{"id":"https://openalex.org/W7143479983","doi":"https://doi.org/10.5336/978-625-395-881-7_p137","title":"CARDIAC INVOLVEMENT IN HEMOLYTIC-UREMIC SYNDROME","display_name":"CARDIAC INVOLVEMENT IN HEMOLYTIC-UREMIC SYNDROME","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7143479983","doi":"https://doi.org/10.5336/978-625-395-881-7_p137"},"language":"en","primary_location":{"id":"doi:10.5336/978-625-395-881-7_p137","doi":"https://doi.org/10.5336/978-625-395-881-7_p137","is_oa":false,"landing_page_url":"https://doi.org/10.5336/978-625-395-881-7_p137","pdf_url":null,"source":{"id":"https://openalex.org/S4306481088","display_name":"Turkiye Klinikleri eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323283784","host_organization_name":"Turkiye Klinikleri","host_organization_lineage":["https://openalex.org/P4323283784"],"host_organization_lineage_names":["Turkiye Klinikleri"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Heart and Systemic Diseases Interactions and Clinical Implications","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7143289021","display_name":"The Heart and Systemic Diseases Interactions and Clinical Implications"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017879469","display_name":"Ey\u00fcp Aslan","orcid":"https://orcid.org/0000-0002-2595-9213","observed_orcids":["https://orcid.org/0000-0002-2595-9213"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"EY\u00dcP ASLAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017879469"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"137","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemolytic-uremic-syndrome","display_name":"hemolytic uremic syndrome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cardiac-involvement","display_name":"cardiac involvement","score":0.8970000147819519},{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/atypical-hus","display_name":"atypical HUS","score":0.7670000195503235},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.8240000009536743},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.6570000052452087},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.48100000619888306},{"id":"https://openalex.org/keywords/myocardial-edema","display_name":"myocardial edema","score":0.460999995470047},{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8403000235557556},{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.781499981880188},{"id":"https://openalex.org/C2781127562","wikidata":"https://www.wikidata.org/wiki/Q2063651","display_name":"Microangiopathic hemolytic anemia","level":4,"score":0.683899998664856},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.5473999977111816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5385000109672546},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5080000162124634},{"id":"https://openalex.org/C2776513394","wikidata":"https://www.wikidata.org/wiki/Q1412400","display_name":"Microangiopathy","level":3,"score":0.5074999928474426},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4699000120162964},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.44510000944137573},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4348999857902527},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.38659998774528503},{"id":"https://openalex.org/C2911202535","wikidata":"https://www.wikidata.org/wiki/Q18345704","display_name":"Pulmonary Veno-Occlusive Disease","level":3,"score":0.35989999771118164},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2946999967098236},{"id":"https://openalex.org/C65245452","wikidata":"https://www.wikidata.org/wiki/Q623225","display_name":"Schistocyte","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.28870001435279846},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5336/978-625-395-881-7_p137","doi":"https://doi.org/10.5336/978-625-395-881-7_p137","is_oa":false,"landing_page_url":"https://doi.org/10.5336/978-625-395-881-7_p137","pdf_url":null,"source":{"id":"https://openalex.org/S4306481088","display_name":"Turkiye Klinikleri eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323283784","host_organization_name":"Turkiye Klinikleri","host_organization_lineage":["https://openalex.org/P4323283784"],"host_organization_lineage_names":["Turkiye Klinikleri"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Heart and Systemic Diseases Interactions and Clinical Implications","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2586314287","https://openalex.org/W1998334483","https://openalex.org/W1988268546","https://openalex.org/W4407306831","https://openalex.org/W2007130742","https://openalex.org/W159348438","https://openalex.org/W2338953598","https://openalex.org/W1569413384","https://openalex.org/W4283011757","https://openalex.org/W4301887097"],"abstract_inverted_index":{"Hemolytic-uremic":[0],"syndrome":[1],"(HUS)":[2],"is":[3,77,95,184,189],"a":[4,19,27,230],"rare":[5],"disease":[6,194,327],"characterized":[7],"by":[8,65,79],"microvascular":[9,40],"hemolytic":[10,62,81],"anemia,":[11,82],"thrombocytopenia,":[12,80],"and":[13,39,45,72,83,107,166,196,202,217,220,296,300],"acute":[14],"kidney":[15],"injury.":[16],"HUS":[17,101,111,146,174,226,315],"comprises":[18],"diverse":[20],"range":[21],"of":[22,30,58,121,138,170,249,255,314,318],"conditions":[23],"that":[24],"present":[25,244],"with":[26,130,191,240],"pathological":[28],"picture":[29],"thrombotic":[31],"microangiopathy":[32],"(TMA),":[33],"which":[34,210],"refers":[35],"to":[36,54,92,103,178,212,309],"endothelial":[37,203],"damage":[38],"thrombosis":[41],"in":[42,48,154,173,245,316],"capillaries,":[43],"arterioles,":[44],"venules":[46],"resulting":[47],"platelet":[49],"aggregations.":[50],"This":[51,76],"condition":[52],"leads":[53,211],"the":[55,117,135,250,311,319],"mechanical":[56],"disruption":[57],"erythrocytes,":[59],"causing":[60],"microangiopathic":[61],"anemia":[63],"(characterized":[64],"schistocyte":[66],"formation),":[67],"elevated":[68,273],"lactate":[69],"dehydrogenase":[70],"levels,":[71],"decreased":[73],"haptoglobin":[74],"levels.":[75],"followed":[78],"ischemic":[84],"end-organ":[85],"damage.":[86],"While":[87],"most":[88],"cases":[89,125,139],"develop":[90],"secondary":[91],"infection,":[93],"there":[94],"no":[96],"universally":[97],"accepted":[98],"classification":[99],"for":[100],"due":[102],"some":[104],"genetic":[105],"predisposition":[106],"environmental":[108],"triggers.":[109],"Conventionally,":[110],"classifications":[112],"have":[113,140],"been":[114,142,176],"based":[115],"on":[116,238],"presence":[118],"or":[119],"absence":[120],"bloody":[122],"diarrhea.":[123],"Most":[124],"(90%)":[126],"occur":[127],"after":[128],"infection":[129],"enterohemorrhagic":[131],"E.":[132],"coli,":[133],"while":[134],"remaining":[136],"10%":[137],"usually":[141],"grouped":[143],"as":[144,162,259],"atypical":[145],"(aHUS).":[147],"Although":[148],"renal":[149],"findings":[150,157],"are":[151],"more":[152,192],"common":[153],"HUS,":[155],"extrarenal":[156,251],"may":[158],"also":[159],"occur,":[160],"such":[161],"neurological,":[163],"gastrointestinal,":[164],"cardiological,":[165],"ophthalmological":[167],"findings.The":[168],"incidence":[169],"cardiovascular":[171,312],"complications":[172],"has":[175],"reported":[177],"be":[179],"approximately":[180],"3\u201310%.":[181],"Cardiac":[182],"involvement":[183,242],"particularly":[185],"important":[186],"because":[187],"it":[188],"associated":[190],"severe":[193],"progression":[195],"higher":[197],"mortality":[198],"rates.":[199],"Microthrombi,":[200],"microaneurysms,":[201],"cell":[204],"abnormalities":[205],"can":[206],"cause":[207],"vascular":[208],"occlusion,":[209],"myocardial":[213],"ischemia,":[214],"cardiomyopathy,":[215],"systolic":[216],"diastolic":[218],"dysfunction,":[219],"congestive":[221],"heart":[222],"failure.":[223],"The":[224,253],"Turkish":[225],"Registry":[227],"Group":[228],"published":[229],"nationwide":[231],"study":[232],"analyzing":[233],"data":[234],"from":[235],"26":[236],"centers,":[237],"patients":[239],"aHUS":[241],"was":[243,258],"7%":[246],"(12":[247],"patients)":[248],"involvements.":[252],"distribution":[254],"these":[256],"involvements":[257],"follows:":[260],"dilated":[261],"cardiomyopathy":[262,266],"3":[263],"(1.7%),":[264],"hypertrophic":[265],"2":[267],"(1.1%),":[268],"intracardiac":[269],"thrombus":[270],"1":[271,275,280,285,288,293,303],"(0.5%),":[272,276,281,286,289,294],"CK-MB":[274],"aortic":[277],"valve":[278,298],"regurgitation":[279],"left":[282],"ventricular":[283],"hypertrophy":[284],"tachycardia":[287],"gangrenous":[290],"fingertip":[291],"lesions":[292],"mitral":[295],"tricuspid":[297],"regurgitation,":[299],"papillary":[301],"ischemia":[302],"(0.5%).In":[304],"this":[305],"review,":[306],"we":[307],"aimed":[308],"evaluate":[310],"effects":[313],"light":[317],"recent":[320],"literature.Keywords:":[321],"Anemia;":[322],"Hemolytic":[323],"\u00fcremic":[324],"syndrome;":[325],"Heart":[326],"risk":[328],"factors;":[329],"Renal":[330],"insufficency;":[331],"Thrombocytopenia":[332]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-03-31T00:00:00"}