{"id":"https://openalex.org/W7143581978","doi":null,"title":"Preuves de l'utilit\u00e9 th\u00e9rapeutique du cannabidiol dans la prise en charge des douleurs des patients souffrant du syndrome de Nail-Patella","display_name":"Preuves de l'utilit\u00e9 th\u00e9rapeutique du cannabidiol dans la prise en charge des douleurs des patients souffrant du syndrome de Nail-Patella","publication_year":2026,"publication_date":"2026-01-07","ids":{"openalex":"https://openalex.org/W7143581978"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:dumas-05568550v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550","pdf_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine humaine et pathologie. 2026","raw_type":"info:eu-repo/semantics/masterThesis"},"parent_works":[],"lineage":["https://openalex.org/W7143581978"],"child_works_count":0,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130932358","display_name":"Thibaud Lebret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Lebret, Thibaud","raw_affiliation_strings":["UFR M\u00e9decine [Sant\u00e9] - Universit\u00e9 Paris Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UFR M\u00e9decine [Sant\u00e9] - Universit\u00e9 Paris Cit\u00e9","institution_ids":["https://openalex.org/I204730241"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5130932358"],"corresponding_institution_ids":["https://openalex.org/I204730241"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nail-patella-syndrome","display_name":"nail-patella syndrome","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cannabinoids","display_name":"cannabinoids","score":0.7699999809265137},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8479999899864197},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.7179999947547913},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.6909999847412109},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.492000013589859},{"id":"https://openalex.org/keywords/rare-genetic-disorders","display_name":"rare genetic disorders","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9259999990463257},{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.8705999851226807},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.5932999849319458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4153999984264374},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3571000099182129},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.35370001196861267},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33730000257492065},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.3093999922275543},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C2776237595","wikidata":"https://www.wikidata.org/wiki/Q683498","display_name":"Joint pain","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2780368125","wikidata":"https://www.wikidata.org/wiki/Q229081","display_name":"Patella","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:dumas-05568550v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550","pdf_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine humaine et pathologie. 2026","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:HAL:dumas-05568550v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550","pdf_url":"https://dumas.ccsd.cnrs.fr/dumas-05568550/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine humaine et pathologie. 2026","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7143581978.pdf","grobid_xml":"https://content.openalex.org/works/W7143581978.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W178452000","https://openalex.org/W1517571421","https://openalex.org/W1573204039","https://openalex.org/W1940834207","https://openalex.org/W1963623384","https://openalex.org/W1967743357","https://openalex.org/W1968621921","https://openalex.org/W1970860973","https://openalex.org/W1979952341","https://openalex.org/W2003527755","https://openalex.org/W2005662659","https://openalex.org/W2026666148","https://openalex.org/W2035221267","https://openalex.org/W2046214587","https://openalex.org/W2050005660","https://openalex.org/W2053420658","https://openalex.org/W2062301233","https://openalex.org/W2074513082","https://openalex.org/W2074888335","https://openalex.org/W2079357599","https://openalex.org/W2085189002","https://openalex.org/W2104665463","https://openalex.org/W2149110258","https://openalex.org/W2168111104","https://openalex.org/W2218751580","https://openalex.org/W2272647845","https://openalex.org/W2338139543","https://openalex.org/W2399492758","https://openalex.org/W2460664196","https://openalex.org/W2476178999","https://openalex.org/W2766629246","https://openalex.org/W2888624236","https://openalex.org/W2949348859","https://openalex.org/W2958634512","https://openalex.org/W2986647456","https://openalex.org/W2992061658","https://openalex.org/W3138527354","https://openalex.org/W3165181713","https://openalex.org/W4239455853","https://openalex.org/W4285587142","https://openalex.org/W4310222549","https://openalex.org/W4317434652","https://openalex.org/W4320491129","https://openalex.org/W4385565768","https://openalex.org/W4414871025"],"related_works":["https://openalex.org/W4404962985","https://openalex.org/W2748353507","https://openalex.org/W2099735197","https://openalex.org/W2992991283","https://openalex.org/W2112026566","https://openalex.org/W3215887594","https://openalex.org/W2051861183","https://openalex.org/W3159904901","https://openalex.org/W2167045148","https://openalex.org/W4400510901"],"abstract_inverted_index":{"Nail-patella":[0],"syndrome":[1],"(NPS)":[2],"is":[3,24],"a":[4,91,100,116,170],"rare":[5],"genetic":[6],"disease":[7],"characterized":[8],"by":[9],"dysplastic":[10],"nails,":[11],"patella":[12],"abnormalities,":[13],"skeletal":[14],"malformation,":[15],"and":[16,29,73,141,155,172],"chronic":[17,20,47,179],"pain.":[18,48,180],"Although":[19],"pain":[21,57,67,84,120],"in":[22,68,119,147,158],"NPS":[23,97],"mainly":[25],"due":[26],"to":[27,44,168],"bone":[28],"musculoskeletal":[30],"symptoms,":[31],"it":[32],"can":[33],"also":[34,145],"result":[35],"from":[36,90],"neurological":[37],"dysfunction.":[38],"Conventional":[39],"analgesics":[40],"are":[41],"often":[42],"insufficient":[43],"relieve":[45],"NPS-associated":[46,83,178],"Cannabinoids,":[49],"which":[50],"act":[51],"on":[52],"the":[53,80],"serotonergic":[54],"and/or":[55],"noradrenergic":[56],"systems,":[58],"may":[59],"therefore":[60,166],"represent":[61],"valuable":[62],"non-psychoactive":[63],"alternatives":[64],"for":[65,79,176],"managing":[66,177],"these":[69],"patients.":[70,149],"The":[71,106],"effectiveness":[72],"safety":[74],"of":[75,82,94,110,124,139],"synthetic":[76],"cannabidiol":[77],"(CBD)":[78],"management":[81],"was":[85,113,152],"assessed":[86],"using":[87],"real-world":[88],"data":[89],"pilot":[92],"cohort":[93],"patients":[95],"with":[96,103,115],"who":[98],"received":[99],"3-month":[101],"treatment":[102,107,151,174],"oral":[104],"CBD.":[105],"(median":[108],"dose":[109],"900":[111],"mg/day)":[112],"associated":[114],"significant":[117],"reduction":[118],"intensity":[121],"(mean":[122],"score":[123],"7.04\u00b10.24":[125],"at":[126,130],"initiation":[127],"versus":[128],"4.04\u00b10.38":[129],"3":[131],"months,":[132],"N=28,":[133],"p":[134],"<":[135],"0.0001).":[136],"Health-related":[137],"quality":[138],"life":[140],"other":[142],"NPSassociated":[143],"symptoms":[144],"improved":[146],"most":[148],"CBD":[150,165],"well":[153],"tolerated":[154],"no":[156],"elevations":[157],"liver":[159],"enzyme":[160],"levels":[161],"were":[162],"reported.":[163],"Synthetic":[164],"appears":[167],"be":[169],"safe":[171],"effective":[173],"option":[175]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-03-31T00:00:00"}
