{"id":"https://openalex.org/W7146733487","doi":null,"title":"\u904e\u5ea6\u306e\u7e70\u308a\u8fd4\u3057\u4f38\u5f35\u523a\u6fc0\u306b\u3088\u308a\u6a5f\u68b0\u7684\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u305f\u9aa8\u7d30\u80de\u304c\u9aa8\u9ac4\u7d30\u80de\u306e\u5206\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff","display_name":"\u904e\u5ea6\u306e\u7e70\u308a\u8fd4\u3057\u4f38\u5f35\u523a\u6fc0\u306b\u3088\u308a\u6a5f\u68b0\u7684\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u305f\u9aa8\u7d30\u80de\u304c\u9aa8\u9ac4\u7d30\u80de\u306e\u5206\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W7146733487"},"language":"ja","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005979987","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2324/1955372","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u65e5\u672c\u6a5f\u68b0\u5b66\u4f1a\u8ad6\u6587\u96c6C\u7de8","raw_type":"journal article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059774215","display_name":"Takanobu Fukunaga","orcid":"https://orcid.org/0000-0002-2187-5610","observed_orcids":["https://orcid.org/0000-0002-2187-5610"]},"institutions":[{"id":"https://openalex.org/I199028557","display_name":"Kyushu Sangyo University","ror":"https://ror.org/01wqrpc44","country_code":"JP","type":"education","lineage":["https://openalex.org/I199028557"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fukunaga, Takanobu","raw_affiliation_strings":["Department of Mechanical Engineering, Graduate School of Engineering, Kyushu Sangyo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Graduate School of Engineering, Kyushu Sangyo University","institution_ids":["https://openalex.org/I199028557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069739590","display_name":"K. Kurata","orcid":"https://orcid.org/0000-0002-3261-5363","observed_orcids":["https://orcid.org/0000-0002-3261-5363"]},"institutions":[{"id":"https://openalex.org/I199028557","display_name":"Kyushu Sangyo University","ror":"https://ror.org/01wqrpc44","country_code":"JP","type":"education","lineage":["https://openalex.org/I199028557"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kurata, Kosaku","raw_affiliation_strings":["Kyushu Sangyo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu Sangyo University","institution_ids":["https://openalex.org/I199028557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108634276","display_name":"Junpei MATSUDA","orcid":"https://orcid.org/0009-0002-2794-0708","observed_orcids":["https://orcid.org/0009-0002-2794-0708"]},"institutions":[{"id":"https://openalex.org/I199028557","display_name":"Kyushu Sangyo University","ror":"https://ror.org/01wqrpc44","country_code":"JP","type":"education","lineage":["https://openalex.org/I199028557"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Matsuda, Junpei","raw_affiliation_strings":["Department of Mechanical Engineering, Graduate School of Engineering, Kyushu Sangyo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Graduate School of Engineering, Kyushu Sangyo University","institution_ids":["https://openalex.org/I199028557"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108571745","display_name":"Hidehiko HIGAKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199028557","display_name":"Kyushu Sangyo University","ror":"https://ror.org/01wqrpc44","country_code":"JP","type":"education","lineage":["https://openalex.org/I199028557"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Higaki, Hidehiko","raw_affiliation_strings":["Kyushu Sangyo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu Sangyo University","institution_ids":["https://openalex.org/I199028557"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I199028557"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40426236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"726","first_page":"541","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.060100000351667404,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/bone-microdamage","display_name":"bone microdamage","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cyclic-loading","display_name":"cyclic loading","score":0.5899999737739563},{"id":"https://openalex.org/keywords/osteocyte-death","display_name":"osteocyte death","score":0.6169999837875366},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.7559999823570251},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.7170000076293945},{"id":"https://openalex.org/keywords/mlo-y4-cells","display_name":"MLO-Y4 cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/collagen-gel-culture","display_name":"collagen gel culture","score":0.8040000200271606},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bone-fractures","display_name":"bone fractures","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.9088000059127808},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6552000045776367},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5738999843597412},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5241000056266785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5047000050544739},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44749999046325684},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4287000000476837},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42329999804496765},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3937000036239624},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.3467000126838684},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.34459999203681946},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3230000138282776},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005979987","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2324/1955372","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u65e5\u672c\u6a5f\u68b0\u5b66\u4f1a\u8ad6\u6587\u96c6C\u7de8","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320791141","https://openalex.org/W2742559014","https://openalex.org/W1971902869","https://openalex.org/W2136254777","https://openalex.org/W2744965065","https://openalex.org/W2026020016","https://openalex.org/W1852304021","https://openalex.org/W2243806047","https://openalex.org/W1563819461","https://openalex.org/W2563044483"],"abstract_inverted_index":{"Bone":[0],"is":[1,16],"continuously":[2],"subjected":[3,113],"to":[4,9,77,114,164,182,185],"repetitive":[5],"loading,":[6],"which":[7,100],"leads":[8],"microdamage":[10,37,45],"even":[11],"if":[12],"the":[13,34,44,67,127,141,158,173],"strain":[14,119],"level":[15],"within":[17],"physiological":[18],"range.":[19],"The":[20,70],"damaged":[21,68,126,142,159],"site":[22],"must":[23],"be":[24],"sensed":[25],"and":[26,56,112,169],"promptly":[27],"repaired":[28],"by":[29,157],"remodeling":[30,60,184],"process":[31],";":[32],"otherwise":[33],"accumulation":[35],"of":[36,66,72,88,134,148,176],"results":[38],"in":[39,51,57,81,91,99,117,131],"bone":[40,59],"fracture.":[41],"Osteocytes":[42],"neighboring":[43],"should":[46],"play":[47],"an":[48,179],"important":[49,180],"role":[50],"detecting":[52],"local":[53,174],"mechanical":[54,86],"environment":[55],"initiating":[58],"process,":[61],"i.":[62],"e.":[63],"osteoclastic":[64,166],"resorption,":[65],"area.":[69],"aims":[71],"this":[73],"study":[74],"were,":[75],"therefore,":[76],"establish":[78],"a":[79,96,162],"relevant":[80],"vitro":[82],"model":[83],"for":[84],"studying":[85],"responses":[87],"stretched":[89],"osteocytes":[90,160,177],"three-dimensional":[92],"culture.":[93],"We":[94],"established":[95],"loading":[97],"apparatus":[98],"osteocyte-like":[101],"cell":[102,135,167],"line":[103],"MLO-Y4":[104],"cells":[105],"were":[106],"three-dimensionally":[107],"cultured":[108],"inside":[109],"collagen":[110],"gel":[111],"cyclic":[115],"stretching":[116,122],"over-physiological":[118],"level.":[120],"Excessive":[121],"at":[123],"10000":[124],"\u03bc\u03b5":[125],"gel-embedded":[128],"osteocyte,":[129],"resulting":[130],"significant":[132,146],"amount":[133,147],"death.":[136],"Conditioned":[137],"medium":[138],"obtained":[139],"from":[140],"osteocyte":[143],"culture":[144],"induced":[145],"TRACP-positive":[149],"cells.":[150],"It":[151],"demonstrates":[152],"that":[153,172],"soluble":[154],"factors":[155],"secreted":[156],"have":[161],"potential":[163],"promote":[165],"formation,":[168],"further":[170],"suggests":[171],"death":[175],"provides":[178],"mechanism":[181],"target":[183],"microdamaged":[186],"site.":[187]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2026-04-01T00:00:00"}
