{"id":"https://openalex.org/W7144473653","doi":null,"title":"\u30e9\u30c3\u30c8\u7aa9\u6d1e\u5f62\u6210\u4e0b\u306b\u304a\u3051\u308b\u8001\u5316\u7d30\u80de\u306e\u5c40\u5728\u3068\u8001\u5316\u7d30\u80de\u9664\u53bb\u85ac\u306b\u3088\u308b\u4fee\u5fa9\u8c61\u7259\u8cea\u5f62\u6210\u306e\u56de\u5fa9","display_name":"\u30e9\u30c3\u30c8\u7aa9\u6d1e\u5f62\u6210\u4e0b\u306b\u304a\u3051\u308b\u8001\u5316\u7d30\u80de\u306e\u5c40\u5728\u3068\u8001\u5316\u7d30\u80de\u9664\u53bb\u85ac\u306b\u3088\u308b\u4fee\u5fa9\u8c61\u7259\u8cea\u5f62\u6210\u306e\u56de\u5fa9","publication_year":2023,"publication_date":"2023-03-03","ids":{"openalex":"https://openalex.org/W7144473653"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01067:0005757186","doi":null,"is_oa":true,"landing_page_url":"https://osaka-dent.repo.nii.ac.jp/records/352","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://osaka-dent.repo.nii.ac.jp/records/352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092739707","display_name":"Haitao Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liu, Haitao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5092739707"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.42750000953674316,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senescent-cells","display_name":"senescent cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/reparative-dentin","display_name":"reparative dentin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cavity-preparation","display_name":"cavity preparation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pulp-horn","display_name":"pulp horn","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9390000104904175},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9070000052452087},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":1.0},{"id":"https://openalex.org/keywords/pulp-protection","display_name":"pulp protection","score":0.5339999794960022},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.4569999873638153},{"id":"https://openalex.org/keywords/restorative-dentistry","display_name":"restorative dentistry","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.6729000210762024},{"id":"https://openalex.org/C188442228","wikidata":"https://www.wikidata.org/wiki/Q48286","display_name":"Pulp (tooth)","level":2,"score":0.5349000096321106},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.4794999957084656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40299999713897705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.384799987077713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2856000065803528},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23680000007152557},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2214999943971634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21729999780654907}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01067:0005757186","doi":null,"is_oa":true,"landing_page_url":"https://osaka-dent.repo.nii.ac.jp/records/352","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01067:0005757186","doi":null,"is_oa":true,"landing_page_url":"https://osaka-dent.repo.nii.ac.jp/records/352","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322707054","https://openalex.org/W7163397802","https://openalex.org/W2046922531","https://openalex.org/W2002315085","https://openalex.org/W2378790237","https://openalex.org/W4389862012","https://openalex.org/W4362507367","https://openalex.org/W7144193307","https://openalex.org/W2090825603","https://openalex.org/W7017116164"],"abstract_inverted_index":{"Reparative":[0],"dentin":[1,118],"formed":[2],"by":[3,30,127],"dental":[4],"cavity":[5],"preparation":[6],"(DCP)":[7],"is":[8],"frequently":[9],"used":[10],"in":[11,19,79],"clinical":[12],"operations":[13],"and":[14,57,71,87,105],"plays":[15],"a":[16,66],"pivotal":[17],"role":[18],"pulp":[20,95],"protection.":[21],"Recent":[22],"reports":[23],"have":[24],"shown":[25],"that":[26,45,85,123],"senescent":[27,48,55,77,89,110,124],"cells":[28,78,90,125,137],"induced":[29,126],"various":[31],"stressors":[32],"aggravate":[33],"many":[34],"diseases.":[35],"They":[36],"can":[37],"be":[38,139],"treated":[39],"using":[40],"senolytics,":[41],"which":[42],"are":[43],"drugs":[44],"selectively":[46],"eliminate":[47],"cells.":[49],"However,":[50],"the":[51,73,80,94,114,131,142],"association":[52],"between":[53],"DCP,":[54],"cells,":[56,111],"senolytics":[58,103],"remains":[59],"unclear.":[60],"In":[61],"this":[62],"study,":[63],"we":[64],"established":[65],"rat":[67],"model":[68],"of":[69,76,102,116,133,144],"DCP":[70,128],"analyzed":[72],"spatiotemporal":[74],"localization":[75],"pulp.":[81],"The":[82],"results":[83],"showed":[84],"p21-":[86],"p16-positive":[88],"appeared":[91],"mostly":[92],"around":[93],"horn":[96],"(PH)":[97],"under":[98],"DCP.":[99],"Furthermore,":[100],"administration":[101],"(dasatinib":[104],"quercetin)":[106],"successfully":[107],"eliminated":[108],"these":[109],"thereby":[112],"restoring":[113],"volume":[115],"reparative":[117,134],"formation.":[119],"These":[120],"data":[121],"indicate":[122],"may":[129,138],"hamper":[130],"formation":[132],"dentin.":[135],"Senescent":[136],"targets":[140],"for":[141],"development":[143],"new":[145],"restorative":[146],"dentistry":[147],"therapies.":[148]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-04-01T00:00:00"}
