{"id":"https://openalex.org/W7143662986","doi":"https://doi.org/10.1093/bjd/ljag113","title":"Unanchored by two hits: interferon-\u03b3 and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo","display_name":"Unanchored by two hits: interferon-\u03b3 and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo","publication_year":2026,"publication_date":"2026-03-30","ids":{"openalex":"https://openalex.org/W7143662986","doi":"https://doi.org/10.1093/bjd/ljag113","pmid":"https://pubmed.ncbi.nlm.nih.gov/41913313"},"language":"en","primary_location":{"id":"doi:10.1093/bjd/ljag113","doi":"https://doi.org/10.1093/bjd/ljag113","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bjd/ljag113","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100321875","display_name":"Eun Jung Lee","orcid":"https://orcid.org/0000-0002-8401-2652","observed_orcids":["https://orcid.org/0000-0002-8401-2652"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Jung Lee","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":"https://orcid.org/0000-0002-8401-2652","affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012719099","display_name":"Il Joo Kwon","orcid":"https://orcid.org/0000-0003-1314-6829","observed_orcids":["https://orcid.org/0000-0003-1314-6829"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Il Joo Kwon","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131108394","display_name":"Ji Young Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Young Kim","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105974911","display_name":"S. Y. Park","orcid":"https://orcid.org/0009-0003-6649-308X","observed_orcids":["https://orcid.org/0009-0003-6649-308X","https://orcid.org/0009-0006-1886-7181"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seohyun Park","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114212774","display_name":"Hui-Ting Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hui-ting Han","raw_affiliation_strings":["Institute of Human\u2013Environment Interface Biology, Medical Research Center, Seoul National University College of Medicine , Seoul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human\u2013Environment Interface Biology, Medical Research Center, Seoul National University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055033346","display_name":"Shinwon Hwang","orcid":"https://orcid.org/0000-0002-0202-7800","observed_orcids":["https://orcid.org/0000-0002-0202-7800"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Shinwon Hwang","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069042669","display_name":"Yu Jeong Bae","orcid":"https://orcid.org/0000-0001-8861-600X","observed_orcids":["https://orcid.org/0000-0001-8861-600X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu\u00a0Jeong Bae","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615132","display_name":"A-Ram Kim","orcid":"https://orcid.org/0000-0002-5458-1985","observed_orcids":["https://orcid.org/0000-0002-5458-1985"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"A Ram Kim","raw_affiliation_strings":["Department of Dermatology, School of Medicine, CHA University , Pocheon ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, CHA University , Pocheon ,","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033758207","display_name":"Jamal Mohammed Alqahtani","orcid":"https://orcid.org/0000-0002-0927-5540","observed_orcids":["https://orcid.org/0000-0002-0927-5540"]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Jamal Mohammed Alqahtani","raw_affiliation_strings":["Department of Dermatology, Imam Abdulrahman Bin Faisal University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Imam Abdulrahman Bin Faisal University ,","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131096242","display_name":"Dong Hyun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Hyun Kim","raw_affiliation_strings":["Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine , Seongnam ,","Department of Dermatology, School of Medicine, CHA University , Pocheon ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine , Seongnam ,","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Department of Dermatology, School of Medicine, CHA University , Pocheon ,","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055439291","display_name":"Jinu Lee","orcid":"https://orcid.org/0000-0002-8997-448X","observed_orcids":["https://orcid.org/0000-0002-8997-448X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinu Lee","raw_affiliation_strings":["College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University , Incheon ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University , Incheon ,","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101834941","display_name":"Si\u2010Hyung Lee","orcid":"https://orcid.org/0000-0001-7709-5384","observed_orcids":["https://orcid.org/0000-0001-7709-5384"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Si-Hyung Lee","raw_affiliation_strings":["Institute of Human\u2013Environment Interface Biology, Medical Research Center, Seoul National University College of Medicine , Seoul ,"],"raw_orcid":"https://orcid.org/0000-0001-7709-5384","affiliations":[{"raw_affiliation_string":"Institute of Human\u2013Environment Interface Biology, Medical Research Center, Seoul National University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030041708","display_name":"Sang Ho Oh","orcid":"https://orcid.org/0000-0002-4477-1400","observed_orcids":["https://orcid.org/0000-0002-4477-1400"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Ho Oh","raw_affiliation_strings":["Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,"],"raw_orcid":"https://orcid.org/0000-0002-4477-1400","affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5030041708"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":3.2302,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88827908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"195","issue":"1","first_page":"109","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":0.996999979019165},{"id":"https://openalex.org/keywords/baricitinib","display_name":"baricitinib","score":0.9160000085830688},{"id":"https://openalex.org/keywords/jak-inhibition","display_name":"JAK inhibition","score":0.7990000247955322},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.6499999761581421},{"id":"https://openalex.org/keywords/koebner-phenomenon","display_name":"Koebner phenomenon","score":0.8799999952316284},{"id":"https://openalex.org/keywords/melanocyte-loss","display_name":"melanocyte loss","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.9254000186920166},{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.7516999840736389},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5131999850273132},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48420000076293945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4519999921321869},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4207000136375427},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.40689998865127563},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4027000069618225},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.3874000012874603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3813999891281128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3675000071525574},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3573000133037567},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C2779179668","wikidata":"https://www.wikidata.org/wiki/Q7193408","display_name":"Pigmentation disorder","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.31540000438690186},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3041999936103821},{"id":"https://openalex.org/C25834368","wikidata":"https://www.wikidata.org/wiki/Q5262737","display_name":"Dermoepidermal junction","level":3,"score":0.30079999566078186},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C2776972258","wikidata":"https://www.wikidata.org/wiki/Q3705665","display_name":"Depigmentation","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2630000114440918}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bjd/ljag113","doi":"https://doi.org/10.1093/bjd/ljag113","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bjd/ljag113","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:41913313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41913313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7011289502","display_name":null,"funder_award_id":"RS-2023-NR077086","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"}],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1521858627","https://openalex.org/W1866826175","https://openalex.org/W1888764902","https://openalex.org/W1971069223","https://openalex.org/W1986532631","https://openalex.org/W1995134644","https://openalex.org/W2005792499","https://openalex.org/W2037299986","https://openalex.org/W2044794199","https://openalex.org/W2055539585","https://openalex.org/W2056144049","https://openalex.org/W2070508477","https://openalex.org/W2098218273","https://openalex.org/W2105556214","https://openalex.org/W2108770100","https://openalex.org/W2137949057","https://openalex.org/W2146966558","https://openalex.org/W2155649238","https://openalex.org/W2159703967","https://openalex.org/W2172053587","https://openalex.org/W2314057835","https://openalex.org/W2509300671","https://openalex.org/W2511684231","https://openalex.org/W2799310786","https://openalex.org/W2808825101","https://openalex.org/W2998938145","https://openalex.org/W3004467513","https://openalex.org/W3012531490","https://openalex.org/W3041901315","https://openalex.org/W3100014595","https://openalex.org/W3115441703","https://openalex.org/W3119509510","https://openalex.org/W4206804045","https://openalex.org/W4210955641","https://openalex.org/W4229446476","https://openalex.org/W4251360987","https://openalex.org/W4281484949","https://openalex.org/W4292506191","https://openalex.org/W4293767921","https://openalex.org/W4309361728","https://openalex.org/W4362720397","https://openalex.org/W4386102800","https://openalex.org/W4388491027","https://openalex.org/W4399753714","https://openalex.org/W4400554217","https://openalex.org/W4411196818"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Vitiligo":[1],"is":[2],"a":[3,120,188],"chronic":[4],"depigmentation":[5],"disorder":[6],"caused":[7],"by":[8,112],"selective":[9],"melanocyte":[10,85,152,185,200],"loss.":[11],"Autoreactive":[12],"CD8+":[13],"T":[14],"cells":[15],"are":[16],"known":[17],"contributors,":[18],"but":[19],"impaired":[20],"melanocyte-keratinocyte":[21],"adhesion":[22,39,136,220],"due":[23],"to":[24,35,46,52,74,127,171,199],"E-cadherin":[25],"dysfunction":[26],"has":[27],"also":[28,157],"been":[29],"implicated.":[30],"OBJECTIVES:":[31],"This":[32],"study":[33],"aimed":[34],"identify":[36,80],"the":[37,165,176,203,215,228],"key":[38,81],"molecules":[40,82,155],"mediating":[41],"melanocyte-basement":[42,106,218],"membrane":[43,107,205,219],"interactions":[44],"and":[45,57,66,76,131,139,146,162,195,209,224],"investigate":[47],"their":[48],"modulation":[49],"in":[50,84,105,122,144,159,181,221,231],"response":[51],"vitiligo-associated":[53],"factors,":[54],"including":[55],"IFN\u03b3":[56,75,194],"mechanical":[58,77,132,196],"stress.":[59,78],"METHODS:":[60],"Primary":[61],"human":[62,69,149],"epidermal":[63],"melanocytes":[64,145,163],"(PHEMs)":[65],"ex":[67,147],"vivo":[68,148],"skin":[70,166],"tissues":[71],"were":[72,156],"exposed":[73],"To":[79],"involved":[83],"adhesion,":[86],"we":[87],"integrated":[88],"RNA":[89],"sequencing":[90],"data":[91],"from":[92,164,202],"prior":[93],"studies":[94],"with":[95,175],"antibody":[96],"array":[97],"profiling.":[98],"The":[99],"involvement":[100],"of":[101,115,167,217],"focal":[102,135],"adhesion-associated":[103],"proteins":[104],"attachment":[108],"was":[109],"further":[110],"assessed":[111],"confocal":[113],"imaging":[114],"vitiligo":[116,168,182,222],"patient":[117],"skin,":[118,150],"revealing":[119],"reduction":[121],"these":[123],"molecules.":[124],"RESULTS:":[125],"Exposure":[126],"interferon":[128],"gamma":[129],"(IFN\u03b3)":[130],"stress":[133,197],"reduced":[134,184],"kinase":[137],"(FAK)":[138],"integrin":[140],"\u03b21":[141],"(ITG\u03b21)":[142],"expression":[143],"increasing":[151],"detachment.":[153],"Both":[154],"decreased":[158],"basal":[160],"keratinocytes":[161],"patients":[169],"compared":[170],"healthy":[172],"controls.":[173],"Pre-treatment":[174],"JAK":[177],"inhibitor":[178],"baricitinib,":[179],"used":[180],"therapy,":[183],"detachment":[186,201],"through":[187],"cathepsin":[189],"L":[190],"(CTSL)-dependent":[191],"mechanism.":[192],"CONCLUSIONS:":[193],"contribute":[198],"basement":[204],"via":[206],"CTSL,":[207],"FAK,":[208],"ITG\u03b21":[210],"regulation.":[211],"These":[212],"findings":[213],"highlight":[214],"importance":[216],"pathogenesis":[223],"offer":[225],"insight":[226],"into":[227],"Koebner":[229],"phenomenon":[230],"disease":[232],"progression.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-04-01T00:00:00"}