{"id":"https://openalex.org/W7148975270","doi":"https://doi.org/10.1590/1806-9282.20250307","title":"Six-minute walk test to assess muscular fatigability and mobility in children with congenital myasthenic syndrome: a pilot study","display_name":"Six-minute walk test to assess muscular fatigability and mobility in children with congenital myasthenic syndrome: a pilot study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7148975270","doi":"https://doi.org/10.1590/1806-9282.20250307","pmid":"https://pubmed.ncbi.nlm.nih.gov/42090667","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13138699"},"language":"en","primary_location":{"id":"doi:10.1590/1806-9282.20250307","doi":"https://doi.org/10.1590/1806-9282.20250307","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1806-9282.20250307","pdf_url":null,"source":{"id":"https://openalex.org/S11235429","display_name":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","issn_l":"0004-5241","issn":["0004-5241","0102-843X","0104-4230","1806-9282"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310311978","host_organization_name":"Brazilian Medical Association","host_organization_lineage":["https://openalex.org/P4310311978"],"host_organization_lineage_names":["Brazilian Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1590/1806-9282.20250307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022671026","display_name":"Numan Bulut","orcid":"https://orcid.org/0000-0001-5427-1103","observed_orcids":["https://orcid.org/0000-0001-5427-1103"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Numan Bulut","raw_affiliation_strings":["Hacettepe University,  Turkey"],"raw_orcid":"https://orcid.org/0000-0001-5427-1103","affiliations":[{"raw_affiliation_string":"Hacettepe University,  Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101985315","display_name":"G\u00fcll\u00fc Ayd\u0131n Ya\u011fc\u0131o\u011flu","orcid":"https://orcid.org/0000-0003-1658-7697","observed_orcids":["https://orcid.org/0000-0003-1658-7697"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcll\u00fc Ayd\u0131n Ya\u011fc\u0131o\u011flu","raw_affiliation_strings":["University of Health Sciences,  Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1658-7697","affiliations":[{"raw_affiliation_string":"University of Health Sciences,  Turkey","institution_ids":["https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132876946","display_name":"Aykut Demir","orcid":"https://orcid.org/0000-0002-8110-8720","observed_orcids":["https://orcid.org/0000-0002-8110-8720"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aykut Demir","raw_affiliation_strings":["Hacettepe University,  Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8110-8720","affiliations":[{"raw_affiliation_string":"Hacettepe University,  Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044827899","display_name":"\u0130pek Alemdaro\u011flu-G\u00fcrb\u00fcz","orcid":"https://orcid.org/0000-0001-5556-6608","observed_orcids":["https://orcid.org/0000-0001-5556-6608"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130pek Alemdaro\u011flu-G\u00fcrb\u00fcz","raw_affiliation_strings":["Hacettepe University,  Turkey"],"raw_orcid":"https://orcid.org/0000-0001-5556-6608","affiliations":[{"raw_affiliation_string":"Hacettepe University,  Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072390968","display_name":"G\u00f6knur Halilo\u011flu","orcid":"https://orcid.org/0000-0003-1813-275X","observed_orcids":["https://orcid.org/0000-0003-1813-275X"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00f6knur Halilo\u011flu","raw_affiliation_strings":["Hacettepe University,  Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1813-275X","affiliations":[{"raw_affiliation_string":"Hacettepe University,  Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128774224","display_name":"\u00d6znur Tunca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6znur Tunca","raw_affiliation_strings":["Hacettepe University,  Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0855-9541","affiliations":[{"raw_affiliation_string":"Hacettepe University,  Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022671026"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"1","first_page":"e20250307","last_page":"e20250307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-myasthenic-syndrome","display_name":"congenital myasthenic syndrome","score":0.9300000071525574},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.996999979019165},{"id":"https://openalex.org/keywords/mobility-assessment","display_name":"mobility assessment","score":0.8240000009536743},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7120000123977661},{"id":"https://openalex.org/keywords/stair-climbing","display_name":"stair climbing","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2777295749","wikidata":"https://www.wikidata.org/wiki/Q12511","display_name":"Stairs","level":2,"score":0.86080002784729},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.6175000071525574},{"id":"https://openalex.org/C95038775","wikidata":"https://www.wikidata.org/wiki/Q22857","display_name":"Climbing","level":2,"score":0.5723000168800354},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5490000247955322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5338000059127808},{"id":"https://openalex.org/C111459926","wikidata":"https://www.wikidata.org/wiki/Q7244468","display_name":"Walk-in","level":3,"score":0.5288000106811523},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5101000070571899},{"id":"https://openalex.org/C2777210258","wikidata":"https://www.wikidata.org/wiki/Q3508800","display_name":"Congenital myasthenic syndrome","level":4,"score":0.4259999990463257},{"id":"https://openalex.org/C2776319952","wikidata":"https://www.wikidata.org/wiki/Q2451755","display_name":"Stair climbing","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2849999964237213},{"id":"https://openalex.org/C2776356578","wikidata":"https://www.wikidata.org/wiki/Q2246789","display_name":"Neuromuscular disease","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000070857","descriptor_name":"Walk Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016138","descriptor_name":"Walking","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018763","descriptor_name":"Muscle Fatigue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020294","descriptor_name":"Myasthenic Syndromes, Congenital","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1590/1806-9282.20250307","doi":"https://doi.org/10.1590/1806-9282.20250307","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1806-9282.20250307","pdf_url":null,"source":{"id":"https://openalex.org/S11235429","display_name":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","issn_l":"0004-5241","issn":["0004-5241","0102-843X","0104-4230","1806-9282"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310311978","host_organization_name":"Brazilian Medical Association","host_organization_lineage":["https://openalex.org/P4310311978"],"host_organization_lineage_names":["Brazilian Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13138699","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13138699/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13138699/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Assoc Med Bras (1992)","raw_type":"Text"},{"id":"pmid:42090667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42090667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista da Associacao Medica Brasileira (1992)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1590/1806-9282.20250307","doi":"https://doi.org/10.1590/1806-9282.20250307","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1806-9282.20250307","pdf_url":null,"source":{"id":"https://openalex.org/S11235429","display_name":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","issn_l":"0004-5241","issn":["0004-5241","0102-843X","0104-4230","1806-9282"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310311978","host_organization_name":"Brazilian Medical Association","host_organization_lineage":["https://openalex.org/P4310311978"],"host_organization_lineage_names":["Brazilian Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7148975270.pdf","grobid_xml":"https://content.openalex.org/works/W7148975270.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1635308923","https://openalex.org/W2167790027","https://openalex.org/W2177836927","https://openalex.org/W2478685917","https://openalex.org/W2768319010","https://openalex.org/W2811364956","https://openalex.org/W2886368623","https://openalex.org/W2891765621","https://openalex.org/W2990643959","https://openalex.org/W3018853056","https://openalex.org/W3093016691","https://openalex.org/W3173739285","https://openalex.org/W3177435603","https://openalex.org/W3201576465","https://openalex.org/W3209743052","https://openalex.org/W4206053361","https://openalex.org/W4245666729","https://openalex.org/W4311475974","https://openalex.org/W4320492744","https://openalex.org/W4323317770","https://openalex.org/W4366975061","https://openalex.org/W4387965585","https://openalex.org/W4388721418","https://openalex.org/W4401300500","https://openalex.org/W4403112344"],"related_works":["https://openalex.org/W7008582039","https://openalex.org/W2167790027","https://openalex.org/W2316828649","https://openalex.org/W7216642342","https://openalex.org/W7055071396","https://openalex.org/W2194865507","https://openalex.org/W2202509713","https://openalex.org/W6945342101","https://openalex.org/W2336683729","https://openalex.org/W2553132273"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,60,75,95,133,161,187],"aims":[2],"of":[3,62,124],"this":[4,201],"study":[5,203],"were":[6,53,153,164],"to":[7,25,72,184,196,217],"determine":[8],"whether":[9],"the":[10,27,30,66,79,85,109,115,125,128,138,144,172,206],"six-minute":[11,31,67,97,129,167,188,207],"walk":[12,32,68,98,130,168,189,208],"test":[13,33,69,99,131,169,190,209],"predicts":[14],"muscular":[15,198],"fatigability":[16],"in":[17,220],"ambulant":[18],"children":[19,39,56],"with":[20,45],"congenital":[21,46,221],"myasthenic":[22,47,222],"syndrome":[23,48],"and":[24,34,42,87,90,111,117,121,146,149,157,170,215],"examine":[26],"relationship":[28],"between":[29,108,114,122,166],"mobility":[35,76,173,219],"tests.":[36],"METHODS:":[37],"Eight":[38],"(four":[40],"girls":[41],"four":[43,92,151,179],"boys)":[44],"(mean":[49],"age:":[50],"11.75\u00b13.54":[51],"years)":[52],"included.":[54],"Five":[55],"had":[57],"COLQ":[58],"variants.":[59],"distance":[61,100],"each":[63],"minute":[64],"for":[65,136,176],"was":[70,101,105],"determined":[71,165],"evaluate":[73],"fatigability.":[74,199],"tests":[77],"included":[78],"10-m":[80,139],"walk/run":[81,140],"test,":[82,141],"rising":[83,142],"from":[84,143],"floor,":[86,145],"climbing":[88,147,177],"up":[89,148],"down":[91,150,178],"stairs.":[93],"RESULTS:":[94],"mean":[96,134],"463.38\u00b1132.59":[102],"m.":[103],"There":[104],"no":[106],"difference":[107],"first":[110,116],"last":[112,118],"minute,":[113],"two":[119],"minutes,":[120],"any":[123],"minutes":[126],"during":[127],"(p>0.05).":[132],"times":[135],"performing":[137],"stairs":[152,180],"8.59\u00b13.36,":[154],"6.38\u00b14.49,":[155],"4.38\u00b15.07,":[156],"3.35\u00b13.69":[158],"s,":[159],"respectively.":[160],"strong":[162],"correlations":[163],"all":[171],"tests,":[174],"except":[175],"(p<":[181],"0.05,":[182],"rs=-0.72":[183],"-0.83).":[185],"CONCLUSION:":[186],"did":[191],"not":[192],"provide":[193],"sufficient":[194],"evidence":[195],"predict":[197],"However,":[200],"preliminary":[202],"suggested":[204],"that":[205],"may":[210],"be":[211],"used":[212],"by":[213],"clinicians":[214],"researchers":[216],"assess":[218],"syndrome.":[223]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-04-04T00:00:00"}