{"id":"https://openalex.org/W7143469408","doi":"https://doi.org/10.2169/internalmedicine.6545-25","title":"Fatal Edwardsiella tarda Sepsis in a Patient with End-stage Multiple Myeloma: A Case of Suspected Zoonotic Transmission","display_name":"Fatal Edwardsiella tarda Sepsis in a Patient with End-stage Multiple Myeloma: A Case of Suspected Zoonotic Transmission","publication_year":2026,"publication_date":"2026-03-30","ids":{"openalex":"https://openalex.org/W7143469408","doi":"https://doi.org/10.2169/internalmedicine.6545-25","pmid":"https://pubmed.ncbi.nlm.nih.gov/41922229"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.6545-25","doi":"https://doi.org/10.2169/internalmedicine.6545-25","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.6545-25","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6545-25/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6545-25/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5131002772","display_name":"Yuka Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158816","display_name":"Otemae Hospital","ror":"https://ror.org/05m7r3n78","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Tanaka","raw_affiliation_strings":["Department of Hematology, Otemae Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Otemae Hospital, Japan","institution_ids":["https://openalex.org/I4210158816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130947719","display_name":"Keita Sugihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158816","display_name":"Otemae Hospital","ror":"https://ror.org/05m7r3n78","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita Sugihara","raw_affiliation_strings":["Department of Hematology, Otemae Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Otemae Hospital, Japan","institution_ids":["https://openalex.org/I4210158816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130909753","display_name":"Ryota Minami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158816","display_name":"Otemae Hospital","ror":"https://ror.org/05m7r3n78","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota Minami","raw_affiliation_strings":["Department of Hematology, Otemae Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Otemae Hospital, Japan","institution_ids":["https://openalex.org/I4210158816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032581577","display_name":"Mioka Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158816","display_name":"Otemae Hospital","ror":"https://ror.org/05m7r3n78","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mioka Matsumoto","raw_affiliation_strings":["Department of Diagnostic Pathology, Otemae Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Otemae Hospital, Japan","institution_ids":["https://openalex.org/I4210158816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160259471","display_name":"Norimitsu Saitoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158816","display_name":"Otemae Hospital","ror":"https://ror.org/05m7r3n78","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norimitsu Saitoh","raw_affiliation_strings":["Department of Hematology, Otemae Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Otemae Hospital, Japan","institution_ids":["https://openalex.org/I4210158816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210158816"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14655914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"21","first_page":"2940","last_page":"2943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/edwardsiella-tarda","display_name":"Edwardsiella tarda","score":0.9990000128746033},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.7229999899864197},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.7749999761581421},{"id":"https://openalex.org/keywords/zoonotic-transmission","display_name":"zoonotic transmission","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tropical-fish","display_name":"tropical fish","score":0.878000020980835},{"id":"https://openalex.org/keywords/iatrogenic-immunodeficiency","display_name":"iatrogenic immunodeficiency","score":0.847000002861023},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-cd38-monoclonal-antibody","display_name":"anti-CD38 monoclonal antibody","score":0.9440000057220459},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.7459999918937683},{"id":"https://openalex.org/keywords/environmental-history","display_name":"environmental history","score":0.46399998664855957},{"id":"https://openalex.org/keywords/meropenem-susceptibility","display_name":"meropenem susceptibility","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.963699996471405},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5103999972343445},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.43369999527931213},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4016999900341034},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C2992243407","wikidata":"https://www.wikidata.org/wiki/Q525512","display_name":"Disease transmission","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C3018527248","wikidata":"https://www.wikidata.org/wiki/Q182672","display_name":"Zoonotic disease","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2498999983072281},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.24619999527931213}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015047","descriptor_name":"Zoonoses","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D020609","descriptor_name":"Edwardsiella tarda","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2169/internalmedicine.6545-25","doi":"https://doi.org/10.2169/internalmedicine.6545-25","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.6545-25","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6545-25/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:41922229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41922229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.6545-25","doi":"https://doi.org/10.2169/internalmedicine.6545-25","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.6545-25","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6545-25/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7143469408.pdf","grobid_xml":"https://content.openalex.org/works/W7143469408.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1825860090","https://openalex.org/W1857774792","https://openalex.org/W2059611232","https://openalex.org/W2077407702","https://openalex.org/W2118596294","https://openalex.org/W2160088903","https://openalex.org/W2209605722","https://openalex.org/W2774461578","https://openalex.org/W2901666364","https://openalex.org/W2973121935","https://openalex.org/W3198450728","https://openalex.org/W4237659442","https://openalex.org/W4283164816","https://openalex.org/W4318025586","https://openalex.org/W4383217103","https://openalex.org/W4384263928","https://openalex.org/W4388832281","https://openalex.org/W4398142605"],"related_works":["https://openalex.org/W4405586496","https://openalex.org/W7128441824","https://openalex.org/W7204554015","https://openalex.org/W4384263928","https://openalex.org/W4416210881","https://openalex.org/W2015855774","https://openalex.org/W3214454933","https://openalex.org/W2118596294","https://openalex.org/W109044834","https://openalex.org/W3084071545"],"abstract_inverted_index":{"Edwardsiella":[0],"tarda":[1],"is":[2],"an":[3],"opportunistic":[4],"aquatic":[5],"pathogen":[6],"that":[7],"rarely":[8],"causes":[9],"human":[10],"bacteremia,":[11],"but":[12],"it":[13],"carries":[14],"high":[15],"mortality,":[16],"particularly":[17],"in":[18,106],"immunocompromised":[19,123],"hosts.":[20],"We":[21,94],"report":[22,66],"the":[23,48,57,68,76,88,111,126],"fatal":[24],"case":[25,109],"of":[26,63,91,103,128],"a":[27,96],"74-year-old":[28],"man":[29],"with":[30],"refractory":[31],"multiple":[32],"myeloma":[33],"and":[34,87,100,118],"profound":[35],"iatrogenic":[36],"immunodeficiency":[37],"who":[38],"developed":[39],"septic":[40],"shock":[41],"shortly":[42],"after":[43],"acquiring":[44],"tropical":[45],"fish.":[46],"Despite":[47],"isolate's":[49],"susceptibility":[50],"to":[51],"administered":[52],"broad-spectrum":[53],"antibiotics,":[54],"including":[55],"meropenem,":[56],"patient":[58],"died":[59],"within":[60],"72":[61],"hours":[62],"admission.":[64],"This":[65,108],"highlights":[67],"lethal":[69],"synergy":[70],"between":[71],"modern":[72],"anti-myeloma":[73],"therapies,":[74],"specifically":[75],"cumulative":[77],"immunosuppression":[78],"from":[79],"proteasome":[80],"inhibitors,":[81],"immunomodulatory":[82],"drugs,":[83],"anti-CD38":[84],"monoclonal":[85],"antibodies,":[86],"virulence":[89],"factors":[90],"E.":[92],"tarda.":[93],"provide":[95],"detailed":[97],"clinical":[98],"course":[99],"comparative":[101],"discussion":[102],"hematological":[104],"cases":[105],"Japan.":[107],"underscores":[110],"critical":[112],"need":[113],"for":[114,121],"thorough":[115],"environmental":[116],"history-taking":[117],"specific":[119],"counseling":[120],"profoundly":[122],"patients":[124],"regarding":[125],"risks":[127],"exotic":[129],"pet":[130],"ownership.":[131]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-03-31T00:00:00"}