{"id":"https://openalex.org/W7148394685","doi":"https://doi.org/10.2174/0115680096426616260214221301","title":"Artesunate overcomes lenvatinib resistance by inhibiting the STAT3/SLC25A27 pathway and promoting ferroptosis in hepatocellular carcinoma","display_name":"Artesunate overcomes lenvatinib resistance by inhibiting the STAT3/SLC25A27 pathway and promoting ferroptosis in hepatocellular carcinoma","publication_year":2026,"publication_date":"2026-03-31","ids":{"openalex":"https://openalex.org/W7148394685","doi":"https://doi.org/10.2174/0115680096426616260214221301","pmid":"https://pubmed.ncbi.nlm.nih.gov/41926301"},"language":"en","primary_location":{"id":"doi:10.2174/0115680096426616260214221301","doi":"https://doi.org/10.2174/0115680096426616260214221301","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115680096426616260214221301","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112968941","display_name":"Ranran Bi","orcid":"https://orcid.org/0009-0006-7798-1291","observed_orcids":["https://orcid.org/0009-0006-7798-1291"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ranran Bi","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":"https://orcid.org/0009-0006-7798-1291","affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luyuan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyuan Ma","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125210423","display_name":"Ruolan Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruolan Gu","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132780120","display_name":"Shilong Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shilong Dong","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373653","display_name":"Xinyang Li","orcid":"https://orcid.org/0000-0002-6755-7650","observed_orcids":["https://orcid.org/0000-0002-6755-7650"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyang Li","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenpeng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenpeng Liu","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Hepatobiliary Surgery Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Hepatobiliary Surgery Shijiazhuang China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132810154","display_name":"Pengfei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Zhang","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Hepatobiliary Surgery Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Hepatobiliary Surgery Shijiazhuang China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132815510","display_name":"Feng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Pathology Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Pathology Shijiazhuang China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132820832","display_name":"Chuan Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan Shen","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5132754227","display_name":"Caiyan Zhao","orcid":"https://orcid.org/0000-0003-0954-199X","observed_orcids":["https://orcid.org/0000-0003-0954-199X"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiyan Zhao","raw_affiliation_strings":["Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China"],"raw_orcid":"https://orcid.org/0000-0003-0954-199X","affiliations":[{"raw_affiliation_string":"Third Hospital of Hebei Medical University Department of Infectious Diseases Shijiazhuang China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112968941"],"corresponding_institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21389017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artesunate","display_name":"artesunate","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lenvatinib-resistance","display_name":"lenvatinib resistance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.9800000190734863},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9850000143051147},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.43799999356269836},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6610000133514404},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.7429999709129333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.633400022983551},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5652999877929688},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5412999987602234},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5216000080108643},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48080000281333923},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45419999957084656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42649999260902405},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42239999771118164},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4083000123500824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.391400009393692},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3880000114440918},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.3797000050544739},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.34369999170303345},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.33970001339912415},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C2778059366","wikidata":"https://www.wikidata.org/wiki/Q707939","display_name":"Artesunate","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.2628999948501587},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2551000118255615}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/0115680096426616260214221301","doi":"https://doi.org/10.2174/0115680096426616260214221301","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115680096426616260214221301","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},{"id":"pmid:41926301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41926301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current cancer drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Lenvatinib":[0],"is":[1,19,56,70],"the":[2,7,30,122,148,222,235,243],"first-line":[3],"drug":[4],"used":[5,119,145],"in":[6,36,58,72,91,178,226,229,255],"systemic":[8],"treatment":[9],"of":[10,124,131,150,208,237,246],"advanced":[11],"hepatocellular":[12],"carcinoma":[13],"(HCC),":[14],"although":[15],"its":[16],"therapeutic":[17,43,250],"efficacy":[18],"limited":[20],"by":[21,63,134,220],"emerging":[22],"resistance":[23,35,177,254],"mechanisms.":[24],"Our":[25,45],"study":[26,233],"aims":[27],"to":[28,38,102,111,120,146,252],"investigate":[29],"molecular":[31],"pathways":[32],"underlying":[33],"lenvatinib":[34,176,240],"HCC":[37,61,77],"inform":[39],"circumvention":[40],"strategies":[41],"for":[42],"resistance.":[44],"findings":[46],"demonstrated":[47,169],"that":[48,170,183],"solute":[49,190],"carrier":[50,191],"family":[51,192],"25":[52],"member":[53,194],"27":[54],"(SLC25A27)":[55],"upregulated":[57],"lenvatinib-resistant":[59],"(Lenva-R)":[60],"cells":[62,78],"RNA":[64],"sequencing":[65],"(RNA-seq).":[66],"Similarly,":[67],"SLC25A27":[68,171,184,214],"expression":[69],"higher":[71],"Lenva-R":[73],"than":[74],"lenvatinib-sensitive":[75],"(Lenva-S)":[76],"and":[79,88,93,160,166,175,206,228,239],"tissues":[80],"via":[81,188],"Quantitative":[82],"real-time":[83],"PCR":[84],"(qRT-PCR),":[85],"western":[86],"blot,":[87],"immunohistochemistry":[89],"(IHC)":[90],"vitro":[92],"vivo.":[94],"Cell":[95],"Counting":[96],"Kit-8":[97],"(CCK-8)":[98],"assay":[99,108,142],"was":[100,109,118],"performed":[101,110],"determine":[103,112],"cell":[104,113],"viability.":[105],"Colony":[106],"formation":[107],"proliferation":[114,174],"capacity.":[115],"DCFH-DA":[116],"staining":[117],"detect":[121],"levels":[123,149],"intracellular":[125],"reactive":[126],"oxygen":[127],"species":[128],"(ROS).":[129],"Observation":[130],"mitochondrial":[132,161],"morphology":[133],"using":[135],"transmission":[136],"electron":[137],"microscopy":[138],"(TEM).":[139],"The":[140],"corresponding":[141],"kits":[143],"were":[144],"analyze":[147],"malondialdehyde":[151],"(MDA),":[152],"glutathione":[153,156],"(GSH)/":[154],"oxidized":[155],"disulfide":[157],"(GSSG)":[158],"ratio,":[159],"membrane":[162],"potential":[163],"(MMP).":[164],"Gain-":[165],"loss-of-function":[167],"experiments":[168,202],"promotes":[172,218],"survival,":[173],"vitro.":[179,230],"Mechanistic":[180],"studies":[181],"showed":[182],"inhibits":[185],"ferroptosis":[186,219],"pathway":[187],"activating":[189],"7":[193],"A11":[195],"(SLC7A11)/glutathione":[196],"peroxidase":[197],"4":[198],"(GPX4).":[199],"Dual-luciferase":[200],"reporter":[201],"confirmed":[203,234],"signal":[204],"transducer":[205],"activator":[207],"transcription":[209],"3":[210],"(STAT3)":[211],"significantly":[212,241],"enhances":[213,242],"transcription.":[215],"Moreover,":[216],"artesunate":[217,238],"inhibiting":[221],"STAT3/SLC25A27/":[223],"SLC7A11/GPX4":[224],"axis":[225],"vivo":[227],"Overall,":[231],"our":[232],"combination":[236],"anti-HCC":[244],"effect":[245],"lenvatinib,":[247],"which":[248],"promising":[249],"strategy":[251],"circumvent":[253],"HCC.":[256]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-04-03T00:00:00"}
