{"id":"https://openalex.org/W7148728131","doi":"https://doi.org/10.70675/6b177437zf347z443bz8bb8z528243af0fa5","title":"Mise en place et \u00e9tude de mod\u00e8les de progression de la NASH jusqu\u2019au d\u00e9veloppement du CHC : effet du r\u00e9gime hyperlipidique sur l\u2019environnement h\u00e9patique","display_name":"Mise en place et \u00e9tude de mod\u00e8les de progression de la NASH jusqu\u2019au d\u00e9veloppement du CHC : effet du r\u00e9gime hyperlipidique sur l\u2019environnement h\u00e9patique","publication_year":2019,"publication_date":"2019-12-19","ids":{"openalex":"https://openalex.org/W7148728131","doi":"https://doi.org/10.70675/6b177437zf347z443bz8bb8z528243af0fa5"},"language":null,"primary_location":{"id":"doi:10.70675/6b177437zf347z443bz8bb8z528243af0fa5","doi":"https://doi.org/10.70675/6b177437zf347z443bz8bb8z528243af0fa5","is_oa":false,"landing_page_url":"https://doi.org/10.70675/6b177437zf347z443bz8bb8z528243af0fa5","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rennes 1","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059155407","display_name":"M\u00e9lanie Simoes Eug\u00e9nio","orcid":"https://orcid.org/0000-0001-6776-4839","observed_orcids":["https://orcid.org/0000-0001-6776-4839"]},"institutions":[{"id":"https://openalex.org/I4405258264","display_name":"Universit\u00e9 Rennes 1","ror":"https://ror.org/00crteh33","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258264","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M\u00e9lanie Simoes Eugenio","raw_affiliation_strings":["Rennes 1"],"raw_orcid":"https://orcid.org/0000-0001-6776-4839","affiliations":[{"raw_affiliation_string":"Rennes 1","institution_ids":["https://openalex.org/I4405258264","https://openalex.org/I56067802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059155407"],"corresponding_institution_ids":["https://openalex.org/I4405258264","https://openalex.org/I56067802"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.4458000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.4458000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.27950000762939453,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.16279999911785126,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/hyperlipidemic-diet","display_name":"hyperlipidemic diet","score":0.9259999990463257},{"id":"https://openalex.org/keywords/trim21","display_name":"TRIM21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ripk1","display_name":"RIPK1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-immune-infiltrate","display_name":"tumor immune infiltrate","score":0.5410000085830688},{"id":"https://openalex.org/keywords/hepatocyte-death","display_name":"hepatocyte death","score":0.6259999871253967},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5120000243186951},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.35499998927116394},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dietary-fat-composition","display_name":"dietary fat composition","score":0.3720000088214874},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.597000002861023},{"id":"https://openalex.org/keywords/liver-cancer-risk-factors","display_name":"liver cancer risk factors","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5753999948501587},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.3188000023365021},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2892000079154968},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.28700000047683716},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.18549999594688416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13619999587535858},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.13279999792575836},{"id":"https://openalex.org/C2993880109","wikidata":"https://www.wikidata.org/wiki/Q1163564","display_name":"Medical screening","level":2,"score":0.12549999356269836},{"id":"https://openalex.org/C2993312423","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medical practice","level":2,"score":0.12380000203847885}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.70675/6b177437zf347z443bz8bb8z528243af0fa5","doi":"https://doi.org/10.70675/6b177437zf347z443bz8bb8z528243af0fa5","is_oa":false,"landing_page_url":"https://doi.org/10.70675/6b177437zf347z443bz8bb8z528243af0fa5","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rennes 1","raw_type":"dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44340965151786804,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":296,"referenced_works":["https://openalex.org/W85359513","https://openalex.org/W116732461","https://openalex.org/W150150563","https://openalex.org/W159782486","https://openalex.org/W647830955","https://openalex.org/W1035050697","https://openalex.org/W1174036299","https://openalex.org/W1266054284","https://openalex.org/W1484817497","https://openalex.org/W1499561015","https://openalex.org/W1508110130","https://openalex.org/W1523845694","https://openalex.org/W1537951595","https://openalex.org/W1557138983","https://openalex.org/W1558228229","https://openalex.org/W1567429215","https://openalex.org/W1576720150","https://openalex.org/W1595691099","https://openalex.org/W1702807959","https://openalex.org/W1803162504","https://openalex.org/W1850224498","https://openalex.org/W1854470074","https://openalex.org/W1859746580","https://openalex.org/W1862988248","https://openalex.org/W1901445830","https://openalex.org/W1902176173","https://openalex.org/W1915589840","https://openalex.org/W1949373242","https://openalex.org/W1964182229","https://openalex.org/W1964249139","https://openalex.org/W1965114923","https://openalex.org/W1966420007","https://openalex.org/W1967761542","https://openalex.org/W1967972402","https://openalex.org/W1969776963","https://openalex.org/W1970136916","https://openalex.org/W1971094896","https://openalex.org/W1973187958","https://openalex.org/W1973981365","https://openalex.org/W1974089719","https://openalex.org/W1974941717","https://openalex.org/W1977081419","https://openalex.org/W1977548433","https://openalex.org/W1979032223","https://openalex.org/W1979290233","https://openalex.org/W1980050556","https://openalex.org/W1981860684","https://openalex.org/W1982486203","https://openalex.org/W1982658621","https://openalex.org/W1983734516","https://openalex.org/W1984077928","https://openalex.org/W1984709119","https://openalex.org/W1985194097","https://openalex.org/W1985333297","https://openalex.org/W1987186266","https://openalex.org/W1987432765","https://openalex.org/W1988073619","https://openalex.org/W1988789277","https://openalex.org/W1988951379","https://openalex.org/W1989908272","https://openalex.org/W1992450231","https://openalex.org/W1993485143","https://openalex.org/W1994018301","https://openalex.org/W1995744610","https://openalex.org/W1996104117","https://openalex.org/W1996840415","https://openalex.org/W1999444858","https://openalex.org/W2000307707","https://openalex.org/W2001383283","https://openalex.org/W2001591494","https://openalex.org/W2003066513","https://openalex.org/W2004630197","https://openalex.org/W2004933414","https://openalex.org/W2005790383","https://openalex.org/W2006523638","https://openalex.org/W2006999442","https://openalex.org/W2007505836","https://openalex.org/W2008665199","https://openalex.org/W2009500547","https://openalex.org/W2011814013","https://openalex.org/W2015026654","https://openalex.org/W2016617561","https://openalex.org/W2016828736","https://openalex.org/W2018204131","https://openalex.org/W2018645807","https://openalex.org/W2018653121","https://openalex.org/W2018666410","https://openalex.org/W2019227795","https://openalex.org/W2022771563","https://openalex.org/W2023122823","https://openalex.org/W2024214508","https://openalex.org/W2025619483","https://openalex.org/W2025683866","https://openalex.org/W2026450587","https://openalex.org/W2026483481","https://openalex.org/W2026537091","https://openalex.org/W2027233915","https://openalex.org/W2027902093","https://openalex.org/W2030125843","https://openalex.org/W2030407395","https://openalex.org/W2030634808","https://openalex.org/W2033267708","https://openalex.org/W2033578672","https://openalex.org/W2033627940","https://openalex.org/W2034006241","https://openalex.org/W2034188379","https://openalex.org/W2034231350","https://openalex.org/W2035809865","https://openalex.org/W2036167505","https://openalex.org/W2036536337","https://openalex.org/W2037555606","https://openalex.org/W2039254613","https://openalex.org/W2041465430","https://openalex.org/W2043961188","https://openalex.org/W2044046394","https://openalex.org/W2048588387","https://openalex.org/W2048613643","https://openalex.org/W2049186181","https://openalex.org/W2049463960","https://openalex.org/W2051304099","https://openalex.org/W2052605153","https://openalex.org/W2054341494","https://openalex.org/W2054717287","https://openalex.org/W2056078734","https://openalex.org/W2060204808","https://openalex.org/W2060847352","https://openalex.org/W2060859797","https://openalex.org/W2062030781","https://openalex.org/W2064299413","https://openalex.org/W2067492025","https://openalex.org/W2068041970","https://openalex.org/W2068049794","https://openalex.org/W2078210389","https://openalex.org/W2081053802","https://openalex.org/W2081871084","https://openalex.org/W2083068177","https://openalex.org/W2086665516","https://openalex.org/W2088012387","https://openalex.org/W2088031788","https://openalex.org/W2089394364","https://openalex.org/W2091171233","https://openalex.org/W2092169341","https://openalex.org/W2093927266","https://openalex.org/W2097916072","https://openalex.org/W2098012175","https://openalex.org/W2098394215","https://openalex.org/W2100114947","https://openalex.org/W2102653231","https://openalex.org/W2102775105","https://openalex.org/W2103672897","https://openalex.org/W2104421483","https://openalex.org/W2106284224","https://openalex.org/W2106490639","https://openalex.org/W2107336310","https://openalex.org/W2107564997","https://openalex.org/W2108250096","https://openalex.org/W2111288662","https://openalex.org/W2112589698","https://openalex.org/W2114239400","https://openalex.org/W2116773729","https://openalex.org/W2118621467","https://openalex.org/W2119304571","https://openalex.org/W2119498734","https://openalex.org/W2121906319","https://openalex.org/W2123104430","https://openalex.org/W2127999679","https://openalex.org/W2129587857","https://openalex.org/W2131037087","https://openalex.org/W2131357993","https://openalex.org/W2132161879","https://openalex.org/W2133079836","https://openalex.org/W2136084746","https://openalex.org/W2137969636","https://openalex.org/W2139884774","https://openalex.org/W2142225943","https://openalex.org/W2144178804","https://openalex.org/W2145185779","https://openalex.org/W2146295783","https://openalex.org/W2147437748","https://openalex.org/W2149809888","https://openalex.org/W2150679087","https://openalex.org/W2150854253","https://openalex.org/W2152445095","https://openalex.org/W2156320420","https://openalex.org/W2158025151","https://openalex.org/W2158662692","https://openalex.org/W2159190959","https://openalex.org/W2161706122","https://openalex.org/W2161818053","https://openalex.org/W2163926878","https://openalex.org/W2170005129","https://openalex.org/W2170042025","https://openalex.org/W2170832326","https://openalex.org/W2172485318","https://openalex.org/W2186318742","https://openalex.org/W2187131378","https://openalex.org/W2204688218","https://openalex.org/W2210672989","https://openalex.org/W2260130220","https://openalex.org/W2260903586","https://openalex.org/W2263333995","https://openalex.org/W2264105514","https://openalex.org/W2272315791","https://openalex.org/W2273689975","https://openalex.org/W2274766370","https://openalex.org/W2288805110","https://openalex.org/W2289400344","https://openalex.org/W2321179708","https://openalex.org/W2325672943","https://openalex.org/W2332839246","https://openalex.org/W2333014531","https://openalex.org/W2335877122","https://openalex.org/W2360439189","https://openalex.org/W2399995929","https://openalex.org/W2401798088","https://openalex.org/W2402677148","https://openalex.org/W2404952942","https://openalex.org/W2422935239","https://openalex.org/W2434220618","https://openalex.org/W2474828131","https://openalex.org/W2490099107","https://openalex.org/W2510282950","https://openalex.org/W2514631354","https://openalex.org/W2518249323","https://openalex.org/W2519582051","https://openalex.org/W2519952210","https://openalex.org/W2523136825","https://openalex.org/W2525599958","https://openalex.org/W2529871702","https://openalex.org/W2544788703","https://openalex.org/W2549277500","https://openalex.org/W2558370604","https://openalex.org/W2560286627","https://openalex.org/W2564880418","https://openalex.org/W2577302353","https://openalex.org/W2585517132","https://openalex.org/W2594607272","https://openalex.org/W2602163211","https://openalex.org/W2605526341","https://openalex.org/W2612992021","https://openalex.org/W2620898633","https://openalex.org/W2622908974","https://openalex.org/W2625096745","https://openalex.org/W2699763950","https://openalex.org/W2741420231","https://openalex.org/W2743379798","https://openalex.org/W2746363445","https://openalex.org/W2746994223","https://openalex.org/W2757303996","https://openalex.org/W2757854240","https://openalex.org/W2759997926","https://openalex.org/W2763700772","https://openalex.org/W2767554904","https://openalex.org/W2770631209","https://openalex.org/W2771020040","https://openalex.org/W2788004032","https://openalex.org/W2789124918","https://openalex.org/W2791644447","https://openalex.org/W2796067155","https://openalex.org/W2801929531","https://openalex.org/W2818331228","https://openalex.org/W2883726874","https://openalex.org/W2889270422","https://openalex.org/W2889646458","https://openalex.org/W2890271012","https://openalex.org/W2890337997","https://openalex.org/W2890609902","https://openalex.org/W2894361728","https://openalex.org/W2898314774","https://openalex.org/W2898361474","https://openalex.org/W2899548289","https://openalex.org/W2899748139","https://openalex.org/W2900470961","https://openalex.org/W2900958958","https://openalex.org/W2910109445","https://openalex.org/W2913384788","https://openalex.org/W2914396734","https://openalex.org/W2920010073","https://openalex.org/W2925499610","https://openalex.org/W2933348020","https://openalex.org/W2949675716","https://openalex.org/W2954476990","https://openalex.org/W2959566316","https://openalex.org/W2973068330","https://openalex.org/W2977114849","https://openalex.org/W2978070590","https://openalex.org/W2980941398","https://openalex.org/W3022268500","https://openalex.org/W4210848872","https://openalex.org/W4211190222","https://openalex.org/W4230280576","https://openalex.org/W4241696882","https://openalex.org/W4245318832","https://openalex.org/W4248563977","https://openalex.org/W4255712601","https://openalex.org/W7212086632"],"related_works":[],"abstract_inverted_index":{"Le":[0],"carcinome":[1],"h\u00e9patocellulaire":[2],"(CHC)":[3],"repr\u00e9sente":[4],"plus":[5,27,249,253],"de":[6,15,19,28,48,53,58,62,70,82,92,97,105,142,157,164,176,188,208,256,262,278,288,296,300,322,332,344,354,357,359,368,371],"85%":[7],"des":[8,46,68,198],"cancers":[9],"primitifs":[10],"du":[11,72,74,171,182,342],"foie.":[12],"Il":[13,76],"s\u2019agit":[14],"la":[16,54,109,112,124,131,143,158,162,165,186,189,221,228,263,272,279,286,289,315,323,327,345],"4\u00e8me":[17],"cause":[18],"d\u00e9c\u00e8s":[20,31],"par":[21,32,115,146],"cancer":[22],"dans":[23,85,130,271,276,285,304],"le":[24,116,147,169,260,320,351,375],"monde":[25],"avec":[26,204],"750":[29],"000":[30],"an.":[33],"Son":[34],"incidence":[35],"est":[36,41,302,377],"en":[37,122,211,312,379],"perp\u00e9tuelle":[38],"progression":[39,163,187,287],"et":[40,50,134,150,168,214,235,251,347,356,381],"principalement":[42],"li\u00e9e":[43,107],"aux":[44],"modifications":[45],"modes":[47],"vie":[49],"\u00e0":[51,108,140,227,336],"l\u2019augmentation":[52],"population":[55],"atteinte":[56],"d\u2019ob\u00e9sit\u00e9,":[57],"diab\u00e8te":[59],"ainsi":[60],"que":[61,80,136,151,220,314],"st\u00e9atoh\u00e9patite":[63],"non-alcoolique":[64],"(NASH)":[65],"qui":[66,266],"repr\u00e9sentent":[67],"facteurs":[69],"risques":[71],"d\u00e9veloppement":[73,170,248,321,343],"CHC.":[75],"a":[77,178,192,282],"\u00e9t\u00e9":[78,179,193,202,283],"d\u00e9montr\u00e9":[79,135,219],"l\u2019exc\u00e8s":[81],"mort":[83,110,280],"cellulaire":[84],"les":[86,90,305,339,364],"h\u00e9patocytes":[87],"pouvait":[88],"acc\u00e9l\u00e9rer":[89],"processus":[91],"carcinogen\u00e8se.":[93],"Une":[94],"premi\u00e8re":[95],"partie":[96],"nos":[98],"travaux":[99],"portait":[100],"sur":[101,185],"l\u2019\u00e9tude":[102],"d\u2019une":[103,126,223,293],"voie":[104],"signalisation":[106],"cellulaire,":[111,281],"n\u00e9croptose":[113,144],"induite":[114,145],"ligand":[117,148],"TRAIL.":[118],"Nous":[119],"avons":[120,310],"mis":[121,311],"\u00e9vidence":[123,313],"pr\u00e9sence":[125,222,229],"nouvelle":[127],"prot\u00e9ine":[128,138,264,316],"impliqu\u00e9e":[129],"n\u00e9croptose,":[132],"TRIM21,":[133],"cette":[137],"participait":[139],"l\u2019induction":[141,277],"TRAIL":[149],"son":[152,348],"absence":[153],"entra\u00eenait":[154],"un":[155,173,268],"ralentissement":[156],"signalisation.":[159],"Afin":[160],"d\u2019\u00e9tudier":[161,338],"maladie":[166,190],"h\u00e9patique":[167,191],"CHC,":[172],"mod\u00e8le":[174,330],"murin":[175,331],"NASH-HCC":[177,333],"d\u00e9velopp\u00e9.":[180],"L\u2019influence":[181],"r\u00e9gime":[183,376],"hyperlipidique":[184],"\u00e9tudi\u00e9e":[194],":":[195],"pour":[196,363],"cela":[197],"souris":[199,297],"diab\u00e9tiques":[200],"ont":[201,218],"nourries":[203],"deux":[205],"r\u00e9gimes":[206],"hyperlipidiques":[207],"composition":[209],"diff\u00e9rente":[210],"lipides,":[212],"glucides":[213],"prot\u00e9ines.":[215],"Nos":[216],"r\u00e9sultats":[217],"NASH":[224,241,324,346],"s\u00e9v\u00e8re":[225],"associ\u00e9e":[226],"d\u2019un":[230,252],"infiltrat":[231,244],"immunitaire":[232,245,373],"limitait":[233],"l\u2019apparition":[234],"l\u2019expansion":[236],"tumorale.":[237],"Au":[238],"contraire,":[239],"une":[240],"mod\u00e9r\u00e9e":[242],"sans":[243],"aboutit":[246],"au":[247],"rapide":[250],"grand":[254],"nombre":[255],"tumeurs":[257],"h\u00e9patiques.":[258],"Enfin,":[259],"r\u00f4le":[261,270],"RIPK1,":[265],"poss\u00e8de":[267],"double":[269],"survie":[273],"mais":[274,325,366],"\u00e9galement":[275,367],"\u00e9tudi\u00e9":[284],"NASH.":[290],"A":[291],"l\u2019aide":[292],"lign\u00e9e":[294],"transg\u00e9nique":[295],"dont":[298],"l\u2019expression":[299],"RIPK1":[301,317],"d\u00e9l\u00e9t\u00e9e":[303],"cellules":[306],"parenchymateuses":[307],"h\u00e9patiques,":[308],"nous":[309],"n\u2019impactait":[318],"pas":[319],"limiterait":[326],"fibrogen\u00e8se.":[328],"Ce":[329],"pourrait":[334],"permettre":[335],"l\u2019avenir":[337],"m\u00e9canismes":[340],"physiopathologiques":[341],"\u00e9volution":[349],"vers":[350],"CHC":[352],"afin":[353],"d\u00e9couvrir":[355],"tester":[358],"nouvelles":[360],"cibles":[361],"th\u00e9rapeutiques":[362],"patients":[365],"comprendre":[369],"l\u2019absence":[370],"r\u00e9ponse":[372],"lorsque":[374],"enrichi":[378],"lipides":[380],"glucides.":[382]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-04-04T00:00:00"}