{"id":"https://openalex.org/W7141509870","doi":"https://doi.org/10.1371/journal.pone.0343939","title":"Contrasting effects of SARS-CoV-2 vaccination vs. infection on antibody and TCR repertoires","display_name":"Contrasting effects of SARS-CoV-2 vaccination vs. infection on antibody and TCR repertoires","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7141509870","doi":"https://doi.org/10.1371/journal.pone.0343939","pmid":"https://pubmed.ncbi.nlm.nih.gov/41894441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13028327"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0343939","doi":"https://doi.org/10.1371/journal.pone.0343939","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0343939","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0343939&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0343939&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030529470","display_name":"Jasper Braun","orcid":"https://orcid.org/0000-0003-1250-4399","observed_orcids":["https://orcid.org/0000-0003-1250-4399"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasper Braun","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019856418","display_name":"Elliot D. Hill","orcid":"https://orcid.org/0009-0004-1987-3749","observed_orcids":["https://orcid.org/0009-0004-1987-3749"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot D. Hill","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110990315","display_name":"Elisa Contreras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisa Contreras","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040095485","display_name":"Michie Yasuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michie Yasuda","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008911220","display_name":"Alexandra Morgan","orcid":"https://orcid.org/0000-0001-7787-0547","observed_orcids":["https://orcid.org/0000-0001-7787-0547"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Morgan","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":"https://orcid.org/0000-0001-7787-0547","affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060918523","display_name":"Sarah Ditelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Ditelberg","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111037874","display_name":"Ethan Winter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Winter","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069818833","display_name":"Cody J. Callahan","orcid":"https://orcid.org/0000-0002-0267-7096","observed_orcids":["https://orcid.org/0000-0002-0267-7096"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cody Callahan","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113087359","display_name":"Gabrielle Mazzoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabrielle Mazzoni","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011940344","display_name":"Andrea Kirmaier","orcid":"https://orcid.org/0000-0001-7206-7640","observed_orcids":["https://orcid.org/0000-0001-7206-7640"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Kirmaier","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066995427","display_name":"Ghee Rye Lee","orcid":"https://orcid.org/0000-0001-6614-0223","observed_orcids":["https://orcid.org/0000-0001-6614-0223"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghee Rye Lee","raw_affiliation_strings":["Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013891322","display_name":"Hamid Mirebrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid Mirebrahim","raw_affiliation_strings":["Roche Sequencing Solutions, Pleasanton, CA 94588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Sequencing Solutions, Pleasanton, CA 94588, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049787538","display_name":"Hosseinali Asgharian","orcid":"https://orcid.org/0000-0001-7085-5045","observed_orcids":["https://orcid.org/0000-0001-7085-5045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hosseinali Asgharian","raw_affiliation_strings":["Roche Sequencing Solutions, Pleasanton, CA 94588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Sequencing Solutions, Pleasanton, CA 94588, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012726911","display_name":"Dilduz Telman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dilduz Telman","raw_affiliation_strings":["Roche Sequencing Solutions, Pleasanton, CA 94588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Sequencing Solutions, Pleasanton, CA 94588, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007604692","display_name":"Ai-ris Yonekura Collier","orcid":"https://orcid.org/0000-0002-8539-3960","observed_orcids":["https://orcid.org/0000-0002-8539-3960"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ai-Ris Y. Collier","raw_affiliation_strings":["Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts","Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts","Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":"https://orcid.org/0000-0002-8539-3960","affiliations":[{"raw_affiliation_string":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054247332","display_name":"Dan H. Barouch","orcid":"https://orcid.org/0000-0001-5127-4659","observed_orcids":["https://orcid.org/0000-0001-5127-4659"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan H. Barouch","raw_affiliation_strings":["Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts","Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts","Harvard Medical School, Boston, MA 02215, USA","Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036797204","display_name":"Stefan F. Riedel","orcid":"https://orcid.org/0000-0002-0573-4957","observed_orcids":["https://orcid.org/0000-0002-0573-4957"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Riedel","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680733","display_name":"Sanjucta Dutta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjucta Dutta","raw_affiliation_strings":["Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112258904","display_name":"Florian Rubelt","orcid":"https://orcid.org/0000-0001-7593-5511","observed_orcids":["https://orcid.org/0000-0001-7593-5511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florian Rubelt","raw_affiliation_strings":["Roche Sequencing Solutions, Pleasanton, CA 94588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Sequencing Solutions, Pleasanton, CA 94588, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076537498","display_name":"Ramy Arnaout","orcid":"https://orcid.org/0000-0001-6955-9310","observed_orcids":["https://orcid.org/0000-0001-6955-9310"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramy Arnaout","raw_affiliation_strings":["Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Division of Clinical Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076537498"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"3","first_page":"e0343939","last_page":"e0343939"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.9559999704360962},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9240000247955322},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cdr3","display_name":"CDR3","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.5440000295639038},{"id":"https://openalex.org/keywords/clonal-selection","display_name":"clonal selection","score":0.7490000128746033},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.7311000227928162},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7192000150680542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6621999740600586},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6554999947547913},{"id":"https://openalex.org/C81566733","wikidata":"https://www.wikidata.org/wiki/Q1047544","display_name":"Hypervariable region","level":3,"score":0.6500999927520752},{"id":"https://openalex.org/C2910693471","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody Repertoire","level":3,"score":0.6197999715805054},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6162999868392944},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.45680001378059387},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40610000491142273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.37540000677108765},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3221000134944916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31290000677108765},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.28279998898506165},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.25540000200271606},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25519999861717224}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0343939","doi":"https://doi.org/10.1371/journal.pone.0343939","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0343939","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0343939&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"doi:10.1101/2023.09.08.556703","doi":"https://doi.org/10.1101/2023.09.08.556703","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.09.08.556703","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/09/11/2023.09.08.556703.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13028327","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13028327/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13028327/pdf/pone.0343939.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:39829775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39829775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41894441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41894441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11741250","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11741250/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11306403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11741250","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:25c1dead19854d968c894f314e20dad3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/25c1dead19854d968c894f314e20dad3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 21, Iss 3, p e0343939 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0343939","doi":"https://doi.org/10.1371/journal.pone.0343939","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0343939","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0343939&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2730243414","display_name":"An Integrated Multilevel Modeling Framework for Repertoire-Based Diagnostics","funder_award_id":"R01AI148747","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320312826","display_name":"Massachusetts Life Sciences Center","ror":"https://ror.org/033km2469"},{"id":"https://openalex.org/F4320316545","display_name":"San Diego Supercomputer Center","ror":"https://ror.org/04mg3nk07"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7141509870.pdf","grobid_xml":"https://content.openalex.org/works/W7141509870.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1520434148","https://openalex.org/W2000445173","https://openalex.org/W2057780602","https://openalex.org/W2069644412","https://openalex.org/W2112330417","https://openalex.org/W2130479394","https://openalex.org/W2148100754","https://openalex.org/W2188890094","https://openalex.org/W2233981766","https://openalex.org/W2887700639","https://openalex.org/W2894531697","https://openalex.org/W2926687552","https://openalex.org/W2951070274","https://openalex.org/W3020331344","https://openalex.org/W3024602798","https://openalex.org/W3034425032","https://openalex.org/W3034816694","https://openalex.org/W3036199133","https://openalex.org/W3049166744","https://openalex.org/W3086119226","https://openalex.org/W3090344202","https://openalex.org/W3111287171","https://openalex.org/W3128019209","https://openalex.org/W3136200177","https://openalex.org/W3136437538","https://openalex.org/W3136616180","https://openalex.org/W3139321392","https://openalex.org/W3165586542","https://openalex.org/W3172231205","https://openalex.org/W3175655926","https://openalex.org/W3183923345","https://openalex.org/W3189387362","https://openalex.org/W3193968841","https://openalex.org/W3197558366","https://openalex.org/W3202955428","https://openalex.org/W3203460516","https://openalex.org/W4200276175","https://openalex.org/W4206111746","https://openalex.org/W4210272290","https://openalex.org/W4210792795","https://openalex.org/W4224067369","https://openalex.org/W4225371391","https://openalex.org/W4229026561","https://openalex.org/W4280510743","https://openalex.org/W4291019297","https://openalex.org/W4291624945","https://openalex.org/W4291652282","https://openalex.org/W4311330242","https://openalex.org/W4317037527","https://openalex.org/W4321600864","https://openalex.org/W4372782530","https://openalex.org/W4378349019","https://openalex.org/W4407668627"],"related_works":["https://openalex.org/W4221047175","https://openalex.org/W4288429849","https://openalex.org/W4224232618","https://openalex.org/W7165040740","https://openalex.org/W4226096713","https://openalex.org/W4313405726","https://openalex.org/W4414742851","https://openalex.org/W4390651567","https://openalex.org/W4200087343","https://openalex.org/W4206108557"],"abstract_inverted_index":{"Antibodies":[0],"and":[1,11,16,28,60,72,86,93,118,173,191,198,203,208,216,222,225],"helper":[2],"T":[3],"cells":[4],"play":[5],"important":[6],"roles":[7],"in":[8,64,75,108,212],"SARS-CoV-2":[9,40,196],"infection":[10,119,197],"vaccination.":[12],"We":[13,52,101,134,205],"sequenced":[14,53],"B-":[15,71,190],"T-cell":[17,73,192],"receptor":[18],"repertoires":[19,36],"(BCR/TCR)":[20],"from":[21,66,96,180],"the":[22,150],"blood":[23],"of":[24,34,162],"251":[25],"infectees,":[26],"vaccinees,":[27],"controls":[29],"to":[30,141,169,195,214],"investigate":[31],"whether":[32],"features":[33],"these":[35,229],"could":[37],"predict":[38],"subjects'":[39,97],"neutralizing":[41],"antibody":[42],"titer":[43],"(NAbs),":[44],"as":[45,147,149],"measured":[46],"by":[47],"enzyme-linked":[48],"immunosorbent":[49],"assay":[50],"(ELISA).":[51],"recombined":[54,125],"immunoglobulin":[55],"heavy-chain":[56],"(IGH),":[57],"TCR\u03b2":[58],"(TRB),":[59],"TCR\u03b4":[61],"(TRD)":[62],"genes":[63],"parallel":[65],"all":[67],"subjects,":[68],"including":[69],"select":[70],"subsets":[74],"most":[76],"cases,":[77],"with":[78,91,122],"a":[79,159],"focus":[80],"on":[81],"their":[82],"hypervariable":[83],"CDR3":[84],"regions,":[85],"correlated":[87],"this":[88,181],"AIRRseq":[89],"data":[90],"demographics":[92],"clinical":[94],"findings":[95],"electronic":[98],"health":[99],"records.":[100],"found":[102,115,135],"that":[103,116,130,136,189],"age":[104],"affected":[105],"NAb":[106],"levels":[107],"vaccinees":[109],"but":[110],"not":[111,174],"infectees.":[112],"Intriguingly,":[113],"we":[114],"vaccination":[117,199],"are":[120,200],"associated":[121],"longer":[123],"non-productively":[124],"IGHs,":[126],"suggesting":[127],"an":[128],"effect":[129],"precedes":[131],"clonal":[132],"selection.":[133],"TRB":[137],"repertoires'":[138],"binding":[139],"capacity":[140],"known":[142],"SARS-CoV-2-specific":[143],"CD4+":[144],"TRBs":[145],"performs":[146],"well":[148,185],"best":[151],"hand-tuned":[152],"approximate":[153],"or":[154],"\"fuzzy\"":[155],"matching":[156],"at":[157],"predicting":[158],"protective":[160],"level":[161],"NAbs,":[163],"while":[164],"also":[165],"being":[166],"more":[167],"robust":[168],"repertoire":[170,220],"sample":[171],"size":[172],"requiring":[175],"hand-tuning.":[176],"The":[177],"overall":[178],"conclusion":[179],"large,":[182],"unbiased,":[183],"clinically":[184],"annotated":[186],"dataset":[187],"is":[188],"adaptive":[193],"responses":[194],"surprising,":[201],"subtle,":[202],"diffuse.":[204],"discuss":[206],"methodological":[207],"statistical":[209],"challenges":[210],"faced":[211],"attempting":[213],"define":[215],"quantify":[217],"such":[218],"strong-but-diffuse":[219],"signatures":[221],"present":[223],"tools":[224],"strategies":[226],"for":[227],"addressing":[228],"challenges.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-03-28T00:00:00"}
