{"id":"https://openalex.org/W7147445015","doi":"https://doi.org/10.1158/1078-0432.31910788","title":"Supplementary Data11 from Dynamic ctDNA Monitoring Guides Early Treatment Intensification in Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemotherapy","display_name":"Supplementary Data11 from Dynamic ctDNA Monitoring Guides Early Treatment Intensification in Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemotherapy","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7147445015","doi":"https://doi.org/10.1158/1078-0432.31910788"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.31910788","doi":"https://doi.org/10.1158/1078-0432.31910788","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.31910788","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.31910788","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054960247","display_name":"Yu Shen","orcid":"https://orcid.org/0000-0002-0167-458X","observed_orcids":["https://orcid.org/0000-0002-0167-458X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Shen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0167-458X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123390487","display_name":"Mingtian Wei","orcid":"https://orcid.org/0009-0006-0093-3830","observed_orcids":["https://orcid.org/0009-0006-0093-3830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingtian Wei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-0093-3830","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132680605","display_name":"Yazhou He","orcid":"https://orcid.org/0000-0003-2358-0143","observed_orcids":["https://orcid.org/0000-0003-2358-0143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yazhou He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2358-0143","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053967662","display_name":"Tinghan Yang","orcid":"https://orcid.org/0000-0003-3784-009X","observed_orcids":["https://orcid.org/0000-0003-3784-009X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tinghan Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3784-009X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123411354","display_name":"Xiangbing Deng","orcid":"https://orcid.org/0000-0002-9208-7398","observed_orcids":["https://orcid.org/0000-0002-9208-7398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangbing Deng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9208-7398","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123187264","display_name":"Qingbin Wu","orcid":"https://orcid.org/0000-0001-8149-5989","observed_orcids":["https://orcid.org/0000-0001-8149-5989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingbin Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8149-5989","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032188580","display_name":"H R Chen","orcid":"https://orcid.org/0000-0003-0104-8498","observed_orcids":["https://orcid.org/0000-0003-0104-8498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haining Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0104-8498","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132580024","display_name":"Rui Fan","orcid":"https://orcid.org/0000-0001-5145-2339","observed_orcids":["https://orcid.org/0000-0001-5145-2339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Fan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5145-2339","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101810484","display_name":"Yiqian Liu","orcid":"https://orcid.org/0009-0000-3284-2745","observed_orcids":["https://orcid.org/0009-0000-3284-2745","https://orcid.org/0000-0001-7434-5077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiqian Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-3284-2745","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132700762","display_name":"Qingyun Li","orcid":"https://orcid.org/0000-0003-0741-4444","observed_orcids":["https://orcid.org/0000-0003-0741-4444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingyun Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0741-4444","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132564620","display_name":"Feifei Li","orcid":"https://orcid.org/0009-0002-7482-1621","observed_orcids":["https://orcid.org/0009-0002-7482-1621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feifei Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-7482-1621","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109770582","display_name":"Xiafei Gu","orcid":"https://orcid.org/0009-0009-7819-4304","observed_orcids":["https://orcid.org/0009-0009-7819-4304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiafei Gu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7819-4304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102509406","display_name":"Zi-Jian Lu","orcid":"https://orcid.org/0000-0001-9660-9002","observed_orcids":["https://orcid.org/0000-0001-9660-9002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zijian Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9660-9002","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054986286","display_name":"Meng Qiu","orcid":"https://orcid.org/0000-0003-3722-6938","observed_orcids":["https://orcid.org/0000-0003-3722-6938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Qiu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3722-6938","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039171620","display_name":"Wenjian Meng","orcid":"https://orcid.org/0000-0002-4578-0560","observed_orcids":["https://orcid.org/0000-0002-4578-0560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjian Meng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4578-0560","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132604116","display_name":"Dan Jiang","orcid":"https://orcid.org/0000-0002-9187-7152","observed_orcids":["https://orcid.org/0000-0002-9187-7152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9187-7152","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059705124","display_name":"Ziqiang Wang","orcid":"https://orcid.org/0000-0002-2874-1535","observed_orcids":["https://orcid.org/0000-0002-2874-1535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ziqiang Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2874-1535","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9779999852180481},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/treatment-intensification","display_name":"treatment intensification","score":0.8970000147819519},{"id":"https://openalex.org/keywords/participant-representativeness","display_name":"study participant representativeness","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9072999954223633},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6531999707221985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6363999843597412},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6215999722480774},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5726000070571899},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.36970001459121704},{"id":"https://openalex.org/C2991871042","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Rectal carcinoma","level":4,"score":0.3675000071525574},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.31910788","doi":"https://doi.org/10.1158/1078-0432.31910788","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.31910788","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.31910788","doi":"https://doi.org/10.1158/1078-0432.31910788","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.31910788","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7124858222","https://openalex.org/W7147362647","https://openalex.org/W4415942773","https://openalex.org/W6989194176","https://openalex.org/W4403797688","https://openalex.org/W7223459559","https://openalex.org/W4391091034","https://openalex.org/W7042771764","https://openalex.org/W2619687134","https://openalex.org/W4417314895"],"abstract_inverted_index":{"Representativeness":[0],"of":[1],"Study":[2],"Participants":[3]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-04-02T00:00:00"}