{"id":"https://openalex.org/W7147259477","doi":"https://doi.org/10.1158/0008-5472.31923355","title":"Supplemental Figure 8 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer","display_name":"Supplemental Figure 8 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer","publication_year":2026,"publication_date":"2026-04-02","ids":{"openalex":"https://openalex.org/W7147259477","doi":"https://doi.org/10.1158/0008-5472.31923355"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.31923355","doi":"https://doi.org/10.1158/0008-5472.31923355","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31923355","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.31923355","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088533475","display_name":"Sarah K. Herzog","orcid":"https://orcid.org/0000-0003-3782-7389","observed_orcids":["https://orcid.org/0000-0003-3782-7389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah K. Herzog","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3782-7389","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053532805","display_name":"Jessica H. Stevens","orcid":"https://orcid.org/0009-0005-9741-9928","observed_orcids":["https://orcid.org/0009-0005-9741-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica H. Stevens","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-9741-9928","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022101967","display_name":"Guowei gu","orcid":"https://orcid.org/0000-0001-8845-4055","observed_orcids":["https://orcid.org/0000-0001-8845-4055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guowei Gu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8845-4055","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055660362","display_name":"Sandra L. Grimm","orcid":"https://orcid.org/0000-0002-0682-3134","observed_orcids":["https://orcid.org/0000-0002-0682-3134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra L. Grimm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0682-3134","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120061357","display_name":"Kloma T Cardoza","orcid":"https://orcid.org/0009-0006-0488-7894","observed_orcids":["https://orcid.org/0009-0006-0488-7894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kloma Cardoza","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-0488-7894","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122007666","display_name":"Autumn G.M. Hawkins","orcid":"https://orcid.org/0009-0001-8189-3159","observed_orcids":["https://orcid.org/0009-0001-8189-3159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Autumn G.M. Hawkins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-8189-3159","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022989159","display_name":"Hangqing Lin","orcid":"https://orcid.org/0009-0009-7691-8364","observed_orcids":["https://orcid.org/0009-0009-7691-8364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hangqing Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7691-8364","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008477330","display_name":"Daniela Ramos","orcid":"https://orcid.org/0000-0002-8940-0232","observed_orcids":["https://orcid.org/0000-0002-8940-0232","https://orcid.org/0000-0002-3848-6478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Ramos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3848-6478","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027523922","display_name":"Amanda R. Beyer","orcid":"https://orcid.org/0009-0009-9244-1439","observed_orcids":["https://orcid.org/0009-0009-9244-1439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda R. Beyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-9244-1439","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132660789","display_name":"David G. Edwards","orcid":"https://orcid.org/0000-0001-8002-0607","observed_orcids":["https://orcid.org/0000-0001-8002-0607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Edwards","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8002-0607","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074873339","display_name":"Derek J. Dustin","orcid":"https://orcid.org/0000-0002-3566-0282","observed_orcids":["https://orcid.org/0000-0002-3566-0282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek Dustin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3566-0282","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121999354","display_name":"Harry J. Yang","orcid":"https://orcid.org/0009-0008-8758-5705","observed_orcids":["https://orcid.org/0009-0008-8758-5705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry J. Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-8758-5705","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132625812","display_name":"Nicole Liang","orcid":"https://orcid.org/0009-0009-7459-8360","observed_orcids":["https://orcid.org/0009-0009-7459-8360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Liang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7459-8360","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001922429","display_name":"Ashfia Fatima Khan","orcid":"https://orcid.org/0000-0002-1730-5383","observed_orcids":["https://orcid.org/0000-0002-1730-5383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashfia F. Khan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1730-5383","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132732093","display_name":"Tasneem Bawa-Khalfe","orcid":"https://orcid.org/0000-0002-5376-4392","observed_orcids":["https://orcid.org/0000-0002-5376-4392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tasneem Bawa-Khalfe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5376-4392","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060285832","display_name":"Daniel James McGrail","orcid":"https://orcid.org/0000-0002-6669-6069","observed_orcids":["https://orcid.org/0000-0002-6669-6069","https://orcid.org/0000-0002-3729-2487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. McGrail","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6669-6069","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044419431","display_name":"Shiaw\u2010Yih Lin","orcid":"https://orcid.org/0000-0002-3838-0358","observed_orcids":["https://orcid.org/0000-0002-3838-0358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiaw-Yih Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3838-0358","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052755605","display_name":"Cristian Coarfa","orcid":"https://orcid.org/0000-0002-4183-4939","observed_orcids":["https://orcid.org/0000-0002-4183-4939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristian Coarfa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4183-4939","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054255756","display_name":"Suzanne A.W. Fuqua","orcid":"https://orcid.org/0000-0001-8886-5161","observed_orcids":["https://orcid.org/0000-0001-8886-5161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne A.W. Fuqua","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8886-5161","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.8769999742507935},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8659999966621399},{"id":"https://openalex.org/keywords/chk1-inhibitor","display_name":"CHK1 inhibitor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.7450000047683716},{"id":"https://openalex.org/keywords/estrogen-deprivation","display_name":"estrogen deprivation","score":0.42899999022483826},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cell-cycle-synchronization","display_name":"cell cycle synchronization","score":0.6359999775886536},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.7074000239372253},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5404999852180481},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5378000140190125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.519599974155426},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4961000084877014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4609000086784363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763999938964844},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3416000008583069},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32679998874664307},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.322299987077713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3151000142097473},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C2780940807","wikidata":"https://www.wikidata.org/wiki/Q417740","display_name":"Lovastatin","level":3,"score":0.3082999885082245},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.30300000309944153},{"id":"https://openalex.org/C526406351","wikidata":"https://www.wikidata.org/wiki/Q177463","display_name":"Charcoal","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2987000048160553},{"id":"https://openalex.org/C3018561737","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver damage","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26750001311302185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.31923355","doi":"https://doi.org/10.1158/0008-5472.31923355","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31923355","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.31923355","doi":"https://doi.org/10.1158/0008-5472.31923355","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31923355","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7147056485","https://openalex.org/W7118669765","https://openalex.org/W4394245802","https://openalex.org/W4394372841","https://openalex.org/W4394107135","https://openalex.org/W4394490564","https://openalex.org/W2739626600","https://openalex.org/W2485356081","https://openalex.org/W2570951758","https://openalex.org/W2797814625"],"abstract_inverted_index":{"BrdU":[0,25],"uptake":[1,26],"is":[2],"attenuated":[3],"in":[4,14,27,95,107,117],"Y537C":[5,28],"cells":[6,29,45,52,67],"using":[7,57],"Chk1i":[8,80],"as":[9,101],"a":[10],"single":[11],"agent":[12],"or":[13,83],"combination":[15,96],"with":[16,97],"Olap":[17],"under":[18],"replication":[19],"stress":[20],"induced":[21],"by":[22,31,88,122],"HU":[23,94],"Percent":[24],"analyzed":[30],"flow":[32],"cytometry.":[33],"Bars":[34],"represent":[35],"the":[36],"average":[37],"+":[38],"standard":[39],"deviation":[40],"of":[41,43,79,91,114,125],"percentage":[42],"BrdU+":[44],"relative":[46],"to":[47,64,68,129],"total":[48],"propidium":[49],"iodide":[50],"positive":[51],"(n=2).":[53],"Significance":[54],"was":[55],"calculated":[56],"two-way":[58],"ANOVA":[59],"corrected":[60],"for":[61,76],"multiple":[62],"comparisons":[63],"compare":[65],"treated":[66,75],"Ctrl":[69],"conditions,":[70],"*p<0.05,":[71],"****p<0.0001.":[72],"Cells":[73],"were":[74,105],"24":[77,89],"hours":[78,90,113,124],"(500":[81],"nM)":[82],"Chk1i+Olap":[84],"(5":[85],"\u00b5M)":[86,128],"followed":[87,121],"0.5":[92],"mM":[93],"indicated":[98],"drug":[99],"treatments":[100,104],"applicable.":[102],"All":[103],"performed":[106],"charcoal":[108,118],"stripped":[109,119],"media":[110,120],"after":[111],"48":[112],"estrogen":[115],"deprivation":[116],"36":[123],"Lovastatin":[126],"(10":[127],"synchronize":[130],"cell":[131],"cycles":[132],"before":[133],"inhibitor":[134],"treatment.":[135]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-04-02T00:00:00"}
