{"id":"https://openalex.org/W7143405243","doi":"https://doi.org/10.1016/j.celrep.2026.117207","title":"A neuropeptide regulates cell non-autonomous protein homeostasis","display_name":"A neuropeptide regulates cell non-autonomous protein homeostasis","publication_year":2026,"publication_date":"2026-03-30","ids":{"openalex":"https://openalex.org/W7143405243","doi":"https://doi.org/10.1016/j.celrep.2026.117207","pmid":"https://pubmed.ncbi.nlm.nih.gov/41915471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13220339"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2026.117207","doi":"https://doi.org/10.1016/j.celrep.2026.117207","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117207","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2026.117207","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041406903","display_name":"Carrie A. Sheeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie A. Sheeler","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076087005","display_name":"Jacqueline Y. Lo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Y. Lo","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130950411","display_name":"Areebah Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Areebah Rahman","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031273454","display_name":"Saebom Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saebom Kwon","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116645659","display_name":"Daviana Menendez Escalera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daviana Menendez Escalera","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069182000","display_name":"Emmett Griffin\u2010Baldwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmett Griffin-Baldwin","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karmen Mah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karmen Mah","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093831525","display_name":"Adam Roszczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Roszczyk","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042756187","display_name":"Jennifer L. Garrison","orcid":"https://orcid.org/0000-0002-5621-2139","observed_orcids":["https://orcid.org/0000-0002-5621-2139"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Garrison","raw_affiliation_strings":["Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130976151","display_name":"Ashley E. Frakes","orcid":"https://orcid.org/0000-0001-8424-0770","observed_orcids":["https://orcid.org/0000-0001-8424-0770"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashley E. Frakes","raw_affiliation_strings":["Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA; National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA. Electronic address: ashley.frakes@nih.gov"],"raw_orcid":"https://orcid.org/0000-0001-8424-0770","affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA; National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA. Electronic address: ashley.frakes@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5130976151"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567","https://openalex.org/I4210110767"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"4","first_page":"117207","last_page":"117207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.8009999990463257},{"id":"https://openalex.org/keywords/non-cell-autonomous-signaling","display_name":"non-cell-autonomous signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.878000020980835},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glia","display_name":"glia","score":0.6859999895095825},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/xbp1","display_name":"XBP1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.996999979019165},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7077999711036682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6069999933242798},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5102999806404114},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5070000290870667},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.44859999418258667},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.3273000121116638},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2962000072002411},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.25679999589920044}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.celrep.2026.117207","doi":"https://doi.org/10.1016/j.celrep.2026.117207","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117207","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2025.03.14.643343","doi":"https://doi.org/10.1101/2025.03.14.643343","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.03.14.643343","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41030954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41030954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41915471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41915471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13220339","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13220339/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12478322","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12478322/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2026.117207","doi":"https://doi.org/10.1016/j.celrep.2026.117207","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117207","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1412877851","display_name":null,"funder_award_id":"1ZIADK075172","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000897496","display_name":"Cellular and Circuit Mechanisms of Neuropeptide Signaling","funder_award_id":"R35GM145305","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000908645","display_name":"Glial regulation of ER stress resistance","funder_award_id":"ZIADK075172","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000917930","display_name":"Training in Basic Research on Aging and Age-Related Disease","funder_award_id":"T32AG000266","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306710","display_name":"Glenn Foundation for Medical Research","ror":"https://ror.org/02ebg5q27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1500828543","https://openalex.org/W1549225872","https://openalex.org/W1973733030","https://openalex.org/W1973951644","https://openalex.org/W1977603207","https://openalex.org/W1986737010","https://openalex.org/W1989363180","https://openalex.org/W1995087873","https://openalex.org/W2011277283","https://openalex.org/W2035618305","https://openalex.org/W2037911961","https://openalex.org/W2053470799","https://openalex.org/W2081294646","https://openalex.org/W2096579700","https://openalex.org/W2097557113","https://openalex.org/W2108003717","https://openalex.org/W2113678374","https://openalex.org/W2116437559","https://openalex.org/W2119529730","https://openalex.org/W2120736516","https://openalex.org/W2120998017","https://openalex.org/W2127848114","https://openalex.org/W2149044504","https://openalex.org/W2160938187","https://openalex.org/W2167844024","https://openalex.org/W2179438025","https://openalex.org/W2271597607","https://openalex.org/W2334966793","https://openalex.org/W2519746060","https://openalex.org/W2626395293","https://openalex.org/W2735720719","https://openalex.org/W2782067321","https://openalex.org/W2788460818","https://openalex.org/W2789360440","https://openalex.org/W2810661545","https://openalex.org/W2896192438","https://openalex.org/W2897249806","https://openalex.org/W2900547968","https://openalex.org/W2916113491","https://openalex.org/W2949830473","https://openalex.org/W2950579159","https://openalex.org/W2953151710","https://openalex.org/W3001667810","https://openalex.org/W3010766518","https://openalex.org/W3081051806","https://openalex.org/W3088521497","https://openalex.org/W3109508248","https://openalex.org/W3134470764","https://openalex.org/W3164692211","https://openalex.org/W3175752499","https://openalex.org/W3180956051","https://openalex.org/W4245333275","https://openalex.org/W4311578575","https://openalex.org/W4360796864","https://openalex.org/W4361001954","https://openalex.org/W4385449623","https://openalex.org/W4386315668","https://openalex.org/W4392576416","https://openalex.org/W4393285709","https://openalex.org/W4393306739","https://openalex.org/W4403334336"],"related_works":["https://openalex.org/W4408495097","https://openalex.org/W3001667810","https://openalex.org/W2037911961","https://openalex.org/W4416593268","https://openalex.org/W3132973286","https://openalex.org/W3181713313","https://openalex.org/W4399173043","https://openalex.org/W3003020693","https://openalex.org/W7055289663","https://openalex.org/W3113059149"],"abstract_inverted_index":{"The":[0],"coordination":[1],"of":[2,17,36,60,80],"proteostasis":[3,28],"between":[4],"the":[5,13,32,37,44,81,94],"brain":[6],"and":[7,15,29,84,102,108,141],"peripheral":[8],"tissues":[9],"is":[10,70,121],"essential":[11],"for":[12,112,123],"health":[14],"survival":[16],"all":[18],"animals.":[19],"In":[20],"C":[21],".":[22],"elegans":[23],",":[24],"glia":[25],"coordinate":[26,155],"organismal":[27,124,156],"longevity":[30],"via":[31],"unfolded":[33],"protein":[34],"response":[35],"endoplasmic":[38],"reticulum":[39],"(UPR":[40],"ER":[41,56,83,88,101,116,125,139],").":[42],"However,":[43],"signaling":[45],"molecules":[46],"required":[47,111],"remain":[48],"unknown.":[49],"Here,":[50],"we":[51],"show":[52],"that":[53,69,148],"glial":[54,137],"UPR":[55,82,100,115,138],"activation":[57,79,140],"increases":[58],"levels":[59],"specific":[61],"neuropeptides.":[62],"We":[63],"identify":[64],"a":[65,131,145],"single":[66],"neuropeptide,":[67],"FLP-17,":[68],"sufficient":[71],"but":[72],"not":[73],"necessary":[74,122],"to":[75,97,154],"induce":[76],"cell":[77],"non-autonomous":[78],"protect":[85],"against":[86],"chronic":[87],"stress.":[89],"FLP-17":[90,143],"signals":[91],"partially":[92],"through":[93],"receptor,":[95],"EGL-6,":[96],"activate":[98],"transcellular":[99],"confer":[103],"stress":[104,126],"resistance.":[105,127],"Both":[106],"XBP-1":[107,120],"PERK":[109],"are":[110],"maximal":[113],"FLP-17-induced":[114],"activation,":[117],"though":[118],"only":[119],"This":[128],"work":[129],"reveals":[130],"complex":[132],"neuropeptide":[133],"network":[134],"initiated":[135],"by":[136],"identifies":[142],"as":[144],"critical":[146],"mediator":[147],"coopts":[149],"an":[150],"existing":[151],"sensory-metabolic":[152],"circuit":[153],"proteostasis.":[157]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-03-31T00:00:00"}
