{"id":"https://openalex.org/W7147218820","doi":"https://doi.org/10.1158/0008-5472.31923406","title":"Supplemental Figure 12 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer","display_name":"Supplemental Figure 12 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer","publication_year":2026,"publication_date":"2026-04-02","ids":{"openalex":"https://openalex.org/W7147218820","doi":"https://doi.org/10.1158/0008-5472.31923406"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.31923406","doi":"https://doi.org/10.1158/0008-5472.31923406","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31923406","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.31923406","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088533475","display_name":"Sarah K. Herzog","orcid":"https://orcid.org/0000-0003-3782-7389","observed_orcids":["https://orcid.org/0000-0003-3782-7389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah K. Herzog","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3782-7389","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053532805","display_name":"Jessica H. Stevens","orcid":"https://orcid.org/0009-0005-9741-9928","observed_orcids":["https://orcid.org/0009-0005-9741-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica H. Stevens","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-9741-9928","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022101967","display_name":"Guowei gu","orcid":"https://orcid.org/0000-0001-8845-4055","observed_orcids":["https://orcid.org/0000-0001-8845-4055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guowei Gu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8845-4055","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055660362","display_name":"Sandra L. Grimm","orcid":"https://orcid.org/0000-0002-0682-3134","observed_orcids":["https://orcid.org/0000-0002-0682-3134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra L. Grimm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0682-3134","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120061357","display_name":"Kloma T Cardoza","orcid":"https://orcid.org/0009-0006-0488-7894","observed_orcids":["https://orcid.org/0009-0006-0488-7894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kloma Cardoza","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-0488-7894","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122007666","display_name":"Autumn G.M. Hawkins","orcid":"https://orcid.org/0009-0001-8189-3159","observed_orcids":["https://orcid.org/0009-0001-8189-3159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Autumn G.M. Hawkins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-8189-3159","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022989159","display_name":"Hangqing Lin","orcid":"https://orcid.org/0009-0009-7691-8364","observed_orcids":["https://orcid.org/0009-0009-7691-8364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hangqing Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7691-8364","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008477330","display_name":"Daniela Ramos","orcid":"https://orcid.org/0000-0002-8940-0232","observed_orcids":["https://orcid.org/0000-0002-8940-0232","https://orcid.org/0000-0002-3848-6478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Ramos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3848-6478","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027523922","display_name":"Amanda R. Beyer","orcid":"https://orcid.org/0009-0009-9244-1439","observed_orcids":["https://orcid.org/0009-0009-9244-1439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda R. Beyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-9244-1439","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132660789","display_name":"David G. Edwards","orcid":"https://orcid.org/0000-0001-8002-0607","observed_orcids":["https://orcid.org/0000-0001-8002-0607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Edwards","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8002-0607","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074873339","display_name":"Derek J. Dustin","orcid":"https://orcid.org/0000-0002-3566-0282","observed_orcids":["https://orcid.org/0000-0002-3566-0282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek Dustin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3566-0282","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121999354","display_name":"Harry J. Yang","orcid":"https://orcid.org/0009-0008-8758-5705","observed_orcids":["https://orcid.org/0009-0008-8758-5705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry J. Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-8758-5705","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132625812","display_name":"Nicole Liang","orcid":"https://orcid.org/0009-0009-7459-8360","observed_orcids":["https://orcid.org/0009-0009-7459-8360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Liang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7459-8360","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001922429","display_name":"Ashfia Fatima Khan","orcid":"https://orcid.org/0000-0002-1730-5383","observed_orcids":["https://orcid.org/0000-0002-1730-5383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashfia F. Khan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1730-5383","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132732093","display_name":"Tasneem Bawa-Khalfe","orcid":"https://orcid.org/0000-0002-5376-4392","observed_orcids":["https://orcid.org/0000-0002-5376-4392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tasneem Bawa-Khalfe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5376-4392","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060285832","display_name":"Daniel James McGrail","orcid":"https://orcid.org/0000-0002-6669-6069","observed_orcids":["https://orcid.org/0000-0002-6669-6069","https://orcid.org/0000-0002-3729-2487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. McGrail","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6669-6069","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044419431","display_name":"Shiaw\u2010Yih Lin","orcid":"https://orcid.org/0000-0002-3838-0358","observed_orcids":["https://orcid.org/0000-0002-3838-0358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiaw-Yih Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3838-0358","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052755605","display_name":"Cristian Coarfa","orcid":"https://orcid.org/0000-0002-4183-4939","observed_orcids":["https://orcid.org/0000-0002-4183-4939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristian Coarfa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4183-4939","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054255756","display_name":"Suzanne A.W. Fuqua","orcid":"https://orcid.org/0000-0001-8886-5161","observed_orcids":["https://orcid.org/0000-0001-8886-5161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne A.W. Fuqua","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8886-5161","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9160000085830688},{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.8339999914169312},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9070000052452087},{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/estrogen-deprivation","display_name":"estrogen deprivation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5687000155448914},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.536300003528595},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5321999788284302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5313000082969666},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5234000086784363},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4961000084877014},{"id":"https://openalex.org/C136496925","wikidata":"https://www.wikidata.org/wiki/Q1189807","display_name":"Densitometry","level":2,"score":0.4731999933719635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41999998688697815},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4169999957084656},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.4041000008583069},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.3977000117301941},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3935000002384186},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.385699987411499},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3824999928474426},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36410000920295715},{"id":"https://openalex.org/C130840561","wikidata":"https://www.wikidata.org/wiki/Q2344000","display_name":"Dot blot","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.3292999863624573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2727999985218048},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.27129998803138733},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2777983448","wikidata":"https://www.wikidata.org/wiki/Q2745322","display_name":"STK11","level":5,"score":0.2590000033378601}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.31923406","doi":"https://doi.org/10.1158/0008-5472.31923406","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31923406","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.31923406","doi":"https://doi.org/10.1158/0008-5472.31923406","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31923406","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7147056485","https://openalex.org/W7118669765","https://openalex.org/W4384126490","https://openalex.org/W4385285406","https://openalex.org/W4396587106","https://openalex.org/W1807275187","https://openalex.org/W4410803718","https://openalex.org/W1786554070","https://openalex.org/W4389948617","https://openalex.org/W3181764517"],"abstract_inverted_index":{"Lower":[0],"concentrations":[1],"of":[2,22,30],"Olaparib":[3],"treatment":[4,47],"inhibit":[5],"PARylation":[6],"but":[7],"do":[8],"not":[9],"show":[10],"effect":[11],"on":[12],"estrogen":[13,31],"regulated":[14],"proteins":[15],"in":[16,33,52,67],"ESR1m":[17],"models":[18],"Western":[19],"blot":[20],"analysis":[21],"WT":[23,85],"or":[24],"Y537S":[25],"cells":[26],"after":[27],"48":[28],"hours":[29],"deprivation":[32],"charcoal":[34],"stripped":[35],"serum":[36],"media":[37],"followed":[38],"by":[39],"Olap":[40],"(300":[41],"nM,":[42],"1":[43,84],"\u00b5M,":[44],"2":[45],"\u00b5M)":[46],"harvested":[48],"at":[49],"indicated":[50,75],"timepoints":[51],"hours.":[53],"Densitometry":[54,73],"is":[55,74],"relative":[56],"to":[57,65,82],"untreated":[58],"controls":[59],"within":[60],"each":[61,77],"cell":[62,71],"line":[63],"due":[64],"differences":[66],"protein":[68],"expression":[69],"between":[70],"lines.":[72],"under":[76],"band":[78],"and":[79],"was":[80],"normalized":[81],"lane":[83],"control.":[86]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-04-02T00:00:00"}
