964164160","https://openalex.org/W1967195140","https://openalex.org/W1967422966","https://openalex.org/W1967869632","https://openalex.org/W1968151388","https://openalex.org/W1968554586","https://openalex.org/W1968839626","https://openalex.org/W1968900405","https://openalex.org/W1969053764","https://openalex.org/W1971804032","https://openalex.org/W1972354524","https://openalex.org/W1972447481","https://openalex.org/W1973874617","https://openalex.org/W1977291129","https://openalex.org/W1977806056","https://openalex.org/W1979457838","https://openalex.org/W1980019457","https://openalex.org/W1980284953","https://openalex.org/W1980755128","https://openalex.org/W1981720019","https://openalex.org/W1982716000","https://openalex.org/W1986319564","https://openalex.org/W1986443470","https://openalex.org/W1989388046","https://openalex.org/W1989828555","https://openalex.org/W1990696031","https://openalex.org/W1991498992","https://openalex.org/W1991721204","https://openalex.org/W1991959987","https://openalex.org/W1994233268","https://openalex.org/W1995173287","https://openalex.org/W1998020561","https://openalex.org/W1998493301","https://openalex.org/W1998681751","https://openalex.org/W1998763192","https://openalex.org/W2000774765","https://openalex.org/W2001741162","https://openalex.org/W2003105674","https://openalex.org/W2003493611","https://openalex.org/W2004168381","https://openalex.org/W2005059725","https://openalex.org/W2005284180","https://openalex.org/W2005933611","https://openalex.org/W2006305892","https://openalex.org/W2007068034","https://openalex.org/W2008664826","https://openalex.org/W2008688231","https://openalex.org/W2009380844","https://openalex.org/W2012060176","https://openalex.org/W2013960213","https://openalex.org/W2017167386","https://openalex.org/W2017667126","https://openalex.org/W2018391369","https://openalex.org/W2020197664","https://openalex.org/W2020302737","https://openalex.org/W2020814722","https://openalex.org/W2021601457","https://openalex.org/W2021770402","https://openalex.org/W2022850426","https://openalex.org/W2023059483","https://openalex.org/W2025177545","https://openalex.org/W2030620196","https://openalex.org/W2031314531","https://openalex.org/W2033214472","https://openalex.org/W2033621386","https://openalex.org/W2036635221","https://openalex.org/W2037012265","https://openalex.org/W2040097298","https://openalex.org/W2041881506","https://openalex.org/W2044343076","https://openalex.org/W2048286226","https://openalex.org/W2049429778","https://openalex.org/W2050197030","https://openalex.org/W2050960257","https://openalex.org/W2052773356","https://openalex.org/W2054278500","https://openalex.org/W2054312051","https://openalex.org/W2054586727","https://openalex.org/W2054975682","https://openalex.org/W2058700028","https://openalex.org/W2059516728","https://openalex.org/W2060291707","https://openalex.org/W2062182733","https://openalex.org/W2066444212","https://openalex.org/W2070251759","https://openalex.org/W2072592512","https://openalex.org/W2072864417","https://openalex.org/W2072893292","https://openalex.org/W2072910502","https://openalex.org/W2074169311","https://openalex.org/W2074604913","https://openalex.org/W2075325017","https://openalex.org/W2076028647","https://openalex.org/W2076574273","https://openalex.org/W2077729765","https://openalex.org/W2077914436","https://openalex.org/W2078483179","https://openalex.org/W2078636870","https://openalex.org/W2080322937","https://openalex.org/W2080439042","https://openalex.org/W2080484884","https://openalex.org/W2084550262","https://openalex.org/W2084679717","https://openalex.org/W2087152529","https://openalex.org/W2091979118","https://openalex.org/W2092049851","https://openalex.org/W2093168495","https://openalex.org/W2093172304","https://openalex.org/W2094152652","https://openalex.org/W2094409448","https://openalex.org/W2096168689","https://openalex.org/W2096770920","https://openalex.org/W2100369477","https://openalex.org/W2100662440","https://openalex.org/W2101252590","https://openalex.org/W2103579353","https://openalex.org/W2109425700","https://openalex.org/W2110174460","https://openalex.org/W2112165279","https://openalex.org/W2114457996","https://openalex.org/W2115559222","https://openalex.org/W2116451919","https://openalex.org/W2117155287","https://openalex.org/W2117652311","https://openalex.org/W2118727642","https://openalex.org/W2122426758","https://openalex.org/W2124275517","https://openalex.org/W2128843326","https://openalex.org/W2129763960","https://openalex.org/W2131840065","https://openalex.org/W2133882340","https://openalex.org/W2134424470","https://openalex.org/W2134880640","https://openalex.org/W2138402450","https://openalex.org/W2138744901","https://openalex.org/W2140277412","https://openalex.org/W2140707093","https://openalex.org/W2143287675","https://openalex.org/W2143805561","https://openalex.org/W2146563230","https://openalex.org/W2150391637","https://openalex.org/W2151479493","https://openalex.org/W2152036108","https://openalex.org/W2156562015","https://openalex.org/W2158732413","https://openalex.org/W2162690000","https://openalex.org/W2170271633","https://openalex.org/W2170936453","https://openalex.org/W2171269389","https://openalex.org/W2171612604","https://openalex.org/W2171735284","https://openalex.org/W2281905945","https://openalex.org/W2298551106","https://openalex.org/W2299985800","https://openalex.org/W2319409008","https://openalex.org/W2322620007","https://openalex.org/W2328986776","https://openalex.org/W2329894335","https://openalex.org/W2332231456","https://openalex.org/W2332758681","https://openalex.org/W2339614250","https://openalex.org/W2340717854","https://openalex.org/W2341089887","https://openalex.org/W2417406426","https://openalex.org/W2430779275","https://openalex.org/W2515197937","https://openalex.org/W2519200757","https://openalex.org/W2558562944","https://openalex.org/W2559120577","https://openalex.org/W2565550374","https://openalex.org/W2582311095","https://openalex.org/W2586823907","https://openalex.org/W2587822132","https://openalex.org/W2589854741","https://openalex.org/W2605155855","https://openalex.org/W2605318239","https://openalex.org/W2608853602","https://openalex.org/W2617946428","https://openalex.org/W2618553145","https://openalex.org/W2618880080","https://openalex.org/W2621590149","https://openalex.org/W2738181909","https://openalex.org/W2738884296","https://openalex.org/W2745821103","https://openalex.org/W2746286365","https://openalex.org/W2758220617","https://openalex.org/W2765972933","https://openalex.org/W2768480940","https://openalex.org/W2770886687","https://openalex.org/W2771451550","https://openalex.org/W2779087983","https://openalex.org/W2782708334","https://openalex.org/W2782814017","https://openalex.org/W2783757852","https://openalex.org/W2784628703","https://openalex.org/W2793305358","https://openalex.org/W2797219557","https://openalex.org/W2801570786","https://openalex.org/W2803251723","https://openalex.org/W2804614219","https://openalex.org/W2884196012","https://openalex.org/W2884631984","https://openalex.org/W2886669139","https://openalex.org/W2888184995","https://openalex.org/W2888303476","https://openalex.org/W2889331327","https://openalex.org/W2889951724","https://openalex.org/W2891933205","https://openalex.org/W2892189452","https://openalex.org/W2900252075","https://openalex.org/W2902253109","https://openalex.org/W2902330665","https://openalex.org/W2902717062","https://openalex.org/W2904683464","https://openalex.org/W2909883195","https://openalex.org/W2910073497","https://openalex.org/W2912680348","https://openalex.org/W2916100072","https://openalex.org/W2932315275","https://openalex.org/W2936176039","https://openalex.org/W2938789811","https://openalex.org/W2943223113","https://openalex.org/W2953823826","https://openalex.org/W2964266890","https://openalex.org/W2970241030","https://openalex.org/W2971763914","https://openalex.org/W2975004277","https://openalex.org/W2980182862","https://openalex.org/W2981204842","https://openalex.org/W2981224796","https://openalex.org/W2981456530","https://openalex.org/W2982463278","https://openalex.org/W2985681440","https://openalex.org/W2989761093","https://openalex.org/W2990971121","https://openalex.org/W2995868596","https://openalex.org/W3000333717","https://openalex.org/W3000645697","https://openalex.org/W3005443273","https://openalex.org/W3008440746","https://openalex.org/W3009309823","https://openalex.org/W3010225092","https://openalex.org/W3011856986","https://openalex.org/W3012874101","https://openalex.org/W3014925359","https://openalex.org/W3015126118","https://openalex.org/W3015692634","https://openalex.org/W3019606584","https://openalex.org/W3028752715","https://openalex.org/W3028826150","https://openalex.org/W3035429051","https://openalex.org/W3036193211","https://openalex.org/W3036721340","https://openalex.org/W3038795195","https://openalex.org/W3042151413","https://openalex.org/W3043787700","https://openalex.org/W3047254136","https://openalex.org/W3047698845","https://openalex.org/W3080633124","https://openalex.org/W3082455013","https://openalex.org/W3082912802","https://openalex.org/W3093443465","https://openalex.org/W3097774983","https://openalex.org/W3097924479","https://openalex.org/W3101861594","https://openalex.org/W3109106809","https://openalex.org/W3109746568","https://openalex.org/W3112146910","https://openalex.org/W3112206052","https://openalex.org/W3112666381","https://openalex.org/W3116295293","https://openalex.org/W3117380154","https://openalex.org/W3119331718","https://openalex.org/W3121270402","https://openalex.org/W3121815526","https://openalex.org/W3127889915","https://openalex.org/W3128744902","https://openalex.org/W3131735448","https://openalex.org/W3133319513","https://openalex.org/W3134932075","https://openalex.org/W3140315471","https://openalex.org/W3143156272","https://openalex.org/W3144309086","https://openalex.org/W3149769032","https://openalex.org/W3152045462","https://openalex.org/W3153439613","https://openalex.org/W3155164087","https://openalex.org/W3155966446","https://openalex.org/W3160546684","https://openalex.org/W3164054621","https://openalex.org/W3168898814","https://openalex.org/W3172022498","https://openalex.org/W3178985942","https://openalex.org/W3180905362","https://openalex.org/W3186402549","https://openalex.org/W3190287390","https://openalex.org/W3194707481","https://openalex.org/W3196587339","https://openalex.org/W3197204509","https://openalex.org/W3199295305","https://openalex.org/W3200671605","https://openalex.org/W3202403979","https://openalex.org/W3213471062","https://openalex.org/W3216282807","https://openalex.org/W4200248218","https://openalex.org/W4200390523","https://openalex.org/W4200396325","https://openalex.org/W4200574567","https://openalex.org/W4205691188","https://openalex.org/W4210365236","https://openalex.org/W4211131316","https://openalex.org/W4213033589","https://openalex.org/W4213318317","https://openalex.org/W4214627422","https://openalex.org/W4214894222","https://openalex.org/W4220818967","https://openalex.org/W4220874832","https://openalex.org/W4220904086","https://openalex.org/W4223929823","https://openalex.org/W4224075347","https://openalex.org/W4225907476","https://openalex.org/W4237047466","https://openalex.org/W4239963633","https://openalex.org/W4247419735","https://openalex.org/W4280556165","https://openalex.org/W4282015666","https://openalex.org/W4283776358","https://openalex.org/W4288045175","https://openalex.org/W4289101651","https://openalex.org/W4290998913","https://openalex.org/W4294326357","https://openalex.org/W4294628516","https://openalex.org/W4297272173","https://openalex.org/W4307269794","https://openalex.org/W4312817812","https://openalex.org/W4313455452","https://openalex.org/W4316468335","https://openalex.org/W4317478917","https://openalex.org/W4317717537","https://openalex.org/W4317914870","https://openalex.org/W4318481599","https://openalex.org/W4320489724","https://openalex.org/W4321795898","https://openalex.org/W4327843863","https://openalex.org/W4360602632","https://openalex.org/W4380885251","https://openalex.org/W4382516044","https://openalex.org/W4385077065","https://openalex.org/W4385297035","https://openalex.org/W4385347310","https://openalex.org/W4403862508","https://openalex.org/W7147302647"],"related_works":["https://openalex.org/W6991011162","https://openalex.org/W7152387774","https://openalex.org/W6999744874","https://openalex.org/W7152754670","https://openalex.org/W7151742545","https://openalex.org/W7139618245","https://openalex.org/W7166555170","https://openalex.org/W7165252799","https://openalex.org/W2594596349","https://openalex.org/W7086924070"],"abstract_inverted_index":{"Les":[0],"maladies":[1,5,16],"neurod\u00e9g\u00e9n\u00e9ratives":[2],"sont":[3,109,286],"des":[4,18,130,192,306,311],"chroniques":[6],"progressives":[7],"touchant":[8],"le":[9,57,156,336],"syst\u00e8me":[10],"nerveux":[11],"central.":[12],"Tandis":[13],"que":[14,67,285,310],"ces":[15,115,219],"ont":[17,279,314],"origines":[19],"multifactorielles,":[20],"leur":[21,341],"fr\u00e9quence":[22],"augmente":[23],"avec":[24,253,335],"l'\u00e2ge.":[25],"En":[26],"raison":[27],"du":[28],"vieillissement":[29],"progressif":[30],"de":[31,35,37,44,78,82,91,98,101,114,147,154,159,166,178,196,203,206,208,218,224,228,236,245,258,260,265,270,332],"la":[32,49,92,96,152,190,201,256,263,287,295,303,330],"population,":[33],"et":[34,81,95,168,231,250,262,276,294,320,339],"l'absence":[36],"traitement,":[38],"elles":[39],"deviennent":[40],"un":[41,140],"enjeu":[42],"majeur":[43],"sant\u00e9":[45],"publique.":[46],"Pour":[47],"exemple,":[48],"maladie":[50,80],"d'Alzheimer":[51],"pourrait":[52,125],"toucher":[53],"1":[54],"personne":[55],"dans":[56,64],"monde":[58],"sur":[59,145,176,243,322],"85":[60],"d'ici":[61],"2050.":[62],"C'est":[63],"ce":[65,135,179],"contexte":[66],"les":[68,110,164,251,277],"chercheurs":[69],"\u00e9tudient":[70],"diff\u00e9rentes":[71],"pistes":[72],"pour":[73,161,221],"permettre":[74],"une":[75],"meilleure":[76],"compr\u00e9hension":[77],"cette":[79],"ses":[83],"m\u00e9canismes":[84,131],"pathophysiologies.":[85],"Ils":[86],"savent":[87],"aujourd'hui":[88],"qu'une":[89],"hyperphosphorylation":[90],"prot\u00e9ine":[93],"Tau":[94],"production":[97],"formes":[99],"toxiques":[100],"peptides":[102,307,312],"beta-amylo\u00efdes":[103,313],"s'agglom\u00e9rant":[104],"en":[105,108,149,169,184],"plaques":[106],"s\u00e9niles":[107],"principales":[111],"causes.":[112],"L'origine":[113],"dysfonctionnements":[116],"est":[117],"quant":[118],"\u00e0":[119,254],"elle":[120],"encore":[121],"mal":[122],"connue":[123],"mais":[124],"\u00eatre":[126,274,316],"\u00e9lucid\u00e9e":[127],"par":[128,194,226,232,291,298,318],"l'\u00e9tude":[129,244],"biochimiques":[132],"intracellulaire.":[133],"Dans":[134],"contexte,":[136],"nous":[137,327],"avons":[138,328],"imagin\u00e9":[139],"dispositif":[141],"in":[142],"vitro":[143],"reposant":[144],"l'utilisation":[146],"nanoaiguilles":[148,193],"silicium":[150],"ayant":[151],"facult\u00e9":[153],"sonder":[155],"cytoplasme":[157],"cellulaire":[158,338],"neurones":[160,252],"y":[162],"d\u00e9tecter":[163],"biomarqueurs":[165,261],"l'Alzheimer":[167],"suivre":[170],"l'\u00e9volution.":[171],"Notre":[172],"travail":[173],"a":[174,272],"repos\u00e9":[175],"l'\u00e9laboration":[177],"capteur":[180],"qui":[181],"s'est":[182],"divis\u00e9e":[183],"3":[185],"points.":[186],"Le":[187,213,239],"premier":[188],"\u00e9tait":[189,216],"fabrication":[191],"d\u00e9veloppement":[195],"techniques":[197],"peu":[198],"on\u00e9reuse":[199],"comme":[200],"lithographie":[202,269],"nanosph\u00e8re":[204],"suivit":[205],"m\u00e9thodes":[207],"gravure":[209,288,296,299],"humide":[210,289],"ou":[211],"s\u00e8ches.":[212],"second":[214],"point":[215,241],"l'optimisation":[217],"aiguilles":[220,249,278,334],"l'identification":[222],"bimodale":[223],"mol\u00e9cules":[225],"spectrom\u00e9trie":[227,233],"masse":[229],"(SALDI-MS)":[230],"Raman":[234],"exalt\u00e9e":[235],"surface":[237],"(SERS).":[238],"troisi\u00e8me":[240],"portait":[242],"l'interaction":[246],"entre":[247],"nos":[248,323,333],"l'esprit":[255],"volont\u00e9":[257],"capture":[259],"pr\u00e9servation":[264],"l'int\u00e9grit\u00e9":[266],"cellulaire.":[267],"La":[268],"nanosph\u00e8res":[271],"pu":[273,315],"d\u00e9velopp\u00e9e,":[275],"\u00e9t\u00e9":[280],"fabriqu\u00e9es":[281],"selon":[282],"2":[283],"voies":[284],"assist\u00e9e":[290],"m\u00e9tal":[292],"(MACE)":[293],"s\u00e8che":[297],"plasma":[300],"continue.":[301],"De":[302],"rhodamine":[304],"6G,":[305],"standards":[308],"ainsi":[309],"d\u00e9tect\u00e9s":[317],"SALDI-MS":[319],"SERS":[321],"r\u00e9seaux":[324],"d'aiguilles.":[325],"Enfin":[326],"constat\u00e9":[329],"biocompatibilit\u00e9":[331],"milieu":[337],"caract\u00e9ris\u00e9":[340],"interaction.":[342]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-04-09T00:00:00"}