{"id":"https://openalex.org/W7147040366","doi":"https://doi.org/10.1080/00397911.2026.2642776","title":"Design and synthesis of benzofuran\u2013pyrazole\u2013triazole hybrids via click chemistry: Antimicrobial, anticancer, ADMET, docking, and DFT studies","display_name":"Design and synthesis of benzofuran\u2013pyrazole\u2013triazole hybrids via click chemistry: Antimicrobial, anticancer, ADMET, docking, and DFT studies","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7147040366","doi":"https://doi.org/10.1080/00397911.2026.2642776"},"language":"en","primary_location":{"id":"doi:10.1080/00397911.2026.2642776","doi":"https://doi.org/10.1080/00397911.2026.2642776","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00397911.2026.2642776","pdf_url":null,"source":{"id":"https://openalex.org/S114976158","display_name":"Synthetic Communications","issn_l":"0039-7911","issn":["0039-7911","1532-2432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117127253","display_name":"Ila M. Ram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263164","display_name":"Shri Govind Guru University","ror":"https://ror.org/03f6bd050","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263164"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ila M. Ram","raw_affiliation_strings":["Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra","institution_ids":["https://openalex.org/I4405263164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117127251","display_name":"Jay B. Maheta","orcid":"https://orcid.org/0009-0003-9332-1056","observed_orcids":["https://orcid.org/0009-0003-9332-1056"]},"institutions":[{"id":"https://openalex.org/I4405263164","display_name":"Shri Govind Guru University","ror":"https://ror.org/03f6bd050","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263164"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jay B. Maheta","raw_affiliation_strings":["Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra","institution_ids":["https://openalex.org/I4405263164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117127252","display_name":"Darshna K. Lakhnotra","orcid":"https://orcid.org/0009-0005-0953-2585","observed_orcids":["https://orcid.org/0009-0005-0953-2585"]},"institutions":[{"id":"https://openalex.org/I4405263164","display_name":"Shri Govind Guru University","ror":"https://ror.org/03f6bd050","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263164"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Darshna K. Lakhnotra","raw_affiliation_strings":["Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra","institution_ids":["https://openalex.org/I4405263164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062175350","display_name":"N. Shaikh","orcid":"https://orcid.org/0009-0008-8098-1756","observed_orcids":["https://orcid.org/0009-0008-8098-1756"]},"institutions":[{"id":"https://openalex.org/I4405263164","display_name":"Shri Govind Guru University","ror":"https://ror.org/03f6bd050","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263164"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nargis H. Shaikh","raw_affiliation_strings":["Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra","institution_ids":["https://openalex.org/I4405263164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132627381","display_name":"Viral U. Majethiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3132999081","display_name":"Marwadi University","ror":"https://ror.org/030dn1812","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132999081"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Viral U. Majethiya","raw_affiliation_strings":["Department of Chemistry, Marwadi University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Marwadi University","institution_ids":["https://openalex.org/I3132999081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040358746","display_name":"Yogesh O. Bhola","orcid":"https://orcid.org/0000-0002-8882-5714","observed_orcids":["https://orcid.org/0000-0002-8882-5714"]},"institutions":[{"id":"https://openalex.org/I4405263164","display_name":"Shri Govind Guru University","ror":"https://ror.org/03f6bd050","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263164"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Yogesh O. Bhola","raw_affiliation_strings":["Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Shri M.P. Pandya Science College, Shri Govind Guru University-Godhra","institution_ids":["https://openalex.org/I4405263164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040358746"],"corresponding_institution_ids":["https://openalex.org/I4405263164"],"apc_list":null,"apc_paid":null,"fwci":14.971,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.99275581,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"56","issue":"7","first_page":"537","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.9520000219345093},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.859000027179718},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.703000009059906},{"id":"https://openalex.org/keywords/admet-properties","display_name":"ADMET properties","score":0.5659999847412109},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.753000020980835},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/combretastatin-a-4","display_name":"combretastatin A-4","score":0.6299999952316284},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8971999883651733},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4957999885082245},{"id":"https://openalex.org/C152365726","wikidata":"https://www.wikidata.org/wiki/Q1048589","display_name":"Density functional theory","level":2,"score":0.3995000123977661},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3736000061035156},{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.29420000314712524},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2818000018596649},{"id":"https://openalex.org/C48189365","wikidata":"https://www.wikidata.org/wiki/Q42621","display_name":"Hybrid","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.27129998803138733},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.2612000107765198}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/00397911.2026.2642776","doi":"https://doi.org/10.1080/00397911.2026.2642776","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00397911.2026.2642776","pdf_url":null,"source":{"id":"https://openalex.org/S114976158","display_name":"Synthetic Communications","issn_l":"0039-7911","issn":["0039-7911","1532-2432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic Communications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1831405443","https://openalex.org/W1968630431","https://openalex.org/W1981141858","https://openalex.org/W1985501047","https://openalex.org/W1985588649","https://openalex.org/W2004998386","https://openalex.org/W2009423060","https://openalex.org/W2015185525","https://openalex.org/W2105668062","https://openalex.org/W2135732933","https://openalex.org/W2157574023","https://openalex.org/W2164460325","https://openalex.org/W2341769195","https://openalex.org/W2552289982","https://openalex.org/W2793210811","https://openalex.org/W2912818999","https://openalex.org/W2949820275","https://openalex.org/W3006944237","https://openalex.org/W3148203858","https://openalex.org/W4206677002","https://openalex.org/W4206841660","https://openalex.org/W4295779282","https://openalex.org/W4309530195","https://openalex.org/W4386607677","https://openalex.org/W4414342362","https://openalex.org/W7083182735","https://openalex.org/W7092295482","https://openalex.org/W7106258699","https://openalex.org/W7119736079"],"related_works":["https://openalex.org/W4409478907","https://openalex.org/W4391788122","https://openalex.org/W7119736079","https://openalex.org/W4414712208","https://openalex.org/W4200203564","https://openalex.org/W7222915827","https://openalex.org/W6888846257","https://openalex.org/W4285796169","https://openalex.org/W4361857589","https://openalex.org/W4408042352"],"abstract_inverted_index":{"Ten":[0],"novel":[1],"benzofuran\u2013pyrazole\u2013triazole":[2,177],"hybrid":[3],"compounds":[4,37,67,135],"(10a\u2013j)":[5],"were":[6],"synthesized":[7],"via":[8],"multistep":[9],"methodology":[10],"and":[11,18,31,39,50,69,100,137,164,187],"characterized":[12],"by":[13],"1H":[14],"NMR,13":[15],"CMR,":[16],"IR,":[17],"mass":[19],"spectrometry.":[20],"Molecular":[21],"docking":[22],"studies":[23],"against":[24,97],"epidermal":[25],"growth":[26],"factor":[27],"receptor":[28],"(EGFR)":[29],"(1M17)":[30],"the":[32,64,88,183],"fibrinogen-binding":[33,65],"domain":[34],"(4NYT)":[35],"revealed":[36,120],"10i":[38,136],"10j":[40,105,138],"as":[41,87],"promising":[42,180],"EGFR":[43],"inhibitors,":[44],"with":[45,91,172],"binding":[46,73],"scores":[47],"of":[48,59,94,144,185],"\u22126.22":[49],"\u22126.21":[51],"kcal/mol,":[52],"respectively,":[53],"which":[54],"are":[55],"superior":[56,153],"to":[57,78,142],"that":[58,121,143],"combretastatin-A4":[60],"(\u22126.15":[61],"kcal/mol).":[62,81],"Against":[63],"domain,":[66],"10d":[68],"10h":[70,123,158],"showed":[71,139],"excellent":[72],"(\u22128.65":[74],"kcal/mol":[75],"each)":[76],"compared":[77],"ciprofloxacin":[79],"(\u22127.49":[80],"Anticancer":[82],"evaluation":[83],"demonstrated":[84],"compound":[85,122,157],"10c":[86],"most":[89],"potent":[90],"IC50":[92],"values":[93],"2.18\u20132.50":[95],"\u00b5M":[96],"HT-29,":[98],"MCF-7,":[99],"A549":[101],"cell":[102,116],"lines.":[103,117],"Compound":[104],"also":[106],"exhibited":[107,124],"significant":[108],"activity":[109,126],"(IC50:":[110],"2.61\u20133.82":[111],"\u00b5M)":[112],"across":[113],"multiple":[114],"cancer":[115],"Antimicrobial":[118],"screening":[119],"broad-spectrum":[125],"(minimum":[127],"inhibitory":[128],"concentration":[129],"[MIC]:":[130],"0.0157\u20130.0628":[131],"mg":[132],"ml\u22121),":[133],"while":[134],"efficacy":[140],"comparable":[141],"ciprofloxacin.":[145],"Density":[146],"functional":[147],"theory":[148],"(DFT)":[149],"calculations":[150],"(B3LYP/6\u2013311++G(d,p))":[151],"indicated":[152],"thermodynamic":[154],"stability":[155],"for":[156,182],"over":[159],"10j,":[160],"absorption,":[161],"distribution,":[162],"metabolism,":[163],"excretion":[165],"(ADMET)":[166],"analysis":[167],"confirmed":[168],"acceptable":[169],"drug-like":[170],"properties":[171],"minimal":[173],"Lipinski":[174],"violations.":[175],"These":[176],"hybrids":[178],"represent":[179],"scaffolds":[181],"development":[184],"anticancer":[186],"antimicrobial":[188],"drugs.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-04-02T00:00:00"}