{"id":"https://openalex.org/W7141762012","doi":"https://doi.org/10.1021/acs.joc.5c03005","title":"Synthesis and Anion Recognition by a 1,8-Disulfonamidocarbazole\u2013Isophthalamide Hybrid Macrocycle and Its Thioamide Analogue Containing ortho -Substituted Benzyl Spacers","display_name":"Synthesis and Anion Recognition by a 1,8-Disulfonamidocarbazole\u2013Isophthalamide Hybrid Macrocycle and Its Thioamide Analogue Containing ortho -Substituted Benzyl Spacers","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141762012","doi":"https://doi.org/10.1021/acs.joc.5c03005","pmid":"https://pubmed.ncbi.nlm.nih.gov/41889334"},"language":"en","primary_location":{"id":"doi:10.1021/acs.joc.5c03005","doi":"https://doi.org/10.1021/acs.joc.5c03005","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.joc.5c03005","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324712","display_name":"Shan Li","orcid":"https://orcid.org/0000-0002-6353-0231","observed_orcids":["https://orcid.org/0000-0002-6353-0231"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sha Li","raw_affiliation_strings":["Guizhou University","State Key Laboratory of Green Pesticide, Center for Research and Development of Fine Chemicals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou University","institution_ids":["https://openalex.org/I178232147"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Center for Research and Development of Fine Chemicals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128059054","display_name":"Tingting Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Zhou","raw_affiliation_strings":["College of Pharmacy","Guizhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Guizhou University","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["College of Pharmacy","Guizhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Guizhou University","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenan Yang","raw_affiliation_strings":["College of Pharmacy","Guizhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Guizhou University","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026959535","display_name":"N. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ningjin Zhang","raw_affiliation_strings":["East China Normal University","School of Ecological and Environmental Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China Normal University","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"School of Ecological and Environmental Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055534103","display_name":"Xiaoping Bao","orcid":"https://orcid.org/0000-0001-5306-8525","observed_orcids":["https://orcid.org/0000-0001-5306-8525"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoping Bao","raw_affiliation_strings":["College of Pharmacy","Guizhou University","State Key Laboratory of Green Pesticide, Center for Research and Development of Fine Chemicals"],"raw_orcid":"https://orcid.org/0000-0001-5306-8525","affiliations":[{"raw_affiliation_string":"College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Guizhou University","institution_ids":["https://openalex.org/I178232147"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Center for Research and Development of Fine Chemicals","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026959535","https://openalex.org/A5055534103"],"corresponding_institution_ids":["https://openalex.org/I178232147","https://openalex.org/I66867065"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13597358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"91","issue":"14","first_page":"4936","last_page":"4944"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.42989999055862427,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anion-recognition","display_name":"anion recognition","score":0.7670000195503235},{"id":"https://openalex.org/keywords/macrocyclic-receptors","display_name":"macrocyclic receptors","score":0.796999990940094},{"id":"https://openalex.org/keywords/isophthalamide","display_name":"isophthalamide","score":0.9779999852180481},{"id":"https://openalex.org/keywords/thioamides","display_name":"thioamides","score":0.7110000252723694},{"id":"https://openalex.org/keywords/amides","display_name":"amides","score":0.6119999885559082},{"id":"https://openalex.org/keywords/anion-affinity","display_name":"anion affinity","score":0.5820000171661377},{"id":"https://openalex.org/keywords/anion-selectivity","display_name":"anion selectivity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phosphate","display_name":"phosphate","score":0.46000000834465027},{"id":"https://openalex.org/keywords/chloride","display_name":"chloride","score":0.8199999928474426},{"id":"https://openalex.org/keywords/host-guest-complexes","display_name":"host-guest complexes","score":0.5960000157356262},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2777650178","wikidata":"https://www.wikidata.org/wiki/Q419481","display_name":"Thioamide","level":2,"score":0.8988999724388123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8633999824523926},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.641700029373169},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.59170001745224},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5586000084877014},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.501800000667572},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4912000000476837},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.4388999938964844},{"id":"https://openalex.org/C96765332","wikidata":"https://www.wikidata.org/wiki/Q838084","display_name":"SN2 reaction","level":2,"score":0.35740000009536743},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3330000042915344},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32280001044273376},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3172999918460846},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.27630001306533813},{"id":"https://openalex.org/C107814960","wikidata":"https://www.wikidata.org/wiki/Q611957","display_name":"Solid-state","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C2778448320","wikidata":"https://www.wikidata.org/wiki/Q408395","display_name":"Sulfoxide","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.2567000091075897}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.joc.5c03005","doi":"https://doi.org/10.1021/acs.joc.5c03005","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.joc.5c03005","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:41889334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41889334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8140237453","display_name":"\u65b0\u578b\u73af\u72b6\u9634\u79bb\u5b50\u53d7\u4f53\u7684\u5408\u6210\u53ca\u8bc6\u522b\u4f20\u611f\u6027\u8d28\u7814\u7a76","funder_award_id":"21161005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1970498303","https://openalex.org/W1971956699","https://openalex.org/W1987232462","https://openalex.org/W2019320960","https://openalex.org/W2072141057","https://openalex.org/W2091670619","https://openalex.org/W2120894192","https://openalex.org/W2155469866","https://openalex.org/W2661755230","https://openalex.org/W2787176663","https://openalex.org/W2897257353","https://openalex.org/W2903862825","https://openalex.org/W2991231833","https://openalex.org/W3000220411","https://openalex.org/W3134499192","https://openalex.org/W3134703489","https://openalex.org/W3159502020","https://openalex.org/W3175322998","https://openalex.org/W3178915231","https://openalex.org/W4224992937","https://openalex.org/W4311418814","https://openalex.org/W4317932135","https://openalex.org/W4366463841","https://openalex.org/W4381469403","https://openalex.org/W4386636817","https://openalex.org/W4387134713","https://openalex.org/W4387475792","https://openalex.org/W4387563105","https://openalex.org/W4388730991","https://openalex.org/W4389685483","https://openalex.org/W4392956828","https://openalex.org/W4399439548","https://openalex.org/W4402745303","https://openalex.org/W4404948523","https://openalex.org/W4408562679","https://openalex.org/W4409385369","https://openalex.org/W4410215558","https://openalex.org/W4414320331","https://openalex.org/W7077074058"],"related_works":[],"abstract_inverted_index":{"Novel":[0],"1,8-disulfonamidocarbazole\u2013isophthalamide":[1],"hybrid":[2],"macrocycle":[3,61,88,133,139],"1":[4,26,89,134],"and":[5,29,39,49,66,75,138],"its":[6,70],"thioamide":[7],"analogue":[8],"2":[9,62,77,140],"containing":[10],"ortho":[11],"-substituted":[12],"benzyl":[13],"spacers":[14],"are":[15],"reported,":[16],"together":[17],"with":[18,135,141],"their":[19,46,172],"anion":[20,47,164,169],"recognition":[21,165],"properties":[22],"as":[23,82,112],"determined":[24],"by":[25,114,119,132],"H":[27,76],"NMR":[28],"UV\u2013vis":[30],"titration":[31],"studies":[32],"conducted":[33],"in":[34,45,69,117,144],"a":[35,115,120],"dimethyl":[36],"sulfoxide":[37],"solution":[38],"X-ray":[40,153],"crystallographic":[41],"analyses.":[42],"Notable":[43],"differences":[44],"affinity":[48,118],"selectivity":[50],"were":[51,148],"observed":[52],"for":[53,72,108],"these":[54],"two":[55],"macrocyclic":[56],"receptors.":[57],"In":[58,91],"particular,":[59],"thioamide-bearing":[60],"demonstrated":[63],"nearly":[64],"20-":[65],"30-fold":[67],"improvement":[68],"affinities":[71],"PhCOO":[73],"\u2013":[74,110,137,143],"PO":[78],"4":[79],"\u2013,":[80],"respectively,":[81],"compared":[83],"to":[84,104],"those":[85],"of":[86,95,122,167],"amide-containing":[87],".":[90],"contrast,":[92],"the":[93,100,127,145,162],"conversion":[94],"amides":[96],"into":[97,161],"thioamides":[98],"within":[99],"discussed":[101],"macrocycles":[102],"proved":[103],"be":[105],"exceptionally":[106],"unfavorable":[107],"AcO":[109,142],"binding,":[111],"supported":[113],"reduction":[116],"factor":[121],"at":[123],"least":[124],"27.":[125],"Moreover,":[126],"1:1":[128],"binding":[129],"complexes":[130],"formed":[131],"Cl":[136],"solid":[146],"state":[147],"unambiguously":[149],"confirmed":[150],"via":[151],"single-crystal":[152],"diffraction":[154],"analysis.":[155],"These":[156],"findings":[157],"provide":[158],"deeper":[159],"insight":[160],"contrasting":[163],"behaviors":[166],"thioamide-based":[168],"receptors":[170],"versus":[171],"amide":[173],"counterparts.":[174]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-03-28T00:00:00"}