{"id":"https://openalex.org/W7148975243","doi":"https://doi.org/10.1158/1538-7445.am2026-3859","title":"Abstract 3859: Dynamic systemic immune modulation in metastatic neuroendocrine tumor (NET) patients treated with targeted alpha-emitter212Pb-DOTAMTATE AlphaMedix.","display_name":"Abstract 3859: Dynamic systemic immune modulation in metastatic neuroendocrine tumor (NET) patients treated with targeted alpha-emitter212Pb-DOTAMTATE AlphaMedix.","publication_year":2026,"publication_date":"2026-04-03","ids":{"openalex":"https://openalex.org/W7148975243","doi":"https://doi.org/10.1158/1538-7445.am2026-3859"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2026-3859","doi":"https://doi.org/10.1158/1538-7445.am2026-3859","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-3859","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024397067","display_name":"Alessandra Jordano Conforte","orcid":"https://orcid.org/0000-0003-0597-6531","observed_orcids":["https://orcid.org/0000-0003-0597-6531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandra Jordano Conforte","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018144454","display_name":"Izabela Tworowska","orcid":"https://orcid.org/0000-0002-1461-1801","observed_orcids":["https://orcid.org/0000-0002-1461-1801"]},"institutions":[{"id":"https://openalex.org/I4210120237","display_name":"RadioMedix (United States)","ror":"https://ror.org/01v8a4s08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120237"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Izabela Tworowska","raw_affiliation_strings":["2RadioMedix, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2RadioMedix, Houston, TX;","institution_ids":["https://openalex.org/I4210120237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025744409","display_name":"Sara Fonseca Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Fonseca Costa","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132900726","display_name":"Marta Brzezinska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Brzezinska","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066675852","display_name":"Amaia Mart\u00ednez-Usatorre","orcid":"https://orcid.org/0000-0002-3416-1529","observed_orcids":["https://orcid.org/0000-0002-3416-1529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amaia Martinez Usatorres","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027755246","display_name":"Noushin Hadadi","orcid":"https://orcid.org/0000-0001-6614-4910","observed_orcids":["https://orcid.org/0000-0001-6614-4910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noushin Hadadi","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001546290","display_name":"Sylvain Monnier\u2010Benoit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvain Monnier-Benoit","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000997110","display_name":"Simona Pavan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Pavan","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001658237","display_name":"Rouzbeh Esfandiari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127994","display_name":"Excel Diagnostics Imaging","ror":"https://ror.org/02t9aa070","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210127994"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rouzbeh Esfandiari","raw_affiliation_strings":["3Excel Diagnostics & Nuclear Oncology Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Excel Diagnostics & Nuclear Oncology Center, Houston, TX","institution_ids":["https://openalex.org/I4210127994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132872529","display_name":"Brian Hashemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Hashemi","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101424852","display_name":"Pedro J. Romero","orcid":"https://orcid.org/0000-0002-9688-2882","observed_orcids":["https://orcid.org/0000-0002-9688-2882","https://orcid.org/0000-0002-6995-5193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Romero","raw_affiliation_strings":["1Novigenix SA, Epalinges, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Novigenix SA, Epalinges, Switzerland;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110203912","display_name":"Ebrahim S. Delpassand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120237","display_name":"RadioMedix (United States)","ror":"https://ror.org/01v8a4s08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120237"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ebrahim S. Delpassand","raw_affiliation_strings":["2RadioMedix, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2RadioMedix, Houston, TX;","institution_ids":["https://openalex.org/I4210120237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"7_Supplement","first_page":"3859","last_page":"3859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.10830000042915344,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/177lu-dotatate","display_name":"177Lu-DOTATATE","score":0.875},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.6230000257492065},{"id":"https://openalex.org/keywords/gastrointestinal-neuroendocrine-tumors","display_name":"gastrointestinal neuroendocrine tumors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/systemic-immunomodulation","display_name":"systemic immunomodulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.6759999990463257},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.5669999718666077},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.859000027179718},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.859000027179718},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7343000173568726},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7318999767303467},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6237999796867371},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5794000029563904},{"id":"https://openalex.org/C2993559085","wikidata":"https://www.wikidata.org/wiki/Q2126444","display_name":"Radionuclide therapy","level":2,"score":0.5760999917984009},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5277000069618225},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4997999966144562},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.47040000557899475},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42289999127388},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4106000065803528},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.39089998602867126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33880001306533813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33739998936653137},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.32030001282691956},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2858000099658966},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.26809999346733093},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.26260000467300415},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C2781274730","wikidata":"https://www.wikidata.org/wiki/Q4669679","display_name":"Abscopal effect","level":4,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2026-3859","doi":"https://doi.org/10.1158/1538-7445.am2026-3859","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-3859","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3172930398","https://openalex.org/W3082878430","https://openalex.org/W4415940482","https://openalex.org/W7163586582","https://openalex.org/W4281625793","https://openalex.org/W1991769150","https://openalex.org/W4395037879","https://openalex.org/W4415564039","https://openalex.org/W4253182097","https://openalex.org/W6945892898"],"abstract_inverted_index":{"Abstract":[0],"Peptide":[1],"receptor":[2],"radionuclide":[3],"therapy":[4,123,182,238],"(PRRT)":[5],"has":[6],"been":[7],"increasingly":[8],"explored":[9],"as":[10,19,42,47],"a":[11,29],"therapeutic":[12,71],"strategy":[13],"for":[14,396],"multiple":[15],"solid":[16],"tumors,":[17],"such":[18,41],"prostate":[20],"cancer":[21],"and":[22,85,106,112,124,146,158,173,202,228,249,269,336],"somatostatin":[23],"receptor-expressing":[24],"GEP-NETs.":[25],"While":[26],"Lutathera":[27,150],"(177Lu-DOTATATE),":[28],"\u03b2-emitting":[30,113],"PRRT,":[31],"represents":[32],"the":[33,66,99,118,177,217,223,393],"current":[34],"GEP-NETs":[35],"standard":[36],"of":[37,77,128,167,209,242,257,264,299,320,330,338,341,392],"care.":[38],"\u03b1-emitting":[39],"PRRTs":[40],"AlphaMedix":[43,83,148,181,211,284,388],"(212Pb-DOTAMTATE)":[44],"are":[45],"emerging":[46],"promising":[48],"alternatives":[49],"with":[50,81,89,137,233,282,287,294,311,327,385],"distinct":[51],"radiobiological":[52],"characteristics.":[53],"Ionizing":[54],"radiation":[55],"from":[56,142,196,230],"PRRT":[57],"not":[58],"only":[59],"induces":[60],"DNA":[61,244],"damage":[62],"but":[63],"also":[64],"modulate":[65],"immune":[67,104,170,265,305,308,376],"system,":[68],"contributing":[69],"to":[70,74,86,102,163,204,222,314,333],"response.We":[72],"sought":[73],"identify":[75],"evidence":[76],"systemic":[78,375],"immunomodulation":[79],"associated":[80,310],"\u03b1-emitter":[82],"treatment":[84,129,218],"compare":[87],"it":[88],"that":[90],"elicited":[91],"by":[92,110],"Lutathera.":[93,234,295],"Whole-blood":[94],"immunotranscriptomes":[95],"were":[96,135,161],"analyzed":[97],"using":[98],"LITOSeek":[100],"platform":[101],"characterize":[103,164],"signatures":[105],"pathways":[107],"differentially":[108],"activated":[109],"\u03b1-":[111],"PRRTs.":[114],"This":[115],"approach":[116],"elucidates":[117],"immunological":[119],"mechanisms":[120],"underlying":[121],"\u03b1-particle":[122],"uncovers":[125],"potential":[126,319],"biomarkers":[127,340],"response.":[130,343],"Methods:":[131],"Whole":[132],"blood":[133],"samples":[134],"collected":[136],"PAXgene":[138],"Blood":[139],"RNA":[140,322],"tubes":[141],"GEP-NET":[143],"patients":[144,189,220,231,280,292,383],"before":[145],"throughout":[147,216],"or":[149,192,285],"treatment.":[151,210],"Differential":[152],"expression,":[153],"over-representation":[154],"analysis,":[155],"digital":[156],"cytometry,":[157],"trajectory":[159],"identification":[160,337],"used":[162],"treatment-induced":[165],"regulation":[166],"peripheral":[168,185,304],"immunotranscriptomes,":[169],"cell":[171],"composition,":[172],"heterogenous":[174],"responses":[175],"within":[176],"patient":[178,331],"population.":[179],"Results:":[180],"induced":[183],"strong":[184],"transcriptomic":[186,214],"changes":[187,215,302],"in":[188,279,303,378],"achieving":[190],"complete":[191],"partial":[193],"response,":[194],"detectable":[195],"8":[197],"weeks":[198],"after":[199,207],"first":[200],"infusion,":[201],"up":[203],"6":[205],"months":[206],"end":[208],"triggers":[212,239],"similar":[213],"among":[219,291],"responding":[221],"therapy,":[224,335],"which":[225],"is":[226,325],"stronger":[227],"different":[229],"treated":[232,281,293,384],"The":[235,252,317],"212Pb":[236],"radioligand":[237,315,334],"early":[240,268],"generation":[241],"ROS,":[243],"damage,":[245],"apoptotic":[246],"responses,":[247],"inflammation":[248],"monocyte":[250],"recruitment.":[251],"results":[253],"reveal":[254],"two":[255],"waves":[256],"immunotranscriptome":[258],"modulation,":[259],"likely":[260],"reflecting":[261],"kinetics":[262],"heterogeneity":[263],"activation":[266],"between":[267],"late":[270],"responders.":[271],"Lymphopenia,":[272],"particularly":[273],"affecting":[274],"B":[275],"cells,":[276],"was":[277],"observed":[278],"either":[283],"Luthatera,":[286],"more":[288],"pronounced":[289],"lymphopenia":[290],"Conclusions:":[296],"Data-driven":[297],"characterization":[298],"treatment-associated":[300],"transcriptional":[301],"cells":[306],"underscores":[307],"modulation":[309,377],"clinical":[312,342],"response":[313,332],"therapy.":[316],"translational":[318],"whole-blood":[321],"liquid":[323],"biopsy":[324],"demonstrated":[326],"Immuno-Pharmacodynamic":[328],"profiling":[329],"immune-related":[339],"Citation":[344],"Format:":[345],"Alessandra":[346],"Jordano":[347],"Conforte,":[348],"Izabela":[349],"Tworowska,":[350],"Sara":[351],"Fonseca":[352],"Costa,":[353],"Marta":[354],"Brzezinska,":[355],"Amaia":[356],"Martinez":[357],"Usatorres,":[358],"Noushin":[359],"Hadadi,":[360],"Sylvain":[361],"Monnier-Benoit,":[362],"Simona":[363],"Pavan,":[364],"Rouzbeh":[365],"Esfandiari,":[366],"Brian":[367],"Hashemi,":[368],"Pedro":[369],"Romero,":[370],"Ebrahim":[371],"S.":[372],"Delpassand.":[373],"Dynamic":[374],"metastatic":[379],"neuroendocrine":[380],"tumor":[381],"(NET)":[382],"targeted":[386],"alpha-emitter212Pb-DOTAMTATE":[387],"[abstract].":[389],"In:":[390],"Proceedings":[391],"American":[394],"Association":[395],"Cancer":[397,415],"Research":[398],"Annual":[399],"Meeting":[400],"2026;":[401],"Part":[402],"1":[403],"(Regular":[404],"Abstracts);":[405],"2026":[406],"Apr":[407],"17-22;":[408],"San":[409],"Diego,":[410],"CA.":[411],"Philadelphia":[412],"(PA):":[413],"AACR;":[414],"Res":[416],"2026;86(7":[417],"Suppl):Abstract":[418],"nr":[419],"3859.":[420]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-04-04T00:00:00"}
