{"id":"https://openalex.org/W7148909752","doi":"https://doi.org/10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","title":"Synth\u00e8se de spiro-oxindoles ligands des prohibitines","display_name":"Synth\u00e8se de spiro-oxindoles ligands des prohibitines","publication_year":2019,"publication_date":"2019-09-13","ids":{"openalex":"https://openalex.org/W7148909752","doi":"https://doi.org/10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","mag":"3195985171"},"language":"fr","primary_location":{"id":"doi:10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","doi":"https://doi.org/10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","is_oa":false,"landing_page_url":"https://doi.org/10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strasbourg","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.theses.fr/2019STRAF019/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090184426","display_name":"Sabria Elderwish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sabria Elderwish","raw_affiliation_strings":["Strasbourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strasbourg","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090184426"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.6039999723434448,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.1039000004529953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prohibitin","display_name":"prohibitin","score":0.902999997138977},{"id":"https://openalex.org/keywords/prohibitin-2","display_name":"PHB2","score":0.7300000190734863},{"id":"https://openalex.org/keywords/prohibitin-1","display_name":"prohibitin 1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/spirooxindoles","display_name":"spirooxindoles","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ligand-synthesis","display_name":"ligand synthesis","score":0.718999981880188},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cardiomyocyte-protection","display_name":"cardiomyocyte protection","score":0.9639999866485596},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7059999704360962},{"id":"https://openalex.org/keywords/protein-scaffolds","display_name":"protein scaffolds","score":0.47999998927116394},{"id":"https://openalex.org/keywords/pharmacological-probes","display_name":"pharmacological probes","score":0.5659999847412109},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cardiovascular-drug-development","display_name":"cardiovascular drug development","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4925999939441681},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4153999984264374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2799000144004822},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.20509999990463257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18119999766349792},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16990000009536743},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.14010000228881836},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.11240000277757645},{"id":"https://openalex.org/C3019832315","wikidata":"https://www.wikidata.org/wiki/Q5532355","display_name":"General interest","level":3,"score":0.10859999805688858},{"id":"https://openalex.org/C2992981700","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital disease","level":2,"score":0.10750000178813934}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","doi":"https://doi.org/10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","is_oa":false,"landing_page_url":"https://doi.org/10.70675/f0b397b5z8f74z4cf5zadb7z0d6ef1c41e75","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strasbourg","raw_type":"dissertation"},{"id":"pmh:2019STRAF019","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2019STRAF019/document","pdf_url":"http://www.theses.fr/2019STRAF019/document","source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:HAL:tel-03202913v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/tel-03202913v1","pdf_url":"https://theses.hal.science/tel-03202913/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chimie th\u00e9rapeutique. Universit\u00e9 de Strasbourg, 2019. Fran\u00e7ais. ⟨NNT : 2019STRAF019⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3195985171","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-03202913","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:2019STRAF019","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2019STRAF019/document","pdf_url":"http://www.theses.fr/2019STRAF019/document","source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7148909752.pdf","grobid_xml":"https://content.openalex.org/works/W7148909752.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W585591625","https://openalex.org/W971077972","https://openalex.org/W1608233475","https://openalex.org/W1639017051","https://openalex.org/W1860184706","https://openalex.org/W1886468693","https://openalex.org/W1906765835","https://openalex.org/W1936549086","https://openalex.org/W1964331286","https://openalex.org/W1965487810","https://openalex.org/W1965762829","https://openalex.org/W1970755011","https://openalex.org/W1980115248","https://openalex.org/W1981009152","https://openalex.org/W1990483123","https://openalex.org/W1990735183","https://openalex.org/W1992947288","https://openalex.org/W1997596676","https://openalex.org/W2005073192","https://openalex.org/W2010093414","https://openalex.org/W2013382548","https://openalex.org/W2014429457","https://openalex.org/W2016543925","https://openalex.org/W2022445951","https://openalex.org/W2026536835","https://openalex.org/W2028855357","https://openalex.org/W2038674347","https://openalex.org/W2043476222","https://openalex.org/W2048413883","https://openalex.org/W2052315138","https://openalex.org/W2053186556","https://openalex.org/W2055061094","https://openalex.org/W2055786275","https://openalex.org/W2058258119","https://openalex.org/W2058721805","https://openalex.org/W2066896801","https://openalex.org/W2068526238","https://openalex.org/W2069523895","https://openalex.org/W2082674140","https://openalex.org/W2083503245","https://openalex.org/W2084669236","https://openalex.org/W2092186687","https://openalex.org/W2092566647","https://openalex.org/W2093749726","https://openalex.org/W2095303194","https://openalex.org/W2096111773","https://openalex.org/W2115538789","https://openalex.org/W2121564839","https://openalex.org/W2127851744","https://openalex.org/W2131554720","https://openalex.org/W2134364679","https://openalex.org/W2134980789","https://openalex.org/W2135400601","https://openalex.org/W2136099187","https://openalex.org/W2137257202","https://openalex.org/W2152342778","https://openalex.org/W2154594399","https://openalex.org/W2165675060","https://openalex.org/W2172141000","https://openalex.org/W2235678435","https://openalex.org/W2261583913","https://openalex.org/W2306203053","https://openalex.org/W2408898320","https://openalex.org/W2474597298","https://openalex.org/W2486440605","https://openalex.org/W2510665145","https://openalex.org/W2512831104","https://openalex.org/W2518316928","https://openalex.org/W2607200971","https://openalex.org/W2626048881","https://openalex.org/W2744423643","https://openalex.org/W2781987667","https://openalex.org/W2783922851","https://openalex.org/W2797353782","https://openalex.org/W2808882725","https://openalex.org/W2810257989","https://openalex.org/W2810672264","https://openalex.org/W2886681535","https://openalex.org/W2949170990","https://openalex.org/W2949500576","https://openalex.org/W2950645029","https://openalex.org/W2951144540","https://openalex.org/W2951802641","https://openalex.org/W2951933229","https://openalex.org/W2951952237","https://openalex.org/W2952421284","https://openalex.org/W2952988550","https://openalex.org/W4253313302"],"related_works":["https://openalex.org/W4392484177","https://openalex.org/W3081523236","https://openalex.org/W4407104696","https://openalex.org/W7148682666","https://openalex.org/W3006382914","https://openalex.org/W2289546832","https://openalex.org/W4200305072","https://openalex.org/W2953082069","https://openalex.org/W2951946917","https://openalex.org/W3145379189"],"abstract_inverted_index":{"Les":[0],"prohibitines-1":[1],"et":[2,5,17,25,42,70,89,113,136,152],"2":[3],"(PHB1":[4],"PHB2)":[6],"sont":[7],"des":[8,20,31,77,101,134],"prot\u00e9ines":[9],"d\u2019\u00e9chafaudage":[10],"qui":[11,18,79,103],"coordonnent":[12],"plusieurs":[13],"voies":[14],"de":[15,38,54,65,71,86,106,144],"signalisation":[16],"repr\u00e9sentent":[19],"cibles":[21],"\u00e9mergentes":[22],"en":[23,26],"cardiologie":[24],"oncologie.":[27],"L\u2019\u00e9tude":[28],"du":[29],"r\u00f4le":[30,133],"PHBs":[32,135],"est":[33],"g\u00ean\u00e9e":[34],"par":[35,43],"la":[36,44,66,84,87,109,111,114],"vari\u00e9t\u00e9":[37],"leurs":[39],"modifications":[40],"post-traductionnelles":[41],"l\u00e9talit\u00e9":[45],"cons\u00e9cutive":[46],"\u00e0":[47,118],"leur":[48],"invalidation":[49],"g\u00e9n\u00e9tique.":[50],"Dans":[51],"ce":[52],"travail":[53],"th\u00e8se,":[55],"nous":[56],"avons":[57,75,98],"d\u00e9velopp\u00e9":[58],"deux":[59],"synth\u00e8ses":[60],"reproductibles":[61],"d\u2019un":[62],"nouveau":[63],"ligand":[64],"PHB2,":[67],"le":[68,132,142],"2'-ph\u00e9nylpyrrolidinyl-spirooxindole,":[69],"ses":[72],"analogues.":[73],"Nous":[74,97],"identifi\u00e9":[76],"compos\u00e9s":[78,122],"prot\u00e8gent":[80],"les":[81,91,149,153],"cardiomyocytes":[82],"contre":[83],"toxicit\u00e9":[85],"doxorubicine,":[88],"\u00e9tabli":[90],"requis":[92],"structuraux":[93],"pour":[94,130,141,147],"cette":[95],"activit\u00e9.":[96],"aussi":[99],"synth\u00e9tis\u00e9":[100],"outils":[102],"ont":[104],"permis":[105],"montrer":[107],"qu\u2019\u00e0":[108],"fois":[110],"PHB1":[112],"PHB2":[115],"se":[116],"lient":[117],"ces":[119],"spirooxindoles.":[120],"Ces":[121],"peuvent":[123],"donc":[124],"\u00eatre":[125],"utilis\u00e9s":[126],"comme":[127],"sondes":[128],"pharmacologiques":[129],"\u00e9tudier":[131],"pourraient":[137],"constituer":[138],"une":[139],"base":[140],"d\u00e9veloppement":[143],"nouvelles":[145],"drogues":[146],"traiter":[148],"affections":[150],"cardiaques":[151],"cancers.":[154]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-04-04T00:00:00"}