{"id":"https://openalex.org/W7143405486","doi":"https://doi.org/10.3390/cimb48040360","title":"Novel lncRNA Signature (UFC1/PTENP1) as a Molecular Biomarker for the Diagnosis and Prognosis of Hepatocellular Carcinoma in an Egyptian Cohort","display_name":"Novel lncRNA Signature (UFC1/PTENP1) as a Molecular Biomarker for the Diagnosis and Prognosis of Hepatocellular Carcinoma in an Egyptian Cohort","publication_year":2026,"publication_date":"2026-03-29","ids":{"openalex":"https://openalex.org/W7143405486","doi":"https://doi.org/10.3390/cimb48040360","pmid":"https://pubmed.ncbi.nlm.nih.gov/42042020"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48040360","doi":"https://doi.org/10.3390/cimb48040360","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48040360","pdf_url":"https://www.mdpi.com/1467-3045/48/4/360/pdf?version=1774775640","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1467-3045/48/4/360/pdf?version=1774775640","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101657333","display_name":"Marwa N. M. Hassan","orcid":"https://orcid.org/0000-0001-9751-8129","observed_orcids":["https://orcid.org/0000-0001-9751-8129"]},"institutions":[{"id":"https://openalex.org/I92039331","display_name":"Theodor Bilharz Research Institute","ror":"https://ror.org/04d4dr544","country_code":"EG","type":"facility","lineage":["https://openalex.org/I92039331"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Marwa Hassan","raw_affiliation_strings":["Immunology Department, Theodor Bilharz Research Institute, Giza 12411, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-9751-8129","affiliations":[{"raw_affiliation_string":"Immunology Department, Theodor Bilharz Research Institute, Giza 12411, Egypt","institution_ids":["https://openalex.org/I92039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024258678","display_name":"Lobna Abdelsalam","orcid":"https://orcid.org/0009-0005-1785-359X","observed_orcids":["https://orcid.org/0009-0005-1785-359X"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Lobna Abdelsalam","raw_affiliation_strings":["Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054202496","display_name":"Amal Kotb Behery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amal Kotb Behery","raw_affiliation_strings":["Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092486374","display_name":"Rania Fathy Elnahas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rania Fathy Elnahas","raw_affiliation_strings":["Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt","institution_ids":["https://openalex.org/I84524832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101657333"],"corresponding_institution_ids":["https://openalex.org/I92039331"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":2.6283,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87319054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"48","issue":"4","first_page":"360","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ufc1","display_name":"UFC1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ptenp1","display_name":"PTENP1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.9390000104904175},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6340000033378601},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9879999756813049},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bclc-stage","display_name":"BCLC stage","score":0.796999990940094},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/egyptian-patients","display_name":"Egyptian patients","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.804099977016449},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6531000137329102},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5526000261306763},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5449000000953674},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5437999963760376},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.536899983882904},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5095000267028809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48339998722076416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47369998693466187},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.4625999927520752},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4602000117301941},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4383000135421753},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.40139999985694885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32010000944137573},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.31690001487731934},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314300000667572},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2736999988555908},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.26010000705718994},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.2590999901294708}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cimb48040360","doi":"https://doi.org/10.3390/cimb48040360","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48040360","pdf_url":"https://www.mdpi.com/1467-3045/48/4/360/pdf?version=1774775640","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmid:42042020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42042020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:57e180be56c5463087c2e99ce6938f47","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/57e180be56c5463087c2e99ce6938f47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 48, Iss 4, p 360 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13114740","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42042020/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Curr Issues Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cimb48040360","doi":"https://doi.org/10.3390/cimb48040360","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48040360","pdf_url":"https://www.mdpi.com/1467-3045/48/4/360/pdf?version=1774775640","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7444456815719604}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320326056","display_name":"Alexandria University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7143405486.pdf","grobid_xml":"https://content.openalex.org/works/W7143405486.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Long":[0],"non-coding":[1],"RNAs":[2],"(lncRNAs)":[3],"are":[4],"key":[5],"regulators":[6],"of":[7,19,38,59],"gene":[8],"expression":[9,119],"and":[10,26,35,44,68,71,127,150,168,197],"play":[11],"critical":[12],"roles":[13],"in":[14,53,64,86,182],"cancer-related":[15],"signaling":[16],"networks.":[17],"Dysregulation":[18],"antagonistic":[20,41,186],"lncRNAs":[21,61,101],"may":[22],"contribute":[23],"to":[24,107],"hepatocarcinogenesis":[25],"disease":[27,172],"progression.":[28],"This":[29,185],"study":[30],"investigated":[31],"the":[32,160],"clinical":[33,202],"significance":[34],"predictive":[36],"value":[37],"two":[39],"biologically":[40],"lncRNAs,":[42],"UFC1":[43,75,118,144],"PTENP1,":[45],"as":[46,145,152],"circulating":[47],"biomarkers":[48],"for":[49,156,194],"hepatocellular":[50],"carcinoma":[51],"(HCC)":[52],"an":[54,146],"Egyptian":[55],"cohort.":[56],"Expression":[57],"levels":[58,136],"these":[60],"were":[62],"quantified":[63],"100":[65,69],"HCC":[66,87,195],"patients":[67],"age-":[70],"sex-matched":[72],"healthy":[73],"controls.":[74],"was":[76,82,120],"significantly":[77],"upregulated":[78],"(~2.9-fold),":[79],"while":[80,134],"PTENP1":[81,135,151],"markedly":[83],"downregulated":[84],"(~4-fold)":[85],"patients,":[88],"with":[89,112,123,138,171],"a":[90,153,180,190],"strong":[91],"inverse":[92],"correlation":[93],"(r":[94],"=":[95],"\u22120.609,":[96],"p":[97],"<":[98],"0.001).":[99],"Both":[100],"demonstrated":[102],"higher":[103],"diagnostic":[104,166],"accuracy":[105,167],"compared":[106],"alpha-fetoprotein":[108],"(AFP);":[109],"combining":[110],"them":[111],"AFP":[113],"further":[114,201],"enhanced":[115],"overall":[116],"performance.":[117],"increased":[121],"progressively":[122],"advancing":[124],"fibrosis":[125],"grade":[126],"Barcelona":[128],"Clinic":[129],"Liver":[130],"Cancer":[131],"(BCLC)":[132],"stage,":[133],"diminished":[137],"BCLC":[139],"stage.":[140],"Logistic":[141],"regression":[142],"confirmed":[143],"independent":[147],"risk":[148,198],"factor":[149,155],"protective":[154],"HCC.":[157],"In":[158],"conclusion,":[159],"blood-based":[161],"UFC1/PTENP1":[162],"panel":[163],"exhibits":[164],"promising":[165],"is":[169],"associated":[170],"severity,":[173],"surpassing":[174],"AFP.":[175],"Their":[176],"fibrosis-associated":[177],"dysregulation":[178],"suggests":[179],"role":[181],"early":[183],"hepatocarcinogenesis.":[184],"lncRNA":[187],"signature":[188],"represents":[189],"potential,":[191],"non-invasive":[192],"tool":[193],"detection":[196],"stratification,":[199],"meriting":[200],"validation.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-03-31T00:00:00"}