{"id":"https://openalex.org/W7148780997","doi":"https://doi.org/10.1158/1538-7445.am2026-3802","title":"Abstract 3802: Adaptive cd73 upregulation undermines parp inhibitor efficacy and creates a therapeutic opportunity for combined blockade in advanced prostate cancer","display_name":"Abstract 3802: Adaptive cd73 upregulation undermines parp inhibitor efficacy and creates a therapeutic opportunity for combined blockade in advanced prostate cancer","publication_year":2026,"publication_date":"2026-04-03","ids":{"openalex":"https://openalex.org/W7148780997","doi":"https://doi.org/10.1158/1538-7445.am2026-3802"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2026-3802","doi":"https://doi.org/10.1158/1538-7445.am2026-3802","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-3802","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005367596","display_name":"Ping Xie","orcid":"https://orcid.org/0000-0002-0891-4953","observed_orcids":["https://orcid.org/0000-0002-0891-4953"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping xie","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659633","display_name":"Jie Fan","orcid":"https://orcid.org/0000-0003-3842-2391","observed_orcids":["https://orcid.org/0000-0003-3842-2391"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Fan","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728332","display_name":"Hui Ru Tang","orcid":"https://orcid.org/0000-0002-7274-1487","observed_orcids":["https://orcid.org/0000-0002-7274-1487"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Tang","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049786167","display_name":"Longzhen Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Longzhen Song","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5132833091","display_name":"Bin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"7_Supplement","first_page":"3802","last_page":"3802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nt5e","display_name":"NT5E","score":0.847000002861023},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.996999979019165},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.45399999618530273},{"id":"https://openalex.org/keywords/extracellular-adenosine","display_name":"extracellular adenosine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5669999718666077},{"id":"https://openalex.org/keywords/tgf-beta1-signaling","display_name":"TGF-\u03b21 signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/type-i-interferon-pathway","display_name":"type I interferon pathway","score":0.8349999785423279},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.6809999942779541},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/pten-knockout","display_name":"PTEN knockout","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.8165000081062317},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7457000017166138},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6883000135421753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6567000150680542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6420000195503235},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6176000237464905},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5666999816894531},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5491999983787537},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5041000247001648},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.487199991941452},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4332999885082245},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.38019999861717224},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.34040001034736633},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.2800999879837036},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.25859999656677246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2026-3802","doi":"https://doi.org/10.1158/1538-7445.am2026-3802","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2026-3802","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8578080534934998}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Metastatic":[1],"castration-resistant":[2],"prostate":[3,114,187,247],"cancer":[4,115,188,248],"(mCRPC)":[5],"remains":[6],"a":[7,76,197,208,239],"major":[8],"cause":[9],"of":[10,50,79,215,252],"cancer-related":[11],"mortality":[12],"in":[13,42,52,109,122,245],"the":[14,47,123,136,152,253],"male":[15],"population.":[16],"While":[17],"poly(ADP-ribose)":[18],"polymeraseinhibitors":[19],"(PARPi)":[20],"are":[21],"approved":[22],"for":[23,212,242,256],"selected":[24],"mCRPC":[25],"patients":[26],"with":[27,34,66,118,165],"homologous":[28],"recombination":[29],"repair":[30],"(HRR)":[31],"deficiencies,":[32],"combinations":[33],"PD-1/PD-L1":[35],"inhibitors":[36],"immunotherapy":[37],"have":[38],"demonstrated":[39],"limited":[40],"efficacy":[41,98,236],"unselected":[43],"populations.":[44],"To":[45],"investigate":[46],"immunomodulatory":[48],"effects":[49,121],"PARPi":[51,67,97,106,145,203],"an":[53,82,92],"unbiased":[54],"manner,":[55],"we":[56],"performed":[57],"bulk":[58],"RNA":[59],"sequencing":[60],"on":[61],"HRR-proficient":[62,183],"MyC-CaP":[63],"cells":[64],"treated":[65],"Olaparib":[68,164],"or":[69],"control":[70],"vehicle.":[71],"Pathway":[72],"enrichment":[73],"analysis":[74],"revealed":[75],"marked":[77],"upregulation":[78,195,232],"CD73":[80,103,131,166,194,205],"(NT5E),":[81],"emerging":[83],"immune":[84],"checkpoint":[85],"ectoenzyme":[86],"that":[87,95],"generates":[88],"extracellular":[89],"adenosine,":[90],"suggesting":[91],"adaptive":[93],"mechanism":[94,200],"undermines":[96,233],"and":[99,112,140,157,175,184,201,237],"enables":[100],"unwanted":[101],"immunosuppression.":[102],"induction":[104],"by":[105,150],"was":[107,133],"confirmed":[108],"both":[110],"human":[111],"mouse":[113],"cell":[116,148],"lines,":[117],"more":[119],"pronounced":[120],"HRR-compromised":[124],"PTEN":[125,185],"knock-out":[126],"(KO)":[127],"cells.":[128],"Mechanistically,":[129],"Olaparib-driven":[130],"expression":[132],"mediated":[134],"through":[135],"DNA":[137],"damage-activated":[138],"ATR-CHEK1-IRF1":[139],"TGF-\u03b21-\u0391\u039a\u03a4":[141],"signaling":[142],"pathways.":[143],"Concurrently,":[144],"enhanced":[146],"tumor":[147,170],"immunogenicity":[149],"activating":[151],"type":[153],"I":[154],"interferon":[155],"pathway":[156],"antigen":[158],"presentation":[159],"machinery.":[160],"In":[161],"vivo,":[162],"combining":[163],"blockade":[167,206,244],"therapy":[168],"delayed":[169],"growth,":[171],"improved":[172],"T-cell":[173,179],"infiltration,":[174],"augmented":[176],"antigen-specific":[177],"CD8+":[178],"effector":[180],"function":[181],"across":[182],"KO":[186],"models.":[189],"These":[190],"findings":[191],"highlight":[192],"PARPi-induced":[193],"as":[196,207],"novel":[198],"resistance":[199],"support":[202],"plus":[204],"promising":[209],"therapeutic":[210,240],"strategy":[211],"mCRPC,":[213],"irrespective":[214],"HRR":[216],"status.":[217],"Citation":[218],"Format:":[219],"Ping":[220],"xie,":[221],"Jie":[222],"Fan,":[223],"Hui":[224],"Tang,":[225],"Longzhen":[226],"Song,":[227],"Bin":[228],"Zhang.":[229],"Adaptive":[230],"cd73":[231],"parp":[234],"inhibitor":[235],"creates":[238],"opportunity":[241],"combined":[243],"advanced":[246],"[abstract].":[249],"In:":[250],"Proceedings":[251],"American":[254],"Association":[255],"Cancer":[257,275],"Research":[258],"Annual":[259],"Meeting":[260],"2026;":[261],"Part":[262],"1":[263],"(Regular":[264],"Abstracts);":[265],"2026":[266],"Apr":[267],"17-22;":[268],"San":[269],"Diego,":[270],"CA.":[271],"Philadelphia":[272],"(PA):":[273],"AACR;":[274],"Res":[276],"2026;86(7":[277],"Suppl):Abstract":[278],"nr":[279],"3802.":[280]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-04-04T00:00:00"}
