{"id":"https://openalex.org/W7149874808","doi":null,"title":"Assessing Functional Visual Recovery After Retinal Regeneration in Zebrafish Using the Optokinetic Response (OKR)","display_name":"Assessing Functional Visual Recovery After Retinal Regeneration in Zebrafish Using the Optokinetic Response (OKR)","publication_year":2026,"publication_date":"2026-04-03","ids":{"openalex":"https://openalex.org/W7149874808"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:som_srs-1599","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/som_srs/467","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1599&context=som_srs","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Student Research Symposium","raw_type":"text"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1599&context=som_srs","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132962677","display_name":"Yeganeh Tabatabaei Alavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"alavi, yeganeh tabatabaei","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5132962677"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20872865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-regeneration","display_name":"retinal regeneration","score":0.8970000147819519},{"id":"https://openalex.org/keywords/photoreceptor-regeneration","display_name":"photoreceptor regeneration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/optokinetic-reflex","display_name":"optokinetic response","score":0.9629999995231628},{"id":"https://openalex.org/keywords/light-induced-retinal-injury","display_name":"light-induced retinal damage","score":0.8740000128746033},{"id":"https://openalex.org/keywords/saccade-frequency","display_name":"saccade frequency","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pursuit-gain","display_name":"pursuit gain","score":0.972000002861023},{"id":"https://openalex.org/keywords/contrast-sensitivity","display_name":"contrast sensitivity","score":0.984000027179718},{"id":"https://openalex.org/keywords/spatial-resolution","display_name":"spatial resolution","score":0.7870000004768372},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7630000114440918},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C191789040","wikidata":"https://www.wikidata.org/wiki/Q912716","display_name":"Optokinetic reflex","level":3,"score":0.8129000067710876},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7803000211715698},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5979999899864197},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5837000012397766},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5672000050544739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4666000008583069},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.44760000705718994},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.4311999976634979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37389999628067017},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3140999972820282},{"id":"https://openalex.org/C2779524336","wikidata":"https://www.wikidata.org/wiki/Q369503","display_name":"Saccade","level":3,"score":0.29919999837875366},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2962000072002411},{"id":"https://openalex.org/C177275483","wikidata":"https://www.wikidata.org/wiki/Q7316769","display_name":"Retinal regeneration","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C2779113765","wikidata":"https://www.wikidata.org/wiki/Q681562","display_name":"Electroretinography","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2587999999523163},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C115490710","wikidata":"https://www.wikidata.org/wiki/Q4138732","display_name":"Spontaneous recovery","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:som_srs-1599","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/som_srs/467","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1599&context=som_srs","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Student Research Symposium","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:som_srs-1599","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/som_srs/467","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1599&context=som_srs","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Student Research Symposium","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7149874808.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6987096072","https://openalex.org/W4210706579","https://openalex.org/W4310995249","https://openalex.org/W7084141373","https://openalex.org/W4411362038","https://openalex.org/W3135057290","https://openalex.org/W4323348149","https://openalex.org/W2618612616","https://openalex.org/W2766779477","https://openalex.org/W4394853612"],"abstract_inverted_index":{"Zebrafish":[0],"have":[1],"a":[2,13,41,51,118,194],"unique":[3],"ability":[4],"to":[5,28,55,62],"regenerate":[6],"retinal":[7,201,226],"neurons":[8],"through":[9],"M\u00fcller":[10],"glia-mediated":[11],"reprogramming,":[12],"process":[14],"not":[15],"found":[16],"in":[17,74,182],"mammals.":[18],"While":[19],"structural":[20],"regeneration":[21,66],"has":[22],"been":[23],"extensively":[24],"documented,":[25],"the":[26,155,169,211],"degree":[27],"which":[29],"regenerated":[30],"photoreceptors":[31],"restore":[32],"functional":[33,75,195],"vision":[34],"remains":[35],"unclear.":[36],"The":[37],"optokinetic":[38],"response":[39],"(OKR),":[40],"reflexive":[42],"eye-tracking":[43],"behavior":[44],"triggered":[45],"by":[46,165],"moving":[47],"visual":[48,57,198],"stimuli,":[49],"provides":[50,193],"quantitative,":[52],"non-invasive":[53],"method":[54],"assess":[56],"performance.":[58],"This":[59],"study":[60],"aims":[61],"determine":[63],"whether":[64],"photoreceptor":[65],"following":[67,200],"acute":[68,89,156,204],"and":[69,94,107,114,128,138,147,162,176,184,205,216],"chronic":[70,95,170,206],"light-induced":[71],"injury":[72,90,96,157,171,207],"results":[73],"restoration":[76],"of":[77,124,197,222],"vision.":[78],"Adult":[79],"zebrafish":[80],"will":[81,102,132,159,173,209],"be":[82,103,133],"divided":[83],"into":[84],"three":[85],"groups:":[86],"uninjured":[87],"control,":[88],"(short-term":[91],"high-intensity":[92],"light),":[93],"(long-term":[97],"low-intensity":[98],"light).":[99],"OKR":[100,191],"testing":[101],"conducted":[104],"at":[105],"baseline":[106],"on":[108],"days":[109],"1,":[110],"5,":[111],"10,":[112],"14,":[113],"28":[115],"post-injury":[116],"using":[117],"custom":[119],"setup":[120],"presenting":[121],"rotating":[122],"gratings":[123],"varying":[125],"spatial":[126,148],"frequencies":[127],"contrasts.":[129],"Eye":[130],"movements":[131],"recorded":[134],"via":[135],"high-resolution":[136],"video":[137],"analyzed":[139],"for":[140,225],"saccade":[141],"frequency,":[142],"pursuit":[143],"gain,":[144],"contrast":[145],"sensitivity,":[146],"resolution":[149],"thresholds.":[150],"It":[151],"is":[152],"anticipated":[153],"that":[154],"group":[158,172],"exhibit":[160],"rapid":[161],"near-complete":[163],"recovery":[164,199],"day":[166],"28,":[167],"whereas":[168],"show":[174],"delayed":[175],"incomplete":[177],"recovery,":[178],"with":[179],"persistent":[180],"deficits":[181],"gain":[183],"resolution,":[185],"indicating":[186],"limited":[187],"CNS":[188],"reintegration.":[189],"Quantitative":[190],"analysis":[192],"measure":[196],"regeneration.":[202],"Comparing":[203],"paradigms":[208],"clarify":[210],"link":[212],"between":[213],"cellular":[214],"repair":[215],"restored":[217],"vision,":[218],"advancing":[219],"translational":[220],"understanding":[221],"regeneration-based":[223],"therapies":[224],"degenerative":[227],"diseases.":[228]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-04-05T00:00:00"}