{"id":"https://openalex.org/W7146780736","doi":null,"title":"\u9244\u30ad\u30ec\u30fc\u30c8\u5264\u30c7\u30d5\u30a7\u30e9\u30b7\u30ed\u30af\u30b9\u306f\u809d\u304c\u3093\u7d30\u80de\u682a\u306b\u304a\u3051\u308bNF-\u03baB\u306e\u6d3b\u52d5\u6027\u3092\u963b\u5bb3\u3057\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u304c\u8a98\u5c0e\u3059\u308b\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u5909\u5316\u3055\u305b\u308b","display_name":"\u9244\u30ad\u30ec\u30fc\u30c8\u5264\u30c7\u30d5\u30a7\u30e9\u30b7\u30ed\u30af\u30b9\u306f\u809d\u304c\u3093\u7d30\u80de\u682a\u306b\u304a\u3051\u308bNF-\u03baB\u306e\u6d3b\u52d5\u6027\u3092\u963b\u5bb3\u3057\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u304c\u8a98\u5c0e\u3059\u308b\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u5909\u5316\u3055\u305b\u308b","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7146780736"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01341:0006998331","doi":null,"is_oa":true,"landing_page_url":"https://iuhw.repo.nii.ac.jp/records/2000334","pdf_url":"https://iuhw.repo.nii.ac.jp/record/2000334/files/32206AM27.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iuhw.repo.nii.ac.jp/record/2000334/files/32206AM27.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003766669","display_name":"Wataru Jomen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jomen, Wataru","raw_affiliation_strings":["Department of Clinical Medical Sciences , International University of Health and Welfare Graduate School of Medicine , Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medical Sciences , International University of Health and Welfare Graduate School of Medicine , Tokyo , Japan","institution_ids":["https://openalex.org/I79072001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003766669"],"corresponding_institution_ids":["https://openalex.org/I79072001"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":1.0},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8309999704360962},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.625},{"id":"https://openalex.org/keywords/iron-chelators","display_name":"iron chelators","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ferrostatin-1","display_name":"ferrostatin-1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/necrosulfonamide","display_name":"necrosulfonamide","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.19869999587535858},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.19499999284744263},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1906999945640564},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.1860000044107437},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.18389999866485596},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.16850000619888306},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.16580000519752502},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.16410000622272491},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.16120000183582306},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.15870000422000885}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01341:0006998331","doi":null,"is_oa":true,"landing_page_url":"https://iuhw.repo.nii.ac.jp/records/2000334","pdf_url":"https://iuhw.repo.nii.ac.jp/record/2000334/files/32206AM27.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01341:0006998331","doi":null,"is_oa":true,"landing_page_url":"https://iuhw.repo.nii.ac.jp/records/2000334","pdf_url":"https://iuhw.repo.nii.ac.jp/record/2000334/files/32206AM27.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7146780736.pdf","grobid_xml":"https://content.openalex.org/works/W7146780736.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1513392008","https://openalex.org/W1986766149","https://openalex.org/W1997183854","https://openalex.org/W2004758859","https://openalex.org/W2032531389","https://openalex.org/W2036759829","https://openalex.org/W2043470852","https://openalex.org/W2061900539","https://openalex.org/W2108666727","https://openalex.org/W2114771939","https://openalex.org/W2152065071","https://openalex.org/W2157206660","https://openalex.org/W2159125753","https://openalex.org/W2163038863","https://openalex.org/W2163294546","https://openalex.org/W2295373901","https://openalex.org/W2335737735","https://openalex.org/W2341898654","https://openalex.org/W2344007450","https://openalex.org/W2418456889","https://openalex.org/W2425600461","https://openalex.org/W2554042720","https://openalex.org/W2595800590","https://openalex.org/W2766925293","https://openalex.org/W2906319220","https://openalex.org/W3025987469","https://openalex.org/W3070262287"],"related_works":["https://openalex.org/W4285011238","https://openalex.org/W2332085805","https://openalex.org/W1513392008","https://openalex.org/W2335737735","https://openalex.org/W2302000558","https://openalex.org/W4295222520","https://openalex.org/W4376226360","https://openalex.org/W4220888600","https://openalex.org/W2545478696","https://openalex.org/W2972707862"],"abstract_inverted_index":{"Objective:":[0],"The":[1,46],"improvements":[2],"of":[3,23,27,48,93,145,203,226,234,251],"antitumor":[4,244],"effects":[5,182,245],"and":[6,33,44,54,61,160,168,177,192,196,212,218,221,239,255],"tolerability":[7],"on":[8,124,155,164],"chemotherapy":[9],"for":[10,70,75,246],"advanced":[11],"hepatocellular":[12],"carcinoma":[13],"(HCC)":[14],"are":[15],"warranted.Here,":[16],"we":[17],"aimed":[18],"to":[19,137],"elucidate":[20],"the":[21,24,112,180,201,232,249],"mechanism":[22,250],"combining":[25],"effect":[26,233],"tyrosine":[28],"kinase":[29],"inhibitor":[30,83,86,89],"sorafenib":[31,167],"(SOR)":[32],"iron":[34],"chelator":[35],"deferasirox":[36,169],"(DFX)":[37],"in":[38,108,205,231],"human":[39],"hepatoma":[40],"cell":[41,50,253],"lines,":[42],"HepG2":[43],"Huh-7.Methods:":[45],"types":[47],"programmed":[49],"deaths":[51,254],"(PCDs);":[52],"necrosis/necroptosis":[53],"apoptosis,":[55],"were":[56,162,183],"evaluated":[57],"by":[58,68,80,97,134,141,186,190,210],"flow":[59],"cytometry":[60],"fluorescent":[62],"microscopy.Human":[63],"cleaved":[64,103],"caspase-3":[65,104],"was":[66,73,78,95,106,122,139,149,207,216],"analyzed":[67,79],"ELISA":[69],"apoptosis.GSH":[71],"assay":[72],"used":[74],"ferroptosis.PCDs":[76],"inhibition":[77],"adding":[81],"apoptosis":[82,148,220],"Z-VAD-FMK,":[84],"ferroptosis":[85,161,215],"ferrostatin-1,":[87,187],"necroptosis":[88,159,222],"necrosulfonamide,":[90],"respectively.The":[91],"expression":[92,105,202],"NF-\u03baB":[94,204,227],"quantified":[96],"Western":[98],"blotting.Results:":[99],"In":[100],"SOR":[101,115,118,128,146,176,197,211,238],"monotherapy,":[102,119,147,195],"increased":[107,163,174],"all":[109,156],"concentrations,":[110,157],"confirming":[111],"result":[113],"that":[114,127],"induces":[116],"apoptosis.In":[117],"GSH/GSSG":[120],"ratio":[121],"decreased":[123],"concentrationdependent,":[125],"showing":[126],"also":[129],"induced":[130],"ferroptosis.Lipid":[131],"Peroxidation":[132],"caused":[133],"SOR,":[135],"corresponding":[136],"ferroptosis,":[138],"suppressed":[140,185,189,217],"DFX.In":[142],"fluorescence":[143],"microscopy":[144],"observed":[150],"at":[151],"a":[152,236],"constant":[153],"rate":[154],"while":[158],"high":[165],"concentration.In":[166],"combinations,":[170,179,200],"sub":[171],"G1":[172],"phase":[173],"additively.In":[175],"DFX":[178,199,213,240],"cytotoxic":[181],"not":[184],"but":[188],"Z-VAD-FMK":[191],"necrosulfonamide.In":[193],"each":[194],"+":[198],"nucleus":[206],"suppressed.Regarding":[208],"PCD":[209],"combination,":[214],"both":[219],"became":[223],"dominant.Conclusion:":[224],"Suppression":[225],"is":[228],"possibly":[229],"involved":[230],"DFX.As":[235],"result,":[237],"combination":[241],"showed":[242],"additive":[243],"HCC":[247],"through":[248],"programed":[252],"NF-kB":[256],"signal":[257],"modification.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-01T00:00:00"}