{"id":"https://openalex.org/W7149289995","doi":"https://doi.org/10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","title":"Comprendre le m\u00e9canisme du syst\u00e8me senseur d\u2019h\u00e8me des bact\u00e9ries pathog\u00e8nes, une cible antibiotique innovante","display_name":"Comprendre le m\u00e9canisme du syst\u00e8me senseur d\u2019h\u00e8me des bact\u00e9ries pathog\u00e8nes, une cible antibiotique innovante","publication_year":2020,"publication_date":"2020-11-18","ids":{"openalex":"https://openalex.org/W7149289995","doi":"https://doi.org/10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","mag":"3103435984"},"language":"fr","primary_location":{"id":"doi:10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","doi":"https://doi.org/10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","is_oa":false,"landing_page_url":"https://doi.org/10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"universit\u00e9 Paris-Saclay","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.theses.fr/2020UPASB023/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108126412","display_name":"Vincent Saillant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Vincent Saillant","raw_affiliation_strings":["universit\u00e9 Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108126412"],"corresponding_institution_ids":["https://openalex.org/I277688954"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-sensing","display_name":"heme sensing","score":0.699999988079071},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.6830000281333923},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-targets","display_name":"antibiotic targets","score":0.5989999771118164},{"id":"https://openalex.org/keywords/heme-detoxification","display_name":"heme detoxification","score":0.6809999942779541},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.6520000100135803},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5220000147819519},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3181999921798706},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3111000061035156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2621999979019165},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2531000077724457},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.2011999934911728},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.1623000055551529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1429000049829483},{"id":"https://openalex.org/C3019832315","wikidata":"https://www.wikidata.org/wiki/Q5532355","display_name":"General interest","level":3,"score":0.13899999856948853},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.13619999587535858}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","doi":"https://doi.org/10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","is_oa":false,"landing_page_url":"https://doi.org/10.70675/2c50a6ddz7c94z4048z81bdz04e5cce574fc","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"universit\u00e9 Paris-Saclay","raw_type":"dissertation"},{"id":"pmh:2020UPASB023","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2020UPASB023/document","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:HAL:tel-03435882v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-03435882","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiologie et Parasitologie. Universit\u00e9 Paris-Saclay, 2020. Fran\u00e7ais. ⟨NNT : 2020UPASB023⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3103435984","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/tel-03435882v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:2020UPASB023","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2020UPASB023/document","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":354,"referenced_works":["https://openalex.org/W55987059","https://openalex.org/W90023215","https://openalex.org/W225712468","https://openalex.org/W633326766","https://openalex.org/W1502083078","https://openalex.org/W1507733280","https://openalex.org/W1517048546","https://openalex.org/W1529510611","https://openalex.org/W1531268983","https://openalex.org/W1538718516","https://openalex.org/W1542493215","https://openalex.org/W1549447858","https://openalex.org/W1549798534","https://openalex.org/W1568653786","https://openalex.org/W1573058404","https://openalex.org/W1591477834","https://openalex.org/W1603882315","https://openalex.org/W1607549514","https://openalex.org/W1608357071","https://openalex.org/W1667307942","https://openalex.org/W1762630411","https://openalex.org/W1805256536","https://openalex.org/W1816644759","https://openalex.org/W1823201916","https://openalex.org/W1832474145","https://openalex.org/W1838684513","https://openalex.org/W1844250641","https://openalex.org/W1861622576","https://openalex.org/W1862424926","https://openalex.org/W1871163165","https://openalex.org/W1878404532","https://openalex.org/W1926542189","https://openalex.org/W1928894901","https://openalex.org/W1941322164","https://openalex.org/W1947356700","https://openalex.org/W1963867445","https://openalex.org/W1965844459","https://openalex.org/W1967320582","https://openalex.org/W1967660413","https://openalex.org/W1967719595","https://openalex.org/W1968046235","https://openalex.org/W1968909193","https://openalex.org/W1969422680","https://openalex.org/W1970744314","https://openalex.org/W1972090636","https://openalex.org/W1972987912","https://openalex.org/W1973890975","https://openalex.org/W1975044967","https://openalex.org/W1975944453","https://openalex.org/W1976667730","https://openalex.org/W1977289330","https://openalex.org/W1978163337","https://openalex.org/W1978377186","https://openalex.org/W1979135961","https://openalex.org/W1979194107","https://openalex.org/W1979715674","https://openalex.org/W1980347238","https://openalex.org/W1982855811","https://openalex.org/W1984468583","https://openalex.org/W1985840130","https://openalex.org/W1986401262","https://openalex.org/W1987302249","https://openalex.org/W1987838454","https://openalex.org/W1988657382","https://openalex.org/W1989584376","https://openalex.org/W1989959009","https://openalex.org/W1990369214","https://openalex.org/W1990790749","https://openalex.org/W1991706282","https://openalex.org/W1993887172","https://openalex.org/W1994929831","https://openalex.org/W1995784525","https://openalex.org/W1996577630","https://openalex.org/W1997388387","https://openalex.org/W1998686777","https://openalex.org/W1999189021","https://openalex.org/W2001394772","https://openalex.org/W2001725411","https://openalex.org/W2003590099","https://openalex.org/W2004661177","https://openalex.org/W2005037961","https://openalex.org/W2005417003","https://openalex.org/W2006620950","https://openalex.org/W2006754144","https://openalex.org/W2008200635","https://openalex.org/W2009217296","https://openalex.org/W2011048815","https://openalex.org/W2011155321","https://openalex.org/W2011596188","https://openalex.org/W2013031563","https://openalex.org/W2013932766","https://openalex.org/W2014232133","https://openalex.org/W2014318202","https://openalex.org/W2016805250","https://openalex.org/W2017433201","https://openalex.org/W2017567107","https://openalex.org/W2017654147","https://openalex.org/W2018849855","https://openalex.org/W2018980690","https://openalex.org/W2021456293","https://openalex.org/W2024584374","https://openalex.org/W2025766479","https://openalex.org/W2026182346","https://openalex.org/W2026677195","https://openalex.org/W2027040966","https://openalex.org/W2027981574","https://openalex.org/W2028611514","https://openalex.org/W2030120115","https://openalex.org/W2030742563","https://openalex.org/W2032269392","https://openalex.org/W2032622346","https://openalex.org/W2034553048","https://openalex.org/W2036398696","https://openalex.org/W2036599624","https://openalex.org/W2036604960","https://openalex.org/W2037165584","https://openalex.org/W2037192566","https://openalex.org/W2038436541","https://openalex.org/W2038574420","https://openalex.org/W2039612769","https://openalex.org/W2039679742","https://openalex.org/W2039727644","https://openalex.org/W2039831000","https://openalex.org/W2041397090","https://openalex.org/W2041929490","https://openalex.org/W2043361189","https://openalex.org/W2043624646","https://openalex.org/W2044511581","https://openalex.org/W2044678473","https://openalex.org/W2047145145","https://openalex.org/W2047714123","https://openalex.org/W2048718515","https://openalex.org/W2050090579","https://openalex.org/W2051447459","https://openalex.org/W2053257505","https://openalex.org/W2053762233","https://openalex.org/W2055326033","https://openalex.org/W2055710073","https://openalex.org/W2055751200","https://openalex.org/W2055893635","https://openalex.org/W2056106906","https://openalex.org/W2056510326","https://openalex.org/W2058466508","https://openalex.org/W2059072412","https://openalex.org/W2059343647","https://openalex.org/W2059526824","https://openalex.org/W2059788227","https://openalex.org/W2060976020","https://openalex.org/W2063234149","https://openalex.org/W2064839882","https://openalex.org/W2065481994","https://openalex.org/W2065580598","https://openalex.org/W2067020332","https://openalex.org/W2067440861","https://openalex.org/W2068254342","https://openalex.org/W2069666755","https://openalex.org/W2071053703","https://openalex.org/W2074063169","https://openalex.org/W2074933207","https://openalex.org/W2075153401","https://openalex.org/W2076148773","https://openalex.org/W2076985939","https://openalex.org/W2078970472","https://openalex.org/W2078994321","https://openalex.org/W2079001549","https://openalex.org/W2079738433","https://openalex.org/W2080292048","https://openalex.org/W2081183202","https://openalex.org/W2084266616","https://openalex.org/W2084438536","https://openalex.org/W2085998013","https://openalex.org/W2086406020","https://openalex.org/W2087407176","https://openalex.org/W2087865186","https://openalex.org/W2088061860","https://openalex.org/W2089169348","https://openalex.org/W2091053357","https://openalex.org/W2091961604","https://openalex.org/W2093980244","https://openalex.org/W2094045382","https://openalex.org/W2094190392","https://openalex.org/W2094241872","https://openalex.org/W2097270286","https://openalex.org/W2098980360","https://openalex.org/W2099389334","https://openalex.org/W2101335397","https://openalex.org/W2101817207","https://openalex.org/W2102942119","https://openalex.org/W2102964870","https://openalex.org/W2103314026","https://openalex.org/W2104249477","https://openalex.org/W2104289834","https://openalex.org/W2106529023","https://openalex.org/W2106842812","https://openalex.org/W2107093868","https://openalex.org/W2107600545","https://openalex.org/W2108559568","https://openalex.org/W2108949591","https://openalex.org/W2110043149","https://openalex.org/W2110763275","https://openalex.org/W2111486247","https://openalex.org/W2111877641","https://openalex.org/W2112335996","https://openalex.org/W2112971506","https://openalex.org/W2113273019","https://openalex.org/W2113638991","https://openalex.org/W2114644532","https://openalex.org/W2115708850","https://openalex.org/W2119635659","https://openalex.org/W2120599967","https://openalex.org/W2121017928","https://openalex.org/W2121113752","https://openalex.org/W2121673742","https://openalex.org/W2122023734","https://openalex.org/W2123041259","https://openalex.org/W2123286632","https://openalex.org/W2124299428","https://openalex.org/W2125146313","https://openalex.org/W2125814033","https://openalex.org/W2126361514","https://openalex.org/W2127024458","https://openalex.org/W2127113854","https://openalex.org/W2128619372","https://openalex.org/W2129353256","https://openalex.org/W2129535039","https://openalex.org/W2130381741","https://openalex.org/W2131164917","https://openalex.org/W2132169942","https://openalex.org/W2132639412","https://openalex.org/W2132804815","https://openalex.org/W2133163464","https://openalex.org/W2133848190","https://openalex.org/W2134180244","https://openalex.org/W2137813404","https://openalex.org/W2138304075","https://openalex.org/W2138956992","https://openalex.org/W2140112763","https://openalex.org/W2140252368","https://openalex.org/W2140572324","https://openalex.org/W2140667326","https://openalex.org/W2141355399","https://openalex.org/W2142196823","https://openalex.org/W2142701813","https://openalex.org/W2142847871","https://openalex.org/W2143111495","https://openalex.org/W2143240949","https://openalex.org/W2144089610","https://openalex.org/W2144294539","https://openalex.org/W2146584445","https://openalex.org/W2147723033","https://openalex.org/W2150739289","https://openalex.org/W2151454486","https://openalex.org/W2152863678","https://openalex.org/W2153038986","https://openalex.org/W2153453937","https://openalex.org/W2154701533","https://openalex.org/W2155506532","https://openalex.org/W2155825582","https://openalex.org/W2157489482","https://openalex.org/W2157635452","https://openalex.org/W2158715097","https://openalex.org/W2162101639","https://openalex.org/W2162911098","https://openalex.org/W2165223513","https://openalex.org/W2166435440","https://openalex.org/W2166578833","https://openalex.org/W2166782890","https://openalex.org/W2169435692","https://openalex.org/W2169940011","https://openalex.org/W2170641020","https://openalex.org/W2171385213","https://openalex.org/W2171535756","https://openalex.org/W2171598572","https://openalex.org/W2177832086","https://openalex.org/W2186078128","https://openalex.org/W2192030661","https://openalex.org/W2207265529","https://openalex.org/W2232370058","https://openalex.org/W2293492203","https://openalex.org/W2299156747","https://openalex.org/W2302583618","https://openalex.org/W2306188934","https://openalex.org/W2313821055","https://openalex.org/W2317873538","https://openalex.org/W2324405244","https://openalex.org/W2332590009","https://openalex.org/W2340608964","https://openalex.org/W2343078437","https://openalex.org/W2398608465","https://openalex.org/W2399113987","https://openalex.org/W2403430327","https://openalex.org/W2413056645","https://openalex.org/W2414737381","https://openalex.org/W2415373443","https://openalex.org/W2416087294","https://openalex.org/W2461899760","https://openalex.org/W2498485322","https://openalex.org/W2507915051","https://openalex.org/W2516886587","https://openalex.org/W2559191133","https://openalex.org/W2562205137","https://openalex.org/W2564067034","https://openalex.org/W2573336339","https://openalex.org/W2577290052","https://openalex.org/W2590936917","https://openalex.org/W2613825882","https://openalex.org/W2614245280","https://openalex.org/W2619686716","https://openalex.org/W2621235716","https://openalex.org/W2731057448","https://openalex.org/W2743335493","https://openalex.org/W2745396298","https://openalex.org/W2754073828","https://openalex.org/W2761336143","https://openalex.org/W2770964693","https://openalex.org/W2783025701","https://openalex.org/W2791664372","https://openalex.org/W2791813411","https://openalex.org/W2803662842","https://openalex.org/W2883611877","https://openalex.org/W2884502717","https://openalex.org/W2890031062","https://openalex.org/W2891454794","https://openalex.org/W2906226216","https://openalex.org/W2910201141","https://openalex.org/W2911646665","https://openalex.org/W2914384485","https://openalex.org/W2920904564","https://openalex.org/W2928581379","https://openalex.org/W2954212930","https://openalex.org/W2958583844","https://openalex.org/W2972658789","https://openalex.org/W2972673707","https://openalex.org/W2978361963","https://openalex.org/W2979805180","https://openalex.org/W2991248316","https://openalex.org/W2998933789","https://openalex.org/W3003820224","https://openalex.org/W3009219597","https://openalex.org/W3015050560","https://openalex.org/W3022047275","https://openalex.org/W3023088732","https://openalex.org/W3030876968","https://openalex.org/W3031705300","https://openalex.org/W3035218863","https://openalex.org/W3039562686","https://openalex.org/W3080236904","https://openalex.org/W3082477990","https://openalex.org/W3082681966","https://openalex.org/W4211007694","https://openalex.org/W4211114641","https://openalex.org/W4230357700","https://openalex.org/W4230543984","https://openalex.org/W4247930215"],"related_works":["https://openalex.org/W4392272765","https://openalex.org/W4392272744","https://openalex.org/W7147009148","https://openalex.org/W3126817304","https://openalex.org/W4392273087","https://openalex.org/W2065481994","https://openalex.org/W2329400480","https://openalex.org/W2522606905","https://openalex.org/W2792659620","https://openalex.org/W2101817207"],"abstract_inverted_index":{"L\u2019h\u00e8me,":[0],"une":[1,155,228,261],"structure":[2],"porphyrique":[3],"contenant":[4],"un":[5,10,81,112,126,135,173],"atome":[6],"de":[7,14,21,36,38,51,58,84,95,98,117,132,137,158,168,192,208,211,231,237],"fer,":[8],"est":[9,40,102,144,150,170],"cofacteur":[11],"essentiel":[12],"\u00e0":[13,45,107,120,175,235],"nombreuses":[15],"fonctions":[16],"bact\u00e9riennes.":[17],"Cependant,":[18],"le":[19],"fer":[20],"l\u2019h\u00e8me":[22,39,236],"g\u00e9n\u00e8re":[23],"des":[24,33],"radicaux":[25],"libres,":[26],"ce":[27,59,148],"qui":[28],"explique":[29],"sa":[30,105],"toxicit\u00e9.":[31],"Un":[32],"m\u00e9canismes":[34],"principaux":[35],"d\u00e9toxification":[37],"l\u2019expression,":[41],"par":[42,100,104,172,254],"les":[43],"bact\u00e9ries":[44,66],"Gram":[46],"positif,":[47],"d\u2019un":[48],"transporteur":[49,60],"d\u2019efflux":[50],"la":[52,85,96,118,141,166,189,198,201,232,243,249,264],"famille":[53,86],"ABC,":[54],"HrtBA.":[55,209],"La":[56],"r\u00e9gulation":[57],"a":[61,89,110,124,186],"\u00e9t\u00e9":[62,90],"\u00e9tudi\u00e9e":[63],"chez":[64,140,267],"deux":[65,176,256,269],"pathog\u00e8nes":[67],"opportunistes":[68],"Enterococcus":[69],"faecalis":[70],"et":[71,92,200,239],"Staphylococcus":[72],"aureus,":[73,165],"responsables":[74],"d\u2019infection":[75],"nosocomiales":[76],"multir\u00e9sistantes.":[77],"Chez":[78,163],"E.":[79,153],"faecalis,":[80,154],"nouveau":[82],"r\u00e9gulateur":[83],"TetR,":[87],"FhtR,":[88],"identifi\u00e9":[91],"caract\u00e9ris\u00e9.":[93],"L\u2019inhibition":[94],"transcription":[97,167],"hrtBA":[99,169],"FhtR":[101,109,123],"lev\u00e9e":[103],"liaison":[106,199],"l\u2019h\u00e8me.":[108,133],"aussi":[111],"impact":[113],"important":[114,151],"sur":[115],"l\u2019activit\u00e9":[116],"catalase":[119],"h\u00e8me,":[121],"KatA.":[122],"donc":[125],"r\u00f4le":[127],"majeur":[128],"dans":[129,160,197,242],"l\u2019hom\u00e9ostasie":[130],"intracellulaire":[131],"Dans":[134],"mod\u00e8le":[136],"transit":[138],"intestinal":[139],"souris,":[142],"HrtBA":[143,218,247],"induit,":[145],"sugg\u00e9rant":[146,227],"que":[147,188,217],"m\u00e9canisme":[149,181],"pour":[152,206,263],"bact\u00e9rie":[156],"commensale":[157],"l\u2019intestin,":[159],"cet":[161],"environnement.":[162],"S.":[164],"r\u00e9gul\u00e9e":[171],"syst\u00e8me":[174],"composants":[177],"HssRS.":[178],"L\u2019\u00e9tude":[179],"du":[180,182,203,251],"senseur":[183],"membranaire":[184],"HssS":[185],"r\u00e9v\u00e9l\u00e9":[187],"partie":[190],"cytoplasmique":[191],"l\u2019histidine":[193],"kinase":[194],"\u00e9tait":[195],"impliqu\u00e9e":[196],"transduction":[202,250],"signal":[204,252],"h\u00e8me":[205,253],"l\u2019expression":[207],"L\u2019ensemble":[210],"ces":[212,255,268],"r\u00e9sultats":[213],"d\u00e9montrent":[214],"que,":[215],"bien":[216],"soit":[219],"conserv\u00e9e,":[220],"plusieurs":[221],"syst\u00e8mes":[222],"distincts":[223],"r\u00e9gulent":[224],"son":[225,240],"expression,":[226],"adaptation":[229],"complexe":[230],"r\u00e9ponse":[233],"bact\u00e9rienne":[234],"l\u2019h\u00f4te":[238],"importance":[241],"relation":[244],"h\u00f4te-pathog\u00e8ne.":[245],"Bloquer":[246],"ou":[248],"senseurs":[257],"d\u2019h\u00e8me":[258],"pourrait":[259],"constituer":[260],"cible":[262],"recherche":[265],"antibiotique":[266],"pathog\u00e8nes.":[270]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-04-05T00:00:00"}