{"id":"https://openalex.org/W7148456244","doi":"https://doi.org/10.1016/j.omta.2026.201730","title":"IL-12-engineered human PSMA-CAR T cells for the treatment of advanced prostate cancer","display_name":"IL-12-engineered human PSMA-CAR T cells for the treatment of advanced prostate cancer","publication_year":2026,"publication_date":"2026-04-03","ids":{"openalex":"https://openalex.org/W7148456244","doi":"https://doi.org/10.1016/j.omta.2026.201730","pmid":"https://pubmed.ncbi.nlm.nih.gov/41835393"},"language":"en","primary_location":{"id":"doi:10.1016/j.omta.2026.201730","doi":"https://doi.org/10.1016/j.omta.2026.201730","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omta.2026.201730","pdf_url":null,"source":{"id":"https://openalex.org/S5407055139","display_name":"Molecular Therapy Advances","issn_l":"3117-387X","issn":["3117-387X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.omta.2026.201730","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056191796","display_name":"Lupita S. Lopez","orcid":"https://orcid.org/0000-0002-9151-6197","observed_orcids":["https://orcid.org/0000-0002-9151-6197"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":null,"type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lupita S. Lopez","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA","Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA"],"raw_orcid":"https://orcid.org/0000-0002-9151-6197","affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040134298","display_name":"Ziyou Cui","orcid":"https://orcid.org/0000-0002-4002-2509","observed_orcids":["https://orcid.org/0000-0002-4002-2509"]},"institutions":[{"id":"https://openalex.org/I4210087205","display_name":"Eureka Therapeutics (United States)","ror":"https://ror.org/0056pgw95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyou Cui","raw_affiliation_strings":["Eureka Therapeutics, Inc., Emeryville, CA 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eureka Therapeutics, Inc., Emeryville, CA 94608, USA","institution_ids":["https://openalex.org/I4210087205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023836295","display_name":"Yukiko Yamaguchi","orcid":"https://orcid.org/0009-0007-8461-5000","observed_orcids":["https://orcid.org/0009-0007-8461-5000"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukiko Yamaguchi","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002046107","display_name":"John Paul Murad","orcid":"https://orcid.org/0000-0003-0637-2414","observed_orcids":["https://orcid.org/0000-0003-0637-2414"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Murad","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132814672","display_name":"Zhiyuan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087205","display_name":"Eureka Therapeutics (United States)","ror":"https://ror.org/0056pgw95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Yang","raw_affiliation_strings":["Eureka Therapeutics, Inc., Emeryville, CA 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eureka Therapeutics, Inc., Emeryville, CA 94608, USA","institution_ids":["https://openalex.org/I4210087205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128475944","display_name":"Ke Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087205","display_name":"Eureka Therapeutics (United States)","ror":"https://ror.org/0056pgw95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Zou","raw_affiliation_strings":["Eureka Therapeutics, Inc., Emeryville, CA 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eureka Therapeutics, Inc., Emeryville, CA 94608, USA","institution_ids":["https://openalex.org/I4210087205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132823824","display_name":"Jason Yang","orcid":"https://orcid.org/0000-0003-2791-7874","observed_orcids":["https://orcid.org/0000-0003-2791-7874"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Yang","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028928234","display_name":"Wen-Chung Chang","orcid":"https://orcid.org/0000-0002-1982-0725","observed_orcids":["https://orcid.org/0000-0002-1982-0725"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Chung Chang","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039374832","display_name":"Stephen J. Forman","orcid":"https://orcid.org/0000-0002-2803-4152","observed_orcids":["https://orcid.org/0000-0002-2803-4152"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Forman","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075282478","display_name":"Vivien W.-F. Chan","orcid":"https://orcid.org/0000-0001-7663-1130","observed_orcids":["https://orcid.org/0000-0001-7663-1130"]},"institutions":[{"id":"https://openalex.org/I4210087205","display_name":"Eureka Therapeutics (United States)","ror":"https://ror.org/0056pgw95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivien W. Chan","raw_affiliation_strings":["Eureka Therapeutics, Inc., Emeryville, CA 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eureka Therapeutics, Inc., Emeryville, CA 94608, USA","institution_ids":["https://openalex.org/I4210087205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034608121","display_name":"Saul J. Priceman","orcid":"https://orcid.org/0000-0002-8136-2112","observed_orcids":["https://orcid.org/0000-0002-8136-2112"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saul J. Priceman","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA","KSOM/Norris Center for Cancer Cellular Immunotherapy Research, USC, Los Angeles, CA 90033, USA"],"raw_orcid":"https://orcid.org/0000-0002-8136-2112","affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Keck School of Medicine (KSOM) of USC, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"KSOM/Norris Center for Cancer Cellular Immunotherapy Research, USC, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034608121"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210117038"],"apc_list":null,"apc_paid":null,"fwci":2.7512,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88988585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"34","issue":"2","first_page":"201730","last_page":"201730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8489999771118164},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.7540000081062317},{"id":"https://openalex.org/keywords/macrophage-activation-syndrome","display_name":"macrophage activation syndrome","score":0.9160000085830688},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.796999990940094},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.7289999723434448},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7325000166893005},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6776000261306763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5112000107765198},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46320000290870667},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34950000047683716},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3244999945163727},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.28619998693466187},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.omta.2026.201730","doi":"https://doi.org/10.1016/j.omta.2026.201730","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omta.2026.201730","pdf_url":null,"source":{"id":"https://openalex.org/S5407055139","display_name":"Molecular Therapy Advances","issn_l":"3117-387X","issn":["3117-387X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Advances","raw_type":"journal-article"},{"id":"doi:10.64898/2026.03.05.709907","doi":"https://doi.org/10.64898/2026.03.05.709907","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.03.05.709907","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41835393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41835393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42137597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42137597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12981158","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12981158/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:13148939","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42137597/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Ther Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.omta.2026.201730","doi":"https://doi.org/10.1016/j.omta.2026.201730","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omta.2026.201730","pdf_url":null,"source":{"id":"https://openalex.org/S5407055139","display_name":"Molecular Therapy Advances","issn_l":"3117-387X","issn":["3117-387X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8588464260101318,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000092632","display_name":null,"funder_award_id":"\"P30CA033572","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F5289862134","display_name":"Eureka Therapeutics","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W309078678","https://openalex.org/W1983760836","https://openalex.org/W2013797019","https://openalex.org/W2019749094","https://openalex.org/W2029752064","https://openalex.org/W2057389857","https://openalex.org/W2088438005","https://openalex.org/W2104597364","https://openalex.org/W2168528728","https://openalex.org/W2754837152","https://openalex.org/W2785049735","https://openalex.org/W2790934354","https://openalex.org/W2920922539","https://openalex.org/W2999997703","https://openalex.org/W3037430922","https://openalex.org/W3087866938","https://openalex.org/W3104647211","https://openalex.org/W3123424129","https://openalex.org/W3127285356","https://openalex.org/W3139549049","https://openalex.org/W3176208875","https://openalex.org/W3211072477","https://openalex.org/W4206688598","https://openalex.org/W4220882995","https://openalex.org/W4224115060","https://openalex.org/W4283325152","https://openalex.org/W4315754639","https://openalex.org/W4324136971","https://openalex.org/W4365517625","https://openalex.org/W4378232465","https://openalex.org/W4379281874","https://openalex.org/W4385638646","https://openalex.org/W4389839680","https://openalex.org/W4399578578"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Adoptive":[1],"cell":[2,28,114,120],"therapies":[3],"used":[4],"to":[5,13,156],"treat":[6],"advanced":[7,163],"prostate":[8,129,165],"cancer":[9,130],"are":[10],"being":[11],"developed":[12,149],"target":[14],"several":[15],"tumor-associated":[16],"antigens,":[17],"including":[18],"prostate-specific":[19],"membrane":[20],"antigen":[21,24],"(PSMA).":[22],"Chimeric":[23],"receptor":[25],"(CAR)":[26],"T":[27,113,137],"therapy":[29],"using":[30],"the":[31,39,46,69],"single":[32],"chain":[33],"variable":[34],"fragment":[35],"(scFv)":[36],"derived":[37],"from":[38],"humanized":[40],"murine":[41],"mAb":[42],"clone,":[43],"J591,":[44],"as":[45],"antigen-binding":[47],"domain":[48],"has":[49,56,154],"shown":[50],"promising":[51,151],"anti-tumor":[52,119,143],"activity.":[53],"However,":[54],"it":[55],"also":[57],"been":[58],"associated":[59],"with":[60,77,95,111],"macrophage":[61],"activation":[62],"syndrome":[63],"and":[64,74,84,118,159],"other":[65],"unwanted":[66],"toxicities,":[67],"highlighting":[68],"need":[70],"for":[71,81],"more":[72],"specific":[73],"human-derived":[75],"antigen-binders":[76],"optimized":[78],"construct":[79],"designs":[80],"improved":[82],"safety":[83],"efficacy.":[85],"Here,":[86],"we":[87,132,147],"optimize":[88],"a":[89,103,150],"human":[90],"scFv-based":[91],"PSMA-targeted":[92],"CAR":[93],"(hPSMA-CAR)":[94],"highly":[96],"selective":[97],"PSMA":[98],"targeting.":[99],"We":[100],"further":[101],"introduce":[102],"membrane-bound":[104],"IL-12":[105],"(mbIL12)":[106],"molecule,":[107],"which":[108],"enhances":[109],"potency":[110],"increased":[112],"expansion,":[115],"IFNy":[116],"production":[117],"activity":[121],"in":[122,141],"vitro":[123],".":[124],"Using":[125],"two":[126],"clinically-relevant":[127],"bone-metastatic":[128],"models,":[131],"show":[133],"that":[134,153],"mbIL12-engineered":[135],"hPSMA-CAR":[136],"cells":[138],"drive":[139],"potent":[140],"vivo":[142],"responses.":[144],"In":[145],"summary,":[146],"have":[148],"therapeutic":[152],"potential":[155],"promote":[157],"safe":[158],"effective":[160],"treatment":[161],"of":[162],"PSMA+":[164],"cancer.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-04-03T00:00:00"}