{"id":"https://openalex.org/W7147464582","doi":"https://doi.org/10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","title":"Caract\u00e9risation des voies pro-apoptotiques des r\u00e9cepteurs \u00e0 d\u00e9pendance \u00e0 Shh et strat\u00e9gies anti-tumorales","display_name":"Caract\u00e9risation des voies pro-apoptotiques des r\u00e9cepteurs \u00e0 d\u00e9pendance \u00e0 Shh et strat\u00e9gies anti-tumorales","publication_year":2015,"publication_date":"2015-12-15","ids":{"openalex":"https://openalex.org/W7147464582","doi":"https://doi.org/10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","mag":"2289691982"},"language":"fr","primary_location":{"id":"doi:10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","doi":"https://doi.org/10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","is_oa":false,"landing_page_url":"https://doi.org/10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lyon 1","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030065489","display_name":"Solen Le Guernevel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Solen Le Guernevel","raw_affiliation_strings":["Lyon 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon 1","institution_ids":["https://openalex.org/I100532134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030065489"],"corresponding_institution_ids":["https://openalex.org/I100532134"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.6589999794960022},{"id":"https://openalex.org/keywords/ptc","display_name":"PTC","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cdon","display_name":"CDON","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pro-apoptotic-signaling","display_name":"pro-apoptotic signaling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/igfbp7","display_name":"IGFBP7","score":0.7889999747276306},{"id":"https://openalex.org/keywords/p53-dependent-transcription","display_name":"p53-dependent transcription","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9330000281333923},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8479999899864197},{"id":"https://openalex.org/keywords/rnai-screen","display_name":"RNAi screen","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6664999723434448},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.27390000224113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18209999799728394},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.1777999997138977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16670000553131104},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.16500000655651093},{"id":"https://openalex.org/C2908885563","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Aldesleukin","level":4,"score":0.15039999783039093},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.14309999346733093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11389999836683273},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.11240000277757645}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","doi":"https://doi.org/10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","is_oa":false,"landing_page_url":"https://doi.org/10.70675/ba2fdd79zc5aaz42c2z910cz694997bd4586","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lyon 1","raw_type":"dissertation"},{"id":"pmh:2015LYO10298","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2015LYO10298","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:2289691982","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2015LYO10298","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":406,"referenced_works":["https://openalex.org/W103191746","https://openalex.org/W1498587827","https://openalex.org/W1504277962","https://openalex.org/W1533153036","https://openalex.org/W1560977824","https://openalex.org/W1570946718","https://openalex.org/W1573146315","https://openalex.org/W1585269928","https://openalex.org/W1585922331","https://openalex.org/W1594815607","https://openalex.org/W1595797136","https://openalex.org/W1596473475","https://openalex.org/W1597157477","https://openalex.org/W1598389003","https://openalex.org/W1604791477","https://openalex.org/W1609447875","https://openalex.org/W1616421194","https://openalex.org/W1665675542","https://openalex.org/W1676048097","https://openalex.org/W1697523131","https://openalex.org/W1745634660","https://openalex.org/W1782545213","https://openalex.org/W1785629757","https://openalex.org/W1836073275","https://openalex.org/W1878183969","https://openalex.org/W1902313111","https://openalex.org/W1964793254","https://openalex.org/W1965407839","https://openalex.org/W1966435498","https://openalex.org/W1968328677","https://openalex.org/W1968505830","https://openalex.org/W1968548603","https://openalex.org/W1969179633","https://openalex.org/W1969331809","https://openalex.org/W1969542242","https://openalex.org/W1969690844","https://openalex.org/W1970285990","https://openalex.org/W1972603965","https://openalex.org/W1973372369","https://openalex.org/W1974094726","https://openalex.org/W1974260267","https://openalex.org/W1974522463","https://openalex.org/W1974972940","https://openalex.org/W1975155851","https://openalex.org/W1976141746","https://openalex.org/W1976570855","https://openalex.org/W1976631815","https://openalex.org/W1977078696","https://openalex.org/W1977670652","https://openalex.org/W1978615896","https://openalex.org/W1978653602","https://openalex.org/W1978856493","https://openalex.org/W1979394897","https://openalex.org/W1980007041","https://openalex.org/W1980116118","https://openalex.org/W1981226387","https://openalex.org/W1981396383","https://openalex.org/W1981691061","https://openalex.org/W1982008973","https://openalex.org/W1982087641","https://openalex.org/W1982603620","https://openalex.org/W1982722652","https://openalex.org/W1983031752","https://openalex.org/W1983153157","https://openalex.org/W1983955010","https://openalex.org/W1984357249","https://openalex.org/W1984925149","https://openalex.org/W1985522229","https://openalex.org/W1985923990","https://openalex.org/W1986115299","https://openalex.org/W1986223104","https://openalex.org/W1986308149","https://openalex.org/W1988043250","https://openalex.org/W1988196067","https://openalex.org/W1988518686","https://openalex.org/W1988597220","https://openalex.org/W1988777405","https://openalex.org/W1988924112","https://openalex.org/W1989054271","https://openalex.org/W1989313612","https://openalex.org/W1989324173","https://openalex.org/W1989651175","https://openalex.org/W1989970624","https://openalex.org/W1990073151","https://openalex.org/W1990453562","https://openalex.org/W1991300200","https://openalex.org/W1991821425","https://openalex.org/W1991865867","https://openalex.org/W1992280242","https://openalex.org/W1992438051","https://openalex.org/W1992872682","https://openalex.org/W1993416164","https://openalex.org/W1993418944","https://openalex.org/W1993584752","https://openalex.org/W1994119080","https://openalex.org/W1994620081","https://openalex.org/W1994662145","https://openalex.org/W1995338672","https://openalex.org/W1995469990","https://openalex.org/W1995985499","https://openalex.org/W1996449685","https://openalex.org/W1996473157","https://openalex.org/W1999761234","https://openalex.org/W2000572318","https://openalex.org/W2000992130","https://openalex.org/W2000997159","https://openalex.org/W2001553948","https://openalex.org/W2002355858","https://openalex.org/W2002641980","https://openalex.org/W2003299661","https://openalex.org/W2005434843","https://openalex.org/W2005811410","https://openalex.org/W2006330411","https://openalex.org/W2006483529","https://openalex.org/W2007333388","https://openalex.org/W2007456673","https://openalex.org/W2007827117","https://openalex.org/W2007859564","https://openalex.org/W2007861081","https://openalex.org/W2008306523","https://openalex.org/W2008757142","https://openalex.org/W2009811048","https://openalex.org/W2009928329","https://openalex.org/W2010243701","https://openalex.org/W2010863761","https://openalex.org/W2011070056","https://openalex.org/W2011334502","https://openalex.org/W2011392649","https://openalex.org/W2012505775","https://openalex.org/W2012543502","https://openalex.org/W2013743651","https://openalex.org/W2015044035","https://openalex.org/W2016439537","https://openalex.org/W2018941771","https://openalex.org/W2019136847","https://openalex.org/W2020832324","https://openalex.org/W2021345837","https://openalex.org/W2022285707","https://openalex.org/W2022588964","https://openalex.org/W2023018711","https://openalex.org/W2023330114","https://openalex.org/W2023998484","https://openalex.org/W2024105041","https://openalex.org/W2024865764","https://openalex.org/W2025128734","https://openalex.org/W2025285281","https://openalex.org/W2025767985","https://openalex.org/W2026036357","https://openalex.org/W2026873116","https://openalex.org/W2027250489","https://openalex.org/W2027829683","https://openalex.org/W2027986342","https://openalex.org/W2028361045","https://openalex.org/W2028785149","https://openalex.org/W2030199762","https://openalex.org/W2030943228","https://openalex.org/W2032077813","https://openalex.org/W2032792789","https://openalex.org/W2032878831","https://openalex.org/W2033136080","https://openalex.org/W2033429522","https://openalex.org/W2034148530","https://openalex.org/W2034359832","https://openalex.org/W2034459499","https://openalex.org/W2035846842","https://openalex.org/W2036528355","https://openalex.org/W2036532523","https://openalex.org/W2038090189","https://openalex.org/W2039205449","https://openalex.org/W2039355845","https://openalex.org/W2040360122","https://openalex.org/W2040561534","https://openalex.org/W2040898123","https://openalex.org/W2041115282","https://openalex.org/W2041343947","https://openalex.org/W2041723754","https://openalex.org/W2042141743","https://openalex.org/W2042365294","https://openalex.org/W2042409437","https://openalex.org/W2042435738","https://openalex.org/W2042644232","https://openalex.org/W2043282593","https://openalex.org/W2043310375","https://openalex.org/W2044094920","https://openalex.org/W2044616474","https://openalex.org/W2044965556","https://openalex.org/W2044970136","https://openalex.org/W2045086385","https://openalex.org/W2045307860","https://openalex.org/W2045497115","https://openalex.org/W2045563337","https://openalex.org/W2045753558","https://openalex.org/W2046024621","https://openalex.org/W2047520007","https://openalex.org/W2047562259","https://openalex.org/W2048438235","https://openalex.org/W2048851591","https://openalex.org/W2049910739","https://openalex.org/W2051745191","https://openalex.org/W2052370181","https://openalex.org/W2052728193","https://openalex.org/W2052767351","https://openalex.org/W2052788415","https://openalex.org/W2052853635","https://openalex.org/W2053284575","https://openalex.org/W2055296003","https://openalex.org/W2055850584","https://openalex.org/W2056374213","https://openalex.org/W2056994384","https://openalex.org/W2058594499","https://openalex.org/W2059456940","https://openalex.org/W2059614045","https://openalex.org/W2059666350","https://openalex.org/W2059747767","https://openalex.org/W2060189731","https://openalex.org/W2060832818","https://openalex.org/W2060900500","https://openalex.org/W2061497413","https://openalex.org/W2062014088","https://openalex.org/W2062462227","https://openalex.org/W2062465228","https://openalex.org/W2062860025","https://openalex.org/W2063415707","https://openalex.org/W2063669247","https://openalex.org/W2065147339","https://openalex.org/W2065277366","https://openalex.org/W2065771897","https://openalex.org/W2066894862","https://openalex.org/W2067420381","https://openalex.org/W2067632356","https://openalex.org/W2067759452","https://openalex.org/W2067817632","https://openalex.org/W2068365812","https://openalex.org/W2068451393","https://openalex.org/W2068566729","https://openalex.org/W2068606395","https://openalex.org/W2068611558","https://openalex.org/W2069031289","https://openalex.org/W2069990327","https://openalex.org/W2072380594","https://openalex.org/W2072514327","https://openalex.org/W2072595310","https://openalex.org/W2073488559","https://openalex.org/W2074152898","https://openalex.org/W2074305443","https://openalex.org/W2074587487","https://openalex.org/W2075034631","https://openalex.org/W2075086498","https://openalex.org/W2075126779","https://openalex.org/W2076077499","https://openalex.org/W2076128933","https://openalex.org/W2076219748","https://openalex.org/W2076317085","https://openalex.org/W2077802746","https://openalex.org/W2078581194","https://openalex.org/W2078766485","https://openalex.org/W2079046187","https://openalex.org/W2079342690","https://openalex.org/W2079370988","https://openalex.org/W2080156248","https://openalex.org/W2081546525","https://openalex.org/W2082648259","https://openalex.org/W2082706608","https://openalex.org/W2083542782","https://openalex.org/W2084085797","https://openalex.org/W2084412673","https://openalex.org/W2085391702","https://openalex.org/W2085953508","https://openalex.org/W2086082646","https://openalex.org/W2086152184","https://openalex.org/W2087877138","https://openalex.org/W2087938232","https://openalex.org/W2088238268","https://openalex.org/W2088342479","https://openalex.org/W2089115411","https://openalex.org/W2089358150","https://openalex.org/W2089584150","https://openalex.org/W2090132251","https://openalex.org/W2090176557","https://openalex.org/W2090204462","https://openalex.org/W2090204791","https://openalex.org/W2090898691","https://openalex.org/W2091270752","https://openalex.org/W2091747965","https://openalex.org/W2091976970","https://openalex.org/W2092534798","https://openalex.org/W2093133947","https://openalex.org/W2093624570","https://openalex.org/W2093833189","https://openalex.org/W2094191556","https://openalex.org/W2095252238","https://openalex.org/W2095554214","https://openalex.org/W2096308078","https://openalex.org/W2096624080","https://openalex.org/W2097606482","https://openalex.org/W2100080081","https://openalex.org/W2100562940","https://openalex.org/W2101616608","https://openalex.org/W2102437478","https://openalex.org/W2102929715","https://openalex.org/W2104033956","https://openalex.org/W2108707301","https://openalex.org/W2108901851","https://openalex.org/W2109171783","https://openalex.org/W2109298504","https://openalex.org/W2110321605","https://openalex.org/W2110371901","https://openalex.org/W2111213257","https://openalex.org/W2113071839","https://openalex.org/W2113492051","https://openalex.org/W2113579192","https://openalex.org/W2114344465","https://openalex.org/W2114455979","https://openalex.org/W2114471035","https://openalex.org/W2116610035","https://openalex.org/W2117050355","https://openalex.org/W2117207378","https://openalex.org/W2117387587","https://openalex.org/W2117692326","https://openalex.org/W2117796397","https://openalex.org/W2117820574","https://openalex.org/W2118271123","https://openalex.org/W2118966275","https://openalex.org/W2120010339","https://openalex.org/W2121017846","https://openalex.org/W2121780827","https://openalex.org/W2122589790","https://openalex.org/W2122954559","https://openalex.org/W2123188252","https://openalex.org/W2124076790","https://openalex.org/W2124331303","https://openalex.org/W2124354752","https://openalex.org/W2124479860","https://openalex.org/W2124614410","https://openalex.org/W2125052212","https://openalex.org/W2126176784","https://openalex.org/W2126206931","https://openalex.org/W2126679757","https://openalex.org/W2127001212","https://openalex.org/W2128412799","https://openalex.org/W2128775062","https://openalex.org/W2128960139","https://openalex.org/W2129435178","https://openalex.org/W2129685249","https://openalex.org/W2130742313","https://openalex.org/W2131075994","https://openalex.org/W2133959309","https://openalex.org/W2134205510","https://openalex.org/W2135330594","https://openalex.org/W2136545880","https://openalex.org/W2137276142","https://openalex.org/W2137279272","https://openalex.org/W2139097227","https://openalex.org/W2139499843","https://openalex.org/W2140941004","https://openalex.org/W2141078839","https://openalex.org/W2142728379","https://openalex.org/W2143265930","https://openalex.org/W2143778153","https://openalex.org/W2143859801","https://openalex.org/W2143938651","https://openalex.org/W2144096368","https://openalex.org/W2144678487","https://openalex.org/W2146196731","https://openalex.org/W2146226667","https://openalex.org/W2146906669","https://openalex.org/W2148432857","https://openalex.org/W2149455148","https://openalex.org/W2150912846","https://openalex.org/W2150957189","https://openalex.org/W2151439603","https://openalex.org/W2153188090","https://openalex.org/W2153250887","https://openalex.org/W2153260902","https://openalex.org/W2154279879","https://openalex.org/W2156416422","https://openalex.org/W2156483686","https://openalex.org/W2157952439","https://openalex.org/W2159476762","https://openalex.org/W2159956387","https://openalex.org/W2160010535","https://openalex.org/W2160604905","https://openalex.org/W2161080185","https://openalex.org/W2161735235","https://openalex.org/W2161784983","https://openalex.org/W2162670048","https://openalex.org/W2163067447","https://openalex.org/W2163633179","https://openalex.org/W2164570899","https://openalex.org/W2165222962","https://openalex.org/W2166035372","https://openalex.org/W2167032170","https://openalex.org/W2172162633","https://openalex.org/W2173390200","https://openalex.org/W2186066012","https://openalex.org/W2238291595","https://openalex.org/W2245020166","https://openalex.org/W2252742827","https://openalex.org/W2256754589","https://openalex.org/W2315613727","https://openalex.org/W2325220074","https://openalex.org/W2331702421","https://openalex.org/W2402668722","https://openalex.org/W2526421941","https://openalex.org/W4229861519","https://openalex.org/W7095857417"],"related_works":["https://openalex.org/W7134762307","https://openalex.org/W7143769676","https://openalex.org/W7134423753","https://openalex.org/W1871814825","https://openalex.org/W7149558903","https://openalex.org/W2009826481","https://openalex.org/W7134421008","https://openalex.org/W6884562952","https://openalex.org/W7143366070","https://openalex.org/W2145725953"],"abstract_inverted_index":{"Les":[0],"r\u00e9cepteurs":[1,55,67,96,111,173],"\u00e0":[2,60,113,127,182,225],"d\u00e9pendance":[3],"(RDs)":[4],"ont":[5],"la":[6,14,30,32,36,45,61,80,91,145],"particularit\u00e9":[7],"d\u2019induire":[8],"deux":[9,54,66],"types":[10],"de":[11,16,21,79,83,90,94,106,109,133,136,155,187,230],"signalisation":[12,27,92],"selon":[13],"disponibilit\u00e9":[15],"leur":[17,22],"ligand.":[18],"En":[19],"pr\u00e9sence":[20],"ligand,":[23],"ils":[24,43],"induisent":[25,44],"une":[26,237,250],"positive":[28],"favorisant":[29],"survie,":[31],"prolif\u00e9ration":[33],"ou":[34],"encore":[35,98],"diff\u00e9rentiation":[37],"cellulaire,":[38],"tandis":[39],"qu\u2019en":[40],"son":[41],"absence,":[42],"mort":[46,146],"cellulaire":[47],"par":[48,148,214,218],"apoptose.":[49],"Ptc":[50,149,174,244],"et":[51,82,175,245,247],"CDON,":[52,246],"tous":[53],"du":[56,203],"morphog\u00e8ne":[57],"Shh,":[58],"appartiennent":[59],"famille":[62],"des":[63,87,169,172,178,183,207,239,242],"RDs.":[64],"Ces":[65],"sont":[68,97],"impliqu\u00e9s":[69],"dans":[70,76,135,177,232],"le":[71,77,196,228],"d\u00e9veloppement":[72],"embryonnaire,":[73],"mais":[74],"aussi":[75],"contr\u00f4le":[78,152,211],"tumorigen\u00e8se":[81],"l\u2019hom\u00e9ostasie.":[84],"La":[85,201],"plupart":[86],"m\u00e9canismes":[88,208],"mol\u00e9culaires":[89],"proapoptotique":[93],"ces":[95,110,233],"inconnus.":[99],"Nous":[100,139],"avons":[101,140],"donc":[102],"\u00e9tudi\u00e9":[103],"les":[104,119,215,219],"voies":[105,170,240],"signalisations":[107],"proapoptotiques":[108],"gr\u00e2ce":[112],"un":[114,151,160],"crible":[115],"d\u2019ARN":[116],"interf\u00e9rents.":[117],"Parmi":[118],"partenaires":[120],"potentiels":[121],"identifi\u00e9s,":[122],"nous":[123,124,163,164],"sommes":[125,165],"int\u00e9ress\u00e9s":[126,166],"l\u2019IGFBP7,":[128],"caract\u00e9ris\u00e9":[129],"comme":[130],"g\u00e8ne":[131],"suppresseur":[132],"tumeurs":[134],"nombreux":[137],"cancers.":[138],"mis":[141],"en":[142],"\u00e9vidence":[143],"que":[144,195,227],"induite":[147],"implique":[150],"transcriptionnel":[153],"d\u2019IGFBP7":[154],"fa\u00e7on":[156],"p53":[157],"d\u00e9pendante.":[158],"Dans":[159],"second":[161],"temps,":[162],"au":[167,210],"r\u00f4le":[168],"apoptotiques":[171,241],"CDON":[176],"cancers":[179,234],"colorectaux":[180],"associ\u00e9s":[181],"maladies":[184],"inflammatoires":[185],"chroniques":[186],"l\u2019intestin,":[188],"pour":[189],"lesquels":[190],"il":[191],"a":[192],"\u00e9t\u00e9":[193],"montr\u00e9":[194],"ligand":[197,204],"Shh":[198,231],"est":[199,205],"surexprim\u00e9.":[200],"surexpression":[202],"l\u2019un":[206],"d\u2019\u00e9chappement":[209],"apoptotique":[212],"exerc\u00e9":[213],"RDs":[216,243],"acquit":[217],"cellules":[220],"tumorales.":[221],"Notre":[222],"\u00e9tude":[223],"vise":[224],"d\u00e9montrer":[226],"ciblage":[229],"pourrait":[235],"induire":[236],"r\u00e9activation":[238],"ainsi":[248],"constituer":[249],"nouvelle":[251],"strat\u00e9gie":[252],"anti-tumorale":[253]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-04-02T00:00:00"}