{"id":"https://openalex.org/W7147007748","doi":"https://doi.org/10.66308/air.e2026029","title":"Brain-centred transcriptomic convergence in autism spectrum disorder: synaptic, immune-glial and mitochondrial-transcriptional axes.","display_name":"Brain-centred transcriptomic convergence in autism spectrum disorder: synaptic, immune-glial and mitochondrial-transcriptional axes.","publication_year":2026,"publication_date":"2026-02-05","ids":{"openalex":"https://openalex.org/W7147007748","doi":"https://doi.org/10.66308/air.e2026029"},"language":"en","primary_location":{"id":"doi:10.66308/air.e2026029","doi":"https://doi.org/10.66308/air.e2026029","is_oa":true,"landing_page_url":"https://doi.org/10.66308/air.e2026029","pdf_url":"https://americanimpactreview.com/articles/e2026029.pdf","source":{"id":"https://openalex.org/S7407059477","display_name":"American Impact Review","issn_l":"3071-124X","issn":["3071-124X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Impact Review","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://americanimpactreview.com/articles/e2026029.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122400147","display_name":"Ruslan Kurmashev","orcid":"https://orcid.org/0009-0006-7588-5319","observed_orcids":["https://orcid.org/0009-0006-7588-5319"]},"institutions":[{"id":"https://openalex.org/I4210100923","display_name":"Munster Technological University","ror":"https://ror.org/013xpqh61","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210100923"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Ruslan Kurmashev","raw_affiliation_strings":["Munster Technological University, Cork, Ireland"],"raw_orcid":"https://orcid.org/0009-0006-7588-5319","affiliations":[{"raw_affiliation_string":"Munster Technological University, Cork, Ireland","institution_ids":["https://openalex.org/I4210100923"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5122400147"],"corresponding_institution_ids":["https://openalex.org/I4210100923"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21262537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"e2026029","last_page":"e2026029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-regulation","display_name":"mitochondrial regulation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/single-nucleus-transcriptomics","display_name":"single-nucleus transcriptomics","score":0.8999999761581421},{"id":"https://openalex.org/keywords/peripheral-blood-transcriptomics","display_name":"peripheral blood transcriptomics","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cohort-heterogeneity","display_name":"cohort heterogeneity","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7224000096321106},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.6409000158309937},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5838000178337097},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.555400013923645},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.5493000149726868},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5401999950408936},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4659000039100647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44999998807907104},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44429999589920044},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37689998745918274},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3231000006198883},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.3165999948978424},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3107999861240387},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.30160000920295715},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.28029999136924744},{"id":"https://openalex.org/C58758708","wikidata":"https://www.wikidata.org/wiki/Q7240233","display_name":"Premature convergence","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.66308/air.e2026029","doi":"https://doi.org/10.66308/air.e2026029","is_oa":true,"landing_page_url":"https://doi.org/10.66308/air.e2026029","pdf_url":"https://americanimpactreview.com/articles/e2026029.pdf","source":{"id":"https://openalex.org/S7407059477","display_name":"American Impact Review","issn_l":"3071-124X","issn":["3071-124X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Impact Review","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.66308/air.e2026029","doi":"https://doi.org/10.66308/air.e2026029","is_oa":true,"landing_page_url":"https://doi.org/10.66308/air.e2026029","pdf_url":"https://americanimpactreview.com/articles/e2026029.pdf","source":{"id":"https://openalex.org/S7407059477","display_name":"American Impact Review","issn_l":"3071-124X","issn":["3071-124X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Impact Review","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320331797","display_name":"Munster Technological University","ror":"https://ror.org/013xpqh61"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7147007748.pdf","grobid_xml":"https://content.openalex.org/works/W7147007748.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7167849798","https://openalex.org/W7163757235","https://openalex.org/W7168198879","https://openalex.org/W2116117183","https://openalex.org/W2898876238","https://openalex.org/W2300751727","https://openalex.org/W4411217410","https://openalex.org/W2968722259","https://openalex.org/W4307931650","https://openalex.org/W2464296138"],"abstract_inverted_index":{"Autism":[0],"spectrum":[1],"disorder":[2],"(ASD)":[3],"is":[4,57,147],"a":[5,59,138],"heterogeneous":[6],"neurodevelopmental":[7],"condition":[8],"in":[9,144],"which":[10],"transcriptomic":[11,29,111,142],"findings":[12],"vary":[13],"across":[14],"cohorts,":[15],"brain":[16],"regions,":[17],"developmental":[18],"stages,":[19],"and":[20,38,72,77,89,98,106,123,157],"analytical":[21],"platforms.":[22],"This":[23],"narrative":[24],"review":[25],"synthesises":[26],"human":[27],"ASD":[28,145],"evidence":[30,136],"with":[31],"primary":[32],"emphasis":[33],"on":[34],"post-mortem":[35],"cerebral":[36],"cortex":[37],"examines":[39],"whether":[40],"recurrent":[41],"biological":[42],"programs":[43],"emerge":[44],"despite":[45],"substantial":[46],"heterogeneity":[47],"between":[48],"studies.":[49],"Across":[50],"cortical":[51],"datasets,":[52],"the":[53,68],"most":[54],"reproducible":[55],"pattern":[56],"not":[58],"single":[60],"universal":[61],"molecular":[62],"signature":[63],"but":[64,150],"partial":[65],"convergence":[66,143],"at":[67,95],"level":[69],"of":[70,141],"synaptic":[71],"neuronal":[73],"programs,":[74],"immune-glial":[75],"activation,":[76],"mitochondrial-transcriptional":[78],"regulation.":[79],"Bulk":[80],"RNA-seq":[81],"has":[82],"defined":[83],"broad":[84],"tissue-level":[85],"shifts,":[86],"whereas":[87],"single-cell":[88],"single-nucleus":[90],"approaches":[91],"refine":[92],"these":[93],"signals":[94],"cell-type":[96],"resolution":[97],"long-read":[99],"transcriptomics":[100],"extends":[101],"interpretation":[102],"to":[103],"isoform":[104],"structure":[105],"splicing":[107],"complexity.":[108],"Peripheral":[109],"blood":[110],"studies":[112],"are":[113],"discussed":[114],"only":[115],"as":[116],"secondary":[117],"contextual":[118],"observations":[119],"because":[120],"immune-cell":[121],"composition":[122],"clinical-state":[124],"effects":[125],"limit":[126],"direct":[127],"inference":[128],"about":[129],"central":[130],"nervous":[131],"system":[132],"mechanisms.":[133],"Overall,":[134],"current":[135],"supports":[137],"brain-centred":[139],"model":[140],"that":[146],"mechanistically":[148],"informative":[149],"constrained":[151],"by":[152],"regional":[153],"specificity,":[154],"cohort":[155],"heterogeneity,":[156],"methodological":[158],"variation.":[159]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2026-04-02T00:00:00"}