{"id":"https://openalex.org/W7150814794","doi":"https://doi.org/10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","title":"R\u00f4le des cellules T CD4+ dans la modulation des r\u00e9ponses microgliales au cours de la maladie d\u2019Alzheimer : potentialit\u00e9s th\u00e9rapeutiques","display_name":"R\u00f4le des cellules T CD4+ dans la modulation des r\u00e9ponses microgliales au cours de la maladie d\u2019Alzheimer : potentialit\u00e9s th\u00e9rapeutiques","publication_year":2014,"publication_date":"2014-05-21","ids":{"openalex":"https://openalex.org/W7150814794","doi":"https://doi.org/10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c"},"language":"fr","primary_location":{"id":"doi:10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","doi":"https://doi.org/10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","is_oa":false,"landing_page_url":"https://doi.org/10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paris 6","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039577066","display_name":"Dylla Ait Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Dylla Ai\u0308t Ahmed","raw_affiliation_strings":["Paris 6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paris 6","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039577066"],"corresponding_institution_ids":["https://openalex.org/I4405264447"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.8659999966621399},{"id":"https://openalex.org/keywords/microglial-recruitment","display_name":"microglial recruitment","score":0.5860000252723694},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6927000284194946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3831000030040741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2671999931335449},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.2581999897956848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2540000081062317},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.24459999799728394},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.24379999935626984},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.23430000245571136},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.22669999301433563},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1696999967098236}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","doi":"https://doi.org/10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","is_oa":false,"landing_page_url":"https://doi.org/10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paris 6","raw_type":"dissertation"},{"id":"pmh:2014PA066713","doi":null,"is_oa":false,"landing_page_url":"https://theses.fr/2014PA066713","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":763,"referenced_works":["https://openalex.org/W10297594","https://openalex.org/W43066017","https://openalex.org/W69339080","https://openalex.org/W72465079","https://openalex.org/W79419171","https://openalex.org/W134536487","https://openalex.org/W139300322","https://openalex.org/W199523218","https://openalex.org/W231832547","https://openalex.org/W1482019136","https://openalex.org/W1487232838","https://openalex.org/W1493037973","https://openalex.org/W1494364449","https://openalex.org/W1503511302","https://openalex.org/W1508227800","https://openalex.org/W1509571186","https://openalex.org/W1511517753","https://openalex.org/W1513401887","https://openalex.org/W1515176900","https://openalex.org/W1523796948","https://openalex.org/W1527171303","https://openalex.org/W1532399642","https://openalex.org/W1533029876","https://openalex.org/W1536027939","https://openalex.org/W1536028944","https://openalex.org/W1536472139","https://openalex.org/W1538003756","https://openalex.org/W1541951511","https://openalex.org/W1542136448","https://openalex.org/W1543659825","https://openalex.org/W1546232808","https://openalex.org/W1547758273","https://openalex.org/W1548797188","https://openalex.org/W1548862642","https://openalex.org/W1554329005","https://openalex.org/W1557438503","https://openalex.org/W1558118820","https://openalex.org/W1563116834","https://openalex.org/W1565096249","https://openalex.org/W1567490604","https://openalex.org/W1569630040","https://openalex.org/W1578645292","https://openalex.org/W1595078459","https://openalex.org/W1596984737","https://openalex.org/W1598500272","https://openalex.org/W1600934558","https://openalex.org/W1602771322","https://openalex.org/W1608267968","https://openalex.org/W1621971853","https://openalex.org/W1626267121","https://openalex.org/W1642243794","https://openalex.org/W1648996057","https://openalex.org/W1657671873","https://openalex.org/W1667748077","https://openalex.org/W1668344921","https://openalex.org/W1693283493","https://openalex.org/W1765834125","https://openalex.org/W1811472601","https://openalex.org/W1825604636","https://openalex.org/W1850100528","https://openalex.org/W1895538680","https://openalex.org/W1928316055","https://openalex.org/W1959886281","https://openalex.org/W1963568158","https://openalex.org/W1963773666","https://openalex.org/W1963812982","https://openalex.org/W1964041350","https://openalex.org/W1964464904","https://openalex.org/W1965012535","https://openalex.org/W1965275873","https://openalex.org/W1965442868","https://openalex.org/W1966522871","https://openalex.org/W1966915291","https://openalex.org/W1966977299","https://openalex.org/W1967061503","https://openalex.org/W1967399741","https://openalex.org/W1967449373","https://openalex.org/W1967464880","https://openalex.org/W1967549235","https://openalex.org/W1967642097","https://openalex.org/W1967674023","https://openalex.org/W1967823816","https://openalex.org/W1968057097","https://openalex.org/W1968168309","https://openalex.org/W1968615956","https://openalex.org/W1968973248","https://openalex.org/W1969126678","https://openalex.org/W1969905245","https://openalex.org/W1970332710","https://openalex.org/W1970606114","https://openalex.org/W1971200109","https://openalex.org/W1971210753","https://openalex.org/W1971570784","https://openalex.org/W1972025839","https://openalex.org/W1972285334","https://openalex.org/W1972784541","https://openalex.org/W1973774127","https://openalex.org/W1973855353","https://openalex.org/W1973891258","https://openalex.org/W1974313653","https://openalex.org/W1974966491","https://openalex.org/W1975040221","https://openalex.org/W1975232691","https://openalex.org/W1975563236","https://openalex.org/W1976010325","https://openalex.org/W1976266513","https://openalex.org/W1976597647","https://openalex.org/W1976618296","https://openalex.org/W1977002082","https://openalex.org/W1977257270","https://openalex.org/W1977879845","https://openalex.org/W1977899668","https://openalex.org/W1978063188","https://openalex.org/W1978119802","https://openalex.org/W1978266853","https://openalex.org/W1978812303","https://openalex.org/W1978919116","https://openalex.org/W1979415323","https://openalex.org/W1979987243","https://openalex.org/W1980065553","https://openalex.org/W1980661152","https://openalex.org/W1981127983","https://openalex.org/W1981288814","https://openalex.org/W1981439874","https://openalex.org/W1981580199","https://openalex.org/W1981807851","https://openalex.org/W1981962503","https://openalex.org/W1982506852","https://openalex.org/W1982675433","https://openalex.org/W1982959887","https://openalex.org/W1983019708","https://openalex.org/W1983166842","https://openalex.org/W1983479763","https://openalex.org/W1983673952","https://openalex.org/W1983865214","https://openalex.org/W1984503507","https://openalex.org/W1984865373","https://openalex.org/W1985058290","https://openalex.org/W1985313675","https://openalex.org/W1985613394","https://openalex.org/W1985915754","https://openalex.org/W1986512401","https://openalex.org/W1986830236","https://openalex.org/W1987046654","https://openalex.org/W1987095222","https://openalex.org/W1987735044","https://openalex.org/W1989734927","https://openalex.org/W1990179157","https://openalex.org/W1990596859","https://openalex.org/W1990632702","https://openalex.org/W1990986671","https://openalex.org/W1990998684","https://openalex.org/W1991168471","https://openalex.org/W1991602657","https://openalex.org/W1991838815","https://openalex.org/W1991993391","https://openalex.org/W1992263421","https://openalex.org/W1992275212","https://openalex.org/W1992318681","https://openalex.org/W1992481658","https://openalex.org/W1992783549","https://openalex.org/W1992841111","https://openalex.org/W1993094179","https://openalex.org/W1993250284","https://openalex.org/W1993405199","https://openalex.org/W1993589138","https://openalex.org/W1993748281","https://openalex.org/W1993862136","https://openalex.org/W1993909442","https://openalex.org/W1994017777","https://openalex.org/W1994067502","https://openalex.org/W1994160001","https://openalex.org/W1994183414","https://openalex.org/W1994336523","https://openalex.org/W1994982270","https://openalex.org/W1995344309","https://openalex.org/W1995426930","https://openalex.org/W1995536173","https://openalex.org/W1995834522","https://openalex.org/W1996245114","https://openalex.org/W1998087244","https://openalex.org/W1998208719","https://openalex.org/W1998227221","https://openalex.org/W1998307422","https://openalex.org/W1998440544","https://openalex.org/W1999066993","https://openalex.org/W1999357946","https://openalex.org/W2000397440","https://openalex.org/W2000917982","https://openalex.org/W2001210466","https://openalex.org/W2001436176","https://openalex.org/W2002156069","https://openalex.org/W2002305576","https://openalex.org/W2002352560","https://openalex.org/W2002670780","https://openalex.org/W2002979194","https://openalex.org/W2003030405","https://openalex.org/W2003313487","https://openalex.org/W2003813921","https://openalex.org/W2004150448","https://openalex.org/W2004492484","https://openalex.org/W2004535959","https://openalex.org/W2005076304","https://openalex.org/W2005267396","https://openalex.org/W2005681172","https://openalex.org/W2005719973","https://openalex.org/W2006219887","https://openalex.org/W2006247983","https://openalex.org/W2007362831","https://openalex.org/W2007511428","https://openalex.org/W2007573471","https://openalex.org/W2007852796","https://openalex.org/W2008273601","https://openalex.org/W2008553814","https://openalex.org/W2008815076","https://openalex.org/W2009813808","https://openalex.org/W2009828191","https://openalex.org/W2010377590","https://openalex.org/W2010701298","https://openalex.org/W2010847250","https://openalex.org/W2011197454","https://openalex.org/W2011347889","https://openalex.org/W2012136117","https://openalex.org/W2012364722","https://openalex.org/W2012628829","https://openalex.org/W2013078308","https://openalex.org/W2013279295","https://openalex.org/W2013471403","https://openalex.org/W2013576192","https://openalex.org/W2014456898","https://openalex.org/W2014540704","https://openalex.org/W2014742480","https://openalex.org/W2014886338","https://openalex.org/W2015161609","https://openalex.org/W2015484447","https://openalex.org/W2015522247","https://openalex.org/W2015860144","https://openalex.org/W2015933608","https://openalex.org/W2016758992","https://openalex.org/W2017260345","https://openalex.org/W2017605183","https://openalex.org/W2017779103","https://openalex.org/W2018435435","https://openalex.org/W2018843440","https://openalex.org/W2019042091","https://openalex.org/W2019044369","https://openalex.org/W2020842716","https://openalex.org/W2021626693","https://openalex.org/W2021746954","https://openalex.org/W2022516974","https://openalex.org/W2024524568","https://openalex.org/W2024816116","https://openalex.org/W2024866120","https://openalex.org/W2025018124","https://openalex.org/W2025946388","https://openalex.org/W2026156322","https://openalex.org/W2026279003","https://openalex.org/W2026321461","https://openalex.org/W2026422955","https://openalex.org/W2026737475","https://openalex.org/W2027131229","https://openalex.org/W2027291257","https://openalex.org/W2027676229","https://openalex.org/W2027793359","https://openalex.org/W2028463112","https://openalex.org/W2028471410","https://openalex.org/W2028757687","https://openalex.org/W2028826941","https://openalex.org/W2028937444","https://openalex.org/W2029373420","https://openalex.org/W2029593286","https://openalex.org/W2029640857","https://openalex.org/W2030697317","https://openalex.org/W2030892371","https://openalex.org/W2031231593","https://openalex.org/W2031293980","https://openalex.org/W2031743210","https://openalex.org/W2032694200","https://openalex.org/W2032920422","https://openalex.org/W2033356439","https://openalex.org/W2033366750","https://openalex.org/W2033617297","https://openalex.org/W2033726284","https://openalex.org/W2034147064","https://openalex.org/W2034254855","https://openalex.org/W2034286717","https://openalex.org/W2034295832","https://openalex.org/W2034387476","https://openalex.org/W2034502915","https://openalex.org/W2035036667","https://openalex.org/W2035282018","https://openalex.org/W2035462700","https://openalex.org/W2035680108","https://openalex.org/W2035683560","https://openalex.org/W2036362108","https://openalex.org/W2036566171","https://openalex.org/W2036599501","https://openalex.org/W2036735444","https://openalex.org/W2036755018","https://openalex.org/W2036931179","https://openalex.org/W2036955747","https://openalex.org/W2037617444","https://openalex.org/W2038120434","https://openalex.org/W2038594716","https://openalex.org/W2038967600","https://openalex.org/W2039060098","https://openalex.org/W2039468514","https://openalex.org/W2039716280","https://openalex.org/W2040101760","https://openalex.org/W2040721401","https://openalex.org/W2040912634","https://openalex.org/W2041355017","https://openalex.org/W2042151184","https://openalex.org/W2042427055","https://openalex.org/W2042469294","https://openalex.org/W2042584101","https://openalex.org/W2042670624","https://openalex.org/W2042979672","https://openalex.org/W2043044540","https://openalex.org/W2043087509","https://openalex.org/W2043332654","https://openalex.org/W2043762446","https://openalex.org/W2044699444","https://openalex.org/W2044788039","https://openalex.org/W2044975042","https://openalex.org/W2045007926","https://openalex.org/W2045153164","https://openalex.org/W2045262404","https://openalex.org/W2045772297","https://openalex.org/W2045855955","https://openalex.org/W2045932062","https://openalex.org/W2046161434","https://openalex.org/W2046209489","https://openalex.org/W2046413250","https://openalex.org/W2046599479","https://openalex.org/W2046768931","https://openalex.org/W2047704857","https://openalex.org/W2048161265","https://openalex.org/W2048865592","https://openalex.org/W2049146362","https://openalex.org/W2049167261","https://openalex.org/W2049452297","https://openalex.org/W2049734627","https://openalex.org/W2049808194","https://openalex.org/W2050644696","https://openalex.org/W2050699830","https://openalex.org/W2051064550","https://openalex.org/W2051240154","https://openalex.org/W2051639780","https://openalex.org/W2051947267","https://openalex.org/W2052132290","https://openalex.org/W2052652421","https://openalex.org/W2052741633","https://openalex.org/W2052742260","https://openalex.org/W2052963059","https://openalex.org/W2053063069","https://openalex.org/W2053116497","https://openalex.org/W2053488262","https://openalex.org/W2054082659","https://openalex.org/W2054183594","https://openalex.org/W2055075860","https://openalex.org/W2055092854","https://openalex.org/W2055177082","https://openalex.org/W2055236219","https://openalex.org/W2055487345","https://openalex.org/W2055829587","https://openalex.org/W2056139117","https://openalex.org/W2056666417","https://openalex.org/W2056936299","https://openalex.org/W2057249855","https://openalex.org/W2057766834","https://openalex.org/W2058398958","https://openalex.org/W2058570072","https://openalex.org/W2058614488","https://openalex.org/W2058723245","https://openalex.org/W2058834884","https://openalex.org/W2058880763","https://openalex.org/W2058970680","https://openalex.org/W2059030964","https://openalex.org/W2059452586","https://openalex.org/W2059501379","https://openalex.org/W2059568035","https://openalex.org/W2060444822","https://openalex.org/W2060448382","https://openalex.org/W2060964242","https://openalex.org/W2061216396","https://openalex.org/W2061631515","https://openalex.org/W2061660439","https://openalex.org/W2062396165","https://openalex.org/W2063351395","https://openalex.org/W2063661531","https://openalex.org/W2063795953","https://openalex.org/W2063808031","https://openalex.org/W2064728333","https://openalex.org/W2064836594","https://openalex.org/W2065613337","https://openalex.org/W2065995695","https://openalex.org/W2066384268","https://openalex.org/W2066825835","https://openalex.org/W2066912376","https://openalex.org/W2066943555","https://openalex.org/W2066951766","https://openalex.org/W2067727463","https://openalex.org/W2068011052","https://openalex.org/W2068042361","https://openalex.org/W2068693752","https://openalex.org/W2068859178","https://openalex.org/W2068929145","https://openalex.org/W2069121057","https://openalex.org/W2070137740","https://openalex.org/W2070251027","https://openalex.org/W2070301080","https://openalex.org/W2070665570","https://openalex.org/W2070971554","https://openalex.org/W2071041688","https://openalex.org/W2071698914","https://openalex.org/W2071921522","https://openalex.org/W2071982060","https://openalex.org/W2072275270","https://openalex.org/W2072441360","https://openalex.org/W2072787449","https://openalex.org/W2072983755","https://openalex.org/W2073137315","https://openalex.org/W2074405990","https://openalex.org/W2074502503","https://openalex.org/W2075193321","https://openalex.org/W2075444764","https://openalex.org/W2075471409","https://openalex.org/W2075487392","https://openalex.org/W2075603142","https://openalex.org/W2076034559","https://openalex.org/W2076384868","https://openalex.org/W2076403167","https://openalex.org/W2076407459","https://openalex.org/W2076636473","https://openalex.org/W2077271160","https://openalex.org/W2077377303","https://openalex.org/W2077464099","https://openalex.org/W2077475987","https://openalex.org/W2077783001","https://openalex.org/W2077925351","https://openalex.org/W2077997327","https://openalex.org/W2078624589","https://openalex.org/W2078646014","https://openalex.org/W2079133792","https://openalex.org/W2079320514","https://openalex.org/W2079592978","https://openalex.org/W2079845729","https://openalex.org/W2080196731","https://openalex.org/W2080225612","https://openalex.org/W2080935386","https://openalex.org/W2081117923","https://openalex.org/W2081831345","https://openalex.org/W2081881251","https://openalex.org/W2082504479","https://openalex.org/W2082770210","https://openalex.org/W2082856520","https://openalex.org/W2082899146","https://openalex.org/W2083237411","https://openalex.org/W2083319491","https://openalex.org/W2083355844","https://openalex.org/W2083556882","https://openalex.org/W2083633251","https://openalex.org/W2083752135","https://openalex.org/W2083882468","https://openalex.org/W2084105597","https://openalex.org/W2084221243","https://openalex.org/W2084449734","https://openalex.org/W2084453905","https://openalex.org/W2084972185","https://openalex.org/W2085106134","https://openalex.org/W2085667648","https://openalex.org/W2085778707","https://openalex.org/W2086023016","https://openalex.org/W2086030126","https://openalex.org/W2086278983","https://openalex.org/W2086875238","https://openalex.org/W2087161646","https://openalex.org/W2087563563","https://openalex.org/W2087581471","https://openalex.org/W2088482846","https://openalex.org/W2088677347","https://openalex.org/W2088733194","https://openalex.org/W2088802253","https://openalex.org/W2089665913","https://openalex.org/W2089765922","https://openalex.org/W2090118178","https://openalex.org/W2090349395","https://openalex.org/W2091497743","https://openalex.org/W2091505182","https://openalex.org/W2091899812","https://openalex.org/W2091935655","https://openalex.org/W2092157608","https://openalex.org/W2092765133","https://openalex.org/W2092803321","https://openalex.org/W2093508373","https://openalex.org/W2093705034","https://openalex.org/W2093852116","https://openalex.org/W2093861673","https://openalex.org/W2094294016","https://openalex.org/W2094377640","https://openalex.org/W2094660330","https://openalex.org/W2096142564","https://openalex.org/W2096268925","https://openalex.org/W2096277075","https://openalex.org/W2096330567","https://openalex.org/W2096410114","https://openalex.org/W2096814558","https://openalex.org/W2097075649","https://openalex.org/W2097811455","https://openalex.org/W2097867538","https://openalex.org/W2098393992","https://openalex.org/W2099484254","https://openalex.org/W2100464372","https://openalex.org/W2100610042","https://openalex.org/W2101187328","https://openalex.org/W2101276626","https://openalex.org/W2102206829","https://openalex.org/W2102367456","https://openalex.org/W2102747732","https://openalex.org/W2103024032","https://openalex.org/W2103071556","https://openalex.org/W2103440561","https://openalex.org/W2103711259","https://openalex.org/W2103861118","https://openalex.org/W2104372589","https://openalex.org/W2104757313","https://openalex.org/W2105091430","https://openalex.org/W2105704879","https://openalex.org/W2106083290","https://openalex.org/W2106190040","https://openalex.org/W2106931873","https://openalex.org/W2107015337","https://openalex.org/W2107094473","https://openalex.org/W2107962914","https://openalex.org/W2108216694","https://openalex.org/W2109699895","https://openalex.org/W2109727228","https://openalex.org/W2109909801","https://openalex.org/W2110081525","https://openalex.org/W2110232607","https://openalex.org/W2110286211","https://openalex.org/W2110313965","https://openalex.org/W2110495699","https://openalex.org/W2110670912","https://openalex.org/W2110729320","https://openalex.org/W2110888808","https://openalex.org/W2111464898","https://openalex.org/W2112047897","https://openalex.org/W2112350141","https://openalex.org/W2112360486","https://openalex.org/W2112516157","https://openalex.org/W2112579276","https://openalex.org/W2112660358","https://openalex.org/W2112880160","https://openalex.org/W2113576314","https://openalex.org/W2113690827","https://openalex.org/W2115855931","https://openalex.org/W2115933910","https://openalex.org/W2116904605","https://openalex.org/W2116964904","https://openalex.org/W2117285167","https://openalex.org/W2119098586","https://openalex.org/W2119270366","https://openalex.org/W2119279113","https://openalex.org/W2119309595","https://openalex.org/W2120010406","https://openalex.org/W2120642977","https://openalex.org/W2121713269","https://openalex.org/W2121990787","https://openalex.org/W2122065835","https://openalex.org/W2122412498","https://openalex.org/W2122828560","https://openalex.org/W2122873209","https://openalex.org/W2122948984","https://openalex.org/W2123533032","https://openalex.org/W2124120422","https://openalex.org/W2124490243","https://openalex.org/W2124519976","https://openalex.org/W2125236750","https://openalex.org/W2125311191","https://openalex.org/W2126019582","https://openalex.org/W2126676163","https://openalex.org/W2126800086","https://openalex.org/W2126897233","https://openalex.org/W2127229268","https://openalex.org/W2127432084","https://openalex.org/W2127714088","https://openalex.org/W2128197886","https://openalex.org/W2128251808","https://openalex.org/W2128261193","https://openalex.org/W2128462285","https://openalex.org/W2128613449","https://openalex.org/W2129337589","https://openalex.org/W2129497119","https://openalex.org/W2129677617","https://openalex.org/W2130035294","https://openalex.org/W2130255055","https://openalex.org/W2130365060","https://openalex.org/W2130529018","https://openalex.org/W2130763296","https://openalex.org/W2131047041","https://openalex.org/W2131328232","https://openalex.org/W2131439915","https://openalex.org/W2131830246","https://openalex.org/W2132154794","https://openalex.org/W2132806643","https://openalex.org/W2132810311","https://openalex.org/W2132983470","https://openalex.org/W2133019124","https://openalex.org/W2133447959","https://openalex.org/W2133646735","https://openalex.org/W2133759882","https://openalex.org/W2134203563","https://openalex.org/W2134365974","https://openalex.org/W2134711807","https://openalex.org/W2135309154","https://openalex.org/W2135780456","https://openalex.org/W2136439668","https://openalex.org/W2136749650","https://openalex.org/W2136837252","https://openalex.org/W2139046272","https://openalex.org/W2140050496","https://openalex.org/W2140131793","https://openalex.org/W2140139281","https://openalex.org/W2140665706","https://openalex.org/W2141330531","https://openalex.org/W2141644343","https://openalex.org/W2141918279","https://openalex.org/W2142140888","https://openalex.org/W2142366168","https://openalex.org/W2143095609","https://openalex.org/W2144232916","https://openalex.org/W2145210308","https://openalex.org/W2145258357","https://openalex.org/W2145356433","https://openalex.org/W2145736817","https://openalex.org/W2145828601","https://openalex.org/W2145938600","https://openalex.org/W2146188406","https://openalex.org/W2147319333","https://openalex.org/W2147493255","https://openalex.org/W2147904592","https://openalex.org/W2148034536","https://openalex.org/W2148139455","https://openalex.org/W2148226248","https://openalex.org/W2148752404","https://openalex.org/W2148800099","https://openalex.org/W2148898943","https://openalex.org/W2148911867","https://openalex.org/W2149086197","https://openalex.org/W2150231759","https://openalex.org/W2151380506","https://openalex.org/W2151409678","https://openalex.org/W2151417786","https://openalex.org/W2151585937","https://openalex.org/W2152119060","https://openalex.org/W2152185487","https://openalex.org/W2152446053","https://openalex.org/W2152529094","https://openalex.org/W2152641228","https://openalex.org/W2152719134","https://openalex.org/W2152889673","https://openalex.org/W2153055836","https://openalex.org/W2153240577","https://openalex.org/W2153323361","https://openalex.org/W2153389047","https://openalex.org/W2153655497","https://openalex.org/W2153747061","https://openalex.org/W2154164205","https://openalex.org/W2154508412","https://openalex.org/W2154880023","https://openalex.org/W2155104195","https://openalex.org/W2155237226","https://openalex.org/W2155390548","https://openalex.org/W2155965284","https://openalex.org/W2156093068","https://openalex.org/W2156398762","https://openalex.org/W2156788921","https://openalex.org/W2157064933","https://openalex.org/W2157079522","https://openalex.org/W2157902443","https://openalex.org/W2158766477","https://openalex.org/W2158844055","https://openalex.org/W2159122349","https://openalex.org/W2159223294","https://openalex.org/W2159252214","https://openalex.org/W2159271495","https://openalex.org/W2159377066","https://openalex.org/W2159838014","https://openalex.org/W2159879659","https://openalex.org/W2159987542","https://openalex.org/W2160371310","https://openalex.org/W2161290803","https://openalex.org/W2161576159","https://openalex.org/W2161737267","https://openalex.org/W2161766823","https://openalex.org/W2161874115","https://openalex.org/W2161964141","https://openalex.org/W2161981442","https://openalex.org/W2161997696","https://openalex.org/W2162184517","https://openalex.org/W2162675860","https://openalex.org/W2162698632","https://openalex.org/W2162716229","https://openalex.org/W2163115168","https://openalex.org/W2163179762","https://openalex.org/W2163562064","https://openalex.org/W2163603138","https://openalex.org/W2163751922","https://openalex.org/W2163825883","https://openalex.org/W2164173177","https://openalex.org/W2164201168","https://openalex.org/W2164672119","https://openalex.org/W2164765564","https://openalex.org/W2165021720","https://openalex.org/W2165284149","https://openalex.org/W2165413779","https://openalex.org/W2165441361","https://openalex.org/W2165890579","https://openalex.org/W2165894897","https://openalex.org/W2166503250","https://openalex.org/W2166511841","https://openalex.org/W2167022467","https://openalex.org/W2167276152","https://openalex.org/W2167638846","https://openalex.org/W2167720733","https://openalex.org/W2167840686","https://openalex.org/W2169473035","https://openalex.org/W2169515653","https://openalex.org/W2169831064","https://openalex.org/W2170644095","https://openalex.org/W2170891630","https://openalex.org/W2171250577","https://openalex.org/W2171311951","https://openalex.org/W2171349254","https://openalex.org/W2171403795","https://openalex.org/W2171526610","https://openalex.org/W2171545307","https://openalex.org/W2172007938","https://openalex.org/W2172062051","https://openalex.org/W2185304259","https://openalex.org/W2261912426","https://openalex.org/W2288837755","https://openalex.org/W2315877742","https://openalex.org/W2337947575","https://openalex.org/W2400310660","https://openalex.org/W2725718031","https://openalex.org/W2789870354","https://openalex.org/W3214092816","https://openalex.org/W4210979710","https://openalex.org/W4229639542","https://openalex.org/W4230350248","https://openalex.org/W4230565756","https://openalex.org/W4247759744","https://openalex.org/W4251556408","https://openalex.org/W4252526962","https://openalex.org/W4253040143","https://openalex.org/W4299350037","https://openalex.org/W4313105713","https://openalex.org/W4322701390","https://openalex.org/W7101084658","https://openalex.org/W7212071797"],"related_works":["https://openalex.org/W7084279985","https://openalex.org/W7147676218","https://openalex.org/W4392347387","https://openalex.org/W817893575","https://openalex.org/W4392347223","https://openalex.org/W7150772161","https://openalex.org/W7033706817","https://openalex.org/W1987707269","https://openalex.org/W2024864945","https://openalex.org/W6981675143"],"abstract_inverted_index":{"La":[0,14],"maladie":[1],"d\u2019Alzheimer":[2],"(MA)":[3],"est":[4],"une":[5,18,62,93,184],"pathologie":[6],"neurod\u00e9g\u00e9n\u00e9rative":[7],"caract\u00e9ris\u00e9e":[8],"par":[9,101],"l\u2019accumulation":[10],"de":[11,43,71,78,113,137,140,152,170,186,221,227,237],"peptide":[12],"A\u03b2.":[13],"vaccination":[15],"anti-A\u03b2":[16,100,120],"constitue":[17],"strat\u00e9gie":[19],"th\u00e9rapeutique":[20,77],"prometteuse":[21],"et":[22,74,112,189,224],"des":[23,34,48,64,96,116,155,164,192,196,207,216],"\u00e9tudes":[24,60],"chez":[25,174],"l'animal":[26],"ainsi":[27],"qu\u2019un":[28],"premier":[29],"essai":[30],"clinique":[31],"ont":[32,38,91],"donn\u00e9":[33],"r\u00e9sultats":[35,211],"encourageants.":[36],"Ils":[37],"n\u00e9anmoins":[39],"soulign\u00e9":[40],"la":[41,52,57,69,72,114,150,187,222,238],"n\u00e9cessit\u00e9":[42],"mieux":[44],"comprendre":[45],"le":[46,75,87,235],"r\u00f4le":[47,111,214],"cellules":[49,65,141,193,217],"T":[50,66,98,104,118,142],"dans":[51,68],"r\u00e9action":[53],"neuroinflammatoire":[54],"associ\u00e9e":[55],"\u00e0":[56,134,157,178],"MA.":[58,239],"Diff\u00e9rentes":[59],"sugg\u00e8rent":[61,212],"implication":[63],"CD4+":[67,99,119,143],"physiopathologie":[70],"maladie,":[73],"potentiel":[76],"certaines":[79],"sous-populations.":[80],"Des":[81],"travaux":[82],"r\u00e9alis\u00e9s":[83],"au":[84,162,219],"laboratoire":[85],"sur":[86,144,231],"mod\u00e8le":[88],"murin":[89],"APPPS1":[90],"sugg\u00e9r\u00e9":[92],"modulation":[94],"critique":[95],"r\u00e9ponses":[97,117,146,172],"les":[102,126,145,175],"lymphocytes":[103],"r\u00e9gulateurs":[105],"(Treg).":[106],"Une":[107,129],"meilleure":[108],"compr\u00e9hension":[109],"du":[110,190],"r\u00e9gulation":[115],"semble":[121],"donc":[122],"essentielle":[123],"pour":[124,234],"optimiser":[125],"strat\u00e9gies":[127,228],"d\u2019immunoth\u00e9rapie.":[128],"\u00e9tude":[130],"in":[131,168],"vitro":[132],"visant":[133],"caract\u00e9riser":[135],"l\u2019impact":[136],"diverses":[138],"populations":[139],"microgliales":[147,194],"a":[148],"montr\u00e9":[149],"capacit\u00e9":[151],"cytokines":[153],"caract\u00e9ristiques":[154],"Treg":[156,173,218],"promouvoir":[158],"un":[159,179,213],"ph\u00e9notype":[160],"neuroprotecteur":[161,215],"sein":[163],"phagocytes":[165],"mononucl\u00e9\u00e9s.":[166],"L\u2019amplification":[167],"vivo":[169],"ces":[171],"souris":[176],"APPPS1,":[177],"stade":[180],"pathologique":[181],"pr\u00e9coce,":[182],"induit":[183],"augmentation":[185],"microgliose":[188],"recrutement":[191],"autour":[195],"plaques":[197],"amylo\u00efdes.":[198],"Ces":[199],"modifications":[200],"neuropathologiques":[201],"sont":[202],"accompagn\u00e9es":[203],"d\u2019un":[204],"retard":[205],"d\u2019apparition":[206],"troubles":[208],"cognitifs.":[209],"Nos":[210],"cours":[220],"MA,":[223],"soulignent":[225],"l\u2019int\u00e9r\u00eat":[226],"d\u2019immunoth\u00e9rapie":[229],"bas\u00e9es":[230],"leur":[232],"potentialisation":[233],"traitement":[236]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-04-07T00:00:00"}