{"id":"https://openalex.org/W7148096792","doi":"https://doi.org/10.25077/jka.v15i1.2706","title":"Peran stres oksidatif dalam hipertensi esensial: Systematic review","display_name":"Peran stres oksidatif dalam hipertensi esensial: Systematic review","publication_year":2026,"publication_date":"2026-03-29","ids":{"openalex":"https://openalex.org/W7148096792","doi":"https://doi.org/10.25077/jka.v15i1.2706"},"language":"en","primary_location":{"id":"doi:10.25077/jka.v15i1.2706","doi":"https://doi.org/10.25077/jka.v15i1.2706","is_oa":true,"landing_page_url":"https://doi.org/10.25077/jka.v15i1.2706","pdf_url":"https://jurnal.fk.unand.ac.id/index.php/jka/article/download/2706/2154","source":{"id":"https://openalex.org/S2736648583","display_name":"Jurnal Kesehatan Andalas","issn_l":"2301-7406","issn":["2301-7406","2615-1138"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314987","host_organization_name":"Andalas University","host_organization_lineage":["https://openalex.org/P4310314987"],"host_organization_lineage_names":["Andalas University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kesehatan Andalas","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jurnal.fk.unand.ac.id/index.php/jka/article/download/2706/2154","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132585652","display_name":"Nur Ramadani Arban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I271888150","display_name":"Sriwijaya University","ror":"https://ror.org/030bmb197","country_code":"ID","type":"education","lineage":["https://openalex.org/I271888150"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nur Ramadani Arban","raw_affiliation_strings":["Bagian Ilmu Kedokteran Komunitas dan Ilmu Kedokteran Keluarga, Fakultas Kedokteran, Universitas Sriwijaya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bagian Ilmu Kedokteran Komunitas dan Ilmu Kedokteran Keluarga, Fakultas Kedokteran, Universitas Sriwijaya","institution_ids":["https://openalex.org/I271888150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124714347","display_name":"Mohammad Zulkarnain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I271888150","display_name":"Sriwijaya University","ror":"https://ror.org/030bmb197","country_code":"ID","type":"education","lineage":["https://openalex.org/I271888150"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mohammad Zulkarnain","raw_affiliation_strings":["Bagian Ilmu Kedokteran Komunitas dan Ilmu Kedokteran Keluarga, Fakultas Kedokteran, Universitas Sriwijaya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bagian Ilmu Kedokteran Komunitas dan Ilmu Kedokteran Keluarga, Fakultas Kedokteran, Universitas Sriwijaya","institution_ids":["https://openalex.org/I271888150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024449870","display_name":"Emma Novita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I271888150","display_name":"Sriwijaya University","ror":"https://ror.org/030bmb197","country_code":"ID","type":"education","lineage":["https://openalex.org/I271888150"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Emma Novita","raw_affiliation_strings":["Bagian Ilmu Kedokteran Komunitas dan Ilmu Kedokteran Keluarga, Fakultas Kedokteran, Universitas Sriwijaya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bagian Ilmu Kedokteran Komunitas dan Ilmu Kedokteran Keluarga, Fakultas Kedokteran, Universitas Sriwijaya","institution_ids":["https://openalex.org/I271888150"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I271888150"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"35","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9879999756813049},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9919999837875366},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7870000004768372},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/dietary-nitrate","display_name":"dietary nitrate","score":0.9879999756813049},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9810000061988831},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.48899999260902405},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8823000192642212},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.738099992275238},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6547999978065491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6402000188827515},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6021000146865845},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.5228000283241272},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4404999911785126},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.39010000228881836},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3675999939441681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3605000078678131},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C2777596629","wikidata":"https://www.wikidata.org/wiki/Q10858520","display_name":"Inclusion and exclusion criteria","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.301800012588501},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.25929999351501465}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.25077/jka.v15i1.2706","doi":"https://doi.org/10.25077/jka.v15i1.2706","is_oa":true,"landing_page_url":"https://doi.org/10.25077/jka.v15i1.2706","pdf_url":"https://jurnal.fk.unand.ac.id/index.php/jka/article/download/2706/2154","source":{"id":"https://openalex.org/S2736648583","display_name":"Jurnal Kesehatan Andalas","issn_l":"2301-7406","issn":["2301-7406","2615-1138"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314987","host_organization_name":"Andalas University","host_organization_lineage":["https://openalex.org/P4310314987"],"host_organization_lineage_names":["Andalas University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kesehatan Andalas","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d8c3520a961a499e8c29c5d705ef40ff","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d8c3520a961a499e8c29c5d705ef40ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jurnal Kesehatan Andalas, Vol 15, Iss 1, Pp 35-44 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.25077/jka.v15i1.2706","doi":"https://doi.org/10.25077/jka.v15i1.2706","is_oa":true,"landing_page_url":"https://doi.org/10.25077/jka.v15i1.2706","pdf_url":"https://jurnal.fk.unand.ac.id/index.php/jka/article/download/2706/2154","source":{"id":"https://openalex.org/S2736648583","display_name":"Jurnal Kesehatan Andalas","issn_l":"2301-7406","issn":["2301-7406","2615-1138"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314987","host_organization_name":"Andalas University","host_organization_lineage":["https://openalex.org/P4310314987"],"host_organization_lineage_names":["Andalas University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kesehatan Andalas","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7148096792.pdf","grobid_xml":"https://content.openalex.org/works/W7148096792.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2270763547","https://openalex.org/W1969898963","https://openalex.org/W2520338052","https://openalex.org/W4303953020","https://openalex.org/W2375088425","https://openalex.org/W7119831857","https://openalex.org/W7165030484","https://openalex.org/W2281422803","https://openalex.org/W2124319218","https://openalex.org/W4406299287"],"abstract_inverted_index":{"The":[0],"role":[1,16,49,168],"of":[2,20,38,50,56,119,159,172,182],"oxidative":[3,51,113,147,216],"stress":[4,12,52,114,164],"in":[5,17,53,169],"essential":[6,21,57,173,214],"hypertension:":[7],"A":[8],"systematic":[9],"review":[10,65],"Oxidative":[11,83,163],"plays":[13,165],"a":[14,63,109,166],"crucial":[15],"the":[18,48,54,79,88,95,150,155,170,183],"pathogenesis":[19,55],"hypertension.":[22,58,116],"It":[23],"leads":[24],"to":[25,41,76,193,205],"endothelial":[26,125,176],"dysfunction,":[27,179],"reduced":[28],"nitric":[29,219],"oxide":[30,220],"(NO)":[31],"bioavailability,":[32],"and":[33,71,97,100,115,130,140,146,157,180,197,210],"increased":[34],"arterial":[35,132],"stiffness,":[36],"all":[37],"which":[39],"contribute":[40],"elevated":[42],"blood":[43,199],"pressure.":[44,200],"Objective:":[45],"To":[46],"analyze":[47],"Methods:":[59],"This":[60],"study":[61],"was":[62],"literature":[64],"conducted":[66],"by":[67],"searching":[68],"PubMed,":[69],"ScienceDirect,":[70],"Cochrane":[72],"databases":[73],"from":[74],"2021":[75],"2025":[77],"using":[78,135],"keywords":[80],"\u201cHypertension":[81],"AND":[82,85],"Stress":[84],"Correlation.\u201d":[86],"Of":[87],"2700":[89],"identified":[90],"articles,":[91],"six":[92],"studies":[93,107,202],"met":[94],"inclusion":[96],"exclusion":[98],"criteria":[99],"were":[101],"analyzed":[102],"further.":[103],"Results:":[104],"All":[105],"selected":[106],"demonstrated":[108],"strong":[110],"relationship":[111],"between":[112],"Increased":[117],"production":[118],"Reactive":[120],"Oxygen":[121],"Species":[122],"(ROS)":[123],"impairs":[124],"function,":[126],"reduces":[127],"NO":[128],"levels,":[129],"increases":[131],"stiffness.":[133],"Interventions":[134],"antioxidants,":[136,213],"such":[137],"as":[138],"melatonin,":[139,189,218],"dietary":[141],"nitrates":[142],"improved":[143],"vascular":[144,178],"function":[145],"balance.":[148],"However,":[149],"outcomes":[151],"varied":[152],"depending":[153],"on":[154],"type":[156],"dosage":[158],"antioxidants":[160],"used.":[161],"Conclusion:":[162],"key":[167],"development":[171],"hypertension":[174],"through":[175],"damage,":[177],"activation":[181],"renin-angiotensin":[184],"system.":[185],"Antioxidant-based":[186],"interventions,":[187],"particularly":[188],"show":[190],"promising":[191],"potential":[192],"improve":[194],"redox":[195],"balance":[196],"reduce":[198],"Further":[201],"are":[203],"needed":[204],"establish":[206],"their":[207],"long-term":[208],"efficacy":[209],"safety.":[211],"Keywords:":[212],"hypertension,":[215],"stress,":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-02T00:00:00"}