{"id":"https://openalex.org/W7147351663","doi":"https://doi.org/10.3389/fimmu.2026.1737746","title":"Acupuncture in remodeling the tumor microenvironment: current status and challenges","display_name":"Acupuncture in remodeling the tumor microenvironment: current status and challenges","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7147351663","doi":"https://doi.org/10.3389/fimmu.2026.1737746","pmid":"https://pubmed.ncbi.nlm.nih.gov/41993170"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1737746","doi":"https://doi.org/10.3389/fimmu.2026.1737746","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1737746","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1737746/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1737746/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146866102","display_name":"Jinming Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]},{"id":"https://openalex.org/I4210130148","display_name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/02fsmcz03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinming Liu","raw_affiliation_strings":["First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","National Clinical Research Center for Chinese Medicine","School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210130148"]},{"raw_affiliation_string":"National Clinical Research Center for Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132684811","display_name":"Yanjun Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Jin","raw_affiliation_strings":["School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111531707","display_name":"Yan Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]},{"id":"https://openalex.org/I4210130148","display_name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/02fsmcz03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Ou","raw_affiliation_strings":["First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","National Clinical Research Center for Chinese Medicine","School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210130148"]},{"raw_affiliation_string":"National Clinical Research Center for Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132668877","display_name":"Linbo Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]},{"id":"https://openalex.org/I4210130148","display_name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/02fsmcz03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linbo Liu","raw_affiliation_strings":["First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","National Clinical Research Center for Chinese Medicine","School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210130148"]},{"raw_affiliation_string":"National Clinical Research Center for Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124987449","display_name":"Shanqi Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]},{"id":"https://openalex.org/I4210130148","display_name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/02fsmcz03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanqi Guo","raw_affiliation_strings":["First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","National Clinical Research Center for Chinese Medicine","School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210130148"]},{"raw_affiliation_string":"National Clinical Research Center for Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090891588","display_name":"BinXu Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]},{"id":"https://openalex.org/I4210130148","display_name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/02fsmcz03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130148"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Binxu Sun","raw_affiliation_strings":["First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","National Clinical Research Center for Chinese Medicine","School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210130148"]},{"raw_affiliation_string":"National Clinical Research Center for Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I12411659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090891588"],"corresponding_institution_ids":["https://openalex.org/I12411659","https://openalex.org/I4210130148"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21674458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1737746","last_page":"1737746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":1.0},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9900000095367432},{"id":"https://openalex.org/keywords/supportive-cancer-care","display_name":"cancer supportive care","score":0.8159999847412109},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-vasculature-normalization","display_name":"tumor vasculature normalization","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7459999918937683},{"id":"https://openalex.org/keywords/radiotherapy-toxicity","display_name":"radiotherapy toxicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5889999866485596},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.640999972820282},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immunotherapy-synergy","display_name":"immunotherapy synergy","score":0.671999990940094},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.821399986743927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7914000153541565},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5611000061035156},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.4648999869823456},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45840001106262207},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45320001244544983},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38589999079704285},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3677000105381012},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.35899999737739563},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31200000643730164},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.31189998984336853},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.26589998602867126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2632000148296356},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1737746","doi":"https://doi.org/10.3389/fimmu.2026.1737746","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1737746","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1737746/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:41993170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41993170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13079644","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41993170/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13079644/pdf/fimmu-17-1737746.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a73c59ad122346d6bfd185af17993ee1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a73c59ad122346d6bfd185af17993ee1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1737746","doi":"https://doi.org/10.3389/fimmu.2026.1737746","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1737746","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1737746/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322701","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7147351663.pdf","grobid_xml":"https://content.openalex.org/works/W7147351663.grobid-xml"},"referenced_works_count":122,"referenced_works":["https://openalex.org/W915932446","https://openalex.org/W1260747934","https://openalex.org/W1603230122","https://openalex.org/W1964237371","https://openalex.org/W1965619232","https://openalex.org/W1971712445","https://openalex.org/W1978139448","https://openalex.org/W1986288875","https://openalex.org/W2007553857","https://openalex.org/W2010883608","https://openalex.org/W2034269086","https://openalex.org/W2037603547","https://openalex.org/W2067541859","https://openalex.org/W2073767270","https://openalex.org/W2082320957","https://openalex.org/W2094673905","https://openalex.org/W2100346609","https://openalex.org/W2108067703","https://openalex.org/W2126598991","https://openalex.org/W2150462175","https://openalex.org/W2167973264","https://openalex.org/W2237013884","https://openalex.org/W2314057593","https://openalex.org/W2320426045","https://openalex.org/W2556868315","https://openalex.org/W2597613988","https://openalex.org/W2612892346","https://openalex.org/W2649656222","https://openalex.org/W2745476617","https://openalex.org/W2752198960","https://openalex.org/W2792716055","https://openalex.org/W2795035720","https://openalex.org/W2899113219","https://openalex.org/W2912586987","https://openalex.org/W2912648593","https://openalex.org/W2920863623","https://openalex.org/W2942344638","https://openalex.org/W2951297522","https://openalex.org/W2951894867","https://openalex.org/W2952473224","https://openalex.org/W2969837378","https://openalex.org/W2983881420","https://openalex.org/W2993304482","https://openalex.org/W3003405277","https://openalex.org/W3014537282","https://openalex.org/W3015569276","https://openalex.org/W3031224726","https://openalex.org/W3035430205","https://openalex.org/W3036131095","https://openalex.org/W3048905934","https://openalex.org/W3086659495","https://openalex.org/W3089835536","https://openalex.org/W3109885192","https://openalex.org/W3119081011","https://openalex.org/W3125093155","https://openalex.org/W3132702730","https://openalex.org/W3135078225","https://openalex.org/W3137165353","https://openalex.org/W3165255814","https://openalex.org/W3180950152","https://openalex.org/W3184643124","https://openalex.org/W3184722892","https://openalex.org/W3196381139","https://openalex.org/W4200122968","https://openalex.org/W4200275282","https://openalex.org/W4224692204","https://openalex.org/W4294912122","https://openalex.org/W4300118195","https://openalex.org/W4304889404","https://openalex.org/W4308954518","https://openalex.org/W4310060313","https://openalex.org/W4311858759","https://openalex.org/W4312223431","https://openalex.org/W4320723991","https://openalex.org/W4321018001","https://openalex.org/W4321366863","https://openalex.org/W4324046169","https://openalex.org/W4362582877","https://openalex.org/W4362672046","https://openalex.org/W4380714778","https://openalex.org/W4385616416","https://openalex.org/W4387667094","https://openalex.org/W4388621704","https://openalex.org/W4389617049","https://openalex.org/W4391930867","https://openalex.org/W4392018740","https://openalex.org/W4393251580","https://openalex.org/W4394965016","https://openalex.org/W4395469481","https://openalex.org/W4395469483","https://openalex.org/W4396907525","https://openalex.org/W4396939082","https://openalex.org/W4399028641","https://openalex.org/W4400157793","https://openalex.org/W4400356791","https://openalex.org/W4400781711","https://openalex.org/W4400800934","https://openalex.org/W4401280276","https://openalex.org/W4401667917","https://openalex.org/W4402005527","https://openalex.org/W4402094666","https://openalex.org/W4402299750","https://openalex.org/W4402657149","https://openalex.org/W4404135782","https://openalex.org/W4404839476","https://openalex.org/W4404958168","https://openalex.org/W4405335596","https://openalex.org/W4405350607","https://openalex.org/W4405804938","https://openalex.org/W4406134620","https://openalex.org/W4406385258","https://openalex.org/W4406431707","https://openalex.org/W4406622755","https://openalex.org/W4407490907","https://openalex.org/W4408231536","https://openalex.org/W4409101624","https://openalex.org/W4409733932","https://openalex.org/W4409797389","https://openalex.org/W4410386140","https://openalex.org/W4410607348","https://openalex.org/W4411349863","https://openalex.org/W4412201291"],"related_works":[],"abstract_inverted_index":{"The":[0],"tumor":[1,24,120,126],"microenvironment":[2],"(TME)":[3],"is":[4],"a":[5,20,62,154],"dynamic":[6],"ecosystem":[7],"in":[8,23,46,166,224],"which":[9],"malignant,":[10],"immune,":[11],"stromal,":[12],"and":[13,18,27,52,57,107,109,112,117,128,132,134,142,170,220],"vascular":[14],"compartments":[15],"continuously":[16],"interact,":[17],"plays":[19],"key":[21],"role":[22,163],"initiation,":[25],"development":[26],"treatment":[28],"resistance.":[29],"In":[30],"recent":[31],"years,":[32],"acupuncture,":[33],"as":[34,123,153],"an":[35,191],"ancient":[36],"neuromodulatory":[37],"intervention":[38],"means":[39],"of":[40,78,86,98,164,182,222],"traditional":[41],"medicine,":[42],"has":[43],"shown":[44],"promise":[45],"supportive":[47],"oncology":[48],"by":[49],"attenuating":[50],"chemotherapy-":[51],"radiotherapy-induced":[53],"toxicities,":[54],"modulating":[55],"immunity,":[56],"improving":[58],"quality-of-life":[59],"metrics.":[60],"Yet,":[61],"mechanistic":[63,205],"framework":[64],"that":[65,93,203],"links":[66],"acupuncture":[67,87,94,146,165,223],"to":[68,72,124,160,178,215],"TME":[69,186,206],"reprogramming":[70],"remains":[71],"be":[73],"established.":[74],"From":[75],"the":[76,82,158,162,218],"perspective":[77],"TME,":[79],"we":[80,156,176],"reviews":[81],"latest":[83],"research":[84],"status":[85],"anti-tumor":[88],"mechanism.":[89],"Evidence":[90],"synthesized":[91],"indicates":[92],"(i)":[95],"triggers":[96],"apoptosis":[97],"malignant":[99],"cells,":[100],"(ii)":[101],"re-educates":[102],"innate":[103],"(NK,":[104],"macrophage,":[105],"dendritic,":[106],"mast)":[108],"adaptive":[110],"(T":[111],"B":[113],"lymphocyte)":[114],"immune":[115],"subsets,":[116],"(iii)":[118],"normalizes":[119],"vasculature,":[121],"so":[122],"inhibit":[125],"growth":[127],"metastasis,":[129],"synergize":[130],"chemotherapy":[131],"immunotherapy,":[133],"promote":[135],"physical":[136],"rehabilitation.":[137],"We":[138],"further":[139],"outline":[140],"opportunities":[141],"challenges":[143],"for":[144],"translating":[145],"into":[147],"evidence-based":[148],"oncology.":[149],"Using":[150],"breast":[151],"cancer":[152,225],"paradigm,":[155],"emphasize":[157],"need":[159],"evaluate":[161],"different":[167],"molecular":[168],"subtypes":[169],"within":[171],"integrative":[172],"survivorship":[173],"care.":[174,226],"Furthermore,":[175],"aim":[177],"link":[179],"its":[180],"benefit":[181],"relieving":[183],"symptoms":[184],"with":[185,208],"modulation":[187],"mechanisms,":[188],"thereby":[189],"constructing":[190],"integrated":[192],"evidence":[193],"chain":[194],"connecting":[195],"\"clinical":[196],"symptoms-acupuncture":[197],"intervention-TME":[198],"modulation-long-term":[199],"prognosis.\".":[200],"Interdisciplinary":[201],"trials":[202],"couple":[204],"readouts":[207],"robust":[209],"clinical":[210],"endpoints":[211],"are":[212],"now":[213],"warranted":[214],"definitively":[216],"establish":[217],"efficacy":[219],"safety":[221]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-04-02T00:00:00"}