{"id":"https://openalex.org/W7149111174","doi":"https://doi.org/10.1158/1538-7445.am2026-2002","title":"Abstract 2002: The landscape of X chromosome copy number alterations in cancer.","display_name":"Abstract 2002: The landscape of X chromosome copy number alterations in cancer.","publication_year":2026,"publication_date":"2026-04-03","ids":{"openalex":"https://openalex.org/W7149111174","doi":"https://doi.org/10.1158/1538-7445.am2026-2002"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2026-2002","doi":"https://doi.org/10.1158/1538-7445.am2026-2002","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-2002","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002405280","display_name":"Matthew Joseph Leventhal","orcid":"https://orcid.org/0000-0002-5995-5202","observed_orcids":["https://orcid.org/0000-0002-5995-5202"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Joseph Leventhal","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012519675","display_name":"Chunyang Bao","orcid":"https://orcid.org/0000-0001-7962-346X","observed_orcids":["https://orcid.org/0000-0001-7962-346X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunyang Bao","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125954582","display_name":"Ron Solan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Solan","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111218951","display_name":"Haruna Tomono","orcid":"https://orcid.org/0009-0007-2371-8647","observed_orcids":["https://orcid.org/0009-0007-2371-8647"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haruna Tomono","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030622261","display_name":"Andrew D. Cherniack","orcid":"https://orcid.org/0000-0003-0470-0111","observed_orcids":["https://orcid.org/0000-0003-0470-0111"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Cherniack","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132894763","display_name":"Luis Antonio Corchete Sanchez","orcid":"https://orcid.org/0000-0003-4577-8599","observed_orcids":["https://orcid.org/0000-0003-4577-8599"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis A. Corchete Sanchez","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132861338","display_name":"Rebecca Jang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Jang","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeehee Suh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeehee Suh","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046897508","display_name":"Antonia Kowalewski","orcid":"https://orcid.org/0000-0002-9377-7841","observed_orcids":["https://orcid.org/0000-0002-9377-7841"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonia Kowalewski","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029332910","display_name":"Sam M. Wiseman","orcid":"https://orcid.org/0000-0002-3160-4697","observed_orcids":["https://orcid.org/0000-0002-3160-4697"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam Wiseman","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107529591","display_name":"Samantha Van Seters","orcid":"https://orcid.org/0009-0006-4235-5813","observed_orcids":["https://orcid.org/0009-0006-4235-5813"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Van Seters","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072680958","display_name":"Saveliy Belkin","orcid":"https://orcid.org/0000-0002-1542-8996","observed_orcids":["https://orcid.org/0000-0002-1542-8996"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saveliy Belkin","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064226037","display_name":"David I. Heiman","orcid":"https://orcid.org/0000-0001-7895-4259","observed_orcids":["https://orcid.org/0000-0001-7895-4259"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David I. Heiman","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003120045","display_name":"Chip Stewart","orcid":"https://orcid.org/0000-0003-2245-9552","observed_orcids":["https://orcid.org/0000-0003-2245-9552"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chip Stewart","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115011170","display_name":"David Lehotzky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Lehotzky","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013284431","display_name":"Vasuki Narasimha Swamy","orcid":"https://orcid.org/0000-0001-7718-992X","observed_orcids":["https://orcid.org/0000-0001-7718-992X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasuki N. Swamy","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040474378","display_name":"Brian P. Danysh","orcid":"https://orcid.org/0000-0001-6839-6337","observed_orcids":["https://orcid.org/0000-0001-6839-6337"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P. Danysh","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008462114","display_name":"Gengchao Wang","orcid":"https://orcid.org/0000-0001-8884-0693","observed_orcids":["https://orcid.org/0000-0001-8884-0693"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gengchao Wang","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108309806","display_name":"Xavi Loinaz","orcid":"https://orcid.org/0009-0002-4999-2605","observed_orcids":["https://orcid.org/0009-0002-4999-2605"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xavi Loinaz","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120390060","display_name":"Zachary Joseph Everton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Everton","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112437907","display_name":"Gang-Hee Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang-Hee Lee","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132856126","display_name":"Won-Chul Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Won-Chul Lee","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125640110","display_name":"Hansol Park","orcid":"https://orcid.org/0000-0001-5984-2868","observed_orcids":["https://orcid.org/0000-0001-5984-2868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hansol Park","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026842824","display_name":"Ryul Kim","orcid":"https://orcid.org/0000-0002-9461-3734","observed_orcids":["https://orcid.org/0000-0002-9461-3734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryul Kim","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049364024","display_name":"Young Seok Ju","orcid":"https://orcid.org/0000-0002-5514-4189","observed_orcids":["https://orcid.org/0000-0002-5514-4189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Seok Ju","raw_affiliation_strings":["2Inocras Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Inocras Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086983255","display_name":"Esther Rheinbay","orcid":"https://orcid.org/0000-0002-5566-6729","observed_orcids":["https://orcid.org/0000-0002-5566-6729"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Rheinbay","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001392592","display_name":"Gad A. Getz","orcid":"https://orcid.org/0000-0002-0936-0753","observed_orcids":["https://orcid.org/0000-0002-0936-0753"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gad Getz","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5132837687","display_name":"Cheng-Zhong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng-Zhong Zhang","raw_affiliation_strings":["3Broad Institute of Harvard and MIT, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Broad Institute of Harvard and MIT, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"7_Supplement","first_page":"2002","last_page":"2002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inactive-x-chromosome","display_name":"inactive X chromosome","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cancer-driver-mutations","display_name":"cancer driver mutations","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.8489999771118164},{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/monoallelic-expression","display_name":"monoallelic expression","score":0.6769999861717224},{"id":"https://openalex.org/keywords/female-cancers","display_name":"women's cancer","score":0.4230000078678131},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.7480000257492065},{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":1.0},{"id":"https://openalex.org/keywords/whole-genome-doubling","display_name":"whole-genome duplication","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cancer-gene-census","display_name":"Cancer Gene Census","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tcga-tumors","display_name":"TCGA tumors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7526999711990356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7314000129699707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6647999882698059},{"id":"https://openalex.org/C134925867","wikidata":"https://www.wikidata.org/wiki/Q186380","display_name":"Autosome","level":4,"score":0.6413000226020813},{"id":"https://openalex.org/C35158069","wikidata":"https://www.wikidata.org/wiki/Q61333","display_name":"X chromosome","level":3,"score":0.6215000152587891},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.6193000078201294},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5709999799728394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5471000075340271},{"id":"https://openalex.org/C55548728","wikidata":"https://www.wikidata.org/wiki/Q1465102","display_name":"Gene dosage","level":4,"score":0.48969998955726624},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.46149998903274536},{"id":"https://openalex.org/C4323932","wikidata":"https://www.wikidata.org/wiki/Q898914","display_name":"X-inactivation","level":4,"score":0.3792000114917755},{"id":"https://openalex.org/C47924181","wikidata":"https://www.wikidata.org/wiki/Q668633","display_name":"Chromosome 3","level":4,"score":0.374099999666214},{"id":"https://openalex.org/C167752854","wikidata":"https://www.wikidata.org/wiki/Q220677","display_name":"Chromosome 17 (human)","level":4,"score":0.36800000071525574},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.35350000858306885},{"id":"https://openalex.org/C165237769","wikidata":"https://www.wikidata.org/wiki/Q765245","display_name":"Chromosome 15","level":4,"score":0.33869999647140503},{"id":"https://openalex.org/C130693829","wikidata":"https://www.wikidata.org/wiki/Q510786","display_name":"Chromosome 19","level":4,"score":0.33320000767707825},{"id":"https://openalex.org/C163588314","wikidata":"https://www.wikidata.org/wiki/Q742870","display_name":"Chromosome 16","level":4,"score":0.3271999955177307},{"id":"https://openalex.org/C109748351","wikidata":"https://www.wikidata.org/wiki/Q657319","display_name":"Chromosome 7 (human)","level":4,"score":0.3127000033855438},{"id":"https://openalex.org/C54815482","wikidata":"https://www.wikidata.org/wiki/Q753805","display_name":"Chromosome 22","level":4,"score":0.3116999864578247},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.3068999946117401},{"id":"https://openalex.org/C137555145","wikidata":"https://www.wikidata.org/wiki/Q753218","display_name":"Chromosome 21","level":4,"score":0.3061000108718872},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.3037000000476837},{"id":"https://openalex.org/C57808653","wikidata":"https://www.wikidata.org/wiki/Q7446270","display_name":"Segmental duplication","level":5,"score":0.30300000309944153},{"id":"https://openalex.org/C182483264","wikidata":"https://www.wikidata.org/wiki/Q5113922","display_name":"Chromosome regions","level":4,"score":0.3003999888896942},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.28619998693466187},{"id":"https://openalex.org/C46321384","wikidata":"https://www.wikidata.org/wiki/Q5113917","display_name":"Chromosome engineering","level":4,"score":0.28380000591278076},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C134068817","wikidata":"https://www.wikidata.org/wiki/Q836605","display_name":"Chromosome 4","level":4,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2026-2002","doi":"https://doi.org/10.1158/1538-7445.am2026-2002","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-2002","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401395823","https://openalex.org/W7215812738","https://openalex.org/W3083704502","https://openalex.org/W4246652679","https://openalex.org/W2093255687","https://openalex.org/W2063676080","https://openalex.org/W2007854591","https://openalex.org/W2032863150","https://openalex.org/W1967949850","https://openalex.org/W2556570155"],"abstract_inverted_index":{"Abstract":[0],"Copy":[1],"number":[2,19,46,58,111,141,164,180,262,293,436],"alterations":[3,20,47,112,142,437],"are":[4,67,278,300],"frequent,":[5],"early":[6],"events":[7,251],"in":[8,187,214,256,270,320,333,361,438],"cancer":[9,185,279,305,348,439],"evolution.":[10,129,258],"Previous":[11],"pan-cancer":[12],"analyses":[13],"have":[14,131],"not":[15,210,238],"characterized":[16],"recurrent":[17,162,227,321],"copy":[18,45,57,110,140,163,179,261,292,435],"on":[21,48,62,113,143,166,264,295,349],"the":[22,33,49,63,81,96,114,120,139,144,167,173,188,230,233,265,296,311,350,444],"actively":[23],"and":[24,146,154,202,206,285],"inactively":[25],"transcribed":[26],"X":[27,35,51,65,83,88,115,148,169,177,235,298,313,322,352,433],"chromosome.":[28],"The":[29,175,308,337,430],"monoallelic":[30],"expression":[31,74,89,101],"of":[32,41,73,75,80,93,99,104,122,127,156,229,232,241,304,310,339,347,432,443],"active":[34,50,64,82,145,168,176,234,297,312,351],"chromosome":[36,52,66,84,87,170,178,236,299,314,323,353,434],"predicts":[37],"a":[38,78,105,133,239,301],"higher":[39],"sensitivity":[40,309],"cell":[42],"fitness":[43],"to":[44,71,119,136,315],"than":[53],"expected":[54,97],"from":[55,102,149,192],"autosomal":[56],"alterations.":[59],"Large":[60],"deletions":[61],"likely":[68],"intolerable":[69],"due":[70],"loss":[72],"essential":[76],"genes;":[77],"duplication":[79,103],"will":[85],"increase":[86,98],"by":[90],"100%":[91],"instead":[92],"50%,which":[94],"is":[95],"gene":[100],"single":[106],"autosome":[107],"homolog.":[108],"Recurrent":[109],"chromosomes":[116],"could":[117,253,325,355],"lead":[118],"discovery":[121],"new,":[123,357],"therapeutically":[124],"actionable":[125],"drivers":[126,346],"tumor":[128,257],"We":[130,160],"developed":[132],"new":[134,302,327],"method":[135],"accurately":[137],"determine":[138],"inactive":[147],"combined":[150],"whole":[151,217],"genome":[152,218],"sequencing":[153],"RNA-seq":[155],">8,000":[157],"TCGA":[158],"tumors.":[159],"found":[161],"gains":[165,181,208,228,247,263,294],"q-arm":[171,231,266],"spanning":[172],"telomere.":[174],"overlapped":[182],"previously":[183,344],"identified":[184],"genes":[186,319],"Cancer":[189,448,466],"Gene":[190],"Census":[191],"other":[193],"tumors":[194],"such":[195],"as":[196],"ATP2B3,":[197],"FLNA,":[198],"MTCP1,":[199],"RPL10,":[200],"PHF6":[201],"GPC3.":[203],"These":[204,223],"segmental":[205,260],"arm-level":[207],"were":[209,237,248,267],"significantly":[211],"more":[212],"frequent":[213],"patients":[215],"with":[216],"doubling":[219],"or":[220,273,330],"TP53":[221],"mutations.":[222,307],"results":[224,338],"suggested":[225],"that":[226,245,252,281,291,318,354],"result":[240],"genomic":[242],"instability,":[243],"suggesting":[244],"these":[246],"putative":[249],"driver":[250,306],"be":[254,326,356],"truncal":[255],"Telomere-spanning":[259],"less":[268],"common":[269],"female":[271,286,335],"glioblastoma":[272],"uveal":[274],"melanoma":[275],"tumors,":[276],"which":[277],"types":[280],"affect":[282],"both":[283],"male":[284],"patients.":[287],"This":[288],"work":[289],"shows":[290],"source":[303],"selection":[316],"suggests":[317],"amplifications":[324],"genetic":[328],"dependencies":[329],"therapeutic":[331,359],"targets":[332,360],"treating":[334],"cancers.":[336],"this":[340],"study":[341],"may":[342],"identify":[343],"unknown":[345],"effective":[358],"cancer.":[362],"Citation":[363],"Format:":[364],"Matthew":[365],"Joseph":[366],"Leventhal,":[367],"Chunyang":[368],"Bao,":[369],"Ron":[370],"Solan,":[371],"Haruna":[372],"Tomono,":[373],"Andrew":[374],"D.":[375],"Cherniack,":[376],"Luis":[377],"A.":[378],"Corchete":[379],"Sanchez,":[380],"Rebecca":[381],"Jang,":[382],"Jeehee":[383],"Suh,":[384],"Antonia":[385],"Kowalewski,":[386],"Sam":[387],"Wiseman,":[388],"Samantha":[389],"Van":[390],"Seters,":[391],"Saveliy":[392],"Belkin,":[393],"David":[394,399],"I.":[395],"Heiman,":[396],"Chip":[397],"Stewart,":[398],"Lehotzky,":[400],"Vasuki":[401],"N.":[402],"Swamy,":[403],"Brian":[404],"P.":[405],"Danysh,":[406],"Gengchao":[407],"Wang,":[408],"Xavi":[409],"Loinaz,":[410],"Zachary":[411],"Everton,":[412],"Gang-Hee":[413],"Lee,":[414,416],"Won-Chul":[415],"Hansol":[417],"Park,":[418],"Ryul":[419],"Kim,":[420],"Young":[421],"Seok":[422],"Ju,":[423],"Esther":[424],"Rheinbay,":[425],"Gad":[426],"Getz,":[427],"Cheng-Zhong":[428],"Zhang.":[429],"landscape":[431],"[abstract].":[440],"In:":[441],"Proceedings":[442],"American":[445],"Association":[446],"for":[447],"Research":[449],"Annual":[450],"Meeting":[451],"2026;":[452],"Part":[453],"1":[454],"(Regular":[455],"Abstracts);":[456],"2026":[457],"Apr":[458],"17-22;":[459],"San":[460],"Diego,":[461],"CA.":[462],"Philadelphia":[463],"(PA):":[464],"AACR;":[465],"Res":[467],"2026;86(7":[468],"Suppl):Abstract":[469],"nr":[470],"2002.":[471]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-04-04T00:00:00"}