{"id":"https://openalex.org/W7141541950","doi":"https://doi.org/10.1016/j.matdes.2026.115898","title":"Photothermal-promoted calcium influx-regulated phenotypic transformation of VSMCs and free radical scavenging-mediated endothelialization repair for the prevention of in-stent restenosis","display_name":"Photothermal-promoted calcium influx-regulated phenotypic transformation of VSMCs and free radical scavenging-mediated endothelialization repair for the prevention of in-stent restenosis","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141541950","doi":"https://doi.org/10.1016/j.matdes.2026.115898"},"language":"en","primary_location":{"id":"doi:10.1016/j.matdes.2026.115898","doi":"https://doi.org/10.1016/j.matdes.2026.115898","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.matdes.2026.115898","pdf_url":null,"source":{"id":"https://openalex.org/S8792693","display_name":"Materials & Design","issn_l":"0264-1275","issn":["0264-1275","1873-4197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-3","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials & Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.matdes.2026.115898","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130808911","display_name":"Ying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Department of Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130778334","display_name":"Yadan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadan Yang","raw_affiliation_strings":["Department of Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Guo","raw_affiliation_strings":["School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong 226001, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong 226001, Jiangsu, China","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124761700","display_name":"Xuan Yi","orcid":"https://orcid.org/0000-0002-5287-6608","observed_orcids":["https://orcid.org/0000-0002-5287-6608"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuan Yi","raw_affiliation_strings":["School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong 226001, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-5287-6608","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong 226001, Jiangsu, China","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"last","author":{"id":null,"display_name":"Chen Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Huang","raw_affiliation_strings":["Department of Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5124761700"],"corresponding_institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20178664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"265","issue":null,"first_page":"115898","last_page":"115898"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-stent-restenosis","display_name":"in-stent restenosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.7009999752044678},{"id":"https://openalex.org/keywords/phenotypic-change","display_name":"phenotypic change","score":0.7089999914169312},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.7059999704360962},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7960000038146973},{"id":"https://openalex.org/keywords/polydopamine","display_name":"polydopamine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.8100000023841858},{"id":"https://openalex.org/keywords/stent-coating","display_name":"stent coating","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.9549999833106995},{"id":"https://openalex.org/keywords/endothelialization","display_name":"endothelialization","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bare-metal-stents","display_name":"bare-metal stents","score":0.8090000152587891},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.7919999957084656},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/laser-irradiation","display_name":"laser irradiation","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.8281999826431274},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.7039999961853027},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7009999752044678},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6115999817848206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4945000112056732},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48890000581741333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3589000105857849},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34599998593330383},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3043000102043152},{"id":"https://openalex.org/C2994533308","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary artery calcium","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2705000042915344},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.26460000872612}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.matdes.2026.115898","doi":"https://doi.org/10.1016/j.matdes.2026.115898","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.matdes.2026.115898","pdf_url":null,"source":{"id":"https://openalex.org/S8792693","display_name":"Materials & Design","issn_l":"0264-1275","issn":["0264-1275","1873-4197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-3","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials & Design","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.matdes.2026.115898","doi":"https://doi.org/10.1016/j.matdes.2026.115898","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.matdes.2026.115898","pdf_url":null,"source":{"id":"https://openalex.org/S8792693","display_name":"Materials & Design","issn_l":"0264-1275","issn":["0264-1275","1873-4197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-3","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials & Design","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7316977381706238,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8992343024","display_name":null,"funder_award_id":"82170514","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1661774341","https://openalex.org/W1974175370","https://openalex.org/W1992152105","https://openalex.org/W2006717078","https://openalex.org/W2038550664","https://openalex.org/W2039881470","https://openalex.org/W2119470649","https://openalex.org/W2144979976","https://openalex.org/W2151247869","https://openalex.org/W2168405837","https://openalex.org/W2172082373","https://openalex.org/W2274924551","https://openalex.org/W2322562148","https://openalex.org/W2523950829","https://openalex.org/W2539237186","https://openalex.org/W2769245037","https://openalex.org/W2785667211","https://openalex.org/W2788009719","https://openalex.org/W2796711492","https://openalex.org/W2883552344","https://openalex.org/W2885979628","https://openalex.org/W2889322279","https://openalex.org/W2911786164","https://openalex.org/W2972895312","https://openalex.org/W2980075554","https://openalex.org/W2980896844","https://openalex.org/W3005301545","https://openalex.org/W3011048385","https://openalex.org/W3023230320","https://openalex.org/W3084166280","https://openalex.org/W3087136340","https://openalex.org/W3094528040","https://openalex.org/W3191990332","https://openalex.org/W4200455803","https://openalex.org/W4309336551","https://openalex.org/W4380050547","https://openalex.org/W4398148039"],"related_works":[],"abstract_inverted_index":{"\u2022":[0,31,54],"The":[1,32],"vascular":[2,69,182],"stent":[3,38,86,135,150,163,189,237,251,261,277],"could":[4,39,63,190,224,244],"be":[5,245],"coated":[6,131],"by":[7,234,248],"PDA-Au":[8],"nanostructure":[9],"and":[10,23,92,123,141,194,211,252,262],"then":[11,142],"complexed":[12,143],"with":[13,57,106,137,144,219],"Ca":[14,25,60,145,192,195],"2+":[15,26,61,146,193,196],",":[16,62,147],"resulting":[17,205],"in":[18,36,46,206],"the":[19,24,37,47,51,58,65,80,89,96,107,112,132,152,165,171,207,226,239,276],"photo-thermal":[20],"conversion":[21],"capability":[22],"release":[27,191],"capacity":[28,223],"of":[29,34,68,82,98,121,154,173,181,215,236,242,268,280],"stent.":[30],"present":[33],"PDA":[35,218],"effectively":[40,246],"eliminate":[41],"superfluous":[42],"reactive":[43],"oxygen":[44],"species":[45],"environment":[48],"to":[49,76,199],"promote":[50,64],"endothelialization":[52,227],"repair.":[53,228],"Photothermal,":[55],"together":[56],"released":[59],"phenotypic":[66],"transformation":[67],"smooth":[70,183],"muscle":[71,184],"cells":[72,185],"from":[73],"synthetic":[74,213],"phenotype":[75,210,214],"contractile":[77,209],"phenotype,":[78],"realizing":[79],"prevention":[81,153,267],"in-stent":[83,113],"restenosis.":[84],"Vascular":[85],"implantation":[87,235,278],"is":[88],"most":[90],"direct":[91],"effective":[93],"approach":[94],"for":[95,151,274],"treatment":[97,279],"atherosclerosis-related":[99],"cardiovascular":[100],"diseases.":[101,282],"However,":[102],"although":[103],"various":[104],"stents":[105],"specific":[108],"features":[109],"are":[110],"developed,":[111],"restenosis":[114],"(ISR)":[115],"still":[116],"significantly":[117],"impacts":[118],"long-term":[119],"prognosis":[120],"patients":[122],"imposes":[124],"a":[125,259],"substantial":[126],"medical":[127],"burden.":[128],"Herein,":[129],"we":[130],"bare":[133],"metal":[134],"(BMS)":[136],"polydopamine-Au":[138],"(PDA-Au)":[139],"nano-composite":[140],"obtaining":[148],"BMS@PDA-Au/Ca":[149,162,188,250],"ISR":[155,232],"after":[156],"implantation.":[157],"Under":[158],"808-nm":[159],"laser":[160,253],"irradiation,":[161],"increased":[164],"temperature":[166],"around":[167],"it,":[168],"further":[169],"inducing":[170],"up-expression":[172],"transient":[174],"receptor":[175],"potential":[176],"vanilloid":[177],"subfamily":[178],"1":[179],"(TRPV1)":[180],"(VSMCs).":[186],"Moreover,":[187],"was":[197],"promoted":[198],"enter":[200],"into":[201,238],"VSMCs":[202],"through":[203],"TRPV1,":[204],"enhanced":[208],"decreased":[212],"VSMCs.":[216],"Additionally,":[217],"free":[220],"radical":[221],"scavenging":[222],"accelerate":[225],"In":[229],"this":[230,256],"way,":[231],"caused":[233],"carotid":[240],"arteries":[241],"rabbits":[243],"prevented":[247],"using":[249],"irradiation.":[254],"Therefore,":[255],"study":[257],"constructed":[258],"novel":[260],"explored":[263],"its":[264],"effect":[265],"on":[266],"ISR,":[269],"providing":[270],"an":[271],"innovative":[272],"strategy":[273],"optimizing":[275],"atherosclerotic":[281]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-03-28T00:00:00"}