{"id":"https://openalex.org/W7149979094","doi":"https://doi.org/10.1016/j.ijpharm.2026.126844","title":"Alginate-driven nanotherapeutics in liver cancer: design, applications, and future perspectives","display_name":"Alginate-driven nanotherapeutics in liver cancer: design, applications, and future perspectives","publication_year":2026,"publication_date":"2026-04-06","ids":{"openalex":"https://openalex.org/W7149979094","doi":"https://doi.org/10.1016/j.ijpharm.2026.126844","pmid":"https://pubmed.ncbi.nlm.nih.gov/41946427"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2026.126844","doi":"https://doi.org/10.1016/j.ijpharm.2026.126844","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2026.126844","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101722328","display_name":"Tanvi Desai","orcid":"https://orcid.org/0000-0003-3332-8267","observed_orcids":["https://orcid.org/0000-0003-3332-8267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanvi Desai","raw_affiliation_strings":["Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, 394345 Bardoli, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, 394345 Bardoli, Gujarat, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107549618","display_name":"Ekta Rawat","orcid":"https://orcid.org/0000-0001-5183-3094","observed_orcids":["https://orcid.org/0000-0001-5183-3094"]},"institutions":[{"id":"https://openalex.org/I4405253735","display_name":"Manav Rachna University","ror":"https://ror.org/0117a2k50","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405253735"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ekta Rawat","raw_affiliation_strings":["Department of Sciences, Manav Rachna University, Faridabad 121004 Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sciences, Manav Rachna University, Faridabad 121004 Haryana, India","institution_ids":["https://openalex.org/I4405253735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055471975","display_name":"Nitin G. Haswani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nitin G. Haswani","raw_affiliation_strings":["R.C.Patel Institute of Pharmacy, Shirpur 425405, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R.C.Patel Institute of Pharmacy, Shirpur 425405, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031644040","display_name":"Shadma Wahab","orcid":"https://orcid.org/0000-0001-9941-2918","observed_orcids":["https://orcid.org/0000-0001-9941-2918"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Shadma Wahab","raw_affiliation_strings":["Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004660521","display_name":"Saad Ali Alshehri","orcid":"https://orcid.org/0000-0001-6266-7116","observed_orcids":["https://orcid.org/0000-0001-6266-7116"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Saad Ali Alshehri","raw_affiliation_strings":["Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031625375","display_name":"Devesh U. Kapoor","orcid":"https://orcid.org/0000-0003-4085-8936","observed_orcids":["https://orcid.org/0000-0003-4085-8936"]},"institutions":[{"id":"https://openalex.org/I4405255592","display_name":"Dr. Dayaram Patel Pharmacy College","ror":"https://ror.org/036dmex16","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255592"]},{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Devesh U. Kapoor","raw_affiliation_strings":["Dr. Dayaram Patel Pharmacy College, Bardoli 394601, Gujarat, India; Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura 140417, Punjab, India. Electronic address: deveshkapoor@dppc.ac.in"],"raw_orcid":"https://orcid.org/0000-0003-4085-8936","affiliations":[{"raw_affiliation_string":"Dr. Dayaram Patel Pharmacy College, Bardoli 394601, Gujarat, India; Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura 140417, Punjab, India. Electronic address: deveshkapoor@dppc.ac.in","institution_ids":["https://openalex.org/I4405255592","https://openalex.org/I74319210"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031625375"],"corresponding_institution_ids":["https://openalex.org/I4405255592","https://openalex.org/I74319210"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.6951,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58833845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"696","issue":null,"first_page":"126844","last_page":"126844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alginate","display_name":"alginate","score":0.953000009059906},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.777999997138977},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.8360000252723694},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5519999861717224},{"id":"https://openalex.org/keywords/nanogels","display_name":"nanogels","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.6159999966621399},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-release","display_name":"stimuli-responsive drug release","score":0.7279999852180481},{"id":"https://openalex.org/keywords/enhanced-permeability-and-retention-effect","display_name":"enhanced permeability and retention effect","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mitochondrial-targeting","display_name":"mitochondrial targeting","score":0.984000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.3628000020980835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3127000033855438},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29010000824928284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2653000056743622},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.2401999980211258},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.21979999542236328},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.21860000491142273}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijpharm.2026.126844","doi":"https://doi.org/10.1016/j.ijpharm.2026.126844","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2026.126844","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:41946427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41946427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3951002094","display_name":null,"funder_award_id":"RGP1/178/46","funder_id":"https://openalex.org/F33954902","funder_display_name":"Deanship of Scientific Research, King Khalid University"}],"funders":[{"id":"https://openalex.org/F33954902","display_name":"Deanship of Scientific Research, King Khalid University","ror":null},{"id":"https://openalex.org/F4320324433","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W1582334135","https://openalex.org/W2042249858","https://openalex.org/W2064563957","https://openalex.org/W2067411108","https://openalex.org/W2185840296","https://openalex.org/W2542306406","https://openalex.org/W2605035819","https://openalex.org/W2937161801","https://openalex.org/W2941871458","https://openalex.org/W2955364378","https://openalex.org/W3000448813","https://openalex.org/W3009459883","https://openalex.org/W3016730849","https://openalex.org/W3025718558","https://openalex.org/W3033969339","https://openalex.org/W3092455849","https://openalex.org/W3094731219","https://openalex.org/W3133038783","https://openalex.org/W3175660010","https://openalex.org/W3177998703","https://openalex.org/W3186881105","https://openalex.org/W3191894985","https://openalex.org/W3198198090","https://openalex.org/W3206304660","https://openalex.org/W3215071909","https://openalex.org/W4206033633","https://openalex.org/W4210533541","https://openalex.org/W4211201834","https://openalex.org/W4212876459","https://openalex.org/W4221099652","https://openalex.org/W4223591140","https://openalex.org/W4224230549","https://openalex.org/W4224233166","https://openalex.org/W4281630077","https://openalex.org/W4283013726","https://openalex.org/W4283707838","https://openalex.org/W4286008744","https://openalex.org/W4286515850","https://openalex.org/W4289840936","https://openalex.org/W4295880955","https://openalex.org/W4306811601","https://openalex.org/W4312129234","https://openalex.org/W4313481570","https://openalex.org/W4313639861","https://openalex.org/W4319000905","https://openalex.org/W4322491391","https://openalex.org/W4322631814","https://openalex.org/W4322754630","https://openalex.org/W4323313357","https://openalex.org/W4360999164","https://openalex.org/W4365479148","https://openalex.org/W4367627309","https://openalex.org/W4377224940","https://openalex.org/W4379988166","https://openalex.org/W4380422563","https://openalex.org/W4382051481","https://openalex.org/W4382317851","https://openalex.org/W4385781594","https://openalex.org/W4386141702","https://openalex.org/W4386444620","https://openalex.org/W4388499665","https://openalex.org/W4388635818","https://openalex.org/W4388719831","https://openalex.org/W4388765747","https://openalex.org/W4389334908","https://openalex.org/W4389509491","https://openalex.org/W4390011276","https://openalex.org/W4390637118","https://openalex.org/W4390670420","https://openalex.org/W4391566701","https://openalex.org/W4391650792","https://openalex.org/W4391931507","https://openalex.org/W4392385310","https://openalex.org/W4392404210","https://openalex.org/W4392562022","https://openalex.org/W4394840572","https://openalex.org/W4399653159","https://openalex.org/W4400174569","https://openalex.org/W4400245659","https://openalex.org/W4401621114","https://openalex.org/W4401767103","https://openalex.org/W4402418616","https://openalex.org/W4403615566","https://openalex.org/W4403659360","https://openalex.org/W4404146592","https://openalex.org/W4404455154","https://openalex.org/W4404488935","https://openalex.org/W4405284819","https://openalex.org/W4405463037","https://openalex.org/W4405596581","https://openalex.org/W4405700424","https://openalex.org/W4406078409","https://openalex.org/W4406359319","https://openalex.org/W4406707630","https://openalex.org/W4406814649","https://openalex.org/W4407203105","https://openalex.org/W4407673116","https://openalex.org/W4407731422","https://openalex.org/W4407796386","https://openalex.org/W4408392346","https://openalex.org/W4408597221","https://openalex.org/W4408896337","https://openalex.org/W4408928598","https://openalex.org/W4409275375","https://openalex.org/W4409277188","https://openalex.org/W4409296933","https://openalex.org/W4409345528","https://openalex.org/W4409505712","https://openalex.org/W4409890949","https://openalex.org/W4409963296","https://openalex.org/W4410085752","https://openalex.org/W4410310093","https://openalex.org/W4410392835","https://openalex.org/W4410874911","https://openalex.org/W4410951256","https://openalex.org/W4411148344","https://openalex.org/W4411315344","https://openalex.org/W4411529675","https://openalex.org/W4412855752","https://openalex.org/W4413226903","https://openalex.org/W4413292389","https://openalex.org/W4413313725","https://openalex.org/W4413761363","https://openalex.org/W4413801421","https://openalex.org/W4414518446","https://openalex.org/W4414554310","https://openalex.org/W4414663708","https://openalex.org/W4415349046","https://openalex.org/W4416087278","https://openalex.org/W7125714822","https://openalex.org/W7125969737"],"related_works":["https://openalex.org/W2487258592","https://openalex.org/W7128008312","https://openalex.org/W4297201427","https://openalex.org/W3208774227","https://openalex.org/W3092455849","https://openalex.org/W4390011276","https://openalex.org/W4380422563","https://openalex.org/W3169765835","https://openalex.org/W4226215181","https://openalex.org/W4295880955"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-06T00:00:00"}