{"id":"https://openalex.org/W7143322012","doi":"https://doi.org/10.1038/s41593-026-02226-y","title":"UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration","display_name":"UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration","publication_year":2026,"publication_date":"2026-03-30","ids":{"openalex":"https://openalex.org/W7143322012","doi":"https://doi.org/10.1038/s41593-026-02226-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41912662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13058728"},"language":"en","primary_location":{"id":"doi:10.1038/s41593-026-02226-y","doi":"https://doi.org/10.1038/s41593-026-02226-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41593-026-02226-y","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/s41593-026-02226-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100355651","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0001-5892-7448","observed_orcids":["https://orcid.org/0000-0001-5892-7448"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. yliu238@jh.edu","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. yliu238@jh.edu"],"raw_orcid":"https://orcid.org/0000-0001-5892-7448","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. yliu238@jh.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. yliu238@jh.edu","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040198957","display_name":"Zhiyuan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132652762","display_name":"yu-wen hsu","orcid":"https://orcid.org/0000-0002-6126-8938","observed_orcids":["https://orcid.org/0000-0002-6126-8938"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Wen Hsu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-6126-8938","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085674779","display_name":"Pragney Deme","orcid":"https://orcid.org/0000-0001-9117-891X","observed_orcids":["https://orcid.org/0000-0001-9117-891X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pragney Deme","raw_affiliation_strings":["Department of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009798873","display_name":"Ashley M. Frankenfield","orcid":"https://orcid.org/0000-0001-9311-4194","observed_orcids":["https://orcid.org/0000-0001-9311-4194"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley M. Frankenfield","raw_affiliation_strings":["Department of Chemistry, George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102694003","display_name":"Suheng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suheng Wu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709184","display_name":"Xinyu Zhao","orcid":"https://orcid.org/0000-0002-5128-4424","observed_orcids":["https://orcid.org/0000-0002-5128-4424","https://orcid.org/0009-0001-5187-7713"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Zhao","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121097196","display_name":"Honghe Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Honghe Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130957337","display_name":"Tao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047047565","display_name":"Elizabeth J. Alexander","orcid":"https://orcid.org/0000-0003-3370-5106","observed_orcids":["https://orcid.org/0000-0003-3370-5106"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Alexander","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130954668","display_name":"Mingming Liu","orcid":"https://orcid.org/0000-0003-2614-3678","observed_orcids":["https://orcid.org/0000-0003-2614-3678"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingming Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0000-0003-2614-3678","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130998233","display_name":"Yanjun Zhang","orcid":"https://orcid.org/0009-0002-8531-6604","observed_orcids":["https://orcid.org/0009-0002-8531-6604"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanjun Zhang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":"https://orcid.org/0009-0002-8531-6604","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068091000","display_name":"Haocheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haocheng Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130998761","display_name":"Yixin Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixin Zhou","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010464152","display_name":"Mervyn J. Monteiro","orcid":"https://orcid.org/0000-0002-1740-5309","observed_orcids":["https://orcid.org/0000-0002-1740-5309"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mervyn J. Monteiro","raw_affiliation_strings":["Department of Neurobiology, University of Maryland, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Maryland, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028595660","display_name":"Ling Hao","orcid":"https://orcid.org/0000-0002-0106-5266","observed_orcids":["https://orcid.org/0000-0002-0106-5266"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Hao","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of Maryland, College Park, MD, USA","Department of Chemistry, George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry, George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022491794","display_name":"Norman J. Haughey","orcid":"https://orcid.org/0000-0001-5194-4122","observed_orcids":["https://orcid.org/0000-0001-5194-4122"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman J. Haughey","raw_affiliation_strings":["Department of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130935880","display_name":"Jiou Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiou Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. jiouw@jhmi.edu","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. jiouw@jhmi.edu"],"raw_orcid":"https://orcid.org/0000-0003-0204-8932","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. jiouw@jhmi.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. jiouw@jhmi.edu","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100355651","https://openalex.org/A5130935880"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":{"value":12690,"currency":"USD","value_usd":12690},"fwci":12.1777,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.98294992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"29","issue":"4","first_page":"782","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubqln2","display_name":"UBQLN2","score":0.9470000267028809},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.953000009059906},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":1.0},{"id":"https://openalex.org/keywords/proteotoxicity","display_name":"proteotoxicity","score":0.722000002861023},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7540000081062317},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.746999979019165},{"id":"https://openalex.org/keywords/aldh3a2","display_name":"ALDH3A2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.953000009059906},{"id":"https://openalex.org/keywords/tdp-43-pathology","display_name":"TDP-43 pathology","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8230000138282776},{"id":"https://openalex.org/keywords/metabolic-homeostasis","display_name":"metabolic homeostasis","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7986000180244446},{"id":"https://openalex.org/C2776104650","wikidata":"https://www.wikidata.org/wiki/Q2113512","display_name":"Proteotoxicity","level":3,"score":0.7716000080108643},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.6861000061035156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6406000256538391},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6384000182151794},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.5218999981880188},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5081999897956848},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5055000185966492},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5044999718666077},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.5005999803543091},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4530999958515167},{"id":"https://openalex.org/C132647116","wikidata":"https://www.wikidata.org/wiki/Q18032677","display_name":"TFEB","level":4,"score":0.4422999918460846},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.43869999051094055},{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.39579999446868896},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C2776667301","wikidata":"https://www.wikidata.org/wiki/Q18027324","display_name":"HSF1","level":5,"score":0.350600004196167},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.3481999933719635},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.337799996137619},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.32839998602867126},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.320499986410141},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.30649998784065247},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.25999999046325684},{"id":"https://openalex.org/C193469717","wikidata":"https://www.wikidata.org/wiki/Q6556349","display_name":"Lipid-anchored protein","level":4,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000094403","descriptor_name":"Proteotoxic Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41593-026-02226-y","doi":"https://doi.org/10.1038/s41593-026-02226-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41593-026-02226-y","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13058728","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13058728/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13058728/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Neurosci","raw_type":"Text"},{"id":"pmid:41912662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41912662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41593-026-02226-y","doi":"https://doi.org/10.1038/s41593-026-02226-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41593-026-02226-y","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4042798606","display_name":null,"funder_award_id":"NS098243","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5886767901","display_name":"Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations","funder_award_id":"RF1NS098243","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8655826865","display_name":null,"funder_award_id":"FS-2023-SBF-S6","funder_id":"https://openalex.org/F4320313994","funder_display_name":"Target ALS"},{"id":"https://openalex.org/G9000310707","display_name":null,"funder_award_id":"NS098243","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000861969","display_name":"Molecular Basis of Pathogenic Cascades in ALS/FTD Initiated from C9orf72 Hexanucleotide Repeat Expansion","funder_award_id":"R01NS128494","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000871453","display_name":"Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations","funder_award_id":"R01NS098243","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000889735","display_name":"Mechanisms of Novel Regulators of Proteotoxicity and Quality Control Associated with ALS/FTD","funder_award_id":"R01NS074324","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000892671","display_name":"Investigating the Novel Disease Pathways Associated with C9orf72-Linked ALS/FTD","funder_award_id":"R01NS089616","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000914963","display_name":"Investigating Dysregulation of Stress-related Ribonucleoprotein Granules and Functions of Associated RNA-binding Proteins in ALS/FTD","funder_award_id":"R01NS110098","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320313540","display_name":"Maryland Stem Cell Research Fund","ror":"https://ror.org/02wpjhe84"},{"id":"https://openalex.org/F4320313994","display_name":"Target ALS","ror":"https://ror.org/03fsqvg68"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7143322012.pdf","grobid_xml":"https://content.openalex.org/works/W7143322012.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W842010963","https://openalex.org/W1552569483","https://openalex.org/W1970541648","https://openalex.org/W1972038271","https://openalex.org/W1990559406","https://openalex.org/W2003618511","https://openalex.org/W2011464962","https://openalex.org/W2024130717","https://openalex.org/W2035310767","https://openalex.org/W2038811384","https://openalex.org/W2039456249","https://openalex.org/W2066828509","https://openalex.org/W2072981065","https://openalex.org/W2091657096","https://openalex.org/W2092124807","https://openalex.org/W2092574253","https://openalex.org/W2120469195","https://openalex.org/W2135258480","https://openalex.org/W2136057227","https://openalex.org/W2146512944","https://openalex.org/W2147925453","https://openalex.org/W2152311269","https://openalex.org/W2166058312","https://openalex.org/W2179438025","https://openalex.org/W2312266417","https://openalex.org/W2472573833","https://openalex.org/W2497525607","https://openalex.org/W2556530889","https://openalex.org/W2593303051","https://openalex.org/W2595462418","https://openalex.org/W2708579841","https://openalex.org/W2729569907","https://openalex.org/W2791730664","https://openalex.org/W2792402131","https://openalex.org/W2804378570","https://openalex.org/W2898394985","https://openalex.org/W2900415591","https://openalex.org/W2901765635","https://openalex.org/W2903107073","https://openalex.org/W2904130550","https://openalex.org/W2911590944","https://openalex.org/W2942673887","https://openalex.org/W2949093830","https://openalex.org/W2950985821","https://openalex.org/W2959318704","https://openalex.org/W3011287221","https://openalex.org/W3013373046","https://openalex.org/W3042745311","https://openalex.org/W3044114834","https://openalex.org/W3044822917","https://openalex.org/W3082601255","https://openalex.org/W3118679892","https://openalex.org/W3128445377","https://openalex.org/W3128662823","https://openalex.org/W3137036813","https://openalex.org/W3152881530","https://openalex.org/W3158503114","https://openalex.org/W3163212147","https://openalex.org/W3185470167","https://openalex.org/W3195683533","https://openalex.org/W3212730460","https://openalex.org/W4200192644","https://openalex.org/W4200415658","https://openalex.org/W4210998205","https://openalex.org/W4284882692","https://openalex.org/W4296896693","https://openalex.org/W4307715807","https://openalex.org/W4360600527","https://openalex.org/W4364352078","https://openalex.org/W4372402148","https://openalex.org/W4388725626","https://openalex.org/W4392613039","https://openalex.org/W4399514147","https://openalex.org/W4402060970","https://openalex.org/W4404242014","https://openalex.org/W4409986287","https://openalex.org/W4416573118","https://openalex.org/W7127624013"],"related_works":["https://openalex.org/W4412440364","https://openalex.org/W4283749991","https://openalex.org/W2959318704","https://openalex.org/W6894140482","https://openalex.org/W2289625033","https://openalex.org/W2044697469","https://openalex.org/W4385329986","https://openalex.org/W4205916485","https://openalex.org/W2340319549","https://openalex.org/W2011464962"],"abstract_inverted_index":{"Protein":[0],"homeostasis":[1,150],"and":[2,25,67,85,104,110,122,128,140,153],"lipid":[3,65,98,102],"metabolism":[4],"are":[5],"essential":[6,95],"processes":[7],"frequently":[8],"disrupted":[9],"in":[10,17,137,151],"neurodegenerative":[11,135,156],"diseases.":[12,157],"However,":[13],"their":[14],"mechanistic":[15],"intersection":[16],"disorders":[18],"such":[19],"as":[20,60,144],"amyotrophic":[21],"lateral":[22],"sclerosis":[23],"(ALS)":[24],"frontotemporal":[26],"dementia":[27],"(FTD)":[28],"remains":[29],"unclear.":[30],"Ubiquilin":[31],"2":[32],"(UBQLN2)":[33],"is":[34],"a":[35,61,145],"protein":[36,113],"quality":[37],"control":[38],"factor":[39],"linked":[40],"to":[41,74,125],"ALS/FTD.":[42],"Through":[43],"multi-omic":[44],"analyses":[45],"of":[46,71,80,120,148],"induced":[47],"pluripotent":[48],"stem":[49],"cell":[50],"(iPSC)-derived":[51],"neurons":[52],"harboring":[53],"disease-associated":[54],"UBQLN2":[55,59,76,108,143],"mutations,":[56],"we":[57],"uncovered":[58],"molecular":[62],"hub":[63],"linking":[64],"dysregulation":[66],"proteostasis,":[68],"the":[69,78,118,131],"perturbation":[70],"which":[72],"contributes":[73],"neurodegeneration.":[75,129],"mediated":[77],"degradation":[79,119],"ILVBL":[81,121],"(acetolactate":[82],"synthase-like":[83],"protein)":[84],"ALDH3A2":[86],"(aldehyde":[87],"dehydrogenase":[88],"3":[89],"family":[90],"member":[91],"A2),":[92],"two":[93],"enzymes":[94],"for":[96],"mitochondrial":[97],"catabolism":[99],"associated":[100],"with":[101],"droplets":[103],"neuronal":[105],"viability.":[106],"ALS/FTD-linked":[107],"mutations":[109],"TAR":[111],"DNA-binding":[112],"43":[114],"(TDP-43)":[115],"pathology":[116],"impair":[117],"ALDH3A2,":[123],"leading":[124],"metabolic":[126,149],"dysfunction":[127],"Restoring":[130],"UBQLN2-ILVBL/ALDH3A2":[132],"axis":[133],"attenuates":[134],"phenotypes":[136],"neurons,":[138],"organoids":[139],"mice,":[141],"establishing":[142],"critical":[146],"regulator":[147],"ALS/FTD":[152],"other":[154],"related":[155]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-03-31T00:00:00"}
