{"id":"https://openalex.org/W7148628650","doi":"https://doi.org/10.1007/s40268-026-00543-y","title":"Updated Viloxazine Pharmacology: Experiments Establish Norepinephrine Transporter Occupancy and Serotonin 5-HT2C, 5-HT2B, and 5-HT7 Receptor Binding at Therapeutically Relevant Concentrations","display_name":"Updated Viloxazine Pharmacology: Experiments Establish Norepinephrine Transporter Occupancy and Serotonin 5-HT2C, 5-HT2B, and 5-HT7 Receptor Binding at Therapeutically Relevant Concentrations","publication_year":2026,"publication_date":"2026-03-01","ids":{"openalex":"https://openalex.org/W7148628650","doi":"https://doi.org/10.1007/s40268-026-00543-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41931242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13076852"},"language":"en","primary_location":{"id":"doi:10.1007/s40268-026-00543-y","doi":"https://doi.org/10.1007/s40268-026-00543-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40268-026-00543-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40268-026-00543-y.pdf","source":{"id":"https://openalex.org/S35266406","display_name":"Drugs in R&D","issn_l":"1174-5886","issn":["1174-5886","1179-6901"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&amp;D","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s40268-026-00543-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060557523","display_name":"Jennie Garc\u00eda\u2010Olivares","orcid":"https://orcid.org/0000-0002-6164-0744","observed_orcids":["https://orcid.org/0000-0002-6164-0744"]},"institutions":[{"id":"https://openalex.org/I4210138615","display_name":"Supernus Pharmaceuticals (United States)","ror":"https://ror.org/03sd6kg46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138615"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennie Garcia-Olivares","raw_affiliation_strings":["Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA. jgarciaolivares@supernus.com"],"raw_orcid":"https://orcid.org/0000-0002-6164-0744","affiliations":[{"raw_affiliation_string":"Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA. jgarciaolivares@supernus.com","institution_ids":["https://openalex.org/I4210138615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014854897","display_name":"Brittney Yegla","orcid":"https://orcid.org/0000-0002-1739-8583","observed_orcids":["https://orcid.org/0000-0002-1739-8583"]},"institutions":[{"id":"https://openalex.org/I4210138615","display_name":"Supernus Pharmaceuticals (United States)","ror":"https://ror.org/03sd6kg46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittney Yegla","raw_affiliation_strings":["Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA","institution_ids":["https://openalex.org/I4210138615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009953917","display_name":"Jennifer Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138615","display_name":"Supernus Pharmaceuticals (United States)","ror":"https://ror.org/03sd6kg46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Koch","raw_affiliation_strings":["Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA","institution_ids":["https://openalex.org/I4210138615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132830221","display_name":"Chungping Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138615","display_name":"Supernus Pharmaceuticals (United States)","ror":"https://ror.org/03sd6kg46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chungping Yu","raw_affiliation_strings":["Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA","institution_ids":["https://openalex.org/I4210138615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064633417","display_name":"Jonathan S. Rubin","orcid":"https://orcid.org/0000-0003-4344-4587","observed_orcids":["https://orcid.org/0000-0003-4344-4587"]},"institutions":[{"id":"https://openalex.org/I4210138615","display_name":"Supernus Pharmaceuticals (United States)","ror":"https://ror.org/03sd6kg46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Rubin","raw_affiliation_strings":["Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supernus Pharmaceuticals, Inc., 9715 Key West Avenue, Rockville, MD, 20850, USA","institution_ids":["https://openalex.org/I4210138615"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060557523"],"corresponding_institution_ids":["https://openalex.org/I4210138615"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":1.4322,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.7313177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"26","issue":"1","first_page":"129","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viloxazine","display_name":"viloxazine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"norepinephrine transporter","score":0.9200000166893005},{"id":"https://openalex.org/keywords/noradrenaline-reuptake-inhibition","display_name":"norepinephrine reuptake inhibition","score":0.8009999990463257},{"id":"https://openalex.org/keywords/serotonin-5-ht2c-receptor","display_name":"serotonin 5-HT2C receptor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/5-ht2b-receptor","display_name":"5-HT2B receptor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/5-ht7-receptor","display_name":"5-HT7 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-occupancy","display_name":"receptor occupancy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.6340000033378601},{"id":"https://openalex.org/keywords/receptor-antagonism","display_name":"receptor antagonism","score":0.6010000109672546},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7039999961853027},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.49799999594688416},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.968999981880188},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.6389999985694885},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7342000007629395},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5651999711990356},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5242999792098999},{"id":"https://openalex.org/C176233148","wikidata":"https://www.wikidata.org/wiki/Q14874257","display_name":"Norepinephrine transporter","level":4,"score":0.48260000348091125},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.47699999809265137},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3912999927997589},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.34439998865127563},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3050999939441681},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.3037000000476837},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3018999993801117},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.2978000044822693},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.27799999713897705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C2908747647","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"Serotonin Plasma Membrane Transport Proteins","level":5,"score":0.2599000036716461},{"id":"https://openalex.org/C3018209156","wikidata":"https://www.wikidata.org/wiki/Q287961","display_name":"\u03b22 adrenergic receptor","level":4,"score":0.2574000060558319}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044403","descriptor_name":"Receptor, Serotonin, 5-HT2B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044405","descriptor_name":"Receptor, Serotonin, 5-HT2C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050484","descriptor_name":"Norepinephrine Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s40268-026-00543-y","doi":"https://doi.org/10.1007/s40268-026-00543-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40268-026-00543-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40268-026-00543-y.pdf","source":{"id":"https://openalex.org/S35266406","display_name":"Drugs in R&D","issn_l":"1174-5886","issn":["1174-5886","1179-6901"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&amp;D","raw_type":"journal-article"},{"id":"pmid:41931242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41931242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&D","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13076852","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13076852/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs R D","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:dce673f7151848048e250071986ba2ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dce673f7151848048e250071986ba2ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drugs in R&D, Vol 26, Iss 1, Pp 129-139 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s40268-026-00543-y","doi":"https://doi.org/10.1007/s40268-026-00543-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40268-026-00543-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40268-026-00543-y.pdf","source":{"id":"https://openalex.org/S35266406","display_name":"Drugs in R&D","issn_l":"1174-5886","issn":["1174-5886","1179-6901"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs in R&amp;D","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315664","display_name":"Supernus Pharmaceuticals","ror":"https://ror.org/03sd6kg46"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7148628650.pdf","grobid_xml":"https://content.openalex.org/works/W7148628650.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1493305388","https://openalex.org/W1865055600","https://openalex.org/W1885238897","https://openalex.org/W1966819687","https://openalex.org/W1993194632","https://openalex.org/W1994124114","https://openalex.org/W2018599896","https://openalex.org/W2019083563","https://openalex.org/W2034427185","https://openalex.org/W2039299804","https://openalex.org/W2057760214","https://openalex.org/W2068642707","https://openalex.org/W2074631079","https://openalex.org/W2093113141","https://openalex.org/W2095253451","https://openalex.org/W2101650598","https://openalex.org/W2110412456","https://openalex.org/W2113624561","https://openalex.org/W2141431139","https://openalex.org/W2208234258","https://openalex.org/W2231075894","https://openalex.org/W2297745586","https://openalex.org/W2412428225","https://openalex.org/W2413972415","https://openalex.org/W2592469547","https://openalex.org/W2741398673","https://openalex.org/W2766113328","https://openalex.org/W2782666809","https://openalex.org/W2883523323","https://openalex.org/W2933452394","https://openalex.org/W2958980073","https://openalex.org/W3025751746","https://openalex.org/W3045331755","https://openalex.org/W3080466884","https://openalex.org/W3182735813","https://openalex.org/W4231656018","https://openalex.org/W4281998852","https://openalex.org/W4288068196","https://openalex.org/W4310494020","https://openalex.org/W4387387928","https://openalex.org/W4390894141","https://openalex.org/W4413966814"],"related_works":["https://openalex.org/W7011911391","https://openalex.org/W4366716825","https://openalex.org/W7165681106","https://openalex.org/W4390894141","https://openalex.org/W4365511221","https://openalex.org/W2034427185","https://openalex.org/W2413972415","https://openalex.org/W2402692845","https://openalex.org/W1993194632","https://openalex.org/W2045632985"],"abstract_inverted_index":{"Viloxazine,":[0],"which":[1],"has":[2,12],"been":[3,13],"used":[4],"to":[5,28,85,91,109,115,156,283,324,332],"treat":[6],"depression":[7],"and":[8,30,56,72,87,97,104,108,125,128,144,151,181,198,223,226,248,252,297,303,318,340],"attention-deficit/hyperactivity":[9],"disorder":[10],"(ADHD),":[11],"termed":[14],"a":[15,37,216,290,333],"moderate-affinity,":[16],"selective":[17],"norepinephrine":[18,26,71,101],"reuptake":[19],"inhibitor":[20],"based":[21,43],"on":[22,44],"high":[23,265,285],"selectivity":[24],"for":[25,96,170,311],"relative":[27,155],"serotonin":[29,49,68,106,319],"dopamine":[31],"transporters.":[32],"However,":[33],"accumulated":[34],"research":[35],"suggests":[36],"more":[38,242],"complex":[39],"mechanism":[40,117,343],"of":[41,118,240,245,254,336,344],"action,":[42],"studies":[45,133,211,261],"showing":[46,278],"activity":[47,98,139,321],"at":[48,99,140,269,293,300,307],"5-HT":[50,53,57,145,148,152,182,190,199,219,224,227,246,249,255,294,301,304],"2C":[51,146,183,220,247,295],",":[52,55,147,150,251],"2B":[54,149,191,225,250,302],"7":[58,153,200,228,256,305],"receptors,":[59],"as":[60,62,215,289],"well":[61],"findings":[63,329],"that":[64,279],"viloxazine":[65,138,160,213,234],"increases":[66],"extracellular":[67],"(along":[69],"with":[70],"dopamine)":[73],"in":[74,80,121,134,262,281],"the":[75,100,116],"rat":[76],"prefrontal":[77],"cortex.":[78],"This":[79],"vitro":[81,122,209],"pharmacology":[82],"study":[83],"aimed":[84],"replicate":[86],"expand":[88],"prior":[89],"experiments":[90,277],"better":[92],"characterize":[93],"viloxazine\u2019s":[94,325,337],"affinity":[95,169],"transporter":[102],"(NET)":[103],"individual":[105],"receptors":[107,154,296,306],"clarify":[110],"how":[111],"these":[112],"effects":[113],"contribute":[114,323],"action.":[119,345],"Using":[120],"binding":[123,168],"competition":[124],"functional":[126,210],"assays":[127],"ex":[129,259],"vivo":[130,260],"receptor":[131,320],"occupancy":[132,267],"rats,":[135],"we":[136],"assessed":[137],"human":[141],"NET":[142,171,217,266,286,316],"isoforms":[143],"clinically":[157,231,270,308],"relevant":[158,232,271,309],"unbound":[159],"plasma":[161],"concentrations":[162,310],"(0.4\u20133.6":[163],"\u03bcM).":[164],"Viloxazine":[165],"showed":[166,212],"moderate":[167],"(inhibition":[172],"constant":[173],"[":[174],"K":[175,185,193,202],"i":[176,186,194,203],"]":[177],"=":[178,187,195,204],"0.13":[179],"\u00b5M)":[180,206],"(":[184,192,201],"0.66":[188],"\u00b5M),":[189,197],"0.83":[196],"1.90":[205],"receptors.":[207,257],"In":[208],"acted":[214],"inhibitor,":[218],"partial":[221,291],"agonist,":[222],"antagonist.":[229],"At":[230],"concentrations,":[233],"could":[235],"potentially":[236],"occupy":[237],"nearly":[238],"95%":[239],"NET,":[241],"than":[243],"80%":[244],"65%":[253],"Subsequent":[258],"rats":[263],"confirmed":[264],"(67\u201394%)":[268],"concentrations.":[272],"These":[273,328],"results":[274],"validate":[275],"previous":[276],"viloxazine,":[280],"addition":[282],"displaying":[284],"occupancy,":[287],"acts":[288],"agonist":[292],"an":[298],"antagonist":[299],"ADHD":[312],"treatment.":[313],"Therefore,":[314],"both":[315],"inhibition":[317],"may":[322],"clinical":[326],"efficacy.":[327],"are":[330],"contributing":[331],"renewed":[334],"understanding":[335],"pharmacodynamic":[338],"profile":[339],"likely":[341],"multimodal":[342]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-04-03T00:00:00"}
