{"id":"https://openalex.org/W7143528403","doi":"https://doi.org/10.48087/bjms.2026.130408","title":"Population pharmacokinetics of amikacin in Algeria: implications for dosing optimization and individualized therapy.","display_name":"Population pharmacokinetics of amikacin in Algeria: implications for dosing optimization and individualized therapy.","publication_year":2026,"publication_date":"2026-03-30","ids":{"openalex":"https://openalex.org/W7143528403","doi":"https://doi.org/10.48087/bjms.2026.130408"},"language":"en","primary_location":{"id":"doi:10.48087/bjms.2026.130408","doi":"https://doi.org/10.48087/bjms.2026.130408","is_oa":true,"landing_page_url":"https://doi.org/10.48087/bjms.2026.130408","pdf_url":null,"source":{"id":"https://openalex.org/S4210239123","display_name":"Batna Journal of Medical Sciences (BJMS)","issn_l":"2437-0665","issn":["2437-0665"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Batna Journal of Medical Sciences (BJMS)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.48087/bjms.2026.130408","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5141407116","display_name":"Fatima Zohra BOUAOUA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatima Zohra BOUAOUA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141545579","display_name":"Houari TOUMI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Houari TOUMI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077550035","display_name":"Karim Boulesbiaat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karim BOULESBIAAT","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075828562","display_name":"Habiba Fetati","orcid":"https://orcid.org/0000-0003-4941-3589","observed_orcids":["https://orcid.org/0000-0003-4941-3589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Habiba FETATI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014457241","display_name":"Hocine Gacem","orcid":"https://orcid.org/0000-0002-3202-8468","observed_orcids":["https://orcid.org/0000-0002-3202-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hocine GACEM","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141637820","display_name":"Farida BOUCHNAK","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farida BOUCHNAK","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141635275","display_name":"Abd Elrahmanne ABDAOUI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdelrahmane ABDAOUI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141662884","display_name":"Zahia HAZMOUNE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zahia HAZMOUNE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141651018","display_name":"Badis FOUGHALI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Badis FOUGHALI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141449434","display_name":"Soumia BOUDJEMAA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soumia BOUDJEMAA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042568241","display_name":"Sabah BENBOUDIAF","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabah BENBOUDIAF","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112635050","display_name":"F. Boudia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma Zohra BOUDIA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117811002","display_name":"Rafika LAICHE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafika LAICHE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017282632","display_name":"Faiza BOUCHALA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faiza BOUCHALA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072822177","display_name":"Kamel Mansouri","orcid":"https://orcid.org/0000-0002-6426-8036","observed_orcids":["https://orcid.org/0000-0002-6426-8036","https://orcid.org/0009-0001-9230-4364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamel MANSOURI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16075486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":1.0},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.9570000171661377},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9309999942779541},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.7730000019073486},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.6809999942779541},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7310000061988831},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/multidrug-resistant-gram-negative-bacteria","display_name":"multidrug-resistant Gram-negative bacteria","score":0.7590000033378601},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.7179999947547913},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/probability-of-target-attainment","display_name":"probability of target attainment","score":0.671999990940094},{"id":"https://openalex.org/keywords/algeria","display_name":"Algeria","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8222000002861023},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6614999771118164},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6086999773979187},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.5763999819755554},{"id":"https://openalex.org/C3020755252","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Population pharmacokinetics","level":3,"score":0.52920001745224},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.47600001096725464},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41260001063346863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34360000491142273},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.31690001487731934},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.48087/bjms.2026.130408","doi":"https://doi.org/10.48087/bjms.2026.130408","is_oa":true,"landing_page_url":"https://doi.org/10.48087/bjms.2026.130408","pdf_url":null,"source":{"id":"https://openalex.org/S4210239123","display_name":"Batna Journal of Medical Sciences (BJMS)","issn_l":"2437-0665","issn":["2437-0665"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Batna Journal of Medical Sciences (BJMS)","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ff5d516a2c6e49e9ac8616ee252a2e88","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ff5d516a2c6e49e9ac8616ee252a2e88","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Batna Journal of Medical Sciences, Vol 13, Iss 4 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.48087/bjms.2026.130408","doi":"https://doi.org/10.48087/bjms.2026.130408","is_oa":true,"landing_page_url":"https://doi.org/10.48087/bjms.2026.130408","pdf_url":null,"source":{"id":"https://openalex.org/S4210239123","display_name":"Batna Journal of Medical Sciences (BJMS)","issn_l":"2437-0665","issn":["2437-0665"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Batna Journal of Medical Sciences (BJMS)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2793804628","https://openalex.org/W7168451285","https://openalex.org/W3042404390","https://openalex.org/W7161099178","https://openalex.org/W3006168779","https://openalex.org/W3125397940","https://openalex.org/W4281401290","https://openalex.org/W4409328095","https://openalex.org/W1985627942","https://openalex.org/W2127386605"],"abstract_inverted_index":{"Introduction:":[0],"Amikacin":[1],"is":[2,22],"a":[3,69,113,164,170,185],"bactericidal":[4],"aminoglycoside":[5],"widely":[6],"used":[7],"in":[8,80,97],"the":[9,30,136,151,278],"treatment":[10,274],"of":[11,32,54,138,173,176,189,280],"severe":[12],"infections":[13],"caused":[14],"by":[15,24,225],"multidrug-resistant":[16],"Gram-negative":[17],"bacilli.":[18],"Its":[19,36],"clinical":[20],"use":[21],"limited":[23],"significant":[25],"interindividual":[26],"pharmacokinetic":[27,71],"variability":[28],"and":[29,34,88,92,110,122,144,181,184,194,200,213,235,243,260,276],"risk":[31,279],"nephrotoxicity":[33],"ototoxicity.":[35],"narrow":[37],"therapeutic":[38,76,267],"window":[39],"complicates":[40],"dose":[41,62,271],"individualization,":[42,272],"making":[43],"it":[44],"challenging":[45],"to":[46,58,82,134,220,257],"optimize":[47],"efficacy":[48,259],"while":[49],"minimizing":[50],"toxicity.":[51,281],"The":[52],"objective":[53],"this":[55],"study":[56,94],"was":[57,95,167],"develop":[59],"an":[60,107],"initial":[61],"adjustment":[63],"approach":[64],"for":[65,141,197,233,241],"amikacin":[66],"based":[67],"on":[68,130],"population":[70,171,186,264],"(PKpop)":[72],"model":[73,166,211],"integrated":[74],"with":[75,154,266],"drug":[77,268],"monitoring":[78,269],"(TDM),":[79],"order":[81],"propose":[83],"optimized":[84],"dosing":[85,252],"regimens.":[86],"Materials":[87],"Methods:":[89],"A":[90],"retrospective":[91],"prospective":[93],"conducted":[96],"hospitalized":[98],"patients":[99,133,153],"receiving":[100],"amikacin.":[101],"Plasma":[102],"concentrations":[103,223],"were":[104,128,207],"measured":[105],"using":[106,112],"immunoenzymatic":[108],"method":[109],"modeled":[111],"nonlinear":[114],"mixed-effects":[115],"approach.":[116],"Covariates":[117],"assessed":[118],"included":[119,158],"body":[120],"weight":[121],"creatinine":[123],"clearance.":[124],"Monte":[125],"Carlo":[126],"simulations":[127],"performed":[129],"1,000":[131],"virtual":[132],"evaluate":[135],"probability":[137],"target":[139,222],"attainment":[140],"minimum":[142],"(Cmin)":[143],"maximum":[145],"(Cmax)":[146],"plasma":[147],"concentrations.":[148],"Results:":[149],"Among":[150],"50":[152,228],"normal":[155],"renal":[156],"function":[157],"(MDRD:":[159],"115.8":[160],"\u00b1":[161],"13":[162],"mL/min),":[163],"one-compartment":[165],"selected,":[168],"estimating":[169],"volume":[172],"distribution":[174],"(Vpop)":[175],"23.3":[177],"L,":[178,180,183],"70.8":[179],"21.5":[182],"clearance":[187],"(Clpop)":[188],"2.4":[190],"L/h,":[191,193],"6.5":[192],"2.7":[195],"L/h":[196],"children,":[198],"adults,":[199,234],"elderly":[201,244],"patients,":[202],"respectively.":[203],"Relative":[204],"standard":[205,251],"errors":[206],"low,":[208],"indicating":[209],"good":[210],"precision":[212],"stability.":[214],"Simulations":[215],"demonstrated":[216],"that":[217,250],"optimal":[218],"doses":[219],"achieve":[221],"varied":[224],"age":[226],"group:":[227],"mg/kg":[229,237],"every":[230,238],"24":[231],"hours":[232,240],"20":[236],"36\u201348":[239],"children":[242],"patients.":[245],"Discussion:":[246],"These":[247],"findings":[248],"suggest":[249],"regimens":[253],"are":[254],"often":[255],"insufficient":[256],"meet":[258],"safety":[261],"targets.":[262],"Integrating":[263],"pharmacokinetics":[265],"enables":[270],"improves":[273],"efficacy,":[275],"reduces":[277]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-03-31T00:00:00"}