{"id":"https://openalex.org/W7145420232","doi":null,"title":"\u591a\u8840\u5c0f\u677f\u8840\u6f3f\u7531\u6765\u7d30\u80de\u5916\u5c0f\u80de\u304c\u30de\u30a6\u30b9\u306e\u809d\u786c\u5909\u3092\u6539\u5584\u3059\u308b","display_name":"\u591a\u8840\u5c0f\u677f\u8840\u6f3f\u7531\u6765\u7d30\u80de\u5916\u5c0f\u80de\u304c\u30de\u30a6\u30b9\u306e\u809d\u786c\u5909\u3092\u6539\u5584\u3059\u308b","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7145420232"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01100:0006950187","doi":null,"is_oa":true,"landing_page_url":"https://niigata-u.repo.nii.ac.jp/records/2002083","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://niigata-u.repo.nii.ac.jp/records/2002083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5131711292","display_name":"Yuichirou Maeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maeda, Yuichirou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5131711292"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8240000009536743},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anti-inflammatory-macrophages","display_name":"anti-inflammatory macrophages","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8299999833106995},{"id":"https://openalex.org/keywords/serum-alanine-aminotransferase","display_name":"serum alanine aminotransferase","score":0.8659999966621399},{"id":"https://openalex.org/keywords/extracellular-vesicle-proteome","display_name":"extracellular vesicle proteome","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8230000138282776},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6802999973297119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5943999886512756},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.5462999939918518},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5134000182151794},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5130000114440918},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.43720000982284546},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.398499995470047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39089998602867126},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3792000114917755},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.3594000041484833},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3483000099658966},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.32519999146461487},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2994999885559082},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.26499998569488525},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2639999985694885},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2630999982357025},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26170000433921814},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01100:0006950187","doi":null,"is_oa":true,"landing_page_url":"https://niigata-u.repo.nii.ac.jp/records/2002083","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01100:0006950187","doi":null,"is_oa":true,"landing_page_url":"https://niigata-u.repo.nii.ac.jp/records/2002083","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404063610","https://openalex.org/W7208397844","https://openalex.org/W4407141774","https://openalex.org/W3117099773","https://openalex.org/W2758363155","https://openalex.org/W1973425905","https://openalex.org/W4415345975","https://openalex.org/W4234281458","https://openalex.org/W7118782326","https://openalex.org/W4393070756"],"abstract_inverted_index":{"\"Introduction:":[0],"Cirrhosis":[1],"remains":[2],"a":[3,17,36,141],"significant":[4],"clinical":[5],"challenge":[6],"due":[7],"to":[8,39,74,182],"its":[9],"poor":[10],"prognosis":[11],"and":[12,59,81,92,105,124,148,161,186],"limited":[13],"treatment":[14],"options,":[15],"creating":[16],"high":[18],"unmet":[19],"medical":[20],"need":[21],"for":[22,197],"the":[23,33,76,84,113,169,175,189,195],"development":[24],"of":[25,35,70,78,97,156,171],"novel":[26,37,192],"therapies.":[27],"In":[28,90,127],"this":[29],"study,":[30],"we":[31],"analyzed":[32],"effects":[34],"approach":[38],"treat":[40],"cirrhosis":[41,68,198],"using":[42,57,102],"platelet-rich":[43,55],"plasma-derived":[44],"extracellular":[45],"vesicles":[46],"(PRPEV)":[47],"in":[48,93,143,150,174,188],"mice.":[49],"Methods:":[50],"PRPEV":[51,79,98,117,129,137,179],"were":[52,62,100,159],"collected":[53],"from":[54],"plasma":[56],"ultrafiltration,":[58],"their":[60],"proteomes":[61],"analyzed.":[63],"The":[64],"carbon":[65],"tetrachloride":[66],"(CCl4)-induced":[67],"model":[69],"mice":[71],"was":[72,140,166],"used":[73],"evaluate":[75],"effect":[77],"administration":[80,99],"compared":[82],"with":[83,122],"control":[85],"group":[86],"(n":[87],"\u00bc":[88],"8).":[89],"vitro":[91],"vivo":[94],"mechanistic":[95],"analyses":[96],"confirmed":[101],"real":[103],"time-PCR":[104],"immunostaining.":[106],"Results:":[107],"Gene":[108],"ontology":[109],"analysis":[110],"based":[111],"on":[112],"proteome":[114],"revealed":[115],"that":[116],"contain":[118],"many":[119],"factors":[120,158],"associated":[121],"EV":[123],"immune":[125],"responses.":[126],"vitro,":[128],"polarize":[130],"macrophages":[131,173],"into":[132],"an":[133],"antiinflammatory":[134,172],"phenotype.":[135],"Following":[136],"administration,":[138],"there":[139],"decrease":[142],"serum":[144],"alanine":[145],"aminotransferase":[146],"levels":[147,155],"reduction":[149],"liver":[151,176],"fibrosis,":[152],"while":[153],"mRNA":[154],"regenerative":[157],"upregulated":[160],"transforming":[162],"growth":[163],"factor":[164],"b-1":[165],"downregulated.":[167],"Furthermore,":[168],"number":[170],"increased.":[177],"Conclusions:":[178],"may":[180],"contribute":[181],"hepatocyte":[183],"proliferation,":[184],"anti-inflammation,":[185],"anti-fibrogenesis":[187],"liver.":[190],"This":[191],"concept":[193],"paves":[194],"way":[196],"treatment.\"":[199]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2026-04-01T00:00:00"}