{"id":"https://openalex.org/W7148575554","doi":"https://doi.org/10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","title":"Epig\u00e9n\u00e9tique et cancer de la prostate : R\u00f4les de la d\u00e9m\u00e9thylase JMJD3 et de la m\u00e9thyltransf\u00e9rase EZH2","display_name":"Epig\u00e9n\u00e9tique et cancer de la prostate : R\u00f4les de la d\u00e9m\u00e9thylase JMJD3 et de la m\u00e9thyltransf\u00e9rase EZH2","publication_year":2018,"publication_date":"2018-06-04","ids":{"openalex":"https://openalex.org/W7148575554","doi":"https://doi.org/10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","mag":"2871619129"},"language":"fr","primary_location":{"id":"doi:10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","doi":"https://doi.org/10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","is_oa":false,"landing_page_url":"https://doi.org/10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 Clermont Auvergne\u200e (2017-2020)","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002536086","display_name":"Marine Daures","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marine Daures","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne\u200e (2017-2020)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne\u200e (2017-2020)","institution_ids":["https://openalex.org/I198244214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002536086"],"corresponding_institution_ids":["https://openalex.org/I198244214"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/jmjd3","display_name":"JMJD3","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/histone-demethylation","display_name":"histone demethylation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8809999823570251},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/gsk-j4","display_name":"GSK-J4","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dznep","display_name":"DZNep","score":0.8489999771118164},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.765999972820282},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7480000257492065},{"id":"https://openalex.org/keywords/rarbeta2","display_name":"RAR\u03b22","score":0.671999990940094},{"id":"https://openalex.org/keywords/diagnostic-and-prognostic-biomarkers","display_name":"diagnostic and prognostic markers","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3919999897480011},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.25459998846054077},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.2329999953508377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2011999934911728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18690000474452972},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17829999327659607},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.15489999949932098},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.15320000052452087}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","doi":"https://doi.org/10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","is_oa":false,"landing_page_url":"https://doi.org/10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 Clermont Auvergne\u200e (2017-2020)","raw_type":"dissertation"},{"id":"pmh:2018CLFAS012","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2018CLFAS012","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:2871619129","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2018CLFAS012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":273,"referenced_works":["https://openalex.org/W300603418","https://openalex.org/W346422941","https://openalex.org/W619790032","https://openalex.org/W1129239920","https://openalex.org/W1496105503","https://openalex.org/W1496772673","https://openalex.org/W1507902992","https://openalex.org/W1545430154","https://openalex.org/W1545714520","https://openalex.org/W1804915394","https://openalex.org/W1824851569","https://openalex.org/W1922704711","https://openalex.org/W1963691340","https://openalex.org/W1967648719","https://openalex.org/W1968588600","https://openalex.org/W1969338044","https://openalex.org/W1969656265","https://openalex.org/W1970246059","https://openalex.org/W1970592702","https://openalex.org/W1970840610","https://openalex.org/W1971903332","https://openalex.org/W1972012981","https://openalex.org/W1972169216","https://openalex.org/W1972602074","https://openalex.org/W1973065553","https://openalex.org/W1973752700","https://openalex.org/W1974916817","https://openalex.org/W1977621555","https://openalex.org/W1980255776","https://openalex.org/W1980937575","https://openalex.org/W1982260841","https://openalex.org/W1982688427","https://openalex.org/W1983712096","https://openalex.org/W1983747681","https://openalex.org/W1984535744","https://openalex.org/W1987157140","https://openalex.org/W1987544482","https://openalex.org/W1987562801","https://openalex.org/W1987584325","https://openalex.org/W1987772464","https://openalex.org/W1989435502","https://openalex.org/W1992207445","https://openalex.org/W1992657572","https://openalex.org/W1994182197","https://openalex.org/W1994470823","https://openalex.org/W1994987687","https://openalex.org/W1995652309","https://openalex.org/W1996072637","https://openalex.org/W1996487270","https://openalex.org/W1996846221","https://openalex.org/W1997453048","https://openalex.org/W1997764511","https://openalex.org/W2000961563","https://openalex.org/W2001526794","https://openalex.org/W2001540099","https://openalex.org/W2001858515","https://openalex.org/W2002012961","https://openalex.org/W2002259918","https://openalex.org/W2002698073","https://openalex.org/W2004380688","https://openalex.org/W2004608668","https://openalex.org/W2006752308","https://openalex.org/W2007917971","https://openalex.org/W2008326956","https://openalex.org/W2008735740","https://openalex.org/W2010090348","https://openalex.org/W2010559663","https://openalex.org/W2010790480","https://openalex.org/W2011180717","https://openalex.org/W2011256013","https://openalex.org/W2011336811","https://openalex.org/W2014359105","https://openalex.org/W2015132841","https://openalex.org/W2017916634","https://openalex.org/W2018905452","https://openalex.org/W2020230403","https://openalex.org/W2020901744","https://openalex.org/W2021134987","https://openalex.org/W2022301159","https://openalex.org/W2022930470","https://openalex.org/W2025254126","https://openalex.org/W2025606684","https://openalex.org/W2026821106","https://openalex.org/W2027739551","https://openalex.org/W2028019479","https://openalex.org/W2030774317","https://openalex.org/W2032165027","https://openalex.org/W2033102369","https://openalex.org/W2033182904","https://openalex.org/W2036186427","https://openalex.org/W2039560940","https://openalex.org/W2040182688","https://openalex.org/W2040257851","https://openalex.org/W2041238210","https://openalex.org/W2042830971","https://openalex.org/W2045951374","https://openalex.org/W2046403573","https://openalex.org/W2048074675","https://openalex.org/W2048462825","https://openalex.org/W2051388483","https://openalex.org/W2052609775","https://openalex.org/W2053116646","https://openalex.org/W2053421436","https://openalex.org/W2054621094","https://openalex.org/W2058044693","https://openalex.org/W2058396315","https://openalex.org/W2059273277","https://openalex.org/W2060608189","https://openalex.org/W2060774821","https://openalex.org/W2060870400","https://openalex.org/W2061973650","https://openalex.org/W2062307771","https://openalex.org/W2062336804","https://openalex.org/W2062927905","https://openalex.org/W2063555221","https://openalex.org/W2064922460","https://openalex.org/W2065095304","https://openalex.org/W2066009427","https://openalex.org/W2066669998","https://openalex.org/W2068793888","https://openalex.org/W2069717852","https://openalex.org/W2071141495","https://openalex.org/W2071413911","https://openalex.org/W2073067621","https://openalex.org/W2073587729","https://openalex.org/W2077301757","https://openalex.org/W2078640192","https://openalex.org/W2080585376","https://openalex.org/W2085005232","https://openalex.org/W2085539117","https://openalex.org/W2085667285","https://openalex.org/W2085878806","https://openalex.org/W2086554513","https://openalex.org/W2089191378","https://openalex.org/W2089796707","https://openalex.org/W2090381051","https://openalex.org/W2091098941","https://openalex.org/W2091193918","https://openalex.org/W2092835558","https://openalex.org/W2093800333","https://openalex.org/W2094834873","https://openalex.org/W2096774009","https://openalex.org/W2097445405","https://openalex.org/W2099460616","https://openalex.org/W2100046750","https://openalex.org/W2100065485","https://openalex.org/W2100091900","https://openalex.org/W2100237319","https://openalex.org/W2100703820","https://openalex.org/W2101636442","https://openalex.org/W2102450081","https://openalex.org/W2102983187","https://openalex.org/W2103226094","https://openalex.org/W2103410518","https://openalex.org/W2106787323","https://openalex.org/W2107633226","https://openalex.org/W2108081829","https://openalex.org/W2108979163","https://openalex.org/W2109628305","https://openalex.org/W2110599114","https://openalex.org/W2110907574","https://openalex.org/W2111846773","https://openalex.org/W2113634596","https://openalex.org/W2115314035","https://openalex.org/W2116816603","https://openalex.org/W2117334610","https://openalex.org/W2117692326","https://openalex.org/W2117792530","https://openalex.org/W2118136541","https://openalex.org/W2119199208","https://openalex.org/W2121417064","https://openalex.org/W2123439552","https://openalex.org/W2126315841","https://openalex.org/W2127684282","https://openalex.org/W2128431190","https://openalex.org/W2130478754","https://openalex.org/W2132318505","https://openalex.org/W2132850027","https://openalex.org/W2134692691","https://openalex.org/W2134925003","https://openalex.org/W2137038970","https://openalex.org/W2137798131","https://openalex.org/W2138977391","https://openalex.org/W2139411934","https://openalex.org/W2141996714","https://openalex.org/W2142012032","https://openalex.org/W2142557125","https://openalex.org/W2144001782","https://openalex.org/W2146893734","https://openalex.org/W2147524392","https://openalex.org/W2148531499","https://openalex.org/W2149822406","https://openalex.org/W2150728173","https://openalex.org/W2151548904","https://openalex.org/W2151839642","https://openalex.org/W2153019757","https://openalex.org/W2154176338","https://openalex.org/W2154719999","https://openalex.org/W2157324002","https://openalex.org/W2157495337","https://openalex.org/W2157761330","https://openalex.org/W2159267296","https://openalex.org/W2160630810","https://openalex.org/W2160689782","https://openalex.org/W2160704282","https://openalex.org/W2160769891","https://openalex.org/W2161431826","https://openalex.org/W2161888471","https://openalex.org/W2161988535","https://openalex.org/W2162923066","https://openalex.org/W2164052369","https://openalex.org/W2165544861","https://openalex.org/W2169391650","https://openalex.org/W2171189444","https://openalex.org/W2171439874","https://openalex.org/W2176225670","https://openalex.org/W2185909429","https://openalex.org/W2194294271","https://openalex.org/W2201901373","https://openalex.org/W2216062884","https://openalex.org/W2221473613","https://openalex.org/W2257253633","https://openalex.org/W2261111884","https://openalex.org/W2280698752","https://openalex.org/W2290765198","https://openalex.org/W2294284738","https://openalex.org/W2336067506","https://openalex.org/W2340422569","https://openalex.org/W2342931301","https://openalex.org/W2343576381","https://openalex.org/W2407406252","https://openalex.org/W2408079107","https://openalex.org/W2409350167","https://openalex.org/W2419582531","https://openalex.org/W2470546610","https://openalex.org/W2471903346","https://openalex.org/W2490800977","https://openalex.org/W2508408314","https://openalex.org/W2540844758","https://openalex.org/W2547167998","https://openalex.org/W2548779018","https://openalex.org/W2551361965","https://openalex.org/W2557166265","https://openalex.org/W2604710533","https://openalex.org/W2607354185","https://openalex.org/W2607369364","https://openalex.org/W2608423940","https://openalex.org/W2610260729","https://openalex.org/W2610415879","https://openalex.org/W2612084614","https://openalex.org/W2612112282","https://openalex.org/W2615111921","https://openalex.org/W2625172028","https://openalex.org/W2626743075","https://openalex.org/W2730785100","https://openalex.org/W2731219769","https://openalex.org/W2732794682","https://openalex.org/W2734451580","https://openalex.org/W2734541804","https://openalex.org/W2745556395","https://openalex.org/W2748976505","https://openalex.org/W2754937459","https://openalex.org/W2756292751","https://openalex.org/W2760579883","https://openalex.org/W2765231807","https://openalex.org/W2769685892","https://openalex.org/W2795717679","https://openalex.org/W2799305800","https://openalex.org/W2801218700","https://openalex.org/W2917837889","https://openalex.org/W3021047493","https://openalex.org/W3023299375","https://openalex.org/W4212766227"],"related_works":["https://openalex.org/W7019134521","https://openalex.org/W7151602777","https://openalex.org/W7214250787","https://openalex.org/W2540844758","https://openalex.org/W2765231807","https://openalex.org/W2799305800","https://openalex.org/W2221473613","https://openalex.org/W7147229928","https://openalex.org/W6987348956","https://openalex.org/W2257253633"],"abstract_inverted_index":{"En":[0],"France":[1],"comme":[2,226],"dans":[3,34,60,77,112,150,230,254],"la":[4,12,38,54,61,70,81,93,99,113,154,197,258],"majorit\u00e9":[5],"des":[6,31,50,58,170,200,227],"pays":[7],"d\u00e9velopp\u00e9s,":[8],"le":[9,15,106,116,151,168,193,231,255],"cancer":[10,152,256],"de":[11,37,45,56,80,92,98,104,108,110,118,126,128,131,140,143,153,163,196,212,215,219,233,238,243,245,248,252,257,269,271],"prostate":[13,259],"est":[14,21,67,158],"plus":[16],"fr\u00e9quent":[17],"chez":[18],"l\u2019homme.":[19],"Il":[20],"clairement":[22],"\u00e9tabli":[23],"que":[24],"les":[25,35,78,90,137,264],"alt\u00e9rations":[26],"g\u00e9n\u00e9tiques":[27],"et":[28,73,97,130,142,176,205,209,224,260],"\u00e9pig\u00e9n\u00e9tiques":[29],"sont":[30,85],"\u00e9v\u00e9nements":[32],"communs":[33],"cancers":[36,79],"prostate,":[39],"se":[40,74],"traduisant":[41],"par":[42,87,263],"l\u2019expression":[43,57,214],"aberrante":[44],"g\u00e8nes":[46,59,171,239],"critiques.":[47],"La":[48,63],"m\u00e9thylation":[49],"histones":[51],"participe":[52],"\u00e0":[53,69,160],"r\u00e9gulation":[55],"cellule.":[62],"marque":[64],"\u00e9pig\u00e9n\u00e9tique":[65],"H3K27me3":[66,111],"associ\u00e9e":[68],"r\u00e9pression":[71],"g\u00e9nique":[72,190],"trouve":[75],"d\u00e9r\u00e9gul\u00e9e":[76],"prostate.":[82,155],"Ses":[83],"niveaux":[84,138],"d\u00e9termin\u00e9s":[86],"l\u2019\u00e9quilibre":[88],"entre":[89],"activit\u00e9s":[91],"m\u00e9thyltransf\u00e9rase":[94],"d\u2019histone":[95,101],"EZH2":[96,144,210,225],"d\u00e9m\u00e9thylase":[100],"JMJD3.":[102],"Afin":[103],"comprendre":[105],"m\u00e9canisme":[107],"d\u00e9p\u00f4t":[109],"tumorigen\u00e8se":[114,234],"prostatique,":[115],"travail":[117],"cette":[119],"th\u00e8se":[120],"s\u2019est":[121],"orient\u00e9":[122],"sur":[123,167],"l\u2019\u00e9valuation":[124],"simultan\u00e9e":[125],"l\u2019impact":[127],"JMJD3":[129,141,208,223],"EZH2.":[132],"Dans":[133,178],"un":[134,161,179],"premier":[135],"temps,":[136,181],"d\u2019expression":[139],"ont":[145],"\u00e9t\u00e9":[146],"montr\u00e9s":[147],"augment\u00e9s":[148],"simultan\u00e9ment":[149],"Cette":[156],"augmentation":[157],"corr\u00e9l\u00e9e":[159,191],"enrichissement":[162],"ces":[164,216,220],"deux":[165],"prot\u00e9ines":[166],"promoteur":[169],"RAR\u03b22,":[172],"ER\u03b1,":[173],"RGMA,":[174],"AR":[175],"PGR.":[177],"deuxi\u00e8me":[180],"une":[182,188],"analyse":[183],"transcriptomique":[184],"a":[185],"permis":[186],"d\u2019identifier":[187],"signature":[189],"avec":[192],"niveau":[194],"d\u2019agressivit\u00e9":[195],"tumeur.":[198],"L\u2019utilisation":[199],"\u00ab":[201,265],"\u00e9pidrogues":[202,266],"\u00bb":[203,267],"GSK-J4":[204],"DZNeP":[206],"ciblant":[207],"permettent":[211],"moduler":[213],"g\u00e8nes.":[217],"L\u2019ensemble":[218],"r\u00e9sultats":[221],"caract\u00e9rise":[222],"facteurs":[228],"cl\u00e9s":[229],"processus":[232],"prostatique.":[235],"Le":[236],"panel":[237],"identifi\u00e9":[240],"devrait":[241],"permettre":[242],"d\u00e9velopper":[244,270],"potentiels":[246],"marqueurs":[247],"diagnostic":[249],"mais":[250],"\u00e9galement":[251],"pronostic":[253],"sa":[261],"modulation":[262],"permettra":[268],"nouvelles":[272],"strat\u00e9gies":[273],"th\u00e9rapeutiques.":[274]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-04-03T00:00:00"}