{"id":"https://openalex.org/W71511797","doi":"https://doi.org/10.1182/blood.v93.5.1524","title":"Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2","display_name":"Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W71511797","doi":"https://doi.org/10.1182/blood.v93.5.1524","mag":"71511797","pmid":"https://pubmed.ncbi.nlm.nih.gov/10029580"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v93.5.1524","doi":"https://doi.org/10.1182/blood.v93.5.1524","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.5.1524","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017112437","display_name":"Suzanna Reid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanna Reid","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026325168","display_name":"Alec Ritchie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alec Ritchie","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027645375","display_name":"Landin F. Boring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Landin Boring","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114012785","display_name":"Jennifa Gosling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifa Gosling","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034118912","display_name":"Scott H. Cooper","orcid":"https://orcid.org/0000-0001-9091-8269","observed_orcids":["https://orcid.org/0000-0001-9091-8269"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Cooper","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072748567","display_name":"Giao Hangoc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giao Hangoc","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112383993","display_name":"Israel F. Charo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Israel F. Charo","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hal E. Broxmeyer","raw_affiliation_strings":["From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","The Walther Cancer Institute, Indianapolis, IN","the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Microbiology/Immunology and Medicine, and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN; The Walther Cancer Institute, Indianapolis, IN; the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"The Walther Cancer Institute, Indianapolis, IN","institution_ids":[]},{"raw_affiliation_string":"the Cardiovascular Research Institute, Gladstone Institute of Cardiovascular Disease, and the Department of Medicine, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.9349,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.9084319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"93","issue":"5","first_page":"1524","last_page":"1533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ccr2-deficient-mice","display_name":"CCR2-deficient mice","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6602805852890015},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.5919916033744812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5845718383789062},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5654775500297546},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5229507088661194},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.49732258915901184},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48999467492103577},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.47794368863105774},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.47275668382644653},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4726994037628174},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4355061948299408},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.41168174147605896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3561772108078003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33294743299484253},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.32889223098754883},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3221327066421509},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1406421959400177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09130239486694336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05919426679611206},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019891","descriptor_name":"Leukopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.v93.5.1524","doi":"https://doi.org/10.1182/blood.v93.5.1524","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.5.1524","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v93.5.1524.405k07_1524_1533","doi":"https://doi.org/10.1182/blood.v93.5.1524.405k07_1524_1533","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.5.1524.405k07_1524_1533","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10029580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10029580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.942.5177","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.942.5177","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bloodjournal.org/content/bloodjournal/93/5/1524.full.pdf?sso-checked%3Dtrue","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093411735","display_name":"Mechanisms of Synergistic Regulation of Stem/Progenitors","funder_award_id":"R01HL056416","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1202359724","display_name":"Chemokines/Cytokines and Receptors in Stem Cell Homing","funder_award_id":"R01DK053674","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8491824250","display_name":null,"funder_award_id":"R01 HL 5407","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W80918744","https://openalex.org/W128824071","https://openalex.org/W130474040","https://openalex.org/W174869347","https://openalex.org/W623120400","https://openalex.org/W1020119522","https://openalex.org/W1493060204","https://openalex.org/W1542735558","https://openalex.org/W1543854090","https://openalex.org/W1557986998","https://openalex.org/W1558296954","https://openalex.org/W1563427902","https://openalex.org/W1572034510","https://openalex.org/W1574237079","https://openalex.org/W1580661256","https://openalex.org/W1593116832","https://openalex.org/W1599701369","https://openalex.org/W1940692702","https://openalex.org/W1970503653","https://openalex.org/W1972736348","https://openalex.org/W1979945560","https://openalex.org/W1989506590","https://openalex.org/W1999108069","https://openalex.org/W2010844560","https://openalex.org/W2015524565","https://openalex.org/W2020164587","https://openalex.org/W2025535815","https://openalex.org/W2045840149","https://openalex.org/W2050820037","https://openalex.org/W2055283500","https://openalex.org/W2060641101","https://openalex.org/W2065897990","https://openalex.org/W2067082529","https://openalex.org/W2075620233","https://openalex.org/W2088456430","https://openalex.org/W2091999335","https://openalex.org/W2096978032","https://openalex.org/W2097857054","https://openalex.org/W2119291835","https://openalex.org/W2128045505","https://openalex.org/W2128237788","https://openalex.org/W2128739161","https://openalex.org/W2133029085","https://openalex.org/W2133793569","https://openalex.org/W2149993174","https://openalex.org/W2150802330","https://openalex.org/W2151418316","https://openalex.org/W2156173207","https://openalex.org/W2160272188","https://openalex.org/W2166291746","https://openalex.org/W2169584423","https://openalex.org/W2170097602","https://openalex.org/W2266949108","https://openalex.org/W2405083225","https://openalex.org/W2415661306","https://openalex.org/W2416128265","https://openalex.org/W2460739979","https://openalex.org/W2474600807","https://openalex.org/W2527275336","https://openalex.org/W4211128585","https://openalex.org/W4293279301","https://openalex.org/W4313333764","https://openalex.org/W6605261811","https://openalex.org/W6632672672","https://openalex.org/W6633612207"],"related_works":["https://openalex.org/W7099365983","https://openalex.org/W2588218497","https://openalex.org/W7099221644","https://openalex.org/W2550407830","https://openalex.org/W2979730728","https://openalex.org/W169181863","https://openalex.org/W7097956151","https://openalex.org/W2237768063","https://openalex.org/W4237620180","https://openalex.org/W2054152556"],"abstract_inverted_index":{"Chemokines":[0],"regulate":[1],"hematopoiesis":[2],"in":[3,34,56,63,73,86,122,130,245,266],"part":[4],"by":[5,52,146,157,259],"influencing":[6],"the":[7,215,219,267],"proliferative":[8],"status":[9,113],"of":[10,39,65,79,107,114,125,134,150,163,169,181,199,205,222,228,250,263,273],"myeloid":[11],"progenitor":[12,264],"cells":[13,127,153,171,183,208,240,265],"(MPC).":[14],"Human":[15],"MCP-1/murine":[16],"JE,":[17],"a":[18,31,87,177],"myelosuppressive":[19],"chemokine,":[20],"specifically":[21],"binds":[22],"C-C":[23],"chemokine":[24],"receptor":[25],"2":[26],"(CCR2).":[27],"Transgenic":[28],"mice":[29,84,175],"containing":[30],"targeted":[32],"disruption":[33],"CCR2":[35,40,94,108,115,135,173,187,234,260],"that":[36,47,256],"prevents":[37],"expression":[38],"mRNA":[41],"and":[42,44,54,69,76,154,237],"protein":[43],"have":[45],"MPC":[46,72,118,129,158,232],"are":[48],"insensitive":[49],"to":[50,160,211],"inhibition":[51],"MCP-1":[53],"JE":[55],"vitro":[57,246],"were":[58,85,144],"assessed":[59],"for":[60,140],"potential":[61],"abnormalities":[62],"growth":[64,164,251],"bone":[66],"marrow":[67],"(BM)":[68],"spleen":[70],"MPC.":[71],"both":[74],"unseparated":[75],"c-kit+lin-":[77,151,167,200,207,239],"populations":[78],"BM":[80,117,131,152,170,236],"from":[81,105,172,186,233],"CCR2-deficient":[82],"(-/-)":[83,109,116,136,174,235],"greatly":[88],"increased":[89,123,203],"proliferation":[90,262],"state":[91],"compared":[92],"with":[93,103,196,225],"littermate":[95],"control":[96],"(+/+)":[97,188],"mice,":[98],"an":[99],"effect":[100],"not":[101,120,194,218],"apparent":[102,142],"progenitors":[104],"spleens":[106,133],"mice.":[110,137],"Increased":[111],"cycling":[112],"did":[119],"result":[121],"numbers":[124,198],"nucleated":[126],"or":[128,132],"Possible":[138],"reasons":[139],"this":[141],"discrepancy":[143],"highlighted":[145],"flow":[147],"cytometric":[148],"analysis":[149],"colony":[155],"formation":[156],"subjected":[159],"delayed":[161,248],"addition":[162,249],"factors.":[165,252],"The":[166,202,253],"population":[168],"had":[176],"significantly":[178],"higher":[179],"percentage":[180,204],"apoptotic":[182,206],"than":[184],"those":[185],"BM.":[189],"However,":[190],"elevated":[191,212],"apoptosis":[192,213,227],"was":[193,209],"associated":[195],"decreased":[197,242],"cells.":[201,223,275],"due":[210],"within":[214],"c-kitdimlin-,":[216],"but":[217,269],"c-kitbrightlin-,":[220],"subpopulations":[221],"Consistent":[224],"enhanced":[226],"phenotypically":[229],"defined":[230],"cells,":[231],"purified":[238],"demonstrated":[241],"cell":[243],"survival":[244,272],"upon":[247],"data":[254],"suggest":[255],"signals":[257],"received":[258],"limit":[261],"BM,":[268],"also":[270],"enhance":[271],"these":[274]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}