{"id":"https://openalex.org/W7148430802","doi":"https://doi.org/10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","title":"Approche pluridisciplinaire de la probl\u00e9matique de la r\u00e9sistance bact\u00e9rienne : conception, synth\u00e8se, \u00e9valuation de l'activit\u00e9 biologique et de la biod\u00e9gradabilit\u00e9 de nouveaux agents antibact\u00e9riens","display_name":"Approche pluridisciplinaire de la probl\u00e9matique de la r\u00e9sistance bact\u00e9rienne : conception, synth\u00e8se, \u00e9valuation de l'activit\u00e9 biologique et de la biod\u00e9gradabilit\u00e9 de nouveaux agents antibact\u00e9riens","publication_year":2016,"publication_date":"2016-12-13","ids":{"openalex":"https://openalex.org/W7148430802","doi":"https://doi.org/10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","mag":"2783918445"},"language":"fr","primary_location":{"id":"doi:10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","doi":"https://doi.org/10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","is_oa":false,"landing_page_url":"https://doi.org/10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"N\u00eemes","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-01681283/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043671477","display_name":"Thibaut Boibessot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thibaut Boibessot","raw_affiliation_strings":["N\u00eemes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00eemes","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043671477"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.3012999892234802,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.3012999892234802,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.20579999685287476,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8090000152587891},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.875},{"id":"https://openalex.org/keywords/peptidoglycan-synthesis","display_name":"peptidoglycan biosynthesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antibiotic-adjuvants","display_name":"antibiotic adjuvants","score":0.7749999761581421},{"id":"https://openalex.org/keywords/histidine-kinase","display_name":"histidine kinase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/thiophene-derivatives","display_name":"thiophene derivatives","score":0.9760000109672546},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.6510000228881836},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cefotaxime","display_name":"cefotaxime","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bacterial-growth-inhibition","display_name":"bacterial growth inhibition","score":0.5109999775886536},{"id":"https://openalex.org/keywords/biodegradability","display_name":"biodegradability","score":0.7509999871253967},{"id":"https://openalex.org/keywords/enzymatic-synthesis","display_name":"enzymatic synthesis","score":0.3409999907016754},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6324999928474426},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3776000142097473},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30000001192092896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2556000053882599},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.17900000512599945},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.17350000143051147},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.15330000221729279},{"id":"https://openalex.org/C52909226","wikidata":"https://www.wikidata.org/wiki/Q5462835","display_name":"Fluorescent labelling","level":3,"score":0.14730000495910645},{"id":"https://openalex.org/C3020689752","wikidata":"https://www.wikidata.org/wiki/Q844924","display_name":"Illicit drug","level":3,"score":0.13289999961853027},{"id":"https://openalex.org/C2993880109","wikidata":"https://www.wikidata.org/wiki/Q1163564","display_name":"Medical screening","level":2,"score":0.13009999692440033}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","doi":"https://doi.org/10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","is_oa":false,"landing_page_url":"https://doi.org/10.70675/973ae188zfefbz4e00z9062ze5e3e2ebf2b1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"N\u00eemes","raw_type":"dissertation"},{"id":"pmh:oai:HAL:tel-01681283v2","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-01681283","pdf_url":"https://theses.hal.science/tel-01681283/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chimie th\u00e9rapeutique. N\u00eemes Universit\u00e9, 2016. Fran\u00e7ais. &#x27E8;NNT : 2016NIME0002&#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:2016NIME0002","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2016NIME0002/document","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:2783918445","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-01681283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-01681283v2","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-01681283","pdf_url":"https://theses.hal.science/tel-01681283/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chimie th\u00e9rapeutique. N\u00eemes Universit\u00e9, 2016. Fran\u00e7ais. &#x27E8;NNT : 2016NIME0002&#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7148430802.pdf","grobid_xml":"https://content.openalex.org/works/W7148430802.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392184285","https://openalex.org/W4392222581","https://openalex.org/W3035280036","https://openalex.org/W7151396795","https://openalex.org/W7134757367","https://openalex.org/W4405298742","https://openalex.org/W2924695471","https://openalex.org/W2921629168","https://openalex.org/W7162759486","https://openalex.org/W4402586875"],"abstract_inverted_index":{"Depuis":[0],"une":[1,147,171,194],"vingtaine":[2],"d\u2019ann\u00e9es,":[3],"l\u2019utilisation":[4],"massive":[5],"des":[6,18,41,84,91,95,126,178],"antibiotiques":[7],"a":[8,135],"provoqu\u00e9":[9],"l\u2019apparition":[10],"de":[11,27,38,49,53,75,81,104,120,128,138,173,198,204],"souches":[12,28,199],"bact\u00e9riennes":[13,200],"r\u00e9sistantes":[14],"contre":[15,150,177],"la":[16,73,82,174,196,215],"plupart":[17],"familles":[19],"d\u2019antibiotiques":[20],"disponibles":[21],"sur":[22,114,162],"le":[23,34,115],"march\u00e9":[24],"pharmaceutique.":[25],"L\u2019apparition":[26],"multir\u00e9sistantes":[29],"voire":[30],"totor\u00e9sistantes":[31],"notamment":[32],"dans":[33,72],"milieu":[35],"hospitalier,":[36],"pose":[37],"mani\u00e8re":[39],"croissante":[40],"difficult\u00e9s":[42],"th\u00e9rapeutiques":[43],"et":[44,69,193,210],"constitue":[45],"un":[46],"grave":[47],"probl\u00e8me":[48],"sant\u00e9":[50],"publique.":[51],"Lors":[52],"mon":[54],"doctorat,":[55],"deux":[56,168],"approches":[57],"ont":[58,169],"\u00e9t\u00e9":[59],"abord\u00e9es.La":[60],"premi\u00e8re":[61],"approche":[62,109],"consiste":[63],"\u00e0":[64,180,183,206,214,218],"inhiber":[65],"les":[66,123,163],"enzymes":[67],"DapF":[68],"MurE":[70],"impliqu\u00e9es":[71],"voie":[74],"biosynth\u00e8se":[76],"du":[77,142],"peptidoglycane,":[78],"composant":[79],"principal":[80],"paroi":[83],"cellules":[85],"bact\u00e9riennes.":[86],"Nous":[87],"avons":[88],"donc":[89],"pr\u00e9par\u00e9":[90],"acides":[92],"amin\u00e9s":[93],"comportant":[94],"groupes":[96],"fonctionnels":[97],"triazolyle":[98],"ou":[99],"alcynyle,":[100],"analogues":[101],"st\u00e9riquement":[102],"contraints":[103],"l\u2019acide":[105],"2,6-diaminopim\u00e9lique":[106],"(m\u00e9so-DAP).La":[107],"deuxi\u00e8me":[108],"d\u00e9velopp\u00e9e":[110],"au":[111],"laboratoire":[112],"repose":[113],"d\u00e9veloppement":[116],"d\u2019adjuvants":[117],"d\u2019antibiotiques,":[118],"permettant":[119],"cibler":[121],"sp\u00e9cifiquement":[122],"prot\u00e9ines":[124],"responsables":[125],"m\u00e9canismes":[127],"r\u00e9sistances":[129],"(Histidines":[130],"kinases,":[131],"HKs).":[132],"Ce":[133],"travail":[134],"permis":[136],"l\u2019obtention":[137],"trente-trois":[139],"mol\u00e9cules":[140,165],"d\u00e9riv\u00e9es":[141],"thioph\u00e8ne,":[143],"dont":[144],"huit":[145,164],"pr\u00e9sentent":[146],"activit\u00e9":[148],"biologique":[149],"trois":[151],"HKs":[152],"diff\u00e9rentes":[153],"(1,63":[154],"<":[155,158],"CI50":[156],"(\u03bcM)":[157],"243,9).":[159],"De":[160],"plus,":[161],"biologiquement":[166],"actives,":[167],"pr\u00e9sent\u00e9":[170],"inhibition":[172],"croissance":[175],"bact\u00e9rienne":[176],"bact\u00e9ries":[179],"gram-positif":[181],"et/ou":[182],"gram-n\u00e9gatif":[184],"(B.":[185],"subtilis,":[186],"S.":[187,211],"aureus,":[188],"B.":[189],"anthracis,":[190],"E.":[191],"coli\u2026)":[192],"restaure":[195],"sensibilit\u00e9":[197],"(E.":[201],"coli":[202],"productrice":[203],"\u03b2-lactamases":[205],"spectre":[207],"large":[208],"(BLSE)":[209],"aureus":[212],"r\u00e9sistant":[213],"m\u00e9ticilline":[216],"(SARM))":[217],"l\u2019antibiotique":[219],"appropri\u00e9":[220],"(c\u00e9fotaxime).":[221]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-04-03T00:00:00"}