{"id":"https://openalex.org/W7143300549","doi":"https://doi.org/10.66201/ss.v1.14","title":"El efecto de las terapias biol\u00f3gicas sobre el remodelado de la v\u00eda a\u00e9rea en el asma grave: Una revisi\u00f3n integrativa de la evidencia disponible","display_name":"El efecto de las terapias biol\u00f3gicas sobre el remodelado de la v\u00eda a\u00e9rea en el asma grave: Una revisi\u00f3n integrativa de la evidencia disponible","publication_year":2026,"publication_date":"2026-03-30","ids":{"openalex":"https://openalex.org/W7143300549","doi":"https://doi.org/10.66201/ss.v1.14"},"language":"es","primary_location":{"id":"doi:10.66201/ss.v1.14","doi":"https://doi.org/10.66201/ss.v1.14","is_oa":true,"landing_page_url":"https://doi.org/10.66201/ss.v1.14","pdf_url":"https://scriptascientia.com/sasc/article/download/14/31","source":{"id":"https://openalex.org/S7407054075","display_name":"Scripta Scientia","issn_l":"3134-5824","issn":["3134-5824"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scripta Scientia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://scriptascientia.com/sasc/article/download/14/31","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146083801","display_name":"Francine Aquino de Carvalho Almeida","orcid":"https://orcid.org/0009-0000-6592-0391","observed_orcids":["https://orcid.org/0009-0000-6592-0391"]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Francine Aquino De Carvalho Almeida","raw_affiliation_strings":["Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0000-6592-0391","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146157551","display_name":"Breno Alexandre Rocha Oliveira","orcid":"https://orcid.org/0009-0007-4758-5340","observed_orcids":["https://orcid.org/0009-0007-4758-5340"]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Breno Alexandre Rocha Oliveira","raw_affiliation_strings":["Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0007-4758-5340","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131001848","display_name":"Felipe Bonfim","orcid":"https://orcid.org/0009-0007-4729-7197","observed_orcids":["https://orcid.org/0009-0007-4729-7197"]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Felipe Bonfim","raw_affiliation_strings":["Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0007-4729-7197","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130978844","display_name":"Noemi Siqueira Sim\u00e3o","orcid":"https://orcid.org/0009-0002-4378-2148","observed_orcids":["https://orcid.org/0009-0002-4378-2148"]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Noemi Siqueira Sim\u00e3o","raw_affiliation_strings":["Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0002-4378-2148","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130988370","display_name":"Ot\u00e1vio Gabriel De Souza T\u00f4rres","orcid":"https://orcid.org/0009-0006-2297-5708","observed_orcids":["https://orcid.org/0009-0006-2297-5708"]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Ot\u00e1vio Gabriel De Souza T\u00f4rres","raw_affiliation_strings":["Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0006-2297-5708","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130942576","display_name":"Pedro Arthur Costa Gois","orcid":"https://orcid.org/0009-0008-8800-3519","observed_orcids":["https://orcid.org/0009-0008-8800-3519"]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Pedro Arthur Costa Gois","raw_affiliation_strings":["Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0008-8800-3519","affiliations":[{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093233765","display_name":"Andrea Paola Britos Gomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259934","display_name":"Universidad Privada del Este filial Ciudad del Este","ror":"https://ror.org/02yjf0052","country_code":"PY","type":"education","lineage":["https://openalex.org/I4210157743","https://openalex.org/I4405259934"]},{"id":"https://openalex.org/I4405286419","display_name":"ChauxLab Institute (Paraguay)","ror":"https://ror.org/0235cd723","country_code":"PY","type":"company","lineage":["https://openalex.org/I4405286419"]}],"countries":["PY"],"is_corresponding":false,"raw_author_name":"Paola Britos","raw_affiliation_strings":["ChauxLab Institute (Paraguay)","Universidad Privada del Este filial Ciudad del Este"],"raw_orcid":"https://orcid.org/0009-0000-8655-9881","affiliations":[{"raw_affiliation_string":"ChauxLab Institute (Paraguay)","institution_ids":["https://openalex.org/I4405286419"]},{"raw_affiliation_string":"Universidad Privada del Este filial Ciudad del Este","institution_ids":["https://openalex.org/I4405259934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":"e14","last_page":"e14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/anti-ige-therapy","display_name":"anti-IgE therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anti-il-5-therapy","display_name":"anti-IL-5 therapy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/anti-il-4ralpha-therapy","display_name":"anti-IL-4R\u03b1 therapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/anti-tslp-therapy","display_name":"anti-TSLP therapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mepolizumab","display_name":"mepolizumab","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tezepelumab","display_name":"tezepelumab","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dupilumab","display_name":"dupilumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subepithelial-fibrosis","display_name":"subepithelial fibrosis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/type-2-inflammation","display_name":"type 2 inflammation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/endobronchial-biopsy","display_name":"bronchial biopsy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cetyltrimethylammonium-chloride","display_name":"cetyltrimethylammonium chloride","score":0.3070000112056732},{"id":"https://openalex.org/keywords/endobronchial-ultrasound","display_name":"endobronchial ultrasound","score":0.824999988079071},{"id":"https://openalex.org/keywords/mucous-plugging","display_name":"mucous plugging","score":0.6499999761581421},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/steroid-resistance","display_name":"steroid resistance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/fixed-airflow-obstruction","display_name":"fixed airflow obstruction","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6485000252723694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5465999841690063},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.17000000178813934},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.15209999680519104},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.1445000022649765},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.13779999315738678},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.12860000133514404},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.11490000039339066},{"id":"https://openalex.org/C3019832315","wikidata":"https://www.wikidata.org/wiki/Q5532355","display_name":"General interest","level":3,"score":0.11270000040531158},{"id":"https://openalex.org/C105289051","wikidata":"https://www.wikidata.org/wiki/Q1930094","display_name":"Pillar","level":2,"score":0.10509999841451645}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.66201/ss.v1.14","doi":"https://doi.org/10.66201/ss.v1.14","is_oa":true,"landing_page_url":"https://doi.org/10.66201/ss.v1.14","pdf_url":"https://scriptascientia.com/sasc/article/download/14/31","source":{"id":"https://openalex.org/S7407054075","display_name":"Scripta Scientia","issn_l":"3134-5824","issn":["3134-5824"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scripta Scientia","raw_type":"journal-article"},{"id":"pmh:oai:dialnet.unirioja.es:ART0001850919","doi":null,"is_oa":true,"landing_page_url":"https://dialnet.unirioja.es/servlet/oaiart?codigo=10772258","pdf_url":"https://dialnet.unirioja.es/descarga/articulo/10772258.pdf","source":{"id":"https://openalex.org/S4306401293","display_name":"Dialnet (Universidad de la Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scripta Scientia, ISSN 3134-5824, Vol. 1, N\u00ba. 1, 2026","raw_type":"text (article)"}],"best_oa_location":{"id":"doi:10.66201/ss.v1.14","doi":"https://doi.org/10.66201/ss.v1.14","is_oa":true,"landing_page_url":"https://doi.org/10.66201/ss.v1.14","pdf_url":"https://scriptascientia.com/sasc/article/download/14/31","source":{"id":"https://openalex.org/S7407054075","display_name":"Scripta Scientia","issn_l":"3134-5824","issn":["3134-5824"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scripta Scientia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7143300549.pdf","grobid_xml":"https://content.openalex.org/works/W7143300549.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2113373290","https://openalex.org/W2970684805","https://openalex.org/W3026239379","https://openalex.org/W3118615836","https://openalex.org/W3129394104","https://openalex.org/W3163970761","https://openalex.org/W3171850684","https://openalex.org/W3180672846","https://openalex.org/W4213038030","https://openalex.org/W4291020200","https://openalex.org/W4293070794","https://openalex.org/W4309717859","https://openalex.org/W4317387856","https://openalex.org/W4383998996","https://openalex.org/W4386887147","https://openalex.org/W4388446641","https://openalex.org/W4388941629","https://openalex.org/W4392711465","https://openalex.org/W4394751597","https://openalex.org/W4400112069","https://openalex.org/W4403096570","https://openalex.org/W4404206961","https://openalex.org/W4405510084","https://openalex.org/W4407307605","https://openalex.org/W4407779582","https://openalex.org/W4409466467","https://openalex.org/W4411296241","https://openalex.org/W4413120934","https://openalex.org/W4415850241"],"related_works":["https://openalex.org/W7029241812","https://openalex.org/W7128674645","https://openalex.org/W7169928983","https://openalex.org/W3018788897","https://openalex.org/W4399322068","https://openalex.org/W7083220909","https://openalex.org/W3164796590","https://openalex.org/W7047146495","https://openalex.org/W1483082449","https://openalex.org/W4403837246"],"abstract_inverted_index":{"Antecedentes:":[0],"El":[1,63,264],"asma":[2,112],"grave":[3,113],"se":[4,211,270],"caracteriza":[5],"por":[6,122,229],"el":[7,53,142,173,201,207,249,259],"remodelado":[8,54,119,257],"de":[9,86,95,104,118,127,153,163,175,187,203,219,237,262,267,276],"la":[10,46,57,67,87,151,154,176,180,204,214,217,225,235,238,245,254,274],"v\u00eda":[11],"a\u00e9rea,":[12],"que":[13,114,234],"incluye":[14],"alteraciones":[15],"estructurales":[16],"persistentes":[17],"como":[18],"fibrosis":[19,226,246],"subepitelial":[20],"(MBR)":[21],"e":[22,79],"hiperplasia":[23],"del":[24,182,256],"m\u00fasculo":[25],"liso":[26],"bronquial":[27],"(MLB).":[28],"Estos":[29],"cambios":[30,171],"provocan":[31],"obstrucci\u00f3n":[32],"fija":[33,227],"y":[34,72,157,206,258],"resistencia":[35],"a":[36,253,273],"corticosteroides.":[37],"Las":[38],"terapias":[39],"biol\u00f3gicas":[40],"(anti-IgE,":[41],"anti-IL-5,":[42],"anti-IL-4R\u03b1,":[43],"anti-TSLP)":[44],"controlan":[45],"inflamaci\u00f3n,":[47],"pero":[48],"su":[49],"capacidad":[50],"para":[51,141,243],"revertir":[52,244],"establecido":[55],"es":[56,241],"principal":[58],"pregunta":[59],"cl\u00ednica":[60],"sin":[61],"resolver.":[62],"objetivo":[64],"fue":[65],"sintetizar":[66],"evidencia":[68,232],"sobre":[69],"este":[70],"efecto":[71],"evaluar":[73],"las":[74],"discrepancias":[75],"entre":[76,150],"hallazgos":[77],"histol\u00f3gicos":[78],"imagenol\u00f3gicos.M\u00e9todos:":[80],"Se":[81,106,131,145],"ejecut\u00f3":[82],"una":[83,147],"revisi\u00f3n":[84],"integrativa":[85],"literatura":[88],"con":[89,111],"b\u00fasqueda":[90],"sistem\u00e1tica":[91],"en":[92,109,172,179,200,248],"cuatro":[93],"bases":[94],"datos":[96],"primarias":[97],"(PubMed,":[98],"Scopus,":[99],"Embase,":[100],"CENTRAL),":[101],"hasta":[102],"marzo":[103],"2026.":[105],"incluyeron":[107],"estudios":[108,193],"adultos":[110],"reportaron":[115,197],"desenlaces":[116],"cuantificados":[117],"estructural":[120,266],"medido":[121],"biopsia":[123],"endobronquial":[124],"o":[125],"t\u00e9cnicas":[126],"imagen":[128],"(TCAR,":[129],"EBUS).":[130],"seleccionaron":[132],"23":[133],"estudios,":[134],"incluyendo":[135],"cinco":[136],"ensayos":[137],"cl\u00ednicos":[138],"aleatorizados":[139],"(ECA),":[140],"an\u00e1lisis":[143],"cualitativo.Resultados:":[144],"identific\u00f3":[146],"disociaci\u00f3n":[148],"consistente":[149],"supresi\u00f3n":[152,188,236],"inflamaci\u00f3n":[155,239],"T2":[156,240],"los":[158,268],"efectos":[159],"histol\u00f3gicos.":[160],"Los":[161],"ECA":[162],"alto":[164],"rigor":[165],"metodol\u00f3gico":[166],"(mepolizumab-BOBCAT,":[167],"tezepelumab-CASCADE)":[168],"no":[169,224],"mostraron":[170],"grosor":[174,202],"MBR":[177],"ni":[178],"masa":[181],"MLB":[183],"tras":[184],"12":[185],"meses":[186],"eosinof\u00edlica":[189],"profunda.":[190],"Sin":[191],"embargo,":[192],"imagenol\u00f3gicos":[194],"(dupilumab,":[195],"tezepelumab)":[196],"reducciones":[198],"significativas":[199],"pared":[205],"taponamiento":[208],"mucoso.":[209],"Esto":[210],"explica":[212],"porque":[213],"TCAR":[215],"detecta":[216],"resoluci\u00f3n":[218],"componentes":[220,277],"l\u00e1biles":[221],"(moco,":[222],"edema),":[223],"medida":[228],"biopsia.Conclusiones:":[230],"La":[231],"sugiere":[233],"insuficiente":[242],"establecida":[247],"corto":[250],"plazo,":[251],"debido":[252],"autonom\u00eda":[255],"lento":[260],"recambio":[261],"col\u00e1geno.":[263],"beneficio":[265],"biol\u00f3gicos":[269],"asocia":[271],"principalmente":[272],"modulaci\u00f3n":[275],"l\u00e1biles.":[278]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-03-31T00:00:00"}
