{"id":"https://openalex.org/W7148799472","doi":"https://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","title":"Cardiac manifestations of inherited metabolic disease linked to cellular metabolism of vitamin B12 : study in two murine models of invalidation of Mtr and MMACHC genes","display_name":"Cardiac manifestations of inherited metabolic disease linked to cellular metabolism of vitamin B12 : study in two murine models of invalidation of Mtr and MMACHC genes","publication_year":2019,"publication_date":"2019-12-10","ids":{"openalex":"https://openalex.org/W7148799472","doi":"https://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","mag":"3036686977"},"language":"fr","primary_location":{"id":"doi:10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","doi":"https://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","is_oa":false,"landing_page_url":"https://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 de Lorraine","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.theses.fr/2019LORR0319/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029490686","display_name":"Viola Jepchumba Kosgei","orcid":"https://orcid.org/0000-0001-6419-9555","observed_orcids":["https://orcid.org/0000-0001-6419-9555"]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Viola Jepchumba Kosgei","raw_affiliation_strings":["Universit\u00e9 de Lorraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine","institution_ids":["https://openalex.org/I90183372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029490686"],"corresponding_institution_ids":["https://openalex.org/I90183372"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b12-metabolism","display_name":"vitamin B12 metabolism","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mtr-gene","display_name":"MTR gene","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mmachc-gene","display_name":"MMACHC gene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/methionine-synthase","display_name":"methionine synthase","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cblc","display_name":"cblC","score":0.9670000076293945},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.45500001311302185},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.6539999842643738},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.3149999976158142},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.43700000643730164},{"id":"https://openalex.org/keywords/mitochondrial-dna-damage","display_name":"mitochondrial DNA damage","score":0.3089999854564667},{"id":"https://openalex.org/keywords/cardiomyocyte-senescence","display_name":"cardiomyocyte senescence","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5299999713897705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4553000032901764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34619998931884766},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.30790001153945923},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21279999613761902},{"id":"https://openalex.org/C12387725","wikidata":"https://www.wikidata.org/wiki/Q937024","display_name":"Phenocopy","level":4,"score":0.21130000054836273},{"id":"https://openalex.org/C2781016418","wikidata":"https://www.wikidata.org/wiki/Q194435","display_name":"Vitamin deficiency","level":3,"score":0.21080000698566437},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.20839999616146088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2070000022649765}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","doi":"https://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","is_oa":false,"landing_page_url":"https://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4d","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 de Lorraine","raw_type":"dissertation"},{"id":"pmh:2019LORR0319","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2019LORR0319/document","pdf_url":"http://www.theses.fr/2019LORR0319/document","source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:3036686977","doi":null,"is_oa":true,"landing_page_url":"https://hal.univ-lorraine.fr/tel-02874823","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},{"id":"pmh:oai:HAL:tel-02874823v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/tel-02874823v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry, Molecular Biology. Universit\u00e9 de Lorraine, 2019. English. ⟨NNT : 2019LORR0319⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3094587538","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2019LORR0319","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:2019LORR0319","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2019LORR0319/document","pdf_url":"http://www.theses.fr/2019LORR0319/document","source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7148799472.pdf","grobid_xml":"https://content.openalex.org/works/W7148799472.grobid-xml"},"referenced_works_count":473,"referenced_works":["https://openalex.org/W10416642","https://openalex.org/W41564383","https://openalex.org/W60125212","https://openalex.org/W85155932","https://openalex.org/W90417353","https://openalex.org/W148810285","https://openalex.org/W153351502","https://openalex.org/W219187680","https://openalex.org/W1255743570","https://openalex.org/W1482519045","https://openalex.org/W1483096648","https://openalex.org/W1486644147","https://openalex.org/W1491296468","https://openalex.org/W1495212988","https://openalex.org/W1501004865","https://openalex.org/W1508961223","https://openalex.org/W1521995042","https://openalex.org/W1525040400","https://openalex.org/W1548252075","https://openalex.org/W1561679936","https://openalex.org/W1569626811","https://openalex.org/W1571553794","https://openalex.org/W1577530404","https://openalex.org/W1580125981","https://openalex.org/W1584301804","https://openalex.org/W1601416041","https://openalex.org/W1603526065","https://openalex.org/W1771909345","https://openalex.org/W1785122941","https://openalex.org/W1821324646","https://openalex.org/W1824195077","https://openalex.org/W1838116823","https://openalex.org/W1853546756","https://openalex.org/W1913878472","https://openalex.org/W1939058481","https://openalex.org/W1951825856","https://openalex.org/W1955583657","https://openalex.org/W1959746285","https://openalex.org/W1963558153","https://openalex.org/W1965769963","https://openalex.org/W1965785232","https://openalex.org/W1965917470","https://openalex.org/W1965976126","https://openalex.org/W1967400215","https://openalex.org/W1967907332","https://openalex.org/W1970826251","https://openalex.org/W1971301784","https://openalex.org/W1972215954","https://openalex.org/W1972761484","https://openalex.org/W1972766737","https://openalex.org/W1972990888","https://openalex.org/W1975029805","https://openalex.org/W1975969451","https://openalex.org/W1976052870","https://openalex.org/W1976205360","https://openalex.org/W1977358870","https://openalex.org/W1978998408","https://openalex.org/W1979534494","https://openalex.org/W1979579109","https://openalex.org/W1979815517","https://openalex.org/W1983248235","https://openalex.org/W1984147168","https://openalex.org/W1985251254","https://openalex.org/W1985737986","https://openalex.org/W1987463343","https://openalex.org/W1988179848","https://openalex.org/W1988816170","https://openalex.org/W1989282030","https://openalex.org/W1990295975","https://openalex.org/W1990538137","https://openalex.org/W1991069219","https://openalex.org/W1991091655","https://openalex.org/W1991507611","https://openalex.org/W1992363298","https://openalex.org/W1992644002","https://openalex.org/W1993972994","https://openalex.org/W1994802183","https://openalex.org/W1995042750","https://openalex.org/W1995152432","https://openalex.org/W1995931698","https://openalex.org/W1996064304","https://openalex.org/W1996071843","https://openalex.org/W1997107394","https://openalex.org/W1997407692","https://openalex.org/W1997427906","https://openalex.org/W1997560040","https://openalex.org/W1997910323","https://openalex.org/W1998173633","https://openalex.org/W1998188098","https://openalex.org/W1998202852","https://openalex.org/W1999690574","https://openalex.org/W1999854946","https://openalex.org/W2000838659","https://openalex.org/W2001093897","https://openalex.org/W2001525363","https://openalex.org/W2001637044","https://openalex.org/W2001837562","https://openalex.org/W2002613261","https://openalex.org/W2003409824","https://openalex.org/W2004310770","https://openalex.org/W2004476301","https://openalex.org/W2004927940","https://openalex.org/W2005076597","https://openalex.org/W2007398545","https://openalex.org/W2008126933","https://openalex.org/W2008982730","https://openalex.org/W2009713314","https://openalex.org/W2010890090","https://openalex.org/W2012323710","https://openalex.org/W2012898950","https://openalex.org/W2013841882","https://openalex.org/W2014072118","https://openalex.org/W2015904681","https://openalex.org/W2016313081","https://openalex.org/W2017011351","https://openalex.org/W2017488615","https://openalex.org/W2018710099","https://openalex.org/W2018773000","https://openalex.org/W2019403967","https://openalex.org/W2019528592","https://openalex.org/W2020016897","https://openalex.org/W2020760006","https://openalex.org/W2021276903","https://openalex.org/W2022289649","https://openalex.org/W2023272768","https://openalex.org/W2023412638","https://openalex.org/W2023765172","https://openalex.org/W2023952336","https://openalex.org/W2024873692","https://openalex.org/W2026560495","https://openalex.org/W2027264255","https://openalex.org/W2027349483","https://openalex.org/W2027931876","https://openalex.org/W2030643479","https://openalex.org/W2030726285","https://openalex.org/W2030867177","https://openalex.org/W2031012399","https://openalex.org/W2031034134","https://openalex.org/W2031846075","https://openalex.org/W2032300647","https://openalex.org/W2032385834","https://openalex.org/W2032933424","https://openalex.org/W2033828125","https://openalex.org/W2034154367","https://openalex.org/W2035797009","https://openalex.org/W2039087156","https://openalex.org/W2039134294","https://openalex.org/W2039332958","https://openalex.org/W2039374791","https://openalex.org/W2040362278","https://openalex.org/W2041537843","https://openalex.org/W2042298135","https://openalex.org/W2044170424","https://openalex.org/W2044881194","https://openalex.org/W2044929970","https://openalex.org/W2045122794","https://openalex.org/W2045291800","https://openalex.org/W2045596295","https://openalex.org/W2046329665","https://openalex.org/W2047798313","https://openalex.org/W2048447205","https://openalex.org/W2048558976","https://openalex.org/W2048672285","https://openalex.org/W2048872450","https://openalex.org/W2049079815","https://openalex.org/W2049266192","https://openalex.org/W2049664335","https://openalex.org/W2049763853","https://openalex.org/W2049934241","https://openalex.org/W2050130395","https://openalex.org/W2050271477","https://openalex.org/W2050318543","https://openalex.org/W2051686810","https://openalex.org/W2052434733","https://openalex.org/W2052751736","https://openalex.org/W2052780003","https://openalex.org/W2052869577","https://openalex.org/W2054847530","https://openalex.org/W2054955565","https://openalex.org/W2056726415","https://openalex.org/W2057469776","https://openalex.org/W2058716305","https://openalex.org/W2059287255","https://openalex.org/W2060300790","https://openalex.org/W2061301580","https://openalex.org/W2062685874","https://openalex.org/W2063633971","https://openalex.org/W2063774663","https://openalex.org/W2063873519","https://openalex.org/W2064438064","https://openalex.org/W2065321644","https://openalex.org/W2065631587","https://openalex.org/W2066688265","https://openalex.org/W2067124266","https://openalex.org/W2067459799","https://openalex.org/W2067761000","https://openalex.org/W2068754413","https://openalex.org/W2069736298","https://openalex.org/W2070259852","https://openalex.org/W2070913319","https://openalex.org/W2072453059","https://openalex.org/W2073408104","https://openalex.org/W2073905883","https://openalex.org/W2074113957","https://openalex.org/W2075094552","https://openalex.org/W2075755327","https://openalex.org/W2075878301","https://openalex.org/W2077342495","https://openalex.org/W2077446001","https://openalex.org/W2078005731","https://openalex.org/W2078767008","https://openalex.org/W2079114612","https://openalex.org/W2080154554","https://openalex.org/W2080659100","https://openalex.org/W2081756018","https://openalex.org/W2082173027","https://openalex.org/W2082937995","https://openalex.org/W2082984525","https://openalex.org/W2083173725","https://openalex.org/W2083400700","https://openalex.org/W2084670219","https://openalex.org/W2085772402","https://openalex.org/W2085815287","https://openalex.org/W2086471361","https://openalex.org/W2087133841","https://openalex.org/W2088686519","https://openalex.org/W2089747267","https://openalex.org/W2090387133","https://openalex.org/W2090627674","https://openalex.org/W2090639347","https://openalex.org/W2090685111","https://openalex.org/W2091911441","https://openalex.org/W2092175020","https://openalex.org/W2092199973","https://openalex.org/W2093110099","https://openalex.org/W2093310120","https://openalex.org/W2094036523","https://openalex.org/W2094078622","https://openalex.org/W2095927193","https://openalex.org/W2097149135","https://openalex.org/W2097757382","https://openalex.org/W2099386409","https://openalex.org/W2099601233","https://openalex.org/W2100094593","https://openalex.org/W2100337644","https://openalex.org/W2100604791","https://openalex.org/W2101961771","https://openalex.org/W2102278945","https://openalex.org/W2102308209","https://openalex.org/W2102991984","https://openalex.org/W2103085707","https://openalex.org/W2104005232","https://openalex.org/W2105211085","https://openalex.org/W2105644109","https://openalex.org/W2106478344","https://openalex.org/W2107018762","https://openalex.org/W2107359871","https://openalex.org/W2107818859","https://openalex.org/W2108053190","https://openalex.org/W2108103091","https://openalex.org/W2108335191","https://openalex.org/W2108484297","https://openalex.org/W2110624042","https://openalex.org/W2111586190","https://openalex.org/W2111732492","https://openalex.org/W2112125919","https://openalex.org/W2112974685","https://openalex.org/W2114082039","https://openalex.org/W2116225082","https://openalex.org/W2116297568","https://openalex.org/W2116351152","https://openalex.org/W2116540510","https://openalex.org/W2119004379","https://openalex.org/W2119226590","https://openalex.org/W2119901011","https://openalex.org/W2119998073","https://openalex.org/W2121099849","https://openalex.org/W2122142898","https://openalex.org/W2122922615","https://openalex.org/W2123066180","https://openalex.org/W2123276271","https://openalex.org/W2125708399","https://openalex.org/W2126286475","https://openalex.org/W2126318057","https://openalex.org/W2126864090","https://openalex.org/W2127010136","https://openalex.org/W2127462854","https://openalex.org/W2127935571","https://openalex.org/W2127995972","https://openalex.org/W2128606426","https://openalex.org/W2128956618","https://openalex.org/W2129669525","https://openalex.org/W2130271075","https://openalex.org/W2131056940","https://openalex.org/W2131062132","https://openalex.org/W2131578695","https://openalex.org/W2131645973","https://openalex.org/W2132040456","https://openalex.org/W2132250523","https://openalex.org/W2134699792","https://openalex.org/W2134747482","https://openalex.org/W2135048894","https://openalex.org/W2135302420","https://openalex.org/W2135410392","https://openalex.org/W2137662702","https://openalex.org/W2138239251","https://openalex.org/W2138439179","https://openalex.org/W2138516874","https://openalex.org/W2138878315","https://openalex.org/W2139535443","https://openalex.org/W2141524637","https://openalex.org/W2142964866","https://openalex.org/W2143135457","https://openalex.org/W2143351258","https://openalex.org/W2144784153","https://openalex.org/W2146512944","https://openalex.org/W2148134248","https://openalex.org/W2148622109","https://openalex.org/W2148725983","https://openalex.org/W2148910374","https://openalex.org/W2149647442","https://openalex.org/W2149775430","https://openalex.org/W2150031347","https://openalex.org/W2150197543","https://openalex.org/W2151548507","https://openalex.org/W2152865365","https://openalex.org/W2153613693","https://openalex.org/W2153819921","https://openalex.org/W2154389444","https://openalex.org/W2154684959","https://openalex.org/W2155014420","https://openalex.org/W2155638653","https://openalex.org/W2155748247","https://openalex.org/W2156435321","https://openalex.org/W2156555817","https://openalex.org/W2156697471","https://openalex.org/W2156878339","https://openalex.org/W2157203835","https://openalex.org/W2157553988","https://openalex.org/W2157703656","https://openalex.org/W2158330490","https://openalex.org/W2158437501","https://openalex.org/W2158738251","https://openalex.org/W2159058075","https://openalex.org/W2159430439","https://openalex.org/W2162262542","https://openalex.org/W2162603090","https://openalex.org/W2163828038","https://openalex.org/W2165715420","https://openalex.org/W2165753570","https://openalex.org/W2165998744","https://openalex.org/W2166727347","https://openalex.org/W2167710732","https://openalex.org/W2167754827","https://openalex.org/W2169170418","https://openalex.org/W2169172243","https://openalex.org/W2170289131","https://openalex.org/W2171000032","https://openalex.org/W2171062435","https://openalex.org/W2171820373","https://openalex.org/W2171994948","https://openalex.org/W2172157436","https://openalex.org/W2178738676","https://openalex.org/W2181350280","https://openalex.org/W2194837889","https://openalex.org/W2195459026","https://openalex.org/W2202869055","https://openalex.org/W2227482793","https://openalex.org/W2228283594","https://openalex.org/W2235776350","https://openalex.org/W2256541296","https://openalex.org/W2259419831","https://openalex.org/W2267510513","https://openalex.org/W2292493149","https://openalex.org/W2297865244","https://openalex.org/W2299189976","https://openalex.org/W2303479602","https://openalex.org/W2305770477","https://openalex.org/W2313801811","https://openalex.org/W2322575290","https://openalex.org/W2335697479","https://openalex.org/W2337190272","https://openalex.org/W2338757077","https://openalex.org/W2341132829","https://openalex.org/W2341328082","https://openalex.org/W2342150662","https://openalex.org/W2345356016","https://openalex.org/W2346293278","https://openalex.org/W2427094903","https://openalex.org/W2438141366","https://openalex.org/W2468838328","https://openalex.org/W2477984157","https://openalex.org/W2506191144","https://openalex.org/W2508586368","https://openalex.org/W2519258210","https://openalex.org/W2520894026","https://openalex.org/W2529406298","https://openalex.org/W2533222226","https://openalex.org/W2533367308","https://openalex.org/W2535142615","https://openalex.org/W2544727711","https://openalex.org/W2547258180","https://openalex.org/W2551839637","https://openalex.org/W2552291955","https://openalex.org/W2557591007","https://openalex.org/W2568662651","https://openalex.org/W2569582501","https://openalex.org/W2574186737","https://openalex.org/W2590445414","https://openalex.org/W2593647943","https://openalex.org/W2612916891","https://openalex.org/W2613961669","https://openalex.org/W2621236711","https://openalex.org/W2664551728","https://openalex.org/W2738206265","https://openalex.org/W2740026264","https://openalex.org/W2748662585","https://openalex.org/W2755193453","https://openalex.org/W2755886755","https://openalex.org/W2755887165","https://openalex.org/W2765534306","https://openalex.org/W2766055881","https://openalex.org/W2769226610","https://openalex.org/W2769502686","https://openalex.org/W2774870330","https://openalex.org/W2777631080","https://openalex.org/W2781937833","https://openalex.org/W2783930983","https://openalex.org/W2785063579","https://openalex.org/W2791656744","https://openalex.org/W2791763080","https://openalex.org/W2792925662","https://openalex.org/W2793885581","https://openalex.org/W2795211629","https://openalex.org/W2796362411","https://openalex.org/W2797890309","https://openalex.org/W2800841088","https://openalex.org/W2801578205","https://openalex.org/W2803600657","https://openalex.org/W2806513592","https://openalex.org/W2861214966","https://openalex.org/W2883078845","https://openalex.org/W2887157456","https://openalex.org/W2887386139","https://openalex.org/W2887984196","https://openalex.org/W2889228234","https://openalex.org/W2889285033","https://openalex.org/W2893547774","https://openalex.org/W2894380554","https://openalex.org/W2896470809","https://openalex.org/W2900668971","https://openalex.org/W2904959546","https://openalex.org/W2905075292","https://openalex.org/W2918474553","https://openalex.org/W2920690937","https://openalex.org/W2921326512","https://openalex.org/W2925253104","https://openalex.org/W2936316583","https://openalex.org/W2939756343","https://openalex.org/W2953102732","https://openalex.org/W2968709399","https://openalex.org/W2972513641","https://openalex.org/W2982666528","https://openalex.org/W3021467166","https://openalex.org/W3023363600","https://openalex.org/W3118993215","https://openalex.org/W3139986256","https://openalex.org/W4206632929","https://openalex.org/W4211082352","https://openalex.org/W4247545573","https://openalex.org/W4253757078","https://openalex.org/W4255519730","https://openalex.org/W4317926744"],"related_works":["https://openalex.org/W3094587538","https://openalex.org/W2906660270","https://openalex.org/W4206730090","https://openalex.org/W4392260998","https://openalex.org/W7148620828","https://openalex.org/W7143493875","https://openalex.org/W4392257046","https://openalex.org/W2023952336","https://openalex.org/W3162574122","https://openalex.org/W7017692887"],"abstract_inverted_index":{"Manifestations":[0],"cardiaques":[1,153,181],"des":[2,19,28,110,138,259,303,307,310],"maladies":[3],"h\u00e9r\u00e9ditaires":[4],"du":[5,99,112,140,197,206,228,252],"m\u00e9tabolisme":[6,100,253,277],"cellulaire":[7,269],"de":[8,33,36,62,66,71,82,85,91,94,101,125,128,167,170,182,184,187,215,257,263,286,288,297,305,317],"la":[9,63,83,92,102,106,118,123,129,185,188,244,264,294],"vitamine":[10,57,130],"B12":[11,58,131],":":[12],"\u00e9tude":[13],"sur":[14],"deux":[15],"mod\u00e9les":[16],"murins":[17],"d\u2019invalidation":[18],"g\u00e9nes":[20],"Mtr":[21,199,216],"et":[22,35,42,55,65,87,134,154,179,203,230,242,262,270,293,309],"MMACHC":[23,142],"L'insuffisance":[24],"cardiaque":[25,202,273],"est":[26],"l'une":[27],"causes":[29],"les":[30,39,47,148,151,155,175,235],"plus":[31],"courantes":[32],"morbidit\u00e9":[34],"mortalit\u00e9":[37],"dans":[38,46,190,217],"pays":[40,48],"occidentaux":[41],"son":[43],"incidence":[44],"augmente":[45],"en":[49,53,56,132],"d\u00e9veloppement.":[50],"Une":[51],"carence":[52],"folates":[54],"(cobalamine)":[59],"au":[60,267,271],"cours":[61],"gestation":[64],"l'allaitement":[67],"entra\u00eene":[68],"un":[69,191,231,315],"effet":[70],"programmation":[72],"f\u0153tale":[73],"avec":[74,223,255,274],"une":[75,80,89,144,221,226,250,284,301],"cardiomyopathie":[76,222,245,318],"m\u00e9tabolique":[77],"li\u00e9e":[78,248],"\u00e0":[79,88,158,173,249,283],"diminution":[81,285],"synth\u00e8se":[84,186],"m\u00e9thionine":[86,119,189],"alt\u00e9ration":[90,251],"r\u00e9m\u00e9thylation":[93],"l'homocyst\u00e9ine.":[95],"Les":[96],"d\u00e9fauts":[97],"g\u00e9n\u00e9tiques":[98],"cobalamine,":[103],"y":[104],"compris":[105],"CblG":[107],"caus\u00e9e":[108,136],"par":[109,137,200],"mutations":[111,139],"g\u00e8ne":[113,141,198,207],"MTR,":[114],"qui":[115],"code":[116],"pour":[117],"synthase":[120],"(qui":[121],"catalyse":[122],"rem\u00e9thylation":[124],"l'homocyst\u00e9ine":[126],"d\u00e9pendante":[127],"m\u00e9thionine),":[133],"CblC":[135],"provoquent":[143],"d\u00e9compensation":[145],"cardiom\u00e9tabolique":[146],"chez":[147,161,234,319],"nourrissons.":[149],"Cependant,":[150],"cons\u00e9quences":[152,176],"m\u00e9canismes":[156],"sous-jacents":[157],"ce":[159,168],"processus":[160],"l'adulte":[162],"sont":[163],"inconnus.":[164],"Le":[165],"but":[166],"projet":[169],"doctorat":[171],"consistait":[172],"\u00e9tudier":[174],"fonctionnelles,":[177],"m\u00e9taboliques":[178],"mol\u00e9culaires":[180],"l'inhibition":[183],"mod\u00e8le":[192],"murin":[193],"transg\u00e9nique":[194],"d'invalidation":[195],"constitutive":[196],"sp\u00e9cificit\u00e9":[201],"invalidation":[204],"syst\u00e9mique":[205],"MMACHC.":[208],"Nous":[209],"avons":[210],"constat\u00e9":[211],"que":[212],"l'invalidation":[213],"s\u00e9lective":[214],"le":[218],"c\u0153ur":[219],"produisait":[220],"insuffisance":[224],"cardiaque,":[225],"hypertrophie":[227],"myocarde":[229],"dysfonctionnement":[232],"systolique":[233],"jeunes":[236,320],"souris":[237],"adultes.":[238],"Au":[239],"niveau":[240],"tissulaire":[241],"mol\u00e9culaire,":[243],"observ\u00e9e":[246],"\u00e9tait":[247,281],"\u00e9nerg\u00e9tique":[254,278],"perturbation":[256],"l'oxydation":[258],"acides":[260],"gras":[261],"phosphorylation":[265],"oxydative,":[266],"stress":[268],"remodelage":[272],"fibrose.":[275],"Un":[276],"alt\u00e9r\u00e9,":[279],"il":[280],"li\u00e9":[282],"l'expression":[287,306],"Sirt3.":[289],"La":[290],"mauvaise":[291],"localisation":[292],"s\u00e9questration":[295],"nucl\u00e9aire":[296],"hnRNPA1":[298],"pourraient":[299],"expliquer":[300],"partie":[302],"modifications":[304],"g\u00e8nes":[308],"prot\u00e9ines.":[311],"Ces":[312],"r\u00e9sultats":[313],"sugg\u00e8rent":[314],"m\u00e9canisme":[316],"adultes":[321],"CblG.":[322]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-04-04T00:00:00"}