{"id":"https://openalex.org/W7145687488","doi":null,"title":"The effect of denosumab on pedicle screw fixation: A prospective 2-year longitudinal study using finite element analysis","display_name":"The effect of denosumab on pedicle screw fixation: A prospective 2-year longitudinal study using finite element analysis","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7145687488"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:00976:0005507378","doi":null,"is_oa":true,"landing_page_url":"https://showa.repo.nii.ac.jp/records/4042","pdf_url":"https://showa.repo.nii.ac.jp/record/4042/files/ko3300_fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://showa.repo.nii.ac.jp/record/4042/files/ko3300_fulltext.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132211971","display_name":"\u8061\u4e8c \u8c37","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u8c37, \u8061\u4e8c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5132211971"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10776","display_name":"Spinal Fractures and Fixation Techniques","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10776","display_name":"Spinal Fractures and Fixation Techniques","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":1.0},{"id":"https://openalex.org/keywords/pedicle-screw-fixation","display_name":"pedicle screw fixation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pedicle-screw-loosening","display_name":"pedicle screw loosening","score":0.8970000147819519},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8360000252723694},{"id":"https://openalex.org/keywords/volumetric-bone-mineral-density","display_name":"volumetric bone mineral density","score":0.8560000061988831},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"quantitative computed tomography","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pullout-strength","display_name":"pull-out strength","score":0.8579999804496765},{"id":"https://openalex.org/keywords/spinal-instrumentation","display_name":"spinal instrumentation","score":0.4699999988079071},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7599999904632568},{"id":"https://openalex.org/keywords/rankl-inhibitor","display_name":"RANKL inhibitor","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6351000070571899},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.6159999966621399},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.4810999929904938},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.3849000036716461},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.3646000027656555},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3411000072956085},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.27799999713897705},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.23649999499320984}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:00976:0005507378","doi":null,"is_oa":true,"landing_page_url":"https://showa.repo.nii.ac.jp/records/4042","pdf_url":"https://showa.repo.nii.ac.jp/record/4042/files/ko3300_fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00976:0005507378","doi":null,"is_oa":true,"landing_page_url":"https://showa.repo.nii.ac.jp/records/4042","pdf_url":"https://showa.repo.nii.ac.jp/record/4042/files/ko3300_fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1485118646","display_name":null,"funder_award_id":"2019-2021","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G384215388","display_name":"An Effect Comparison of Osteoporosis Treatment on Spinal Instrumentation","funder_award_id":"19K18544","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6487973904","display_name":"Predictors of Hypocalcemia Induced by Denosumab in Patients with Bone Metastases: A Prospective Cohort Study","funder_award_id":"17K18114","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7145687488.pdf","grobid_xml":"https://content.openalex.org/works/W7145687488.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1519690824","https://openalex.org/W1580484836","https://openalex.org/W1808538080","https://openalex.org/W1898516150","https://openalex.org/W1991777651","https://openalex.org/W2001110947","https://openalex.org/W2011272591","https://openalex.org/W2029636776","https://openalex.org/W2033327072","https://openalex.org/W2033722154","https://openalex.org/W2037861546","https://openalex.org/W2044178924","https://openalex.org/W2065228449","https://openalex.org/W2073470946","https://openalex.org/W2076825365","https://openalex.org/W2087484885","https://openalex.org/W2105046527","https://openalex.org/W2115028313","https://openalex.org/W2121960517","https://openalex.org/W2132089314","https://openalex.org/W2167243019","https://openalex.org/W2313826693","https://openalex.org/W2329927106","https://openalex.org/W2560355010","https://openalex.org/W2619448414","https://openalex.org/W2753576231","https://openalex.org/W2791054287","https://openalex.org/W2808420007","https://openalex.org/W2887444772","https://openalex.org/W3089679897"],"related_works":["https://openalex.org/W4417162118","https://openalex.org/W7099881303","https://openalex.org/W2392394233","https://openalex.org/W4312567537","https://openalex.org/W2139749222","https://openalex.org/W4392631410","https://openalex.org/W2160599602","https://openalex.org/W2604546486","https://openalex.org/W3117714216","https://openalex.org/W4200099673"],"abstract_inverted_index":{"Background:":[0],"Pedicle":[1],"screw":[2,30,41,110,153,197,206],"loosening":[3],"is":[4,17,32,185],"a":[5,18,50,144],"major":[6],"complication":[7],"following":[8,138],"spinal":[9,221],"fixation":[10,31,42,198],"associated":[11],"with":[12,23,46,64,114,147,165,199,226],"osteoporosis":[13,66,218],"in":[14,21,43,202,223],"elderly.However,":[15],"denosumab":[16,27,37,70,115,139,192,213],"promising":[19],"treatment":[20,38,193,219],"patients":[22,45,63,225],"osteoporosis.The":[24],"effect":[25],"of":[26,99,122,128],"on":[28],"pedicle":[29,40,123,152,196],"unknown.Therefore,":[33],"we":[34,60,78],"investigated":[35],"whether":[36],"improves":[39],"elderly":[44,224],"osteoporosis.Methods:":[47],"This":[48],"was":[49],"2-year":[51],"prospective":[52],"open-label":[53],"study.From":[54],"February":[55],"2015":[56],"to":[57,104,189],"January":[58],"2016,":[59],"included":[61],"21":[62],"postmenopausal":[65],"who":[67],"received":[68],"initial":[69],"treatment.At":[71],"baseline,":[72],"12":[73,134],"months,":[74,77],"and":[75,90,109,125,135,210],"24":[76,136,162,179],"measured":[79],"volumetric":[80,149],"bone":[81,107],"mineral":[82],"density":[83],"(BMD)":[84],"using":[85],"quantitative":[86],"computed":[87],"tomography":[88],"(QCT)":[89],"performed":[91],"CT-based":[92],"finite":[93],"element":[94,97],"analysis":[95],"(FEA).Finite":[96],"models":[98],"L4":[100],"vertebrae":[101],"were":[102],"created":[103],"analyze":[105],"the":[106,129,186,205],"strength":[108,121,142],"fixation.Results:":[111],"BMD":[112,150,168,203],"increased":[113,131],"treatment.FEA":[116],"revealed":[117],"that":[118,191],"both":[119],"pullout":[120,141],"screws":[124],"compression":[126],"force":[127],"vertebra":[130],"significantly":[132],"at":[133,161,178],"months":[137],"treatment.Notably,":[140],"showed":[143],"stronger":[145],"correlation":[146],"three-dimensional":[148],"around":[151,204],"placement":[154],"assessed":[155,169,207],"by":[156,170,208],"QCT":[157,209],"(r":[158,175],"=":[159,176],"0.83,":[160],"months)":[163],"than":[164],"two-dimensional":[166],"areal":[167],"dual":[171],"energy":[172],"X-ray":[173],"absorptiometry":[174],"0.35,":[177],"months).Conclusion:":[180],"To":[181],"our":[182],"knowledge,":[183],"this":[184],"first":[187],"study":[188],"reveal":[190],"achieved":[194],"strong":[195],"an":[200],"increase":[201],"FEA;":[211],"therefore,":[212],"could":[214],"be":[215],"useful":[216],"for":[217],"during":[220],"surgery":[222],"osteoporosis.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-01T00:00:00"}
